|
1
|
Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer.
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N Engl J Med
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2004
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30.26
|
|
2
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Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial.
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Lancet
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2010
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25.32
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3
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Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer.
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J Clin Oncol
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2008
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20.89
|
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4
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Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine.
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N Engl J Med
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2013
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16.24
|
|
5
|
Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis.
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Lancet Oncol
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2010
|
13.25
|
|
6
|
Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebo-controlled, phase 3 trial.
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Lancet
|
2012
|
12.00
|
|
7
|
Sunitinib malate for the treatment of pancreatic neuroendocrine tumors.
|
N Engl J Med
|
2011
|
11.93
|
|
8
|
Everolimus for advanced pancreatic neuroendocrine tumors.
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N Engl J Med
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2011
|
11.55
|
|
9
|
Perioperative chemotherapy with FOLFOX4 and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC Intergroup trial 40983): a randomised controlled trial.
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Lancet
|
2008
|
9.92
|
|
10
|
Association of KRAS p.G13D mutation with outcome in patients with chemotherapy-refractory metastatic colorectal cancer treated with cetuximab.
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JAMA
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2010
|
8.21
|
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11
|
American Society of Clinical Oncology recommendations on adjuvant chemotherapy for stage II colon cancer.
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J Clin Oncol
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2004
|
7.16
|
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12
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Prognostic role of KRAS and BRAF in stage II and III resected colon cancer: results of the translational study on the PETACC-3, EORTC 40993, SAKK 60-00 trial.
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J Clin Oncol
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2009
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7.04
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13
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Bevacizumab in combination with chemotherapy as first-line therapy in advanced gastric cancer: a randomized, double-blind, placebo-controlled phase III study.
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J Clin Oncol
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2011
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6.18
|
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14
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Continuation of bevacizumab after first progression in metastatic colorectal cancer (ML18147): a randomised phase 3 trial.
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Lancet Oncol
|
2012
|
5.86
|
|
15
|
Randomized phase III study of panitumumab with fluorouracil, leucovorin, and irinotecan (FOLFIRI) compared with FOLFIRI alone as second-line treatment in patients with metastatic colorectal cancer.
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J Clin Oncol
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2010
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5.62
|
|
16
|
Benefit of adjuvant chemotherapy for resectable gastric cancer: a meta-analysis.
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JAMA
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2010
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5.04
|
|
17
|
Everolimus plus octreotide long-acting repeatable for the treatment of advanced neuroendocrine tumours associated with carcinoid syndrome (RADIANT-2): a randomised, placebo-controlled, phase 3 study.
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Lancet
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2011
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4.79
|
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18
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Capecitabine plus oxaliplatin compared with fluorouracil and folinic acid as adjuvant therapy for stage III colon cancer.
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J Clin Oncol
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2011
|
3.99
|
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19
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Clinical benefit with docetaxel plus fluorouracil and cisplatin compared with cisplatin and fluorouracil in a phase III trial of advanced gastric or gastroesophageal cancer adenocarcinoma: the V-325 Study Group.
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J Clin Oncol
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2007
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3.51
|
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20
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Adjuvant chemotherapy after potentially curative resection of metastases from colorectal cancer: a pooled analysis of two randomized trials.
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J Clin Oncol
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2008
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3.49
|
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21
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Axitinib plus gemcitabine versus placebo plus gemcitabine in patients with advanced pancreatic adenocarcinoma: a double-blind randomised phase 3 study.
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Lancet Oncol
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2011
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3.44
|
|
22
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Daily oral everolimus activity in patients with metastatic pancreatic neuroendocrine tumors after failure of cytotoxic chemotherapy: a phase II trial.
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J Clin Oncol
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2009
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3.18
|
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23
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XELOX (capecitabine plus oxaliplatin): active first-line therapy for patients with metastatic colorectal cancer.
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J Clin Oncol
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2004
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3.10
|
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24
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Randomized trial of TAS-102 for refractory metastatic colorectal cancer.
