Published in Anal Chem on April 15, 2010
Single-cell analysis and sorting using droplet-based microfluidics. Nat Protoc (2013) 2.34
The future is now: single-cell genomics of bacteria and archaea. FEMS Microbiol Rev (2013) 2.10
The role of physiological heterogeneity in microbial population behavior. Nat Chem Biol (2010) 2.04
Micro total analysis systems for cell biology and biochemical assays. Anal Chem (2011) 1.58
Microfluidic single-cell real-time PCR for comparative analysis of gene expression patterns. Nat Protoc (2012) 1.53
A programmable droplet-based microfluidic device applied to multiparameter analysis of single microbes and microbial communities. Proc Natl Acad Sci U S A (2012) 1.41
Theoretical design and analysis of multivolume digital assays with wide dynamic range validated experimentally with microfluidic digital PCR. Anal Chem (2011) 1.32
Current understanding of the mechanism of benzene-induced leukemia in humans: implications for risk assessment. Carcinogenesis (2011) 1.26
Advances in microfluidic PCR for point-of-care infectious disease diagnostics. Biotechnol Adv (2011) 1.22
DNA copy number concentration measured by digital and droplet digital quantitative PCR using certified reference materials. Anal Bioanal Chem (2015) 1.16
Drop-on-demand single cell isolation and total RNA analysis. PLoS One (2011) 1.11
Lifting gate polydimethylsiloxane microvalves and pumps for microfluidic control. Anal Chem (2012) 1.10
Single-cell multiplex gene detection and sequencing with microfluidically generated agarose emulsions. Angew Chem Int Ed Engl (2011) 1.06
Integrated immunoisolation and protein analysis of circulating exosomes using microfluidic technology. Lab Chip (2014) 1.03
System Integration - A Major Step toward Lab on a Chip. J Biol Eng (2011) 1.03
Lab-on-a-chip pathogen sensors for food safety. Sensors (Basel) (2012) 1.03
Isothermal amplification methods for the detection of nucleic acids in microfluidic devices. Biosensors (Basel) (2012) 1.01
Droplet microfluidics for amplification-free genetic detection of single cells. Lab Chip (2012) 1.00
Identification and manipulation of the molecular determinants influencing poliovirus recombination. PLoS Pathog (2013) 0.98
Microfluidic compartmentalized directed evolution. Chem Biol (2010) 0.94
The potential impact of droplet microfluidics in biology. Anal Chem (2013) 0.94
Review of methods to probe single cell metabolism and bioenergetics. Metab Eng (2014) 0.92
Microvalve Enabled Digital Microfluidic Systems for High Performance Biochemical and Genetic Analysis. JALA Charlottesv Va (2010) 0.91
Droplets formation and merging in two-phase flow microfluidics. Int J Mol Sci (2011) 0.89
Single molecule quantitation and sequencing of rare translocations using microfluidic nested digital PCR. Nucleic Acids Res (2013) 0.88
Massively parallel sequencing of single cells by epicPCR links functional genes with phylogenetic markers. ISME J (2015) 0.87
Massively parallel haplotyping on microscopic beads for the high-throughput phase analysis of single molecules. PLoS One (2012) 0.87
Population transcriptomics with single-cell resolution: a new field made possible by microfluidics: a technology for high throughput transcript counting and data-driven definition of cell types. Bioessays (2012) 0.86
Track-etched magnetic micropores for immunomagnetic isolation of pathogens. Adv Healthc Mater (2014) 0.85
Development of a facile droplet-based single-cell isolation platform for cultivation and genomic analysis in microorganisms. Sci Rep (2017) 0.83
Self-digitization of samples into a high-density microfluidic bottom-well array. Anal Chem (2013) 0.81
