Published in Annu Rev Biochem on January 01, 2010
Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression. Cell (2013) 13.43
An unbiased genome-wide analysis of zinc-finger nuclease specificity. Nat Biotechnol (2011) 6.44
Enhancing zinc-finger-nuclease activity with improved obligate heterodimeric architectures. Nat Methods (2010) 6.00
Assembly of custom TALE-type DNA binding domains by modular cloning. Nucleic Acids Res (2011) 3.22
Transcriptional activators of human genes with programmable DNA-specificity. PLoS One (2011) 3.16
Controlling long-range genomic interactions at a native locus by targeted tethering of a looping factor. Cell (2012) 2.87
Direct production of mouse disease models by embryo microinjection of TALENs and oligodeoxynucleotides. Proc Natl Acad Sci U S A (2013) 2.63
Harnessing the CRISPR/Cas9 system to disrupt latent HIV-1 provirus. Sci Rep (2013) 2.48
Global mitotic phosphorylation of C2H2 zinc finger protein linker peptides. Cell Cycle (2011) 2.25
Differential integrity of TALE nuclease genes following adenoviral and lentiviral vector gene transfer into human cells. Nucleic Acids Res (2012) 2.14
CRISPR interference (CRISPRi) for sequence-specific control of gene expression. Nat Protoc (2013) 2.05
Selective regulation of lymphopoiesis and leukemogenesis by individual zinc fingers of Ikaros. Nat Immunol (2013) 1.88
Genome-wide meta-analysis points to CTC1 and ZNF676 as genes regulating telomere homeostasis in humans. Hum Mol Genet (2012) 1.77
Light-inducible spatiotemporal control of gene activation by customizable zinc finger transcription factors. J Am Chem Soc (2012) 1.69
Foundations for the design and implementation of synthetic genetic circuits. Nat Rev Genet (2012) 1.65
Precision editing of large animal genomes. Adv Genet (2012) 1.34
megaTALs: a rare-cleaving nuclease architecture for therapeutic genome engineering. Nucleic Acids Res (2013) 1.30
Sequence specificity is obtained from the majority of modular C2H2 zinc-finger arrays. Nucleic Acids Res (2011) 1.27
Modeling disease mutations by gene targeting in one-cell mouse embryos. Proc Natl Acad Sci U S A (2012) 1.25
Editing the epigenome: technologies for programmable transcription and epigenetic modulation. Nat Methods (2016) 1.24
Zinc and the modulation of redox homeostasis. Free Radic Biol Med (2012) 1.23
Type II restriction endonucleases--a historical perspective and more. Nucleic Acids Res (2014) 1.22
Clinical lung xenotransplantation--what donor genetic modifications may be necessary? Xenotransplantation (2012) 1.16
Targeting DNA With Fingers and TALENs. Mol Ther Nucleic Acids (2012) 1.12
ZFN-mediated gene targeting of the Arabidopsis protoporphyrinogen oxidase gene through Agrobacterium-mediated floral dip transformation. Plant Biotechnol J (2012) 1.12
Rescuing the failing heart by targeted gene transfer. J Am Coll Cardiol (2011) 1.11
A novel 4EHP-GIGYF2 translational repressor complex is essential for mammalian development. Mol Cell Biol (2012) 1.09
Metal preferences and metallation. J Biol Chem (2014) 1.08
Integrase-defective lentiviral vectors as a delivery platform for targeted modification of adenosine deaminase locus. Mol Ther (2013) 1.08
DNA binding specificities of the long zinc-finger recombination protein PRDM9. Genome Biol (2013) 1.08
Global analysis of Drosophila Cys₂-His₂ zinc finger proteins reveals a multitude of novel recognition motifs and binding determinants. Genome Res (2013) 1.07
Synthetic zinc finger repressors reduce mutant huntingtin expression in the brain of R6/2 mice. Proc Natl Acad Sci U S A (2012) 1.06
Engineering RNA-binding proteins for biology. FEBS J (2013) 1.06
Evolutionary functional analysis and molecular regulation of the ZEB transcription factors. Cell Mol Life Sci (2012) 1.06
Zinc-finger transcription factors are associated with guanine quadruplex motifs in human, chimpanzee, mouse and rat promoters genome-wide. Nucleic Acids Res (2011) 1.04
Wilms tumor protein recognizes 5-carboxylcytosine within a specific DNA sequence. Genes Dev (2014) 1.02
