PubRank

David J Maloney

Author PubWeight™ 49.61‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell-like diffuse large B-cell lymphoma cells. Proc Natl Acad Sci U S A 2014 2.50
2 Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors. PLoS One 2010 1.71
3 Molecular basis for the high-affinity binding and stabilization of firefly luciferase by PTC124. Proc Natl Acad Sci U S A 2010 1.64
4 Complementarity between a docking and a high-throughput screen in discovering new cruzain inhibitors. J Med Chem 2010 1.54
5 Selective inhibition of 12-lipoxygenase protects islets and beta cells from inflammatory cytokine-mediated beta cell dysfunction. Diabetologia 2014 1.49
6 Quantitative analyses of aggregation, autofluorescence, and reactivity artifacts in a screen for inhibitors of a thiol protease. J Med Chem 2010 1.45
7 Targeting the JMJD2 histone demethylases to epigenetically control herpesvirus infection and reactivation from latency. Sci Transl Med 2013 1.36
8 Selective and cell-active inhibitors of the USP1/ UAF1 deubiquitinase complex reverse cisplatin resistance in non-small cell lung cancer cells. Chem Biol 2011 1.35
9 Disrupting malaria parasite AMA1-RON2 interaction with a small molecule prevents erythrocyte invasion. Nat Commun 2013 1.13
10 Structural basis for the activity of the RSK-specific inhibitor, SL0101. Bioorg Med Chem 2007 1.12
11 Integration of pro-inflammatory cytokines, 12-lipoxygenase and NOX-1 in pancreatic islet beta cell dysfunction. Mol Cell Endocrinol 2012 1.10
12 Evaluation of substituted 6-arylquinazolin-4-amines as potent and selective inhibitors of cdc2-like kinases (Clk). Bioorg Med Chem Lett 2009 1.06
13 Structure mechanism insights and the role of nitric oxide donation guide the development of oxadiazole-2-oxides as therapeutic agents against schistosomiasis. J Med Chem 2009 1.05
14 Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB. J Med Chem 2010 1.04
15 A small molecule inhibitor of the BLM helicase modulates chromosome stability in human cells. Chem Biol 2013 1.04
16 The skin cancer chemotherapeutic agent ingenol-3-angelate (PEP005) is a substrate for the epidermal multidrug transporter (ABCB1) and targets tumor vasculature. Cancer Res 2010 1.04
17 Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase. J Med Chem 2011 1.03
18 Discovery of potent and selective inhibitors of human reticulocyte 15-lipoxygenase-1. J Med Chem 2010 1.01
19 Influence of rhamnose substituents on the potency of SL0101, an inhibitor of the Ser/Thr kinase, RSK. Bioorg Med Chem 2006 0.95
20 The pilot phase of the NIH Chemical Genomics Center. Curr Top Med Chem 2009 0.94
21 Inhibitors of DNA polymerase beta: activity and mechanism. Bioorg Med Chem 2008 0.93
22 Synthesis, biological evaluation, and structure-activity relationships of a novel class of apurinic/apyrimidinic endonuclease 1 inhibitors. J Med Chem 2012 0.93
23 Protein kinase C regulation of 12-lipoxygenase-mediated human platelet activation. Mol Pharmacol 2011 0.92
24 Synthesis and structure-activity relationship studies of 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase. J Med Chem 2014 0.89
25 Potent and selective inhibitors of human reticulocyte 12/15-lipoxygenase as anti-stroke therapies. J Med Chem 2014 0.89
26 Potent and selective small molecule inhibitors of specific isoforms of Cdc2-like kinases (Clk) and dual specificity tyrosine-phosphorylation-regulated kinases (Dyrk). Bioorg Med Chem Lett 2011 0.89
27 Synthesis of Oxadiazole-2-oxide Analogues as Potential Antischistosomal Agents. Tetrahedron Lett 2009 0.88
