Published in Mol Cell on February 26, 2010
Networking with AKAPs: context-dependent regulation of anchored enzymes. Mol Interv (2010) 1.69
Creating order from chaos: cellular regulation by kinase anchoring. Annu Rev Pharmacol Toxicol (2012) 1.44
Signalling scaffolds and local organization of cellular behaviour. Nat Rev Mol Cell Biol (2015) 1.35
Protein kinase C pharmacology: refining the toolbox. Biochem J (2013) 1.27
Architecture and dynamics of an A-kinase anchoring protein 79 (AKAP79) signaling complex. Proc Natl Acad Sci U S A (2011) 1.23
Regulation of protein kinase D1 activity. Mol Pharmacol (2011) 1.13
Local control of TRPV4 channels by AKAP150-targeted PKC in arterial smooth muscle. J Gen Physiol (2014) 1.10
Cardiac actions of protein kinase C isoforms. Physiology (Bethesda) (2012) 1.08
Quantitative properties and receptor reserve of the DAG and PKC branch of G(q)-coupled receptor signaling. J Gen Physiol (2013) 1.07
Signal integration through blending, bolstering and bifurcating of intracellular information. Nat Struct Mol Biol (2010) 1.07
STK33 kinase inhibitor BRD-8899 has no effect on KRAS-dependent cancer cell viability. Proc Natl Acad Sci U S A (2012) 1.06
Emergence and natural selection of drug-resistant prions. Mol Biosyst (2010) 1.05
Coordinated signal integration at the M-type potassium channel upon muscarinic stimulation. EMBO J (2012) 1.02
AKAP signaling complexes: pointing towards the next generation of therapeutic targets? Trends Pharmacol Sci (2013) 0.98
Effective inhibitors of the essential kinase PknB and their potential as anti-mycobacterial agents. Tuberculosis (Edinb) (2011) 0.98
Gravin is a transitory effector of polo-like kinase 1 during cell division. Mol Cell (2012) 0.96
Active site inhibitors protect protein kinase C from dephosphorylation and stabilize its mature form. J Biol Chem (2011) 0.96
ATP competitive protein kinase C inhibitors demonstrate distinct state-dependent inhibition. PLoS One (2011) 0.90
Ca2+/calmodulin-dependent protein kinase II inhibitors disrupt AKAP79-dependent PKC signaling to GluA1 AMPA receptors. J Biol Chem (2010) 0.89
Organizing signal transduction through A-kinase anchoring proteins (AKAPs). FEBS J (2010) 0.88
Local cAMP signaling in disease at a glance. J Cell Sci (2013) 0.87
Isoform selectivity of adenylyl cyclase inhibitors: characterization of known and novel compounds. J Pharmacol Exp Ther (2013) 0.86
Serotonin 5-HT2C receptor-mediated inhibition of the M-current in hypothalamic POMC neurons. Am J Physiol Endocrinol Metab (2012) 0.86
Isozyme-specific interaction of protein kinase Cδ with mitochondria dissected using live cell fluorescence imaging. J Biol Chem (2012) 0.86
Protein kinase Cδ-mediated phosphorylation of Connexin43 gap junction channels causes movement within gap junctions followed by vesicle internalization and protein degradation. J Biol Chem (2014) 0.85
Protein kinase C-{delta} regulates the subcellular localization of Shc in H2O2-treated cardiomyocytes. Am J Physiol Cell Physiol (2010) 0.84
Bigger, better, faster: principles and models of AKAP anchoring protein signaling. J Cardiovasc Pharmacol (2011) 0.83
The case of the disappearing drug target. Mol Cell (2010) 0.82
Gain-of-function mutations in protein kinase Cα (PKCα) may promote synaptic defects in Alzheimer's disease. Sci Signal (2016) 0.81
Spatiotemporal dynamics of phosphorylation in lipid second messenger signaling. Mol Cell Proteomics (2013) 0.81
Estrogen signaling in hypothalamic circuits controlling reproduction. Brain Res (2010) 0.81
Shedding light on local kinase activation. BMC Biol (2012) 0.81
Protein Kinase A Opposes the Phosphorylation-dependent Recruitment of Glycogen Synthase Kinase 3β to A-kinase Anchoring Protein 220. J Biol Chem (2015) 0.80
AKAP12 and AKAP5 form higher-order hetero-oligomers. J Mol Signal (2011) 0.80
Peptide structure stabilization by membrane anchoring and its general applicability to the development of potent cell-permeable inhibitors. Chembiochem (2011) 0.80
