Published in Free Radic Biol Med on March 01, 2010
Clustered DNA lesion repair in eukaryotes: relevance to mutagenesis and cell survival. Mutat Res (2010) 1.23
Choosing the right path: does DNA-PK help make the decision? Mutat Res (2011) 1.18
Chemotherapeutic compounds targeting the DNA double-strand break repair pathways: the good, the bad, and the promising. Front Oncol (2014) 1.06
Small Molecules, Inhibitors of DNA-PK, Targeting DNA Repair, and Beyond. Front Pharmacol (2013) 1.05
Base damage immediately upstream from double-strand break ends is a more severe impediment to nonhomologous end joining than blocked 3'-termini. Radiat Res (2011) 0.94
DNA repair targeted therapy: The past or future of cancer treatment? Pharmacol Ther (2016) 0.84
The catalytic subunit of DNA-dependent protein kinase is required for cellular resistance to oxidative stress independent of DNA double-strand break repair. Free Radic Biol Med (2014) 0.82
Detection of clustered DNA lesions: Biological and clinical applications. World J Biol Chem (2011) 0.80
Docosahexaenoic acid (DHA) sensitizes brain tumor cells to etoposide-induced apoptosis. Curr Mol Med (2011) 0.79
Preventing Damage Limitation: Targeting DNA-PKcs and DNA Double-Strand Break Repair Pathways for Ovarian Cancer Therapy. Front Oncol (2015) 0.78
Analysis of telomere length and function in radiosensitive mouse and human cells in response to DNA-PKcs inhibition. Genome Integr (2013) 0.76
Differences in vector-genome processing and illegitimate integration of non-integrating lentiviral vectors. Gene Ther (2016) 0.75
Rapid Diminution in the Level and Activity of DNA-Dependent Protein Kinase in Cancer Cells by a Reactive Nitro-Benzoxadiazole Compound. Int J Mol Sci (2016) 0.75
Damage clusters after gamma irradiation of a nanoparticulate plasmid DNA peptide condensate. Radiat Environ Biophys (2011) 0.75
Megabase chromatin domains involved in DNA double-strand breaks in vivo. J Cell Biol (1999) 16.81
GammaH2AX and cancer. Nat Rev Cancer (2008) 9.77
Regulation of DNA double-strand break repair pathway choice. Cell Res (2008) 6.19
A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci. Mol Cell (2004) 5.29
Gamma-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin. Nucleic Acids Res (2008) 4.79
Absence of p350 subunit of DNA-activated protein kinase from a radiosensitive human cell line. Science (1995) 4.19
Role of non-homologous end joining (NHEJ) in maintaining genomic integrity. DNA Repair (Amst) (2006) 2.67
Ataxia telangiectasia mutated (ATM) is essential for DNA-PKcs phosphorylations at the Thr-2609 cluster upon DNA double strand break. J Biol Chem (2006) 2.66
Catalytic subunit of DNA-dependent protein kinase: impact on lymphocyte development and tumorigenesis. Proc Natl Acad Sci U S A (1999) 2.58
Radiosensitization and DNA repair inhibition by the combined use of novel inhibitors of DNA-dependent protein kinase and poly(ADP-ribose) polymerase-1. Cancer Res (2003) 2.49
Oxidative stress, DNA methylation and carcinogenesis. Cancer Lett (2008) 2.27
The DNA-dependent protein kinase: the director at the end. Immunol Rev (2004) 2.20
DNA-PK: the means to justify the ends? Adv Immunol (2008) 2.14
trans Autophosphorylation at DNA-dependent protein kinase's two major autophosphorylation site clusters facilitates end processing but not end joining. Mol Cell Biol (2007) 1.80
Role of oxidatively induced DNA lesions in human pathogenesis. Mutat Res (2010) 1.78
Collaboration of homologous recombination and nonhomologous end-joining factors for the survival and integrity of mice and cells. Genes Dev (2004) 1.77
Formation of clustered DNA damage after high-LET irradiation: a review. J Radiat Res (2008) 1.76
Deficiency in the catalytic subunit of DNA-dependent protein kinase causes down-regulation of ATM. Cancer Res (2005) 1.65
Abortive base-excision repair of radiation-induced clustered DNA lesions in Escherichia coli. Proc Natl Acad Sci U S A (2001) 1.59
Oxidation of the sugar moiety of DNA by ionizing radiation or bleomycin could induce the formation of a cluster DNA lesion. Proc Natl Acad Sci U S A (2007) 1.47
Mammalian cells are not killed by DNA single-strand breaks caused by hydroxyl radicals from hydrogen peroxide. Radiat Res (1985) 1.45
A deficiency in DNA repair and DNA-PKcs expression in the radiosensitive BALB/c mouse. Cancer Res (2000) 1.44
