Published in Biochem J on September 15, 2014
Nucleosome distortion as a possible mechanism of transcription activation domain function. Epigenetics Chromatin (2016) 0.76
Synthetic genome readers target clustered binding sites across diverse chromatin states. Proc Natl Acad Sci U S A (2016) 0.75
Reprogramming cell fate with a genome-scale library of artificial transcription factors. Proc Natl Acad Sci U S A (2016) 0.75
Genome-wide Mapping of Drug-DNA Interactions in Cells with COSMIC (Crosslinking of Small Molecules to Isolate Chromatin). J Vis Exp (2016) 0.75
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell (2006) 120.51
Induced pluripotent stem cell lines derived from human somatic cells. Science (2007) 71.50
RNA-guided human genome engineering via Cas9. Science (2013) 48.29
A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Science (2012) 48.17
Human DNA methylomes at base resolution show widespread epigenomic differences. Nature (2009) 34.27
A TALE nuclease architecture for efficient genome editing. Nat Biotechnol (2010) 26.47
One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering. Cell (2013) 24.00
Breaking the code of DNA binding specificity of TAL-type III effectors. Science (2009) 22.33
Expression of a single transfected cDNA converts fibroblasts to myoblasts. Cell (1987) 22.17
A short amino acid sequence able to specify nuclear location. Cell (1984) 21.17
A simple cipher governs DNA recognition by TAL effectors. Science (2009) 19.99
DNA targeting specificity of RNA-guided Cas9 nucleases. Nat Biotechnol (2013) 19.99
Highly efficient endogenous human gene correction using designed zinc-finger nucleases. Nature (2005) 19.15
Genome editing with engineered zinc finger nucleases. Nat Rev Genet (2010) 18.88
Selective inhibition of BET bromodomains. Nature (2010) 18.79
High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells. Nat Biotechnol (2013) 18.01
CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III. Nature (2011) 17.38
Cas9-crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria. Proc Natl Acad Sci U S A (2012) 16.48
Establishing, maintaining and modifying DNA methylation patterns in plants and animals. Nat Rev Genet (2010) 15.70
Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming. Cell (2008) 14.17
Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression. Cell (2013) 13.43
Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity. Cell (2013) 13.37
ChIP-seq: advantages and challenges of a maturing technology. Nat Rev Genet (2009) 13.12
Efficient construction of sequence-specific TAL effectors for modulating mammalian transcription. Nat Biotechnol (2011) 12.86
Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases. Nat Biotechnol (2009) 12.40
Hematopoiesis: an evolving paradigm for stem cell biology. Cell (2008) 11.95
Genetic engineering of human pluripotent cells using TALE nucleases. Nat Biotechnol (2011) 11.76
ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering. Trends Biotechnol (2013) 11.58
CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering. Nat Biotechnol (2013) 11.35
Rapid "open-source" engineering of customized zinc-finger nucleases for highly efficient gene modification. Mol Cell (2008) 11.24
CRISPR-Cas systems in bacteria and archaea: versatile small RNAs for adaptive defense and regulation. Annu Rev Genet (2011) 9.88
The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. Annu Rev Biochem (2010) 9.80
CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes. Cell (2013) 9.55
Somatic coding mutations in human induced pluripotent stem cells. Nature (2011) 9.50
TAL effectors: customizable proteins for DNA targeting. Science (2011) 9.47
Active DNA demethylation: many roads lead to Rome. Nat Rev Mol Cell Biol (2010) 9.35
Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells. Nat Biotechnol (2010) 9.24
A census of human transcription factors: function, expression and evolution. Nat Rev Genet (2009) 9.19
