PubRank

Jeffrey N Agar

Author PubWeight™ 34.94‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS. Nat Neurosci 2010 4.25
2 A soluble α-synuclein construct forms a dynamic tetramer. Proc Natl Acad Sci U S A 2011 2.15
3 Mutations in COX10 result in a defect in mitochondrial heme A biosynthesis and account for multiple, early-onset clinical phenotypes associated with isolated COX deficiency. Hum Mol Genet 2003 1.79
4 Protein aggregation and protein instability govern familial amyotrophic lateral sclerosis patient survival. PLoS Biol 2008 1.61
5 Fitting neurological protein aggregation kinetic data via a 2-step, minimal/"Ockham's razor" model: the Finke-Watzky mechanism of nucleation followed by autocatalytic surface growth. Biochemistry 2008 1.60
6 Focal dysfunction of the proteasome: a pathogenic factor in a mouse model of amyotrophic lateral sclerosis. J Neurochem 2004 1.24
7 NifS-mediated assembly of [4Fe-4S] clusters in the N- and C-terminal domains of the NifU scaffold protein. Biochemistry 2005 1.21
8 Molecular imaging of drug transit through the blood-brain barrier with MALDI mass spectrometry imaging. Sci Rep 2013 1.12
9 Sensitive and specific identification of wild type and variant proteins from 8 to 669 kDa using top-down mass spectrometry. Mol Cell Proteomics 2008 1.09
10 A common property of amyotrophic lateral sclerosis-associated variants: destabilization of the copper/zinc superoxide dismutase electrostatic loop. J Biol Chem 2009 1.08
11 Matrix solution fixation: histology-compatible tissue preparation for MALDI mass spectrometry imaging. Anal Chem 2007 1.05
12 Tryptophan 32 potentiates aggregation and cytotoxicity of a copper/zinc superoxide dismutase mutant associated with familial amyotrophic lateral sclerosis. J Biol Chem 2007 1.05
13 Strategies for stabilizing superoxide dismutase (SOD1), the protein destabilized in the most common form of familial amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A 2010 1.01
14 Recent advances in single-cell MALDI mass spectrometry imaging and potential clinical impact. Expert Rev Proteomics 2011 0.99
15 A hierarchical algorithm for calculating the isotopic fine structures of molecules. J Am Soc Mass Spectrom 2008 0.95
16 Structural characterization of intact proteins is enhanced by prevalent fragmentation pathways rarely observed for peptides. J Am Soc Mass Spectrom 2010 0.94
17 Proteasomes remain intact, but show early focal alteration in their composition in a mouse model of amyotrophic lateral sclerosis. J Neurochem 2008 0.92
18 Imaging of meningioma progression by matrix-assisted laser desorption ionization time-of-flight mass spectrometry. Anal Chem 2010 0.91
19 Evidence of the participation of remote residues in the catalytic activity of Co-type nitrile hydratase from Pseudomonas putida. Biochemistry 2011 0.87
20 Post-translational modification by cysteine protects Cu/Zn-superoxide dismutase from oxidative damage. Biochemistry 2013 0.86
21 Impaired proteasome function in sporadic amyotrophic lateral sclerosis. Amyotroph Lateral Scler 2012 0.85
22 Structural consequences of cysteinylation of Cu/Zn-superoxide dismutase. Biochemistry 2013 0.80
23 Overexpression of metallothionein protects cultured motor neurons against oxidative stress, but not mutant Cu/Zn-superoxide dismutase toxicity. Neurotoxicology 2004 0.78
24 Memory-efficient calculation of the isotopic mass states of a molecule. Rapid Commun Mass Spectrom 2010 0.78
25 Tissue preparation for the in situ MALDI MS imaging of proteins, lipids, and small molecules at cellular resolution. Methods Mol Biol 2010 0.78
26 Resolving isotopic fine structure to detect and quantify natural abundance- and hydrogen/deuterium exchange-derived isotopomers. Anal Chem 2013 0.78
27 Transformative effects of higher magnetic field in Fourier transform ion cyclotron resonance mass spectrometry. J Am Soc Mass Spectrom 2010 0.77
28 Proteasome activity or expression is not altered by activation of the heat shock transcription factor Hsf1 in cultured fibroblasts or myoblasts. Cell Stress Chaperones 2005 0.77
29 Artifacts to avoid while taking advantage of top-down mass spectrometry based detection of protein S-thiolation. Proteomics 2014 0.76
30 Mass spectrometry tools for analysis of intermolecular interactions. Methods Mol Biol 2012 0.75
31 Performance comparisons of nano-LC systems, electrospray sources and LC-MS-MS platforms. J Chromatogr Sci 2013 0.75