PubRank

Jau-Shyong Hong

Author PubWeight™ 159.00‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Microglia-mediated neurotoxicity: uncovering the molecular mechanisms. Nat Rev Neurosci 2007 11.24
2 Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration. Glia 2007 5.67
3 Microglia and inflammation-mediated neurodegeneration: multiple triggers with a common mechanism. Prog Neurobiol 2005 4.96
4 Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's disease. FASEB J 2005 3.60
5 Role of microglia in inflammation-mediated neurodegenerative diseases: mechanisms and strategies for therapeutic intervention. J Pharmacol Exp Ther 2003 3.29
6 Microglial activation-mediated delayed and progressive degeneration of rat nigral dopaminergic neurons: relevance to Parkinson's disease. J Neurochem 2002 3.14
7 NADPH oxidase mediates lipopolysaccharide-induced neurotoxicity and proinflammatory gene expression in activated microglia. J Biol Chem 2003 2.92
8 Histone deacetylase inhibitors exhibit anti-inflammatory and neuroprotective effects in a rat permanent ischemic model of stroke: multiple mechanisms of action. J Pharmacol Exp Ther 2007 2.90
9 Why neurodegenerative diseases are progressive: uncontrolled inflammation drives disease progression. Trends Immunol 2008 2.46
10 Increased systemic and brain cytokine production and neuroinflammation by endotoxin following ethanol treatment. J Neuroinflammation 2008 2.25
11 Distinct role for microglia in rotenone-induced degeneration of dopaminergic neurons. J Neurosci 2002 1.87
12 Critical role of microglial NADPH oxidase-derived free radicals in the in vitro MPTP model of Parkinson's disease. FASEB J 2003 1.81
13 Role of nitric oxide in inflammation-mediated neurodegeneration. Ann N Y Acad Sci 2002 1.75
14 Critical role for microglial NADPH oxidase in rotenone-induced degeneration of dopaminergic neurons. J Neurosci 2003 1.73
15 In utero bacterial endotoxin exposure causes loss of tyrosine hydroxylase neurons in the postnatal rat midbrain. Mov Disord 2002 1.68
16 Neuroinflammation is a key player in Parkinson's disease and a prime target for therapy. J Neural Transm (Vienna) 2010 1.66
17 Synergistic dopaminergic neurotoxicity of the pesticide rotenone and inflammogen lipopolysaccharide: relevance to the etiology of Parkinson's disease. J Neurosci 2003 1.58
18 Microglia enhance beta-amyloid peptide-induced toxicity in cortical and mesencephalic neurons by producing reactive oxygen species. J Neurochem 2002 1.58
19 Parkinson's disease and exposure to infectious agents and pesticides and the occurrence of brain injuries: role of neuroinflammation. Environ Health Perspect 2003 1.47
20 Neuroprotective effect of dextromethorphan in the MPTP Parkinson's disease model: role of NADPH oxidase. FASEB J 2004 1.40
21 Diesel exhaust particles induce oxidative stress, proinflammatory signaling, and P-glycoprotein up-regulation at the blood-brain barrier. FASEB J 2008 1.39
22 Astrogliosis in CNS pathologies: is there a role for microglia? Mol Neurobiol 2010 1.38
23 Histone deacetylase inhibitors up-regulate astrocyte GDNF and BDNF gene transcription and protect dopaminergic neurons. Int J Neuropsychopharmacol 2008 1.38
24 HMGB1 acts on microglia Mac1 to mediate chronic neuroinflammation that drives progressive neurodegeneration. J Neurosci 2011 1.38
25 Neuromelanin activates microglia and induces degeneration of dopaminergic neurons: implications for progression of Parkinson's disease. Neurotox Res 2009 1.35
26 The role of microglia in paraquat-induced dopaminergic neurotoxicity. Antioxid Redox Signal 2005 1.34
27 Interactive role of the toll-like receptor 4 and reactive oxygen species in LPS-induced microglia activation. Glia 2005 1.31