Selection-free zinc-finger-nuclease engineering by context-dependent assembly (CoDA). Nat Methods (2010) 8.86
Functional dissection of VP16, the trans-activator of herpes simplex virus immediate early gene expression. Genes Dev (1988) 8.82
Distinct factors control histone variant H3.3 localization at specific genomic regions. Cell (2010) 8.79
DNA-binding factors shape the mouse methylome at distal regulatory regions. Nature (2011) 8.75
Induced pluripotent stem cells and embryonic stem cells are distinguished by gene expression signatures. Cell Stem Cell (2009) 8.62
Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia. Nature (2011) 8.29
One-step generation of mice carrying reporter and conditional alleles by CRISPR/Cas-mediated genome engineering. Cell (2013) 7.99
A novel TALE nuclease scaffold enables high genome editing activity in combination with low toxicity. Nucleic Acids Res (2011) 7.93
Design and selection of novel Cys2His2 zinc finger proteins. Annu Rev Biochem (2001) 7.79
Xanthomonas AvrBs3 family-type III effectors: discovery and function. Annu Rev Phytopathol (2010) 7.70
Super-enhancers in the control of cell identity and disease. Cell (2013) 7.50
Embryonic stem cell differentiation: emergence of a new era in biology and medicine. Genes Dev (2005) 7.27
TALENs: a widely applicable technology for targeted genome editing. Nat Rev Mol Cell Biol (2012) 7.01
Revealing off-target cleavage specificities of zinc-finger nucleases by in vitro selection. Nat Methods (2011) 6.90
DNA recognition by Cys2His2 zinc finger proteins. Annu Rev Biophys Biomol Struct (2000) 6.61
Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations. Cell (2011) 6.56
An unbiased genome-wide analysis of zinc-finger nuclease specificity. Nat Biotechnol (2011) 6.44
Optical control of mammalian endogenous transcription and epigenetic states. Nature (2013) 6.09
Pioneer transcription factors: establishing competence for gene expression. Genes Dev (2011) 6.01
Forcing cells to change lineages. Nature (2009) 5.99
Toward controlling gene expression at will: specific regulation of the erbB-2/HER-2 promoter by using polydactyl zinc finger proteins constructed from modular building blocks. Proc Natl Acad Sci U S A (1998) 5.46
Biological significance of a family of regularly spaced repeats in the genomes of Archaea, Bacteria and mitochondria. Mol Microbiol (2000) 5.46
FokI dimerization is required for DNA cleavage. Proc Natl Acad Sci U S A (1998) 5.31
Zif268 protein-DNA complex refined at 1.6 A: a model system for understanding zinc finger-DNA interactions. Structure (1996) 5.30
Conditional control of gene expression in the mouse. Nat Rev Genet (2001) 5.30
The molecular origin of DNA-drug specificity in netropsin and distamycin. Proc Natl Acad Sci U S A (1985) 5.14
Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds. Science (2013) 4.94
Induced pluripotency: history, mechanisms, and applications. Genes Dev (2010) 4.89
Toward controlling gene expression at will: selection and design of zinc finger domains recognizing each of the 5'-GNN-3' DNA target sequences. Proc Natl Acad Sci U S A (1999) 4.87
Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling. Proc Natl Acad Sci U S A (2012) 4.85
Krüppel-associated boxes are potent transcriptional repression domains. Proc Natl Acad Sci U S A (1994) 4.84
CRISPR RNA-guided activation of endogenous human genes. Nat Methods (2013) 4.69
Orthogonal Cas9 proteins for RNA-guided gene regulation and editing. Nat Methods (2013) 4.61
A nonviral minicircle vector for deriving human iPS cells. Nat Methods (2010) 4.42
Engineering polydactyl zinc-finger transcription factors. Nat Biotechnol (2002) 4.40
Reprogramming of fibroblasts into induced pluripotent stem cells with orphan nuclear receptor Esrrb. Nat Cell Biol (2009) 4.32
Toward rules relating zinc finger protein sequences and DNA binding site preferences. Proc Natl Acad Sci U S A (1992) 4.15
Selection of DNA binding sites for zinc fingers using rationally randomized DNA reveals coded interactions. Proc Natl Acad Sci U S A (1994) 4.12