Resveratrol Enhances Neuroplastic Changes, Including Hippocampal Neurogenesis, and Memory in Balb/C Mice at Six Months of Age. PLoS One (2015) 0.80
Protein Kinase C (PKC)ζ Pseudosubstrate Inhibitor Peptide Promiscuously Binds PKC Family Isoforms and Disrupts Conventional PKC Targeting and Translocation. Mol Pharmacol (2015) 0.79
Anchoring proteins encounter mitotic kinases. Cell Cycle (2013) 0.79
A-kinase Anchoring Protein 79/150 Recruits Protein Kinase C to Phosphorylate Roundabout Receptors. J Biol Chem (2015) 0.79
Modulation of Kv7 channels and excitability in the brain. Cell Mol Life Sci (2016) 0.78
Protein Scaffolds Control Localized Protein Kinase Cζ Activity. J Biol Chem (2016) 0.77
Scaffold state switching amplifies, accelerates, and insulates protein kinase C signaling. J Biol Chem (2013) 0.77
Protein kinase d inhibitors uncouple phosphorylation from activity by promoting agonist-dependent activation loop phosphorylation. Chem Biol (2014) 0.77
Protein kinase C mechanisms that contribute to cardiac remodelling. Clin Sci (Lond) (2016) 0.76
AKAP150 participates in calcineurin/NFAT activation during the down-regulation of voltage-gated K(+) currents in ventricular myocytes following myocardial infarction. Cell Signal (2015) 0.76
Adrenergic regulation of HCN4 channel requires protein association with β2-adrenergic receptor. J Biol Chem (2012) 0.76
M-current preservation contributes to anticonvulsant effects of valproic acid. J Clin Invest (2015) 0.76
"Slow" Voltage-Dependent Inactivation of CaV2.2 Calcium Channels Is Modulated by the PKC Activator Phorbol 12-Myristate 13-Acetate (PMA). PLoS One (2015) 0.75
Spatio-Temporal Regulation of PKC Isoforms Imparts Signaling Specificity. Front Immunol (2016) 0.75
CLEAVAGE ALTERS THE MOLECULAR DETERMINANTS OF PROTEIN KINASE C-δ CATALYTIC ACTIVITY. Mol Cell Biol (2017) 0.75
Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J (2000) 22.23
Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome. N Engl J Med (2001) 11.88
AKAP signalling complexes: focal points in space and time. Nat Rev Mol Cell Biol (2004) 6.97
Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1. Science (1998) 5.62
Inhibitor hijacking of Akt activation. Nat Chem Biol (2009) 4.91
Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm. Biochem J (2003) 4.65
Recovery from muscarinic modulation of M current channels requires phosphatidylinositol 4,5-bisphosphate synthesis. Neuron (2002) 4.58
A genetically encoded fluorescent reporter reveals oscillatory phosphorylation by protein kinase C. J Cell Biol (2003) 4.38
Cell signaling in space and time: where proteins come together and when they're apart. Science (2009) 3.88
Localized effects of cAMP mediated by distinct routes of protein kinase A. Physiol Rev (2004) 3.65
PKC maturation is promoted by nucleotide pocket occupation independently of intrinsic kinase activity. Nat Struct Mol Biol (2009) 3.37
Association of protein kinase A and protein phosphatase 2B with a common anchoring protein. Science (1995) 3.34
Coordination of three signaling enzymes by AKAP79, a mammalian scaffold protein. Science (1996) 3.28
cAMP-dependent regulation of cardiac L-type Ca2+ channels requires membrane targeting of PKA and phosphorylation of channel subunits. Neuron (1997) 3.21
Distinct enzyme combinations in AKAP signalling complexes permit functional diversity. Nat Cell Biol (2005) 2.84
Protein kinase C is regulated in vivo by three functionally distinct phosphorylations. Curr Biol (1995) 2.83
Regulation of conventional protein kinase C isozymes by phosphoinositide-dependent kinase 1 (PDK-1). Curr Biol (1999) 2.74
Regulation of GluR1 by the A-kinase anchoring protein 79 (AKAP79) signaling complex shares properties with long-term depression. J Neurosci (2002) 2.31
Localization of the cAMP-dependent protein kinase to the postsynaptic densities by A-kinase anchoring proteins. Characterization of AKAP 79. J Biol Chem (1992) 2.23