Co-detection and sequencing of genes and transcripts from the same single cells facilitated by a microfluidics platform. Sci Rep (2014) 0.80
Adding reagent to droplets with controlled rupture of encapsulated double emulsions. Biomicrofluidics (2013) 0.79
Parallel generation of uniform fine droplets at hundreds of kilohertz in a flow-focusing module. Biomicrofluidics (2013) 0.78
Discovery in Droplets. Anal Chem (2015) 0.78
Rapid and continuous magnetic separation in droplet microfluidic devices. Lab Chip (2015) 0.77
Integrated Microfluidic Lectin Barcode Platform for High-Performance Focused Glycomic Profiling. Sci Rep (2016) 0.77
A microfluidic device for on-chip agarose microbead generation with ultralow reagent consumption. Biomicrofluidics (2012) 0.77
Technology advancement for integrative stem cell analyses. Tissue Eng Part B Rev (2014) 0.77
Precise pooling and dispensing of microfluidic droplets towards micro- to macro-world interfacing. RSC Adv (2014) 0.76
Rapid fabrication of nickel molds for prototyping embossed plastic microfluidic devices. Lab Chip (2013) 0.76
Deterministic trapping, encapsulation and retrieval of single-cells. Lab Chip (2017) 0.76
Scaling by shrinking: empowering single-cell 'omics' with microfluidic devices. Nat Rev Genet (2017) 0.75
Microfluidic landscapes for evolution. Curr Opin Chem Biol (2010) 0.75
A barcode-free combinatorial screening platform for matrix metalloproteinase screening. Anal Chem (2015) 0.75
Digital PCR using micropatterned superporous absorbent array chips. Analyst (2016) 0.75
Single cell measurement of telomerase expression and splicing using microfluidic emulsion cultures. Nucleic Acids Res (2015) 0.75
Genome sequencing in microfabricated high-density picolitre reactors. Nature (2005) 150.21
The hallmarks of cancer. Cell (2000) 113.05
Food-related illness and death in the United States. Emerg Infect Dis (1999) 39.22
Stochastic gene expression in a single cell. Science (2002) 34.54
The origins and the future of microfluidics. Nature (2006) 16.24
Transforming single DNA molecules into fluorescent magnetic particles for detection and enumeration of genetic variations. Proc Natl Acad Sci U S A (2003) 12.91
Circulating mutant DNA to assess tumor dynamics. Nat Med (2007) 10.33
Stochastic protein expression in individual cells at the single molecule level. Nature (2006) 8.00
Detection, clinical relevance and specific biological properties of disseminating tumour cells. Nat Rev Cancer (2008) 7.99
Droplet microfluidics. Lab Chip (2008) 6.31
Detection and quantification of mutations in the plasma of patients with colorectal tumors. Proc Natl Acad Sci U S A (2005) 5.91
Droplet microfluidic technology for single-cell high-throughput screening. Proc Natl Acad Sci U S A (2009) 3.85
Microfluidic digital PCR enables multigene analysis of individual environmental bacteria. Science (2006) 3.84
Genetic heterogeneity of single disseminated tumour cells in minimal residual cancer. Lancet (2002) 3.45
BEAMing up for detection and quantification of rare sequence variants. Nat Methods (2006) 3.03
Analysis of single mammalian cells on-chip. Lab Chip (2007) 3.03
Self-contained, fully integrated biochip for sample preparation, polymerase chain reaction amplification, and DNA microarray detection. Anal Chem (2004) 2.92
Drop-based microfluidic devices for encapsulation of single cells. Lab Chip (2008) 2.90
High-throughput quantitative polymerase chain reaction in picoliter droplets. Anal Chem (2008) 2.48
Microfluidic single-cell mRNA isolation and analysis. Anal Chem (2006) 2.47
Multiplex polymerase chain reaction: a practical approach. J Clin Lab Anal (2002) 2.42
Quantitative detection of protein expression in single cells using droplet microfluidics. Chem Commun (Camb) (2007) 2.37