Processing of clustered DNA damage generates additional double-strand breaks in mammalian cells post-irradiation. Nucleic Acids Res (2004) 1.37
XRCC1 is phosphorylated by DNA-dependent protein kinase in response to DNA damage. Nucleic Acids Res (2006) 1.32
Processing of bistranded abasic DNA clusters in gamma-irradiated human hematopoietic cells. Nucleic Acids Res (2004) 1.31
Backup pathways of NHEJ are suppressed by DNA-PK. J Cell Biochem (2004) 1.31
Human base excision repair complex is physically associated to DNA replication and cell cycle regulatory proteins. Nucleic Acids Res (2007) 1.30
Elevated breast cancer risk in irradiated BALB/c mice associates with unique functional polymorphism of the Prkdc (DNA-dependent protein kinase catalytic subunit) gene. Cancer Res (2001) 1.24
Telomere dysfunction and DNA-PKcs deficiency: characterization and consequence. Cancer Res (2009) 1.23
Breast cancer risk associated with genotypic polymorphism of the nonhomologous end-joining genes: a multigenic study on cancer susceptibility. Cancer Res (2003) 1.21
Processing of DNA damage clusters in human cells: current status of knowledge. Mol Biosyst (2007) 1.12
DNA repair of clustered lesions in mammalian cells: involvement of non-homologous end-joining. Nucleic Acids Res (2008) 1.09
Base excision repair processing of abasic site/single-strand break lesions within clustered damage sites associated with XRCC1 deficiency. Nucleic Acids Res (2007) 1.08
Frameshift mutation in PRKDC, the gene for DNA-PKcs, in the DNA repair-defective, human, glioma-derived cell line M059J. Radiat Res (2001) 1.05
The association of DNA-dependent protein kinase activity with chromosomal instability and risk of cancer. Carcinogenesis (2005) 1.05
Reduced DNA double strand breaks in chlorambucil resistant cells are related to high DNA-PKcs activity and low oxidative stress. Toxicology (2003) 1.04
The formation of double-strand breaks at multiply damaged sites is driven by the kinetics of excision/incision at base damage in eukaryotic cells. Nucleic Acids Res (2009) 1.02
Focus formation of DNA repair proteins in normal and repair-deficient cells irradiated with high-LET ions. Radiat Res (2004) 1.02
Distinct pathways of nonhomologous end joining that are differentially regulated by DNA-dependent protein kinase-mediated phosphorylation. J Biol Chem (2003) 1.01
Reduced DNA-dependent protein kinase activity is associated with lung cancer. Carcinogenesis (2001) 1.01
DNA-dependent protein kinase inhibitors as drug candidates for the treatment of cancer. Mol Cancer Ther (2003) 1.01
DNA end joining activity is reduced in Alzheimer's disease. Neurobiol Aging (2006) 1.01
Induction and processing of complex DNA damage in human breast cancer cells MCF-7 and nonmalignant MCF-10A cells. Free Radic Biol Med (2007) 1.00
The pyridinylfuranopyrimidine inhibitor, PI-103, chemosensitizes glioblastoma cells for apoptosis by inhibiting DNA repair. Oncogene (2009) 0.99
Accumulation of oxidatively induced clustered DNA lesions in human tumor tissues. Mutat Res (2008) 0.99
Altered expression of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) during gastric carcinogenesis and its clinical implications on gastric cancer. Int J Oncol (2007) 0.97
Repair of clustered DNA lesions. Sequence-specific inhibition of long-patch base excision repair be 8-oxoguanine. J Biol Chem (2002) 0.96
Compromised repair of clustered DNA damage in the human acute lymphoblastic leukemia MSH2-deficient NALM-6 cells. Mutat Res (2008) 0.96
Hippocampal neurons of mice deficient in DNA-dependent protein kinase exhibit increased vulnerability to DNA damage, oxidative stress and excitotoxicity. Brain Res Mol Brain Res (2001) 0.94
A possible role of Ku in mediating sequential repair of closely opposed lesions. J Biol Chem (2001) 0.94
PI3K-Akt signaling regulates basal, but MAP-kinase signaling regulates radiation-induced XRCC1 expression in human tumor cells in vitro. DNA Repair (Amst) (2008) 0.92
Processing of thymine glycol in a clustered DNA damage site: mutagenic or cytotoxic. Nucleic Acids Res (2009) 0.91
Processing of clustered DNA damage in human breast cancer cells MCF-7 with partial DNA-PKcs deficiency. Cancer Lett (2008) 0.89
Decreased DNA-PK activity in human cancer cells exhibiting hypersensitivity to low-dose irradiation. Br J Cancer (2000) 0.89
Detection of complex DNA damage in gamma-irradiated acute lymphoblastic leukemia Pre-b NALM-6 cells. Radiat Res (2007) 0.87