Human zinc fingers as building blocks in the construction of artificial transcription factors. Nat Biotechnol (2003) 4.03
Functional genomics, proteomics, and regulatory DNA analysis in isogenic settings using zinc finger nuclease-driven transgenesis into a safe harbor locus in the human genome. Genome Res (2010) 3.94
Transcription in yeast activated by a putative amphipathic alpha helix linked to a DNA binding unit. Nature (1988) 3.93
Locus-specific editing of histone modifications at endogenous enhancers. Nat Biotechnol (2013) 3.82
Reprogramming of human primary somatic cells by OCT4 and chemical compounds. Cell Stem Cell (2010) 3.82
Recognition of the DNA minor groove by pyrrole-imidazole polyamides. Curr Opin Struct Biol (2003) 3.80
The discovery of zinc fingers and their applications in gene regulation and genome manipulation. Annu Rev Biochem (2010) 3.75
Molecular recognition of DNA by small molecules. Bioorg Med Chem (2001) 3.69
The crystal structure of TAL effector PthXo1 bound to its DNA target. Science (2012) 3.69
Structural basis for sequence-specific recognition of DNA by TAL effectors. Science (2012) 3.64
Comprehensive interrogation of natural TALE DNA-binding modules and transcriptional repressor domains. Nat Commun (2012) 3.60
Efficient genome engineering in human pluripotent stem cells using Cas9 from Neisseria meningitidis. Proc Natl Acad Sci U S A (2013) 3.53
Deregulated homeobox gene expression in cancer: cause or consequence? Nat Rev Cancer (2002) 3.53
Design, construction and in vitro testing of zinc finger nucleases. Nat Protoc (2006) 3.51
Regulation of an endogenous locus using a panel of designed zinc finger proteins targeted to accessible chromatin regions. Activation of vascular endothelial growth factor A. J Biol Chem (2001) 3.38
Development of zinc finger domains for recognition of the 5'-ANN-3' family of DNA sequences and their use in the construction of artificial transcription factors. J Biol Chem (2001) 3.35
Synergistic and tunable human gene activation by combinations of synthetic transcription factors. Nat Methods (2013) 3.26
The role of double-strand break repair - insights from human genetics. Nat Rev Genet (2006) 3.25
Validated zinc finger protein designs for all 16 GNN DNA triplet targets. J Biol Chem (2001) 3.19
A rapid, generally applicable method to engineer zinc fingers illustrated by targeting the HIV-1 promoter. Nat Biotechnol (2001) 3.12
TAL effector RVD specificities and efficiencies. Nat Biotechnol (2012) 3.12
The art and design of genetic screens: RNA interference. Nat Rev Genet (2008) 3.11
Lin28 enhances tissue repair by reprogramming cellular metabolism. Cell (2013) 3.08
Expanding or restricting the target site repertoire of zinc-finger nucleases: the inter-domain linker as a major determinant of target site selectivity. Mol Ther (2008) 3.02
A library of yeast transcription factor motifs reveals a widespread function for Rsc3 in targeting nucleosome exclusion at promoters. Mol Cell (2008) 4.49
Genome-wide distribution of yeast RNA polymerase II and its control by Sen1 helicase. Mol Cell (2006) 3.46
Defining the sequence-recognition profile of DNA-binding molecules. Proc Natl Acad Sci U S A (2006) 2.97
TFIIH kinase places bivalent marks on the carboxy-terminal domain of RNA polymerase II. Mol Cell (2009) 2.61
Gene loops enhance transcriptional directionality. Science (2012) 2.50
Regulator trafficking on bacterial transcription units in vivo. Mol Cell (2009) 2.43
A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II. Mol Cell (2004) 2.27
Two cyclin-dependent kinases promote RNA polymerase II transcription and formation of the scaffold complex. Mol Cell Biol (2004) 2.26
Immobilization of Escherichia coli RNA polymerase and location of binding sites by use of chromatin immunoprecipitation and microarrays. J Bacteriol (2005) 2.06
Chemical-genomic dissection of the CTD code. Nat Struct Mol Biol (2010) 1.76