An improved predictive recognition model for Cys(2)-His(2) zinc finger proteins. Nucleic Acids Res (2014) 1.02
Minimal functional sites allow a classification of zinc sites in proteins. PLoS One (2011) 1.02
Saccharina genomes provide novel insight into kelp biology. Nat Commun (2015) 1.02
Tuning response curves for synthetic biology. ACS Synth Biol (2013) 1.01
Experimental strategies for studying transcription factor-DNA binding specificities. Brief Funct Genomics (2010) 1.01
Structure of an aprataxin-DNA complex with insights into AOA1 neurodegenerative disease. Nat Struct Mol Biol (2011) 1.01
Efficient programmable gene silencing by Cascade. Nucleic Acids Res (2014) 1.00
Zinc-binding cysteines: diverse functions and structural motifs. Biomolecules (2014) 1.00
Nuclear import and DNA binding of the ZHD5 transcription factor is modulated by a competitive peptide inhibitor in Arabidopsis. J Biol Chem (2010) 0.98
Predicting success of oligomerized pool engineering (OPEN) for zinc finger target site sequences. BMC Bioinformatics (2010) 0.96
Structure of a novel phosphotyrosine-binding domain in Hakai that targets E-cadherin. EMBO J (2012) 0.95
Engineering large animal models of human disease. J Pathol (2015) 0.94
Engineering synthetic TALE and CRISPR/Cas9 transcription factors for regulating gene expression. Methods (2014) 0.93
Cell cycle transition from S-phase to G1 in Caulobacter is mediated by ancestral virulence regulators. Nat Commun (2014) 0.93
The BTB-ZF transcription factors. Cell Cycle (2012) 0.93
A novel zinc-finger nuclease platform with a sequence-specific cleavage module. Nucleic Acids Res (2011) 0.92
Concerted genomic targeting of H3K27 demethylase REF6 and chromatin-remodeling ATPase BRM in Arabidopsis. Nat Genet (2016) 0.92
A systematic survey of the Cys2His2 zinc finger DNA-binding landscape. Nucleic Acids Res (2015) 0.92
Targeted gene therapies: tools, applications, optimization. Crit Rev Biochem Mol Biol (2012) 0.91
Genetic variants and blood pressure in a population-based cohort: the Cardiovascular Risk in Young Finns study. Hypertension (2011) 0.91
Genome-wide studies of the multi-zinc finger Drosophila Suppressor of Hairy-wing protein in the ovary. Nucleic Acids Res (2012) 0.91
Oligonucleotide-based strategies to combat polyglutamine diseases. Nucleic Acids Res (2014) 0.90
Bacterial CRISPR/Cas DNA endonucleases: A revolutionary technology that could dramatically impact viral research and treatment. Virology (2015) 0.90
REF6 recognizes a specific DNA sequence to demethylate H3K27me3 and regulate organ boundary formation in Arabidopsis. Nat Genet (2016) 0.89
Generation of mastitis resistance in cows by targeting human lysozyme gene to β-casein locus using zinc-finger nucleases. Proc Biol Sci (2014) 0.89
Physical constraints on biological integral control design for homeostasis and sensory adaptation. Biophys J (2013) 0.89
From face to interface recognition: a differential geometric approach to distinguish DNA from RNA binding surfaces. Nucleic Acids Res (2011) 0.87
Engineered zinc-finger transcription factors activate OCT4 (POU5F1), SOX2, KLF4, c-MYC (MYC) and miR302/367. Nucleic Acids Res (2014) 0.87
An RNA virus-encoded zinc-finger protein acts as a plant transcription factor and induces a regulator of cell size and proliferation in two tobacco species. Plant Cell (2013) 0.87
Structural basis for human PRDM9 action at recombination hot spots. Genes Dev (2016) 0.85
DNA recognition of 5-carboxylcytosine by a Zfp57 mutant at an atomic resolution of 0.97 Å. Biochemistry (2013) 0.84
B lymphocyte lineage specification, commitment and epigenetic control of transcription by early B cell factor 1. Curr Top Microbiol Immunol (2012) 0.84
Histone deacetylase inhibition rescues gene knockout levels achieved with integrase-defective lentiviral vectors encoding zinc-finger nucleases. Hum Gene Ther Methods (2013) 0.84
Zinc-finger recombinase activities in vitro. Nucleic Acids Res (2011) 0.84