28 Covalent small molecule inhibitors of Ca(2+)-bound S100B. Biochemistry 2014 0.88
29 Complementary non-radioactive assays for investigation of human flap endonuclease 1 activity. Nucleic Acids Res 2010 0.88
30 High-affinity inhibitors of human NAD-dependent 15-hydroxyprostaglandin dehydrogenase: mechanisms of inhibition and structure-activity relationships. PLoS One 2010 0.87
31 4-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-methoxypyridin-2-yl)piperazine-1-carbothioamide (ML267), a potent inhibitor of bacterial phosphopantetheinyl transferase that attenuates secondary metabolism and thwarts bacterial growth. J Med Chem 2014 0.86
32 A comparison of the ability of rilpivirine (TMC278) and selected analogues to inhibit clinically relevant HIV-1 reverse transcriptase mutants. Retrovirology 2012 0.85
33 A cell-permeable ester derivative of the JmjC histone demethylase inhibitor IOX1. ChemMedChem 2014 0.83
34 High-throughput screening for modulators of cellular contractile force. Integr Biol (Camb) 2015 0.82
35 Structural insight into exosite binding and discovery of novel exosite inhibitors of botulinum neurotoxin serotype A through in silico screening. J Comput Aided Mol Des 2014 0.82
36 Synthesis and structure-activity relationship studies of N-benzyl-2-phenylpyrimidin-4-amine derivatives as potent USP1/UAF1 deubiquitinase inhibitors with anticancer activity against nonsmall cell lung cancer. J Med Chem 2014 0.81
37 A comprehensive strategy to discover inhibitors of the translesion synthesis DNA polymerase κ. PLoS One 2012 0.81
38 Diverse small molecule inhibitors of human apurinic/apyrimidinic endonuclease APE1 identified from a screen of a large public collection. PLoS One 2012 0.81
39 Targeting human apurinic/apyrimidinic endonuclease 1 (APE1) in phosphatase and tensin homolog (PTEN) deficient melanoma cells for personalized therapy. Oncotarget 2014 0.80
40 High-throughput 1,536-well fluorescence polarization assays for α(1)-acid glycoprotein and human serum albumin binding. PLoS One 2012 0.79
41 The potential of 12/15-lipoxygenase inhibitors in stroke therapy. Future Med Chem 2014 0.79
42 Discovery of a novel general anesthetic chemotype using high-throughput screening. Anesthesiology 2015 0.78
43 Tri-, tetra- and heptacyclic perylene analogues as new potential antineoplastic agents based on DNA telomerase inhibition. Bioorg Med Chem 2006 0.77
44 Discovery of a novel dual fungal CYP51/human 5-lipoxygenase inhibitor: implications for anti-fungal therapy. PLoS One 2013 0.77
45 A furoxan-amodiaquine hybrid as a potential therapeutic for three parasitic diseases(). Medchemcomm 2012 0.76
46 A fluorescence-based high throughput assay for the determination of small molecule-human serum albumin protein binding. Anal Bioanal Chem 2014 0.75
47 High-throughput screen identifies cyclic nucleotide analogs that inhibit prostatic acid phosphatase. J Biomol Screen 2012 0.75
48 Separation of Betti Reaction Product Enantiomers: Absolute Configuration and Inhibition of Botulinum Neurotoxin A. ACS Med Chem Lett 2011 0.75
49 Correction: A High-Throughput Screen Identifies 2,9-Diazaspiro[5.5]Undecanes as Inducers of the Endoplasmic Reticulum Stress Response with Cytotoxic Activity in 3D Glioma Cell Models. PLoS One 2016 0.75
50 Synthesis of bisaminoacylated pdCpAs and tandemly activated transfer RNAs. Bioorg Med Chem 2007 0.75
51 Total synthesis of LL-Z1640-2 utilizing a late-stage intramolecular Nozaki-Hiyama-Kishi reaction. Tetrahedron Lett 2010 0.75