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N Engl J Med
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2015
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3.09
|
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25
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Bevacizumab plus oxaliplatin-based chemotherapy as adjuvant treatment for colon cancer (AVANT): a phase 3 randomised controlled trial.
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Lancet Oncol
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2012
|
3.02
|
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26
|
Perioperative FOLFOX4 chemotherapy and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC 40983): long-term results of a randomised, controlled, phase 3 trial.
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Lancet Oncol
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2013
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2.94
|
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27
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Amphiregulin and epiregulin mRNA expression in primary tumors predicts outcome in metastatic colorectal cancer treated with cetuximab.
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J Clin Oncol
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2009
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2.92
|
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28
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VEGF pathway genetic variants as biomarkers of treatment outcome with bevacizumab: an analysis of data from the AViTA and AVOREN randomised trials.
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Lancet Oncol
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2012
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2.92
|
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29
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Gastric cancer.
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Crit Rev Oncol Hematol
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2009
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2.87
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30
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Association of KRAS G13D tumor mutations with outcome in patients with metastatic colorectal cancer treated with first-line chemotherapy with or without cetuximab.
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J Clin Oncol
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2012
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2.86
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31
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Addition of cetuximab to chemotherapy as first-line treatment for KRAS wild-type metastatic colorectal cancer: pooled analysis of the CRYSTAL and OPUS randomised clinical trials.
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Eur J Cancer
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2012
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2.79
|
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32
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Venous thromboembolic events with chemotherapy plus bevacizumab: a pooled analysis of patients in randomized phase II and III studies.
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J Clin Oncol
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2011
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2.76
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33
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Identification of a poor-prognosis BRAF-mutant-like population of patients with colon cancer.
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J Clin Oncol
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2012
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2.66
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34
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Neoadjuvant chemotherapy compared with surgery alone for locally advanced cancer of the stomach and cardia: European Organisation for Research and Treatment of Cancer randomized trial 40954.
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J Clin Oncol
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2010
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2.66
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35
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Future directions in the treatment of neuroendocrine tumors: consensus report of the National Cancer Institute Neuroendocrine Tumor clinical trials planning meeting.
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J Clin Oncol
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2011
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2.57
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36
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Phase II multi-institutional randomized trial of docetaxel plus cisplatin with or without fluorouracil in patients with untreated, advanced gastric, or gastroesophageal adenocarcinoma.
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J Clin Oncol
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2005
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2.52
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37
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Integrated analysis of molecular and clinical prognostic factors in stage II/III colon cancer.
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J Natl Cancer Inst
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2012
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2.49
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38
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Implications for KRAS status and EGFR-targeted therapies in metastatic CRC.
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Nat Rev Clin Oncol
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2009
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2.48
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39
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Multicenter phase II and translational study of cetuximab in metastatic colorectal carcinoma refractory to irinotecan, oxaliplatin, and fluoropyrimidines.
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J Clin Oncol
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2006
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2.48
|
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40
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Phase II trial of cetuximab in combination with fluorouracil, leucovorin, and oxaliplatin in the first-line treatment of metastatic colorectal cancer.
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J Clin Oncol
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2007
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2.47
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41
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Predictive factors for the benefit of perioperative FOLFOX for resectable liver metastasis in colorectal cancer patients (EORTC Intergroup Trial 40983).
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Ann Surg
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2012
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2.43
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42
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Management of hepatocellular carcinoma in Asia: consensus statement from the Asian Oncology Summit 2009.
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Lancet Oncol
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2009
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2.41
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43
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Quality of life with docetaxel plus cisplatin and fluorouracil compared with cisplatin and fluorouracil from a phase III trial for advanced gastric or gastroesophageal adenocarcinoma: the V-325 Study Group.