Activation of the DNA-dependent protein kinase by drug-induced and radiation-induced DNA strand breaks. Radiat Res (2003) 0.86
Reactive oxygen species elicit apoptosis by concurrently disrupting topoisomerase II and DNA-dependent protein kinase. Mol Pharmacol (2005) 0.83
DNA-PK activation by ionizing radiation-induced DNA single-strand breaks. Int J Radiat Biol (1999) 0.82
Implications of tyrosine phosphoproteomics in cervical carcinogenesis. J Carcinog (2008) 0.81
Induction and processing of oxidative clustered DNA lesions in 56Fe-ion-irradiated human monocytes. Radiat Res (2007) 0.81
Diversity of peripheral blood mononuclear cells as revealed by a novel multiple microgel "comet assay". Environ Mol Mutagen (2000) 0.78
DNA-PK inhibitor wortmannin enhances DNA damage induced by bleomycin in V79 Chinese hamster cells. Teratog Carcinog Mutagen (2002) 0.76
Genomic instability in mice lacking histone H2AX. Science (2002) 10.23
GammaH2AX and cancer. Nat Rev Cancer (2008) 9.77
Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks. Nat Cell Biol (2003) 8.55
DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1. Nat Cell Biol (2002) 5.85
Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks. Nat Cell Biol (2004) 4.87
Distribution and dynamics of chromatin modification induced by a defined DNA double-strand break. Curr Biol (2004) 4.35
Quantitative detection of (125)IdU-induced DNA double-strand breaks with gamma-H2AX antibody. Radiat Res (2002) 4.05
Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes. J Biol Chem (2003) 3.45
H2AX is required for chromatin remodeling and inactivation of sex chromosomes in male mouse meiosis. Dev Cell (2003) 3.42
Characteristics of gamma-H2AX foci at DNA double-strand breaks sites. Biochem Cell Biol (2003) 3.17
The complexity of phosphorylated H2AX foci formation and DNA repair assembly at DNA double-strand breaks. Cell Cycle (2010) 2.84
Histone H2AX in DNA damage and repair. Cancer Biol Ther (2003) 2.59
Role of oxidative stress and DNA damage in human carcinogenesis. Mutat Res (2011) 2.54
H2AX: functional roles and potential applications. Chromosoma (2009) 2.27
Oxidative stress, DNA methylation and carcinogenesis. Cancer Lett (2008) 2.27
Histone gammaH2AX and poly(ADP-ribose) as clinical pharmacodynamic biomarkers. Clin Cancer Res (2010) 2.12
Yeast histone 2A serine 129 is essential for the efficient repair of checkpoint-blind DNA damage. EMBO Rep (2003) 1.96
Reactive oxygen species (ROS)--induced genetic and epigenetic alterations in human carcinogenesis. Mutat Res (2011) 1.90
Delayed kinetics of DNA double-strand break processing in normal and pathological aging. Aging Cell (2007) 1.84
UV-induced replication arrest in the xeroderma pigmentosum variant leads to DNA double-strand breaks, gamma -H2AX formation, and Mre11 relocalization. Proc Natl Acad Sci U S A (2001) 1.83
A unified phylogeny-based nomenclature for histone variants. Epigenetics Chromatin (2012) 1.82
DNA double-strand breaks form in bystander cells after microbeam irradiation of three-dimensional human tissue models. Cancer Res (2007) 1.79
Role of oxidatively induced DNA lesions in human pathogenesis. Mutat Res (2010) 1.78
Formation of clustered DNA damage after high-LET irradiation: a review. J Radiat Res (2008) 1.76
γ-H2AX as a biomarker of DNA damage induced by ionizing radiation in human peripheral blood lymphocytes and artificial skin. Adv Space Res (2009) 1.75
Glutathione depletion is necessary for apoptosis in lymphoid cells independent of reactive oxygen species formation. J Biol Chem (2007) 1.73
Ataxia telangiectasia mutated activation by transcription- and topoisomerase I-induced DNA double-strand breaks. EMBO Rep (2009) 1.69
Techniques for gamma-H2AX detection. Methods Enzymol (2006) 1.61
Ionizing radiation induces DNA double-strand breaks in bystander primary human fibroblasts. Oncogene (2005) 1.58
Both telomeric and non-telomeric DNA damage are determinants of mammalian cellular senescence. Epigenetics Chromatin (2008) 1.50
GammaH2AX in cancer cells: a potential biomarker for cancer diagnostics, prediction and recurrence. Cell Cycle (2006) 1.48
The use of gamma-H2AX as a biodosimeter for total-body radiation exposure in non-human primates. PLoS One (2010) 1.46
Twist1-induced dissemination preserves epithelial identity and requires E-cadherin. J Cell Biol (2014) 1.42