Chemical inhibition of the TFIIH-associated kinase Cdk7/Kin28 does not impair global mRNA synthesis. Proc Natl Acad Sci U S A (2007) 1.71
Fingers reach for the genome. Nat Biotechnol (2003) 1.48
Specificity landscapes of DNA binding molecules elucidate biological function. Proc Natl Acad Sci U S A (2010) 1.39
Holoenzyme switching and stochastic release of sigma factors from RNA polymerase in vivo. Mol Cell (2005) 1.32
Quantitative microarray profiling of DNA-binding molecules. J Am Chem Soc (2007) 1.30
Ssu72 phosphatase-dependent erasure of phospho-Ser7 marks on the RNA polymerase II C-terminal domain is essential for viability and transcription termination. J Biol Chem (2012) 1.30
A TAD further: exogenous control of gene activation. ACS Chem Biol (2007) 1.27
Cooperativity in RNA-protein interactions: global analysis of RNA binding specificity. Cell Rep (2012) 1.22
The conserved bromo-adjacent homology domain of yeast Orc1 functions in the selection of DNA replication origins within chromatin. Genes Dev (2010) 1.11
Design of artificial transcriptional activators with rigid poly-L-proline linkers. J Am Chem Soc (2002) 1.09
The bacterial response regulator ArcA uses a diverse binding site architecture to regulate carbon oxidation globally. PLoS Genet (2013) 1.08
Emerging Views on the CTD Code. Genet Res Int (2012) 1.08
Targeted chemical wedges reveal the role of allosteric DNA modulation in protein-DNA assembly. ACS Chem Biol (2008) 1.06
Toward artificial developmental regulators. J Am Chem Soc (2003) 1.02
The origin recognition complex interacts with a subset of metabolic genes tightly linked to origins of replication. PLoS Genet (2009) 0.98
Minimization of a protein-DNA dimerizer. J Am Chem Soc (2007) 0.97
RNA sequences that work as transcriptional activating regions. Nucleic Acids Res (2003) 0.97
Jarid2 (Jumonji, AT rich interactive domain 2) regulates NOTCH1 expression via histone modification in the developing heart. J Biol Chem (2011) 0.96
CSI-FID: high throughput label-free detection of DNA binding molecules. Bioorg Med Chem Lett (2009) 0.96
Temperature-sensitive protein-DNA dimerizers. Proc Natl Acad Sci U S A (2005) 0.92
A target essential for the activity of a nonacidic yeast transcriptional activator. Proc Natl Acad Sci U S A (2002) 0.91
Interactions of Sen1, Nrd1, and Nab3 with multiple phosphorylated forms of the Rpb1 C-terminal domain in Saccharomyces cerevisiae. Eukaryot Cell (2012) 0.90
Sequence-specificity and energy landscapes of DNA-binding molecules. Methods Enzymol (2011) 0.89
CSI-Tree: a regression tree approach for modeling binding properties of DNA-binding molecules based on cognate site identification (CSI) data. Nucleic Acids Res (2008) 0.88
Chemical biology: A Notch above other inhibitors. Nature (2009) 0.87
Cognate Site Identifier analysis reveals novel binding properties of the Sex Inducer homeodomain proteins of Cryptococcus neoformans. Mol Microbiol (2009) 0.84
Mapping E. coli RNA polymerase and associated transcription factors and identifying promoters genome-wide. Methods Enzymol (2011) 0.83
Determining DNA sequence specificity of natural and artificial transcription factors by cognate site identifier analysis. Methods Mol Biol (2009) 0.83
Expanding the specificity of DNA targeting by harnessing cooperative assembly. Biochimie (2008) 0.83
Mapping polyamide-DNA interactions in human cells reveals a new design strategy for effective targeting of genomic sites. Angew Chem Int Ed Engl (2014) 0.82
Nucleating the assembly of macromolecular complexes. Chembiochem (2010) 0.80
Small-molecule regulators that mimic transcription factors. Biochim Biophys Acta (2010) 0.80
Unraveling the mechanism of a potent transcriptional activator. J Biol Chem (2005) 0.80
Fabrication of duplex DNA microarrays incorporating methyl-5-cytosine. Lab Chip (2011) 0.80
Converting inactive peptides into potent transcriptional activators. ACS Chem Biol (2006) 0.78
Har Gobind Khorana 1922-2011. Cell (2011) 0.75