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J Clin Oncol
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2007
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2.36
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44
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PIK3CA mutations are not a major determinant of resistance to the epidermal growth factor receptor inhibitor cetuximab in metastatic colorectal cancer.
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Clin Cancer Res
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2009
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2.25
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45
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Disease course patterns after discontinuation of bevacizumab: pooled analysis of randomized phase III trials.
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J Clin Oncol
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2010
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2.19
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46
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Rapid and sustained relief from the symptoms of carcinoid syndrome: results from an open 6-month study of the 28-day prolonged-release formulation of lanreotide.
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Neuroendocrinology
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2004
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2.16
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47
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Everolimus for previously treated advanced gastric cancer: results of the randomized, double-blind, phase III GRANITE-1 study.
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J Clin Oncol
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2013
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2.14
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48
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Magnesium wasting associated with epidermal-growth-factor receptor-targeting antibodies in colorectal cancer: a prospective study.
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Lancet Oncol
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2007
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2.14
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49
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Use of early tumor shrinkage to predict long-term outcome in metastatic colorectal cancer treated with cetuximab.
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J Clin Oncol
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2013
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2.14
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50
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Cediranib with mFOLFOX6 versus bevacizumab with mFOLFOX6 as first-line treatment for patients with advanced colorectal cancer: a double-blind, randomized phase III study (HORIZON III).
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J Clin Oncol
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2012
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2.07
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51
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Minimally invasive liver surgery for metastases from colorectal cancer: oncologic outcome and prognostic factors.
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Surg Endosc
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2.04
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52
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Massively parallel tumor multigene sequencing to evaluate response to panitumumab in a randomized phase III study of metastatic colorectal cancer.
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Clin Cancer Res
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2013
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2.03
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53
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Irinotecan/fluorouracil combination in first-line therapy of older and younger patients with metastatic colorectal cancer: combined analysis of 2,691 patients in randomized controlled trials.
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J Clin Oncol
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2008
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1.97
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54
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Mutant KRAS codon 12 and 13 alleles in patients with metastatic colorectal cancer: assessment as prognostic and predictive biomarkers of response to panitumumab.
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J Clin Oncol
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2012
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1.97
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55
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Potential regional differences for the tolerability profiles of fluoropyrimidines.
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J Clin Oncol
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2008
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1.92
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56
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The continuum of care: a paradigm for the management of metastatic colorectal cancer.
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Oncologist
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2007
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1.89
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57
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Model-based prediction of phase III overall survival in colorectal cancer on the basis of phase II tumor dynamics.
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J Clin Oncol
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2009
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1.87
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58
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Clinical usefulness of EGFR gene copy number as a predictive marker in colorectal cancer patients treated with cetuximab: a fluorescent in situ hybridization study.
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Clin Cancer Res
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2008
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1.80
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59
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Phase III trial of capecitabine plus oxaliplatin as adjuvant therapy for stage III colon cancer: a planned safety analysis in 1,864 patients.
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J Clin Oncol
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2007
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1.79
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60
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The oncosurgery approach to managing liver metastases from colorectal cancer: a multidisciplinary international consensus.
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Oncologist
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2012
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1.76
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61
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European experts consensus statement on cystic tumours of the pancreas.
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Dig Liver Dis
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2013
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1.75
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62
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Prognostic and predictive biomarkers in resected colon cancer: current status and future perspectives for integrating genomics into biomarker discovery.
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Oncologist
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2010
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1.72
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63
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Adjuvant gemcitabine alone versus gemcitabine-based chemoradiotherapy after curative resection for pancreatic cancer: a randomized EORTC-40013-22012/FFCD-9203/GERCOR phase II study.
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J Clin Oncol
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2010
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1.65
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64
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Weekly infusional high-dose fluorouracil (HD-FU), HD-FU plus folinic acid (HD-FU/FA), or HD-FU/FA plus biweekly cisplatin in advanced gastric cancer: randomized phase II trial 40953 of the European Organisation for Research and Treatment of Cancer Gastrointestinal Group and the Arbeitsgemeinschaft Internistische Onkologie.