AKAP150 signaling complex promotes suppression of the M-current by muscarinic agonists. Nat Neurosci (2003) 2.08
Dynamic regulation of cAMP synthesis through anchored PKA-adenylyl cyclase V/VI complexes. Mol Cell (2006) 2.05
Membrane-targeting sequences on AKAP79 bind phosphatidylinositol-4, 5-bisphosphate. EMBO J (1998) 2.01
Targeting protein kinase C activity reporter to discrete intracellular regions reveals spatiotemporal differences in agonist-dependent signaling. J Biol Chem (2006) 1.99
Loss of AKAP150 perturbs distinct neuronal processes in mice. Proc Natl Acad Sci U S A (2008) 1.96
Assembly of an A kinase-anchoring protein-beta(2)-adrenergic receptor complex facilitates receptor phosphorylation and signaling. Curr Biol (2000) 1.90
Inhibition of KCNQ1-4 potassium channels expressed in mammalian cells via M1 muscarinic acetylcholine receptors. J Physiol (2000) 1.79
Circumventing resistance to kinase-inhibitor therapy. N Engl J Med (2006) 1.75
AKAP150 is required for stuttering persistent Ca2+ sparklets and angiotensin II-induced hypertension. Circ Res (2008) 1.72
Proinflammatory mediators modulate the heat-activated ion channel TRPV1 via the scaffolding protein AKAP79/150. Neuron (2008) 1.61
AKAP-Lbc mobilizes a cardiac hypertrophy signaling pathway. Mol Cell (2008) 1.57
Regulation of the AKAP79-protein kinase C interaction by Ca2+/Calmodulin. J Biol Chem (1997) 1.43
Structure of the catalytic domain of human protein kinase C beta II complexed with a bisindolylmaleimide inhibitor. Biochemistry (2006) 1.39
The carboxyl terminus of protein kinase c provides a switch to regulate its interaction with the phosphoinositide-dependent kinase, PDK-1. J Biol Chem (2001) 1.36
Spatial restriction of PDK1 activation cascades by anchoring to mAKAPalpha. Mol Cell (2005) 1.29
The phosphoinositide-dependent kinase, PDK-1, phosphorylates conventional protein kinase C isozymes by a mechanism that is independent of phosphoinositide 3-kinase. J Biol Chem (2001) 1.27
Reversible exposure of the pseudosubstrate domain of protein kinase C by phosphatidylserine and diacylglycerol. J Biol Chem (1992) 1.27
Mechanism of A-kinase-anchoring protein 79 (AKAP79) and protein kinase C interaction. Biochem J (1999) 1.26
Protein kinase C is not necessary for peptide-induced suppression of M current or for desensitization of the peptide receptors. Proc Natl Acad Sci U S A (1989) 1.22
Partitioning of lipid-modified monomeric GFPs into membrane microdomains of live cells. Science (2002) 18.89
PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth. Mol Cell (2005) 8.22
AKAP signalling complexes: focal points in space and time. Nat Rev Mol Cell Biol (2004) 6.97
PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms. Mol Cell (2007) 6.00
The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C. EMBO J (2008) 4.49
A genetically encoded fluorescent reporter reveals oscillatory phosphorylation by protein kinase C. J Cell Biol (2003) 4.38
The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways. Nature (2005) 3.82
Ubiquitination regulates PSD-95 degradation and AMPA receptor surface expression. Neuron (2003) 3.62
Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. Curr Biol (2004) 3.45
Protein phosphorylation in signaling--50 years and counting. Trends Biochem Sci (2005) 3.19
The prevalence of cirrhosis and hepatocellular carcinoma in patients with human immunodeficiency virus infection. Hepatology (2013) 2.98
Distinct enzyme combinations in AKAP signalling complexes permit functional diversity. Nat Cell Biol (2005) 2.84
GATA2 deficiency: a protean disorder of hematopoiesis, lymphatics, and immunity. Blood (2013) 2.82
Phosphorylation of WAVE1 regulates actin polymerization and dendritic spine morphology. Nature (2006) 2.77
Molecular basis of AKAP specificity for PKA regulatory subunits. Mol Cell (2006) 2.33
