Published in J Med Chem on January 06, 2014
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Valsartan protects pancreatic islets and adipose tissue from the inflammatory and metabolic consequences of a high-fat diet in mice. Hypertension (2010) 1.74
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Three classes of glucocerebrosidase inhibitors identified by quantitative high-throughput screening are chaperone leads for Gaucher disease. Proc Natl Acad Sci U S A (2007) 1.70
Critical role of macrophage 12/15-lipoxygenase for atherosclerosis in apolipoprotein E-deficient mice. Circulation (2004) 1.70
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5-Lipoxygenase, but not 12/15-lipoxygenase, contributes to degeneration of retinal capillaries in a mouse model of diabetic retinopathy. Diabetes (2008) 1.48
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12/15-lipoxygenase products induce inflammation and impair insulin signaling in 3T3-L1 adipocytes. Obesity (Silver Spring) (2009) 1.46
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Quantitative analyses of aggregation, autofluorescence, and reactivity artifacts in a screen for inhibitors of a thiol protease. J Med Chem (2010) 1.45
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A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth. Nat Commun (2013) 1.37
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Targeting the JMJD2 histone demethylases to epigenetically control herpesvirus infection and reactivation from latency. Sci Transl Med (2013) 1.36
Selective and cell-active inhibitors of the USP1/ UAF1 deubiquitinase complex reverse cisplatin resistance in non-small cell lung cancer cells. Chem Biol (2011) 1.35
Novel lipoxygenase inhibitors as neuroprotective reagents. J Neurosci Res (2008) 1.34
Racial differences in human platelet PAR4 reactivity reflect expression of PCTP and miR-376c. Nat Med (2013) 1.34
Fluorescence polarization assays in small molecule screening. Expert Opin Drug Discov (2011) 1.33
Inflammatory mechanisms of diabetic complications. Curr Diab Rep (2007) 1.32
Identification and characterization of inhibitors of human apurinic/apyrimidinic endonuclease APE1. PLoS One (2009) 1.32
Baicalein is a potent in vitro inhibitor against both reticulocyte 15-human and platelet 12-human lipoxygenases. Bioorg Med Chem (2006) 1.29
Noninvasive assessment of pancreatic beta-cell function in vivo with manganese-enhanced magnetic resonance imaging. Am J Physiol Endocrinol Metab (2008) 1.28
A miniaturized screen for inhibitors of Jumonji histone demethylases. Mol Biosyst (2009) 1.27
Impact of lifestyle intervention on lost productivity and disability: improving control with activity and nutrition. J Occup Environ Med (2009) 1.26
The role of 12/15-lipoxygenase in the expression of interleukin-6 and tumor necrosis factor-alpha in macrophages. Endocrinology (2006) 1.26
Quantitative high-throughput screening using a live-cell cAMP assay identifies small-molecule agonists of the TSH receptor. J Biomol Screen (2008) 1.25
Structure-activity relationship studies of nordihydroguaiaretic acid inhibitors toward soybean, 12-human, and 15-human lipoxygenase. J Med Chem (2002) 1.25
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Small molecule inhibitors of DNA repair nuclease activities of APE1. Cell Mol Life Sci (2010) 1.21
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Identification of pregnane X receptor ligands using time-resolved fluorescence resonance energy transfer and quantitative high-throughput screening. Assay Drug Dev Technol (2009) 1.20
Evidence for activation of inflammatory lipoxygenase pathways in visceral adipose tissue of obese Zucker rats. Am J Physiol Endocrinol Metab (2010) 1.20