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J Clin Oncol
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2007
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1.63
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65
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Impact of age on the efficacy of newer adjuvant therapies in patients with stage II/III colon cancer: findings from the ACCENT database.
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2013
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1.62
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66
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Phase III trial comparing protracted intravenous fluorouracil infusion alone or with yttrium-90 resin microspheres radioembolization for liver-limited metastatic colorectal cancer refractory to standard chemotherapy.
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1.61
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67
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Does chemotherapy prior to liver resection increase the potential for cure in patients with metastatic colorectal cancer? A report from the European Colorectal Metastases Treatment Group.
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Eur J Cancer
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2007
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1.58
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68
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Hypoxia-driven gene expression is an independent prognostic factor in stage II and III colon cancer patients.
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Clin Cancer Res
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2014
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1.55
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69
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Multidisciplinary Rectal Cancer Management: 2nd European Rectal Cancer Consensus Conference (EURECA-CC2).
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Radiother Oncol
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2009
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1.55
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70
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Gastric electrical stimulation in intractable symptomatic gastroparesis.
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Digestion
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2002
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1.51
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71
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90Y-edotreotide for metastatic carcinoid refractory to octreotide.
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J Clin Oncol
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2010
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1.49
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72
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Epidermal growth factor receptor activity determines response of colorectal cancer cells to gefitinib alone and in combination with chemotherapy.
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Clin Cancer Res
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2005
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1.45
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73
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Early phase II trial of oral vorinostat in relapsed or refractory breast, colorectal, or non-small cell lung cancer.
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Invest New Drugs
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2008
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1.36
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74
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Pharmacodynamic studies of gefitinib in tumor biopsy specimens from patients with advanced gastric carcinoma.
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J Clin Oncol
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2006
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1.34
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Uptake of KRAS mutation testing in patients with metastatic colorectal cancer in Europe, Latin America and Asia.
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2011
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Association of progression-free survival, overall survival, and patient-reported outcomes by skin toxicity and KRAS status in patients receiving panitumumab monotherapy.
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77
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The management of skin reactions in cancer patients receiving epidermal growth factor receptor targeted therapies.
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J Natl Cancer Inst
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Predictive value of epidermal growth factor receptor expression for first-line chemotherapy plus cetuximab in patients with head and neck and colorectal cancer: analysis of data from the EXTREME and CRYSTAL studies.
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1.27
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Impact of interval between neoadjuvant chemoradiotherapy and TME for locally advanced rectal cancer on pathologic response and oncologic outcome.
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1.25
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Lessons from the adjuvant bevacizumab trial on colon cancer: what next?
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Chemotherapy-induced epidermal growth factor receptor activation determines response to combined gefitinib/chemotherapy treatment in non-small cell lung cancer cells.
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Mol Cancer Ther
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Long-term exposure to sorafenib of liver cancer cells induces resistance with epithelial-to-mesenchymal transition, increased invasion and risk of rebound growth.
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Cancer Lett
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1.24
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84
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Role of chemotherapy for advanced/recurrent gastric cancer: an individual-patient-data meta-analysis.
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1.24
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Role of targeted agents in metastatic colorectal cancer.
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Gastric MALT lymphoma: a model of chronic inflammation-induced tumor development.
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Nat Rev Gastroenterol Hepatol
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Does a patient's self-reported health-related quality of life predict survival beyond key biomedical data in advanced colorectal cancer?
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1.20
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88
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New strategies for treatment of KRAS mutant metastatic colorectal cancer.
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Gastric cancer.
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Crit Rev Oncol Hematol
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2005
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1.16
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Fluorouracil, leucovorin, and irinotecan plus either sunitinib or placebo in metastatic colorectal cancer: a randomized, phase III trial.
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1.12
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A multicenter, phase II study of infliximab plus gemcitabine in pancreatic cancer cachexia.