The phosphorylation status of PAS-B distinguishes HIF-1alpha from HIF-2alpha in NBS1 repression. EMBO J (2006) 1.38
Environmental toxicity, oxidative stress and apoptosis: ménage à trois. Mutat Res (2008) 1.38
Recent developments in the use of γ-H2AX as a quantitative DNA double-strand break biomarker. Aging (Albany NY) (2011) 1.36
Development of a validated immunofluorescence assay for γH2AX as a pharmacodynamic marker of topoisomerase I inhibitor activity. Clin Cancer Res (2010) 1.35
DNA damage and autophagy. Mutat Res (2011) 1.34
The antioxidant transcription factor Nrf2 negatively regulates autophagy and growth arrest induced by the anticancer redox agent mitoquinone. J Biol Chem (2010) 1.33
Tumors induce complex DNA damage in distant proliferative tissues in vivo. Proc Natl Acad Sci U S A (2010) 1.29
Oxidative stress, redox signaling, and autophagy: cell death versus survival. Antioxid Redox Signal (2014) 1.25
Intercellular communication of cellular stress monitored by gamma-H2AX induction. Carcinogenesis (2009) 1.23
gamma-H2AX in bystander cells: not just a radiation-triggered event, a cellular response to stress mediated by intercellular communication. Cell Cycle (2007) 1.22
γ-H2AX detection in peripheral blood lymphocytes, splenocytes, bone marrow, xenografts, and skin. Methods Mol Biol (2011) 1.20
Twist1 suppresses senescence programs and thereby accelerates and maintains mutant Kras-induced lung tumorigenesis. PLoS Genet (2012) 1.15
DNA damage induced by endogenous aldehydes: current state of knowledge. Mutat Res (2011) 1.13
Molecular mechanisms of pesticide-induced neurotoxicity: Relevance to Parkinson's disease. Chem Biol Interact (2010) 1.10
Duodenal carcinoma at the ligament of Treitz. A molecular and clinical perspective. BMC Gastroenterol (2010) 1.09
Bimodal recognition of DNA geometry by human topoisomerase II alpha: preferential relaxation of positively supercoiled DNA requires elements in the C-terminal domain. Biochemistry (2008) 1.09
Telomere-dependent and telomere-independent origins of endogenous DNA damage in tumor cells. Aging (Albany NY) (2009) 1.08
γ-H2AX and other histone post-translational modifications in the clinic. Biochim Biophys Acta (2012) 1.07
Cdc6 expression represses E-cadherin transcription and activates adjacent replication origins. J Cell Biol (2011) 1.04
Autocrine signaling involved in cell volume regulation: the role of released transmitters and plasma membrane receptors. J Cell Physiol (2008) 1.04
Repair of radiation-induced DNA double-strand breaks is dependent upon radiation quality and the structural complexity of double-strand breaks. Radiat Res (2003) 1.04
The role of reactive oxygen species and oxidative stress in environmental carcinogenesis and biomarker development. Chem Biol Interact (2010) 1.03
γH2AX foci as a measure of DNA damage: a computational approach to automatic analysis. Mutat Res (2011) 1.01
Effects of radiation quality and oxygen on clustered DNA lesions and cell death. Radiat Res (2011) 1.01
Quantifying clustered DNA damage induction and repair by gel electrophoresis, electronic imaging and number average length analysis. Mutat Res (2003) 1.01
Induction and processing of complex DNA damage in human breast cancer cells MCF-7 and nonmalignant MCF-10A cells. Free Radic Biol Med (2007) 1.00
Characterization of complex apurinic/apyrimidinic-site clustering associated with an authentic site-specific radiation-induced DNA double-strand break. Proc Natl Acad Sci U S A (2005) 1.00
microRNAome changes in bystander three-dimensional human tissue models suggest priming of apoptotic pathways. Carcinogenesis (2010) 0.99
Accumulation of oxidatively induced clustered DNA lesions in human tumor tissues. Mutat Res (2008) 0.99
Airway fibroblasts in asthma manifest an invasive phenotype. Am J Respir Crit Care Med (2011) 0.98
The twist box domain is required for Twist1-induced prostate cancer metastasis. Mol Cancer Res (2013) 0.97
Site-specific DNA cleavage by Chlorella virus topoisomerase II. Biochemistry (2002) 0.97
Novel Hsp90 inhibitor NVP-AUY922 radiosensitizes prostate cancer cells. Cancer Biol Ther (2013) 0.96
Molecular analysis of base damage clustering associated with a site-specific radiation-induced DNA double-strand break. Radiat Res (2006) 0.96
Compromised repair of clustered DNA damage in the human acute lymphoblastic leukemia MSH2-deficient NALM-6 cells. Mutat Res (2008) 0.96