Published in Eur J Pharmacol on March 01, 2010
Signals for sorting of transmembrane proteins to endosomes and lysosomes. Annu Rev Biochem (2003) 13.66
Beta-arrestins and cell signaling. Annu Rev Physiol (2007) 8.65
Signal-dependent membrane protein trafficking in the endocytic pathway. Annu Rev Cell Biol (1993) 7.16
Beta-arrestin acts as a clathrin adaptor in endocytosis of the beta2-adrenergic receptor. Nature (1996) 6.32
A novel di-leucine motif and a tyrosine-based motif independently mediate lysosomal targeting and endocytosis of CD3 chains. Cell (1992) 4.39
The beta2-adrenergic receptor/betaarrestin complex recruits the clathrin adaptor AP-2 during endocytosis. Proc Natl Acad Sci U S A (1999) 3.43
Beta-adrenergic receptor kinase: identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor. Proc Natl Acad Sci U S A (1986) 3.38
Ligand-regulated internalization and recycling of human beta 2-adrenergic receptors between the plasma membrane and endosomes containing transferrin receptors. J Biol Chem (1992) 2.91
Protein targeting by tyrosine- and di-leucine-based signals: evidence for distinct saturable components. J Cell Biol (1996) 2.78
The use of a charge-coupled device for quantitative optical microscopy of biological structures. Science (1987) 2.64
Amino and carboxyl terminal modifications to facilitate the production and purification of a G protein-coupled receptor. Anal Biochem (1995) 2.62
A structural explanation for the binding of endocytic dileucine motifs by the AP2 complex. Nature (2008) 2.17
Characterization of agonist stimulation of cAMP-dependent protein kinase and G protein-coupled receptor kinase phosphorylation of the beta2-adrenergic receptor using phosphoserine-specific antibodies. Mol Pharmacol (2004) 1.79
Role of clathrin-mediated endocytosis in agonist-induced down-regulation of the beta2-adrenergic receptor. J Biol Chem (1998) 1.71
Cargo recognition during clathrin-mediated endocytosis: a team effort. Curr Opin Cell Biol (2004) 1.62
The residues Leu(Ile)475-Ile(Leu, Val, Ala)476, contained in the extended carboxyl cytoplasmic tail, are critical for targeting of the resident lysosomal membrane protein LIMP II to lysosomes. J Biol Chem (1994) 1.44
Rab11 regulates the recycling and lysosome targeting of beta2-adrenergic receptors. J Cell Sci (2004) 1.38
Role of the G protein-coupled receptor kinase site serine cluster in beta2-adrenergic receptor internalization, desensitization, and beta-arrestin translocation. J Biol Chem (2006) 1.33
Localization of the sites mediating desensitization of the beta(2)-adrenergic receptor by the GRK pathway. Mol Pharmacol (2000) 1.32
beta2-adrenergic receptor desensitization, internalization, and phosphorylation in response to full and partial agonists. J Biol Chem (1997) 1.30
Anterograde trafficking of G protein-coupled receptors: function of the C-terminal F(X)6LL motif in export from the endoplasmic reticulum. Mol Pharmacol (2008) 1.25
Distinct reading of different structural determinants modulates the dileucine-mediated transport steps of the lysosomal membrane protein LIMPII and the insulin-sensitive glucose transporter GLUT4. J Biol Chem (2000) 1.21
Differential phosphorylation and dephosphorylation of beta2-adrenoceptor sites Ser262 and Ser355,356. Br J Pharmacol (2006) 1.20
Agonist-induced sorting of human beta2-adrenergic receptors to lysosomes during downregulation. J Cell Sci (1999) 1.17
Repetitive endocytosis and recycling of the beta 2-adrenergic receptor during agonist-induced steady state redistribution. Mol Pharmacol (1996) 1.13
Activation of cAMP-dependent protein kinase is required for heterologous desensitization of adenylyl cyclase in S49 wild-type lymphoma cells. Proc Natl Acad Sci U S A (1988) 1.11
Role of helix 8 in G protein-coupled receptors based on structure-function studies on the type 1 angiotensin receptor. Mol Cell Endocrinol (2009) 0.98
A dileucine motif in the C terminus of the beta2-adrenergic receptor is involved in receptor internalization. Proc Natl Acad Sci U S A (1997) 0.95