Sensitive digital quantification of DNA methylation in clinical samples. Nat Biotechnol (2009) 2.34
On-chip, real-time, single-copy polymerase chain reaction in picoliter droplets. Anal Chem (2007) 2.18
A microfluidic processor for gene expression profiling of single human embryonic stem cells. Lab Chip (2007) 2.17
The ups and downs of p53: understanding protein dynamics in single cells. Nat Rev Cancer (2009) 2.13
On-chip single-copy real-time reverse-transcription PCR in isolated picoliter droplets. Anal Chem (2008) 1.96
A high-throughput microfluidic real-time gene expression living cell array. Lab Chip (2006) 1.93
Development and multiplexed control of latching pneumatic valves using microfluidic logical structures. Lab Chip (2006) 1.89
Integrated portable genetic analysis microsystem for pathogen/infectious disease detection. Anal Chem (2004) 1.87
Integrated microfluidic bioprocessor for single-cell gene expression analysis. Proc Natl Acad Sci U S A (2008) 1.73
High-throughput single copy DNA amplification and cell analysis in engineered nanoliter droplets. Anal Chem (2008) 1.71
Droplet-based microfluidic systems for high-throughput single DNA molecule isothermal amplification and analysis. Anal Chem (2009) 1.66
Static microdroplet arrays: a microfluidic device for droplet trapping, incubation and release for enzymatic and cell-based assays. Lab Chip (2008) 1.59
Single-molecule PCR using water-in-oil emulsion. J Biotechnol (2003) 1.34
Integrated capture, concentration, polymerase chain reaction, and capillary electrophoretic analysis of pathogens on a chip. Anal Chem (2009) 1.20
Materials science. Food pathogen detection. Science (2007) 1.17
High-resolution array comparative genomic hybridization of single micrometastatic tumor cells. Nucleic Acids Res (2008) 1.12
Same-single-cell analysis for the study of drug efflux modulation of multidrug resistant cells using a microfluidic chip. Anal Chem (2008) 1.10
A fast and efficient microfluidic system for highly selective one-to-one droplet fusion. Lab Chip (2009) 1.04
Polymerase chain reaction-capillary electrophoresis genetic analysis microdevice with in-line affinity capture sample injection. Anal Chem (2009) 0.93
Trends and opportunities in food pathogen detection. Anal Bioanal Chem (2008) 0.88
A quantitative approach to characterizing cell lysis caused by mechanical agitation of Streptomyces clavuligerus. Biotechnol Prog (2001) 0.86
Epidemiology. Environment and disease risks. Science (2010) 4.64
Epidemiology of myelodysplastic syndromes and chronic myeloproliferative disorders in the United States, 2001-2004, using data from the NAACCR and SEER programs. Blood (2008) 4.41
Hematotoxicity in workers exposed to low levels of benzene. Science (2004) 4.19
Genetic variation in TNF and IL10 and risk of non-Hodgkin lymphoma: a report from the InterLymph Consortium. Lancet Oncol (2006) 4.13
Femtosecond stimulated Raman spectroscopy. Annu Rev Phys Chem (2007) 2.87
Tumor necrosis factor (TNF) and lymphotoxin-alpha (LTA) polymorphisms and risk of non-Hodgkin lymphoma in the InterLymph Consortium. Am J Epidemiol (2010) 2.86
Microfabricated bioprocessor for integrated nanoliter-scale Sanger DNA sequencing. Proc Natl Acad Sci U S A (2006) 2.73
Genetic variants at 6p21.33 are associated with susceptibility to follicular lymphoma. Nat Genet (2009) 2.73
Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32. Nat Genet (2010) 2.37
Occupational exposure to formaldehyde, hematotoxicity, and leukemia-specific chromosome changes in cultured myeloid progenitor cells. Cancer Epidemiol Biomarkers Prev (2010) 2.34
An emerging role for epigenetic dysregulation in arsenic toxicity and carcinogenesis. Environ Health Perspect (2010) 2.16