28 Neuroinflammation and α-synuclein dysfunction potentiate each other, driving chronic progression of neurodegeneration in a mouse model of Parkinson's disease. Environ Health Perspect 2011 1.30
29 Dextromethorphan protects dopaminergic neurons against inflammation-mediated degeneration through inhibition of microglial activation. J Pharmacol Exp Ther 2003 1.30
30 Sinomenine, a natural dextrorotatory morphinan analog, is anti-inflammatory and neuroprotective through inhibition of microglial NADPH oxidase. J Neuroinflammation 2007 1.27
31 Microglial PHOX and Mac-1 are essential to the enhanced dopaminergic neurodegeneration elicited by A30P and A53T mutant alpha-synuclein. Glia 2007 1.26
32 Interleukin-10 protects lipopolysaccharide-induced neurotoxicity in primary midbrain cultures by inhibiting the function of NADPH oxidase. J Pharmacol Exp Ther 2006 1.25
33 Role of reactive oxygen species in LPS-induced production of prostaglandin E2 in microglia. J Neurochem 2004 1.24
34 A pivotal role of matrix metalloproteinase-3 activity in dopaminergic neuronal degeneration via microglial activation. FASEB J 2006 1.22
35 Role of oxidative stress in epileptic seizures. Neurochem Int 2011 1.20
36 Macrophage antigen complex-1 mediates reactive microgliosis and progressive dopaminergic neurodegeneration in the MPTP model of Parkinson's disease. J Immunol 2008 1.18
37 Valproate pretreatment protects dopaminergic neurons from LPS-induced neurotoxicity in rat primary midbrain cultures: role of microglia. Brain Res Mol Brain Res 2004 1.18
38 Silymarin protects dopaminergic neurons against lipopolysaccharide-induced neurotoxicity by inhibiting microglia activation. Eur J Neurosci 2002 1.16
39 NADPH oxidase and aging drive microglial activation, oxidative stress, and dopaminergic neurodegeneration following systemic LPS administration. Glia 2013 1.16
40 Pro-inflammatory cytokines and lipopolysaccharide induce changes in cell morphology, and upregulation of ERK1/2, iNOS and sPLA₂-IIA expression in astrocytes and microglia. J Neuroinflammation 2011 1.16
41 Microglial NADPH oxidase is a novel target for femtomolar neuroprotection against oxidative stress. FASEB J 2005 1.15
42 Gene-environment interactions: key to unraveling the mystery of Parkinson's disease. Prog Neurobiol 2011 1.14
43 Potent anti-inflammatory and neuroprotective effects of TGF-beta1 are mediated through the inhibition of ERK and p47phox-Ser345 phosphorylation and translocation in microglia. J Immunol 2008 1.13
44 Microglia-mediated neurotoxicity is inhibited by morphine through an opioid receptor-independent reduction of NADPH oxidase activity. J Immunol 2007 1.13
45 MAC1 mediates LPS-induced production of superoxide by microglia: the role of pattern recognition receptors in dopaminergic neurotoxicity. Glia 2007 1.11
46 Reactive microgliosis: extracellular micro-calpain and microglia-mediated dopaminergic neurotoxicity. Brain 2010 1.10
47 Study of hepatotoxicity of naltrexone in the treatment of alcoholism. Alcohol 2006 1.09
48 NADPH oxidases: novel therapeutic targets for neurodegenerative diseases. Trends Pharmacol Sci 2012 1.08
49 Synergistic dopaminergic neurotoxicity of MPTP and inflammogen lipopolysaccharide: relevance to the etiology of Parkinson's disease. FASEB J 2003 1.07
50 Novel neuroprotective mechanisms of memantine: increase in neurotrophic factor release from astroglia and anti-inflammation by preventing microglial activation. Neuropsychopharmacology 2009 1.07
51 Inhibition by naloxone stereoisomers of beta-amyloid peptide (1-42)-induced superoxide production in microglia and degeneration of cortical and mesencephalic neurons. J Pharmacol Exp Ther 2002 1.07
52 Inhibition of IkappaB kinase-beta protects dopamine neurons against lipopolysaccharide-induced neurotoxicity. J Pharmacol Exp Ther 2010 1.03