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Management of advanced gastric cancer.
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Clinical and psychometric validation of a questionnaire module, the EORTC QLQ-OG25, to assess health-related quality of life in patients with cancer of the oesophagus, the oesophago-gastric junction and the stomach.
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2007
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1.07
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Value of diffusion-weighted magnetic resonance imaging for prediction and early assessment of response to neoadjuvant radiochemotherapy in rectal cancer: preliminary results.
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Int J Radiat Oncol Biol Phys
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2011
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95
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Investigating the potential of bevacizumab in other indications: metastatic renal cell, non-small cell lung, pancreatic and breast cancer.
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Oncology
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2005
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1.06
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Sorafenib in combination with oxaliplatin, leucovorin, and fluorouracil (modified FOLFOX6) as first-line treatment of metastatic colorectal cancer: the RESPECT trial.
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Clin Cancer Res
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2013
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Randomized phase III trial of regorafenib in metastatic colorectal cancer: analysis of the CORRECT Japanese and non-Japanese subpopulations.
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98
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Outcome standards for an organ preservation strategy in stage II and III rectal adenocarcinoma after neoadjuvant chemoradiation.
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Ann Surg Oncol
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2010
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0.99
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Tissue biomarker development in a multicentre trial context: a feasibility study on the PETACC3 stage II and III colon cancer adjuvant treatment trial.
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Clin Cancer Res
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2009
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100
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Comparison of magnetic resonance imaging and histopathological response to chemoradiotherapy in locally advanced rectal cancer.
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101
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Quality of life analysis in patients with KRAS wild-type metastatic colorectal cancer treated first-line with cetuximab plus irinotecan, fluorouracil and leucovorin.
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Eur J Cancer
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2012
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0.96
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102
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Acute and long-term gastrointestinal consequences of chemotherapy.
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Best Pract Res Clin Gastroenterol
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Genetic variability of VEGF pathway genes in six randomized phase III trials assessing the addition of bevacizumab to standard therapy.
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Is there a role for FGD-PET in radiotherapy planning in esophageal carcinoma?
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Clinical presentation and pathophysiology of EGFRI dermatologic toxicities.
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The treatment of peritoneal carcinomatosis of colorectal cancer with complete cytoreductive surgery and hyperthermic intraperitoneal peroperative chemotherapy (HIPEC) with oxaliplatin: a Belgian multicentre prospective phase II clinical study.
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European Organisation of Research and Treatment of Cancer (EORTC) Gastrointestinal Group: Workshop on the role of metabolic imaging in the neoadjuvant treatment of gastrointestinal cancer.
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Intravenous aflibercept administered in combination with irinotecan, 5-fluorouracil and leucovorin in patients with advanced solid tumours: results from the expansion cohort of a phase I study.
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An analysis of the treatment effect of panitumumab on overall survival from a phase 3, randomized, controlled, multicenter trial (20020408) in patients with chemotherapy refractory metastatic colorectal cancer.
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Progress in the adjuvant treatment of colon cancer: has it influenced clinical practice?
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Comparison of outcomes after fluorouracil-based adjuvant therapy for stages II and III colon cancer between 1978 to 1995 and 1996 to 2007: evidence of stage migration from the ACCENT database.
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Clinical research of EGFR inhibitors and related dermatologic toxicities.
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Stool tagging applied in thin-slice multidetector computed tomography colonography.
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What to choose as radical local treatment for lung metastases from colo-rectal cancer: surgery or radiofrequency ablation?
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A seven-gene set associated with chronic hypoxia of prognostic importance in hepatocellular carcinoma.
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Management of adverse events and other practical considerations in patients receiving capecitabine (Xeloda).
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Prospective comparison of hydrogel-coated microcoils versus fibered platinum microcoils in the prophylactic embolization of the gastroduodenal artery before yttrium-90 radioembolization.
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