Femtosecond Time-Resolved Stimulated Raman Spectroscopy: Application to the Ultrafast Internal Conversion in beta-Carotene. J Phys Chem A (2003) 2.13
Biological sample collection and processing for molecular epidemiological studies. Mutat Res (2003) 2.13
Structural observation of the primary isomerization in vision with femtosecond-stimulated Raman. Science (2005) 2.02
Polymorphisms and haplotypes in folate-metabolizing genes and risk of non-Hodgkin lymphoma. Blood (2004) 1.93
Femtosecond Time-Resolved Stimulated Raman Spectroscopy of the S(2) (1B(u)) Excited State of beta-Carotene. J Phys Chem A (2004) 1.90
Development and multiplexed control of latching pneumatic valves using microfluidic logical structures. Lab Chip (2006) 1.89
Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia. Nat Genet (2013) 1.85
Personalized exposure assessment: promising approaches for human environmental health research. Environ Health Perspect (2005) 1.83
Body mass index, leptin and leptin receptor polymorphisms, and non-hodgkin lymphoma. Cancer Epidemiol Biomarkers Prev (2004) 1.80
Spectroscopic characterization of the soluble guanylate cyclase-like heme domains from Vibrio cholerae and Thermoanaerobacter tengcongensis. Biochemistry (2004) 1.80
Conical intersection dynamics of the primary photoisomerization event in vision. Nature (2010) 1.78
Retinal counterion switch in the photoactivation of the G protein-coupled receptor rhodopsin. Proc Natl Acad Sci U S A (2003) 1.77
Integrated microfluidic bioprocessor for single-cell gene expression analysis. Proc Natl Acad Sci U S A (2008) 1.73
Research recommendations for selected IARC-classified agents. Environ Health Perspect (2010) 1.73
In utero origin of t(8;21) AML1-ETO translocations in childhood acute myeloid leukemia. Blood (2002) 1.71
High-throughput single copy DNA amplification and cell analysis in engineered nanoliter droplets. Anal Chem (2008) 1.71
Polymorphisms in the oxidative stress genes, superoxide dismutase, glutathione peroxidase and catalase and risk of non-Hodgkin's lymphoma. Haematologica (2006) 1.64
Polymorphisms in the estrogen receptor 1 and vitamin C and matrix metalloproteinase gene families are associated with susceptibility to lymphoma. PLoS One (2008) 1.61
Femtosecond broadband stimulated Raman: a new approach for high-performance vibrational spectroscopy. Appl Spectrosc (2003) 1.60
GWAS of follicular lymphoma reveals allelic heterogeneity at 6p21.32 and suggests shared genetic susceptibility with diffuse large B-cell lymphoma. PLoS Genet (2011) 1.58
Femtosecond broadband stimulated Raman spectroscopy: Apparatus and methods. Rev Sci Instrum (2004) 1.55
Decreased urinary beta-defensin-1 expression as a biomarker of response to arsenic. Toxicol Sci (2008) 1.54
Functional FAS promoter polymorphisms are associated with increased risk of acute myeloid leukemia. Cancer Res (2003) 1.53
Ultrafast excited-state isomerization in phytochrome revealed by femtosecond stimulated Raman spectroscopy. Proc Natl Acad Sci U S A (2009) 1.53
Critical windows of exposure to household pesticides and risk of childhood leukemia. Environ Health Perspect (2002) 1.52
Cytogenetics of Hispanic and White children with acute lymphoblastic leukemia in California. Cancer Epidemiol Biomarkers Prev (2006) 1.51
Comparison of standard and immune-enhancing oral formulas in asymptomatic HIV-infected persons: a multicenter randomized controlled clinical trial. JPEN J Parenter Enteral Nutr (2002) 1.49
Accuracy of multiplexed Illumina platform-based single-nucleotide polymorphism genotyping compared between genomic and whole genome amplified DNA collected from multiple sources. Cancer Epidemiol Biomarkers Prev (2006) 1.45