53 Glycogen synthase kinase-3 negatively regulates anti-inflammatory interleukin-10 for lipopolysaccharide-induced iNOS/NO biosynthesis and RANTES production in microglial cells. Immunology 2008 1.03
54 Endotoxin induces a delayed loss of TH-IR neurons in substantia nigra and motor behavioral deficits. Neurotoxicology 2008 1.03
55 3-Hydroxymorphinan, a metabolite of dextromethorphan, protects nigrostriatal pathway against MPTP-elicited damage both in vivo and in vitro. FASEB J 2006 1.02
56 Proteomic analysis of microglial contribution to mouse strain-dependent dopaminergic neurotoxicity. Glia 2006 1.02
57 Protective effect of dextromethorphan against endotoxic shock in mice. Biochem Pharmacol 2004 1.02
58 Low-dose lipopolysaccharide selectively sensitizes hypoxic ischemia-induced white matter injury in the immature brain. Pediatr Res 2010 1.01
59 Femtomolar concentrations of dextromethorphan protect mesencephalic dopaminergic neurons from inflammatory damage. FASEB J 2005 1.01
60 Primary rat mesencephalic neuron-glia, neuron-enriched, microglia-enriched, and astroglia-enriched cultures. Methods Mol Med 2003 0.98
61 Research on the premotor symptoms of Parkinson's disease: clinical and etiological implications. Environ Health Perspect 2013 0.98
62 In vitro model of glial scarring around neuroelectrodes chronically implanted in the CNS. Biomaterials 2006 0.98
63 3-hydroxymorphinan is neurotrophic to dopaminergic neurons and is also neuroprotective against LPS-induced neurotoxicity. FASEB J 2004 0.98
64 Naloxone inhibits immune cell function by suppressing superoxide production through a direct interaction with gp91phox subunit of NADPH oxidase. J Neuroinflammation 2012 0.97
65 Andrographolide reduces inflammation-mediated dopaminergic neurodegeneration in mesencephalic neuron-glia cultures by inhibiting microglial activation. J Pharmacol Exp Ther 2004 0.96
66 MPP+-induced COX-2 activation and subsequent dopaminergic neurodegeneration. FASEB J 2005 0.96
67 Resveratrol protects dopamine neurons against lipopolysaccharide-induced neurotoxicity through its anti-inflammatory actions. Mol Pharmacol 2010 0.95
68 Stereoselective action of (+)-morphine over (-)-morphine in attenuating the (-)-morphine-produced antinociception via the naloxone-sensitive sigma receptor in the mouse. Eur J Pharmacol 2007 0.95
69 Microglial MAC1 receptor and PI3K are essential in mediating β-amyloid peptide-induced microglial activation and subsequent neurotoxicity. J Neuroinflammation 2011 0.94
70 Fluoxetine protects neurons against microglial activation-mediated neurotoxicity. Parkinsonism Relat Disord 2012 0.94
71 Endogenous dynorphin protects against neurotoxin-elicited nigrostriatal dopaminergic neuron damage and motor deficits in mice. J Neuroinflammation 2012 0.94
72 Microglial NADPH oxidase mediates leucine enkephalin dopaminergic neuroprotection. Ann N Y Acad Sci 2005 0.92
73 NeuroAIDS, drug abuse, and inflammation: building collaborative research activities. J Neuroimmune Pharmacol 2006 0.91
74 Pituitary adenylate cyclase-activating polypeptide (PACAP) 38 and PACAP4-6 are neuroprotective through inhibition of NADPH oxidase: potent regulators of microglia-mediated oxidative stress. J Pharmacol Exp Ther 2006 0.91
75 Curcumin protects dopaminergic neuron against LPS induced neurotoxicity in primary rat neuron/glia culture. Neurochem Res 2008 0.90
76 Role of phagocyte oxidase in UVA-induced oxidative stress and apoptosis in keratinocytes. J Invest Dermatol 2005 0.90
77 Formyl-methionyl-leucyl-phenylalanine-induced dopaminergic neurotoxicity via microglial activation: a mediator between peripheral infection and neurodegeneration? Environ Health Perspect 2008 0.90