Regulation of GluR1 by the A-kinase anchoring protein 79 (AKAP79) signaling complex shares properties with long-term depression. J Neurosci (2002) 2.31
AKAP signaling complexes: getting to the heart of the matter. Trends Mol Med (2006) 2.29
AKAP mediated signal transduction. Annu Rev Pharmacol Toxicol (2002) 2.26
The phosphatase PHLPP controls the cellular levels of protein kinase C. J Biol Chem (2007) 2.24
Cost-effectiveness and population outcomes of general population screening for hepatitis C. Clin Infect Dis (2012) 2.19
AKAP150 signaling complex promotes suppression of the M-current by muscarinic agonists. Nat Neurosci (2003) 2.08
Dynamic regulation of cAMP synthesis through anchored PKA-adenylyl cyclase V/VI complexes. Mol Cell (2006) 2.05
A-kinase anchoring proteins take shape. Curr Opin Cell Biol (2007) 2.03
An anchored PKA and PDE4 complex regulates subplasmalemmal cAMP dynamics. EMBO J (2006) 1.99
Targeting protein kinase C activity reporter to discrete intracellular regions reveals spatiotemporal differences in agonist-dependent signaling. J Biol Chem (2006) 1.99
A WAVE-1 and WRP signaling complex regulates spine density, synaptic plasticity, and memory. J Neurosci (2007) 1.97
Loss of AKAP150 perturbs distinct neuronal processes in mice. Proc Natl Acad Sci U S A (2008) 1.96
Spatio-temporal dynamics of protein kinase B/Akt signaling revealed by a genetically encoded fluorescent reporter. J Biol Chem (2004) 1.96
Retinal detachment and prophylaxis in type 1 Stickler syndrome. Ophthalmology (2007) 1.95
PHLPP-1 negatively regulates Akt activity and survival in the heart. Circ Res (2010) 1.93
Rab32 is an A-kinase anchoring protein and participates in mitochondrial dynamics. J Cell Biol (2002) 1.93
PHLiPPing the switch on Akt and protein kinase C signaling. Trends Endocrinol Metab (2008) 1.92
A-kinase anchoring proteins: from protein complexes to physiology and disease. IUBMB Life (2009) 1.89
Loss of WAVE-1 causes sensorimotor retardation and reduced learning and memory in mice. Proc Natl Acad Sci U S A (2003) 1.86
Mapping the protein phosphatase-2B anchoring site on AKAP79. Binding and inhibition of phosphatase activity are mediated by residues 315-360. J Biol Chem (2002) 1.86
The where's and when's of kinase anchoring. Trends Biochem Sci (2006) 1.83
AKAP-Lbc nucleates a protein kinase D activation scaffold. Mol Cell (2004) 1.81
Bioinformatic design of A-kinase anchoring protein-in silico: a potent and selective peptide antagonist of type II protein kinase A anchoring. Proc Natl Acad Sci U S A (2003) 1.80
The WRP component of the WAVE-1 complex attenuates Rac-mediated signalling. Nat Cell Biol (2002) 1.77
Identification of PHLPP1 as a tumor suppressor reveals the role of feedback activation in PTEN-mutant prostate cancer progression. Cancer Cell (2011) 1.74
A single residue in the C1 domain sensitizes novel protein kinase C isoforms to cellular diacylglycerol production. J Biol Chem (2006) 1.69
Networking with AKAPs: context-dependent regulation of anchored enzymes. Mol Interv (2010) 1.69
Compartmentalisation of phosphodiesterases and protein kinase A: opposites attract. FEBS Lett (2005) 1.66
Regulation of novel protein kinase C epsilon by phosphorylation. Biochem J (2002) 1.65
AKAP-Lbc enhances cyclic AMP control of the ERK1/2 cascade. Nat Cell Biol (2010) 1.64
AKAP150 contributes to enhanced vascular tone by facilitating large-conductance Ca2+-activated K+ channel remodeling in hyperglycemia and diabetes mellitus. Circ Res (2013) 1.59
Trafficking of L-type calcium channels mediated by the postsynaptic scaffolding protein AKAP79. J Biol Chem (2002) 1.58
AKAP-Lbc mobilizes a cardiac hypertrophy signaling pathway. Mol Cell (2008) 1.57
Prolonged incubation and extensive subculturing do not increase recovery of clinically significant microorganisms from standard automated blood cultures. Clin Infect Dis (2005) 1.57