Detailed exposure assessment for a molecular epidemiology study of benzene in two shoe factories in China. Ann Occup Hyg (2004) 1.44
Programmable cell adhesion encoded by DNA hybridization. Angew Chem Int Ed Engl (2006) 1.39
Using urinary biomarkers to elucidate dose-related patterns of human benzene metabolism. Carcinogenesis (2005) 1.37
Formaldehyde exposure and leukemia: a new meta-analysis and potential mechanisms. Mutat Res (2008) 1.36
High-temperature microfluidic synthesis of CdSe nanocrystals in nanoliter droplets. J Am Chem Soc (2005) 1.35
Polymorphisms in the thymidylate synthase and serine hydroxymethyltransferase genes and risk of adult acute lymphocytic leukemia. Blood (2002) 1.34
Anti-stokes Raman study of vibrational cooling dynamics in the primary photochemistry of rhodopsin. J Phys Chem A (2002) 1.32
Direct cell surface modification with DNA for the capture of primary cells and the investigation of myotube formation on defined patterns. Langmuir (2009) 1.30
Toxicogenomic profiling of chemically exposed humans in risk assessment. Mutat Res (2010) 1.30
Individual differences in arsenic metabolism and lung cancer in a case-control study in Cordoba, Argentina. Toxicol Appl Pharmacol (2010) 1.30
High throughput DNA sequencing with a microfabricated 96-lane capillary array electrophoresis bioprocessor. Proc Natl Acad Sci U S A (2002) 1.30
Formaldehyde in China: production, consumption, exposure levels, and health effects. Environ Int (2009) 1.28
Arsenic immunotoxicity: a review. Environ Health (2013) 1.27
Theory of femtosecond stimulated Raman spectroscopy. J Chem Phys (2004) 1.27
Current understanding of the mechanism of benzene-induced leukemia in humans: implications for risk assessment. Carcinogenesis (2011) 1.26
Modeling human metabolism of benzene following occupational and environmental exposures. Cancer Epidemiol Biomarkers Prev (2006) 1.26
NQO1 polymorphisms and de novo childhood leukemia: a HuGE review and meta-analysis. Am J Epidemiol (2008) 1.25
Function of extracellular loop 2 in rhodopsin: glutamic acid 181 modulates stability and absorption wavelength of metarhodopsin II. Biochemistry (2002) 1.24
Discovery of novel biomarkers by microarray analysis of peripheral blood mononuclear cell gene expression in benzene-exposed workers. Environ Health Perspect (2005) 1.24
The role of inflammation in age-related disease. Aging (Albany NY) (2013) 1.22
Vibrational Relaxation in beta-Carotene Probed by Picosecond Stokes and Anti-Stokes Resonance Raman Spectroscopy. J Phys Chem A (2002) 1.21
Characterization of functional heme domains from soluble guanylate cyclase. Biochemistry (2005) 1.21
Development and evaluation of a microdevice for amino acid biomarker detection and analysis on Mars. Proc Natl Acad Sci U S A (2005) 1.20
Mapping GFP structure evolution during proton transfer with femtosecond Raman spectroscopy. Nature (2009) 1.20
Integrated hydrogenated amorphous Si photodiode detector for microfluidic bioanalytical devices. Anal Chem (2003) 1.20
Integrated capture, concentration, polymerase chain reaction, and capillary electrophoretic analysis of pathogens on a chip. Anal Chem (2009) 1.20
Aberrations in chromosomes associated with lymphoma and therapy-related leukemia in benzene-exposed workers. Environ Mol Mutagen (2007) 1.17
Microfabricated 384-lane capillary array electrophoresis bioanalyzer for ultrahigh-throughput genetic analysis. Anal Chem (2002) 1.17
Site-specific translocation and evidence of postnatal origin of the t(1;19) E2A-PBX1 fusion in childhood acute lymphoblastic leukemia. Proc Natl Acad Sci U S A (2002) 1.16
Polymorphisms in innate immunity genes and risk of non-Hodgkin lymphoma. Br J Haematol (2006) 1.16