Diversification of transcription factor paralogs via noncanonical modularity in C2H2 zinc finger DNA binding. Mol Cell (2014) 0.84
Zinc finger protein Loz1 is required for zinc-responsive regulation of gene expression in fission yeast. Proc Natl Acad Sci U S A (2013) 0.84
Transcriptomics and identification of the chemoreceptor superfamily of the pupal parasitoid of the oriental fruit fly, Spalangia endius Walker (Hymenoptera: Pteromalidae). PLoS One (2014) 0.83
Programming and reprogramming neuronal subtypes in the central nervous system. Dev Neurobiol (2012) 0.83
Targeting sarcoplasmic reticulum calcium ATPase by gene therapy. Hum Gene Ther (2013) 0.81
Engineered zinc-finger proteins can compensate genetic haploinsufficiency by transcriptional activation of the wild-type allele: application to Willams-Beuren syndrome and supravalvular aortic stenosis. Hum Gene Ther (2012) 0.81
Molecular underpinnings of Aprataxin RNA/DNA deadenylase function and dysfunction in neurological disease. Prog Biophys Mol Biol (2015) 0.81
Gene and protein therapies utilizing VEGF for ALS. Pharmacol Ther (2013) 0.80
The double zinc finger domain and adjacent accessory domain from the transcription factor loss of zinc sensing 1 (loz1) are necessary for DNA binding and zinc sensing. J Biol Chem (2014) 0.80
Sensor specific imaging of proteomic Zn2+ with zinquin and TSQ after cellular exposure to N-ethylmaleimide. Metallomics (2012) 0.80
Small-molecule regulators that mimic transcription factors. Biochim Biophys Acta (2010) 0.80
Sequence-specific biosensors report drug-induced changes in epigenetic silencing in living cells. DNA Cell Biol (2012) 0.80
Progress and Prospects of Anti-HBV Gene Therapy Development. Int J Mol Sci (2015) 0.80
TALE-PvuII fusion proteins--novel tools for gene targeting. PLoS One (2013) 0.80
Emerging therapies for mitochondrial disorders. Brain (2016) 0.80
UtroUp is a novel six zinc finger artificial transcription factor that recognises 18 base pairs of the utrophin promoter and efficiently drives utrophin upregulation. BMC Mol Biol (2013) 0.79
Comparative transcriptome of wild type and selected strains of the microalgae Tisochrysis lutea provides insights into the genetic basis, lipid metabolism and the life cycle. PLoS One (2014) 0.79
Evaluation of novel design strategies for developing zinc finger nucleases tools for treating human diseases. Biotechnol Res Int (2014) 0.79
Consumer acceptance of food crops developed by genome editing. Plant Cell Rep (2016) 0.78
Evolution and quantitative comparison of genome-wide protein domain distributions. Genes (Basel) (2011) 0.78
Controlling gene networks and cell fate with precision-targeted DNA-binding proteins and small-molecule-based genome readers. Biochem J (2014) 0.78
Involvement of PG2212 zinc finger protein in the regulation of oxidative stress resistance in Porphyromonas gingivalis W83. J Bacteriol (2014) 0.78
Conservation of the three-dimensional structure in non-homologous or unrelated proteins. Hum Genomics (2012) 0.78
Reduction in C-terminal amidated species of recombinant monoclonal antibodies by genetic modification of CHO cells. BMC Biotechnol (2014) 0.78
The zinc-finger domain was essential for porcine reproductive and respiratory syndrome virus nonstructural protein-1α to inhibit the production of interferon-β. J Interferon Cytokine Res (2013) 0.78
Control of enzyme reaction by a designed metal-ion-dependent α-helical coiled-coil protein. J Biol Inorg Chem (2012) 0.78
Alternative splicing regulates Prdm1/Blimp-1 DNA binding activities and corepressor interactions. Mol Cell Biol (2012) 0.78
Salient Features of Endonuclease Platforms for Therapeutic Genome Editing. Mol Ther (2016) 0.78
A designed DNA binding motif that recognizes extended sites and spans two adjacent major grooves. Chem Sci (2016) 0.78
Single-Base Pair Genome Editing in Human Cells by Using Site-Specific Endonucleases. Int J Mol Sci (2015) 0.77
From virus structure to chromatin: X-ray diffraction to three-dimensional electron microscopy. Annu Rev Biochem (2010) 0.76