Specific changes in beta2-adrenoceptor trafficking kinetics and intracellular sorting during downregulation. Eur J Pharmacol (1999) 0.84
Role of the carboxyl terminal di-leucine in phosphorylation and internalization of C5a receptor. Biochim Biophys Acta (2008) 0.83
A dileucine signal situated in the C-terminal tail of the lysosomal membrane protein p40 is responsible for its targeting to lysosomes. Biochem J (2008) 0.78
Chronic exposure to beta-blockers attenuates inflammation and mucin content in a murine asthma model. Am J Respir Cell Mol Biol (2007) 2.24
Effects of acute and chronic administration of beta-adrenoceptor ligands on airway function in a murine model of asthma. Proc Natl Acad Sci U S A (2004) 1.85
Characterization of agonist stimulation of cAMP-dependent protein kinase and G protein-coupled receptor kinase phosphorylation of the beta2-adrenergic receptor using phosphoserine-specific antibodies. Mol Pharmacol (2004) 1.79
β2-Adrenoceptor agonists are required for development of the asthma phenotype in a murine model. Am J Respir Cell Mol Biol (2012) 1.73
Beta2-adrenoceptor signaling is required for the development of an asthma phenotype in a murine model. Proc Natl Acad Sci U S A (2009) 1.53
Rab11 regulates the recycling and lysosome targeting of beta2-adrenergic receptors. J Cell Sci (2004) 1.38
Role of the G protein-coupled receptor kinase site serine cluster in beta2-adrenergic receptor internalization, desensitization, and beta-arrestin translocation. J Biol Chem (2006) 1.33
Changes in beta 2-adrenoceptor and other signaling proteins produced by chronic administration of 'beta-blockers' in a murine asthma model. Pulm Pharmacol Ther (2007) 1.30
Regulation of inducible nitric oxide synthase by aggresome formation. Proc Natl Acad Sci U S A (2005) 1.23
Differential phosphorylation and dephosphorylation of beta2-adrenoceptor sites Ser262 and Ser355,356. Br J Pharmacol (2006) 1.20
Characterization of beta2-adrenergic receptor dephosphorylation: Comparison with the rate of resensitization. Mol Pharmacol (2006) 1.13
Salmeterol stimulation dissociates beta2-adrenergic receptor phosphorylation and internalization. Am J Respir Cell Mol Biol (2006) 1.06
Rapid recycling of beta-adrenergic receptors is dependent on the actin cytoskeleton and myosin Vb. Traffic (2008) 0.98
Regulation of G-protein-coupled receptor activity by rab GTPases. Receptors Channels (2002) 0.91
Anti-inflammatory activities of beta2-agonists. Curr Drug Targets Inflamm Allergy (2004) 0.90
Assembly of a three-dimensional multitype bronchiole coculture model using magnetic levitation. Tissue Eng Part C Methods (2013) 0.89
Endosome sorting of beta 2-adrenoceptors is GRK5 independent. Br J Pharmacol (2003) 0.88
In vivo phosphorylation of the somatostatin 2A receptor in human tumors. J Clin Endocrinol Metab (2003) 0.88
Measurement of receptor desensitization and internalization in intact cells. Methods Enzymol (2002) 0.81
The role of intrinsic efficacy in determining response to a beta2-agonist in acute severe asthma. Respir Med (2006) 0.80
Rapid and progressive pulmonary fibrosis in 2 families with DNA repair deficiencies of undetermined etiology. J Pediatr (2012) 0.78
Inhibitors of phosphoinositide 3-kinase cause defects in the postendocytic sorting of beta2-adrenergic receptors. Exp Cell Res (2007) 0.78
Recurrent pneumonias secondary to an endobronchial inflammatory myofibroblastic tumor. Am J Respir Crit Care Med (2013) 0.76
The effects of acute and chronic nadolol treatment on β2AR signaling in HEK293 cells. Naunyn Schmiedebergs Arch Pharmacol (2011) 0.75
Intravenous injection of pharmaceutical tablets presenting as multiple pulmonary nodules and declining pulmonary function in an adolescent with cystic fibrosis. Pediatrics (2006) 0.75
Statins in Asthma: A Closer Look into the Pharmacological Mechanism of Action. Pharmacology (2016) 0.75
An unusual cause of chest pain in a child. J Pediatr (2011) 0.75