Polymorphisms in cytokine and cellular adhesion molecule genes and susceptibility to hematotoxicity among workers exposed to benzene. Cancer Res (2005) 1.16
Integrated molecular analysis indicates undetectable change in DNA damage in mice after continuous irradiation at ~ 400-fold natural background radiation. Environ Health Perspect (2012) 1.15
Genetic variation in the folate metabolic pathway and risk of childhood leukemia. Blood (2010) 1.14
Nitric oxide binding to prokaryotic homologs of the soluble guanylate cyclase beta1 H-NOX domain. J Biol Chem (2006) 1.13
Household exposure to paint and petroleum solvents, chromosomal translocations, and the risk of childhood leukemia. Environ Health Perspect (2008) 1.13
Microchip bioprocessor for integrated nanovolume sample purification and DNA sequencing. Anal Chem (2002) 1.13
Performance in omics analyses of blood samples in long-term storage: opportunities for the exploitation of existing biobanks in environmental health research. Environ Health Perspect (2013) 1.13
Microfluidic devices for DNA sequencing: sample preparation and electrophoretic analysis. Curr Opin Biotechnol (2003) 1.12
The flavoring agent dihydrocoumarin reverses epigenetic silencing and inhibits sirtuin deacetylases. PLoS Genet (2005) 1.12
The nature of chromosomal aberrations detected in humans exposed to benzene. Crit Rev Toxicol (2002) 1.12
A digital microfluidic platform for the automation of quantitative biomolecular assays. Lab Chip (2009) 1.11
Lifting gate polydimethylsiloxane microvalves and pumps for microfluidic control. Anal Chem (2012) 1.10
Occupational exposure to trichloroethylene is associated with a decline in lymphocyte subsets and soluble CD27 and CD30 markers. Carcinogenesis (2010) 1.10
Global gene expression profiling of a population exposed to a range of benzene levels. Environ Health Perspect (2010) 1.10
Large-scale evaluation of candidate genes identifies associations between DNA repair and genomic maintenance and development of benzene hematotoxicity. Carcinogenesis (2008) 1.10
Integrated microfluidic systems for high-performance genetic analysis. Trends Biotechnol (2009) 1.07
Formaldehyde and leukemia: epidemiology, potential mechanisms, and implications for risk assessment. Environ Mol Mutagen (2010) 1.07
Risk of non-Hodgkin lymphoma associated with polymorphisms in folate-metabolizing genes. Cancer Epidemiol Biomarkers Prev (2005) 1.06
Single-cell multiplex gene detection and sequencing with microfluidically generated agarose emulsions. Angew Chem Int Ed Engl (2011) 1.06
Self-assembled cellular microarrays patterned using DNA barcodes. Lab Chip (2007) 1.06
Time-resolved resonance Raman analysis of chromophore structural changes in the formation and decay of rhodopsin's BSI intermediate. J Am Chem Soc (2002) 1.05
Improving prediction of chemical carcinogenicity by considering multiple mechanisms and applying toxicogenomic approaches. Mutat Res (2008) 1.05
Surface multiheme c-type cytochromes from Thermincola potens and implications for respiratory metal reduction by Gram-positive bacteria. Proc Natl Acad Sci U S A (2012) 1.04
A functional TNFRSF5 gene variant is associated with risk of lymphoma. Blood (2008) 1.04
Integrated microfluidic bioprocessor for solid phase capture immunoassays. Lab Chip (2011) 1.04
Microfluidic serial dilution circuit. Anal Chem (2006) 1.04
Evidence that humans metabolize benzene via two pathways. Environ Health Perspect (2009) 1.03
IARC monographs: 40 years of evaluating carcinogenic hazards to humans. Environ Health Perspect (2015) 1.03
Low efficiency of the Moloney murine leukemia virus reverse transcriptase during reverse transcription of rare t(8;21) fusion gene transcripts. Biotechniques (2002) 1.03