78 NADPH oxidase inhibitor DPI is neuroprotective at femtomolar concentrations through inhibition of microglia over-activation. Parkinsonism Relat Disord 2007 0.89
79 Reactive microgliosis participates in MPP+-induced dopaminergic neurodegeneration: role of 67 kDa laminin receptor. FASEB J 2006 0.89
80 β2-adrenergic receptor activation prevents rodent dopaminergic neurotoxicity by inhibiting microglia via a novel signaling pathway. J Immunol 2011 0.89
81 Transcriptional Factor NF-κB as a Target for Therapy in Parkinson's Disease. Parkinsons Dis 2011 0.89
82 Preparation of rodent primary cultures for neuron-glia, mixed glia, enriched microglia, and reconstituted cultures with microglia. Methods Mol Biol 2013 0.88
83 Dextromethorphan reduces oxidative stress and inhibits atherosclerosis and neointima formation in mice. Cardiovasc Res 2009 0.88
84 CD11b/CD18 (Mac-1) is a novel surface receptor for extracellular double-stranded RNA to mediate cellular inflammatory responses. J Immunol 2012 0.88
85 Microglial regulation of immunological and neuroprotective functions of astroglia. Glia 2014 0.87
86 Neuroprotective effect of naloxone in inflammation-mediated dopaminergic neurodegeneration. Dissociation from the involvement of opioid receptors. Methods Mol Med 2003 0.87
87 Low-dose memantine attenuated morphine addictive behavior through its anti-inflammation and neurotrophic effects in rats. J Neuroimmune Pharmacol 2011 0.87
88 Suppressed pro-inflammatory response of microglia in CX3CR1 knockout mice. J Neuroimmunol 2013 0.86
89 Squamosamide derivative FLZ protects dopaminergic neurons against inflammation-mediated neurodegeneration through the inhibition of NADPH oxidase activity. J Neuroinflammation 2008 0.86
90 p38 MAP kinase is involved in lipopolysaccharide-induced dopaminergic neuronal cell death in rat mesencephalic neuron-glia cultures. Ann N Y Acad Sci 2002 0.86
91 Prostaglandin E2 released from activated microglia enhances astrocyte proliferation in vitro. Toxicol Appl Pharmacol 2009 0.85
92 A novel inhibitory effect of naloxone on macrophage activation and atherosclerosis formation in mice. J Am Coll Cardiol 2006 0.85
93 Ten years of Nature Reviews Neuroscience: insights from the highly cited. Nat Rev Neurosci 2010 0.84
94 Cadmium-induced toxicity in rat primary mid-brain neuroglia cultures: role of oxidative stress from microglia. Toxicol Sci 2007 0.84
95 Subpicomolar diphenyleneiodonium inhibits microglial NADPH oxidase with high specificity and shows great potential as a therapeutic agent for neurodegenerative diseases. Glia 2014 0.84
96 Clozapine protects dopaminergic neurons from inflammation-induced damage by inhibiting microglial overactivation. J Neuroimmune Pharmacol 2011 0.83
97 Behavior, neurochemistry and histology after intranigral lipopolysaccharide injection. Neuroreport 2002 0.83
98 Verapamil protects dopaminergic neuron damage through a novel anti-inflammatory mechanism by inhibition of microglial activation. Neuropharmacology 2010 0.83
99 Add-on memantine to valproate treatment increased HDL-C in bipolar II disorder. J Psychiatr Res 2013 0.83
100 Control protocol for robust in vitro glial scar formation around microwires: essential roles of bFGF and serum in gliosis. J Neurosci Methods 2009 0.83
101 Low dose dextromethorphan attenuates moderate experimental autoimmune encephalomyelitis by inhibiting NOX2 and reducing peripheral immune cells infiltration in the spinal cord. Neurobiol Dis 2011 0.83
102 Modulation of Endogenous Opioid Systems by Electroconvulsive Shock. Convuls Ther 1989 0.82
103 (+)-Morphine attenuates the (-)-morphine-produced conditioned place preference and the mu-opioid receptor-mediated dopamine increase in the posterior nucleus accumbens of the rat. Eur J Pharmacol 2008 0.82
104 Kainate treatment alters TGF-beta3 gene expression in the rat hippocampus. Brain Res Mol Brain Res 2002 0.82