Calcium-dependent regulation of protein kinase D revealed by a genetically encoded kinase activity reporter. J Biol Chem (2006) 1.56
Increased coupled gating of L-type Ca2+ channels during hypertension and Timothy syndrome. Circ Res (2010) 1.55
Signaling complexes: junctions on the intracellular information super highway. Curr Biol (2002) 1.54
Integrating cardiac PIP3 and cAMP signaling through a PKA anchoring function of p110γ. Mol Cell (2011) 1.52
The turn motif is a phosphorylation switch that regulates the binding of Hsp70 to protein kinase C. J Biol Chem (2002) 1.52
Delineation of type I protein kinase A-selective signaling events using an RI anchoring disruptor. J Biol Chem (2006) 1.48
Compartmentation of cyclic nucleotide signaling in the heart: the role of A-kinase anchoring proteins. Circ Res (2006) 1.48
PKA-phosphorylation of PDE4D3 facilitates recruitment of the mAKAP signalling complex. Biochem J (2004) 1.47
The chaperones Hsp90 and Cdc37 mediate the maturation and stabilization of protein kinase C through a conserved PXXP motif in the C-terminal tail. J Biol Chem (2008) 1.47
Full-length cardiac Na+/Ca2+ exchanger 1 protein is not phosphorylated by protein kinase A. Am J Physiol Cell Physiol (2011) 1.46
The life and death of protein kinase C. Curr Drug Targets (2008) 1.46
Increased membrane affinity of the C1 domain of protein kinase Cdelta compensates for the lack of involvement of its C2 domain in membrane recruitment. J Biol Chem (2005) 1.37
AKAP18 contains a phosphoesterase domain that binds AMP. J Mol Biol (2007) 1.31
Spatial restriction of PDK1 activation cascades by anchoring to mAKAPalpha. Mol Cell (2005) 1.29
AKAP79-mediated targeting of the cyclic AMP-dependent protein kinase to the beta1-adrenergic receptor promotes recycling and functional resensitization of the receptor. J Biol Chem (2006) 1.28
Protein kinase C pharmacology: refining the toolbox. Biochem J (2013) 1.27
An entirely specific type I A-kinase anchoring protein that can sequester two molecules of protein kinase A at mitochondria. Proc Natl Acad Sci U S A (2011) 1.27
Kinase- and phosphatase-anchoring proteins: harnessing the dynamic duo. Nat Cell Biol (2002) 1.27
The A-kinase anchoring protein Yotiao binds and regulates adenylyl cyclase in brain. Proc Natl Acad Sci U S A (2008) 1.27
Spinal phosphinositide 3-kinase-Akt-mammalian target of rapamycin signaling cascades in inflammation-induced hyperalgesia. J Neurosci (2011) 1.26
Association of an A-kinase-anchoring protein signaling scaffold with cadherin adhesion molecules in neurons and epithelial cells. Mol Biol Cell (2005) 1.24
Suppression of survival signalling pathways by the phosphatase PHLPP. FEBS J (2012) 1.23
A-kinase anchoring protein 79/150 facilitates the phosphorylation of GABA(A) receptors by cAMP-dependent protein kinase via selective interaction with receptor beta subunits. Mol Cell Neurosci (2003) 1.23
Architecture and dynamics of an A-kinase anchoring protein 79 (AKAP79) signaling complex. Proc Natl Acad Sci U S A (2011) 1.23
Cellular pharmacology of protein kinase Mζ (PKMζ) contrasts with its in vitro profile: implications for PKMζ as a mediator of memory. J Biol Chem (2012) 1.21
Protein phosphatase PHLPP1 controls the light-induced resetting of the circadian clock. Proc Natl Acad Sci U S A (2010) 1.20
Orchestration of synaptic plasticity through AKAP signaling complexes. Neuropharmacology (2004) 1.20
AKAP79 interacts with multiple adenylyl cyclase (AC) isoforms and scaffolds AC5 and -6 to alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA) receptors. J Biol Chem (2010) 1.19
Migratory songbirds disperse ticks across Canada, and first isolation of the Lyme disease spirochete, Borrelia burgdorferi, from the avian tick, Ixodes auritulus. J Parasitol (2005) 1.19
Rab32 modulates apoptosis onset and mitochondria-associated membrane (MAM) properties. J Biol Chem (2010) 1.19
mAKAP compartmentalizes oxygen-dependent control of HIF-1alpha. Sci Signal (2008) 1.16