105 Human neuromelanin: an endogenous microglial activator for dopaminergic neuron death. Front Biosci (Elite Ed) 2013 0.82
106 Liposomal melatonin rescues methamphetamine-elicited mitochondrial burdens, pro-apoptosis, and dopaminergic degeneration through the inhibition PKCδ gene. J Pineal Res 2014 0.82
107 Morphinan neuroprotection: new insight into the therapy of neurodegeneration. Crit Rev Neurobiol 2004 0.81
108 Amantadine protects dopamine neurons by a dual action: reducing activation of microglia and inducing expression of GDNF in astroglia [corrected]. Neuropharmacology 2011 0.81
109 PGE2 Inhibits IL-10 Production via EP2-Mediated β-Arrestin Signaling in Neuroinflammatory Condition. Mol Neurobiol 2014 0.80
110 beta2 Adrenergic receptor activation induces microglial NADPH oxidase activation and dopaminergic neurotoxicity through an ERK-dependent/protein kinase A-independent pathway. Glia 2009 0.80
111 The effects of add-on low-dose memantine on cytokine levels in bipolar II depression: a 12-week double-blind, randomized controlled trial. J Clin Psychopharmacol 2014 0.80
112 Dextromethorphan inhibits activations and functions in dendritic cells. Clin Dev Immunol 2013 0.80
113 Serum-dependence of LPS-induced neurotoxicity in rat cortical neurons. Ann N Y Acad Sci 2002 0.79
114 Dextromethorphan efficiently increases bactericidal activity, attenuates inflammatory responses, and prevents group a streptococcal sepsis. Antimicrob Agents Chemother 2011 0.79
115 Inflammation in patients with schizophrenia: the therapeutic benefits of risperidone plus add-on dextromethorphan. J Neuroimmune Pharmacol 2012 0.79
116 Pretreatment with antiserum against dynorphin, substance P, or cholecystokinin enhances the morphine-produced anti-allodynia in the sciatic nerve ligated mice. Neurosci Lett 2005 0.79
117 Neuropsychotoxic and neuroprotective potentials of dextromethorphan and its analogs. J Pharmacol Sci 2011 0.78
118 Neuropsychopharmacological understanding for therapeutic application of morphinans. Arch Pharm Res 2010 0.78
119 TPH1 and 5-HTTLPR Genes Specifically Interact in Opiate Dependence but Not in Alcohol Dependence. Eur Addict Res 2016 0.77
120 Inflammation's Association with Metabolic Profiles before and after a Twelve-Week Clinical Trial in Drug-Naïve Patients with Bipolar II Disorder. PLoS One 2013 0.77
121 Gö6976 protects mesencephalic neurons from lipopolysaccharide-elicited death by inhibiting p38 MAP kinase phosphorylation. Ann N Y Acad Sci 2002 0.77
122 Neuroprotective and neurogenesis agent for treating bipolar II disorder: add-on memantine to mood stabilizer works. Med Hypotheses 2012 0.77
123 Dextromethorphan attenuated inflammation and combined opioid use in humans undergoing methadone maintenance treatment. J Neuroimmune Pharmacol 2012 0.77
124 Soluble factor effects on glial cell reactivity at the surface of gel-coated microwires. J Neurosci Methods 2010 0.77
125 Effects of the combined treatment of naloxone and indomethacin on catecholamines and behavior after intranigral lipopolysaccharide injection. Neurochem Res 2004 0.76
126 A novel role of microglial NADPH oxidase in mediating extra-synaptic function of norepinephrine in regulating brain immune homeostasis. Glia 2015 0.76
127 The DRD3 Ser9Gly Polymorphism Predicted Metabolic Change in Drug-Naive Patients With Bipolar II Disorder. Medicine (Baltimore) 2016 0.75
128 Corrigendum: Low-dose add-on memantine treatment may improve cognitive performance and self-reported health conditions in opioid-dependent patients undergoing methadone-maintenance-therapy. Sci Rep 2017 0.75
129 Impairment of an electroconvulsive stimulus on reconsolidation of memories established by conditioning. Chin J Physiol 2013 0.75