Published in Biotechnol Bioeng on June 15, 2010
High-resolution mapping of protein sequence-function relationships. Nat Methods (2010) 3.47
The promise and challenge of high-throughput sequencing of the antibody repertoire. Nat Biotechnol (2014) 2.54
Monoclonal antibodies isolated without screening by analyzing the variable-gene repertoire of plasma cells. Nat Biotechnol (2010) 2.41
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A synthetic genetic edge detection program. Cell (2009) 3.20
Virus-based toolkit for the directed synthesis of magnetic and semiconducting nanowires. Science (2004) 3.08
High-throughput sequencing of the paired human immunoglobulin heavy and light chain repertoire. Nat Biotechnol (2013) 2.81
Protection against anthrax toxin by recombinant antibody fragments correlates with antigen affinity. Nat Biotechnol (2002) 2.77
Aptamer mediated siRNA delivery. Nucleic Acids Res (2006) 2.77
Applications of aptamers as sensors. Annu Rev Anal Chem (Palo Alto Calif) (2009) 2.45
Monoclonal antibodies isolated without screening by analyzing the variable-gene repertoire of plasma cells. Nat Biotechnol (2010) 2.41
Widespread reorganization of metabolic enzymes into reversible assemblies upon nutrient starvation. Proc Natl Acad Sci U S A (2009) 2.39
Folding quality control in the export of proteins by the bacterial twin-arginine translocation pathway. Proc Natl Acad Sci U S A (2003) 2.26
Aptamer:toxin conjugates that specifically target prostate tumor cells. Cancer Res (2006) 2.23
The many faces of glutathione in bacteria. Antioxid Redox Signal (2006) 2.20
The bacterial twin-arginine translocation pathway. Annu Rev Microbiol (2006) 2.13
Bacterial biosynthesis of cadmium sulfide nanocrystals. Chem Biol (2004) 2.02
Protein-dependent ribozymes report molecular interactions in real time. Nat Biotechnol (2002) 2.00
Viral assembly of oriented quantum dot nanowires. Proc Natl Acad Sci U S A (2003) 2.00
Genetic analysis of the twin arginine translocator secretion pathway in bacteria. J Biol Chem (2002) 1.74
Aptamer therapeutics advance. Curr Opin Chem Biol (2006) 1.69
Ribozyme catalysis of metabolism in the RNA world. Chem Biodivers (2007) 1.66
Inhibition of islet amyloid polypeptide fibril formation: a potential role for heteroaromatic interactions. Biochemistry (2004) 1.60
Aptamer database. Nucleic Acids Res (2004) 1.60
Inhibition of cell proliferation by an anti-EGFR aptamer. PLoS One (2011) 1.59
Evolutionarily repurposed networks reveal the well-known antifungal drug thiabendazole to be a novel vascular disrupting agent. PLoS Biol (2012) 1.58
Anchored periplasmic expression, a versatile technology for the isolation of high-affinity antibodies from Escherichia coli-expressed libraries. Proc Natl Acad Sci U S A (2004) 1.54
Detection of anthrax toxin in the serum of animals infected with Bacillus anthracis by using engineered immunoassays. Clin Vaccine Immunol (2006) 1.50
Identification and characterization of the constituent human serum antibodies elicited by vaccination. Proc Natl Acad Sci U S A (2014) 1.50
Rational, modular adaptation of enzyme-free DNA circuits to multiple detection methods. Nucleic Acids Res (2011) 1.48
Engineering of protease variants exhibiting high catalytic activity and exquisite substrate selectivity. Proc Natl Acad Sci U S A (2005) 1.48
Why high-error-rate random mutagenesis libraries are enriched in functional and improved proteins. J Mol Biol (2005) 1.47
Effects of codon usage versus putative 5'-mRNA structure on the expression of Fusarium solani cutinase in the Escherichia coli cytoplasm. Protein Expr Purif (2003) 1.46
DNA hybridization and discrimination of single-nucleotide mismatches using chip-based microbead arrays. Anal Chem (2003) 1.46
Modulating the innate immune response by combinatorial engineering of endotoxin. Proc Natl Acad Sci U S A (2013) 1.45
Functional, structural, and spectroscopic characterization of a glutathione-ligated [2Fe-2S] cluster in poplar glutaredoxin C1. Proc Natl Acad Sci U S A (2007) 1.45
Small RNA profiling reveals antisense transcription throughout the KSHV genome and novel small RNAs. RNA (2010) 1.44
Isolation and expression of recombinant antibody fragments to the biological warfare pathogen Brucella melitensis. J Immunol Methods (2003) 1.44
Detecting lifetime alcohol problems in individuals referred for liver transplantation for nonalcoholic liver failure. Liver Transpl (2008) 1.40
Probing prokaryotic social behaviors with bacterial "lobster traps". MBio (2010) 1.39
High-resolution antibody dynamics of vaccine-induced immune responses. Proc Natl Acad Sci U S A (2014) 1.39
Labeling tumor cells with fluorescent nanocrystal-aptamer bioconjugates. Biosens Bioelectron (2006) 1.38
Human antibody against shiga toxin 2 administered to piglets after the onset of diarrhea due to Escherichia coli O157:H7 prevents fatal systemic complications. Infect Immun (2005) 1.38
Aptamer-based sensor arrays for the detection and quantitation of proteins. Anal Chem (2004) 1.37
Selection of fluorescent aptamer beacons that light up in the presence of zinc. Anal Bioanal Chem (2007) 1.37
Congenital midline cervical cleft: diagnosis, pathologic findings, and early stage treatment. Case Rep Pediatr (2012) 1.37
Arginine-rich motifs present multiple interfaces for specific binding by RNA. RNA (2005) 1.36
Strain engineering for improved expression of recombinant proteins in bacteria. Microb Cell Fact (2011) 1.36
Synthetic RNA circuits. Nat Chem Biol (2007) 1.35
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Phage shock protein PspA of Escherichia coli relieves saturation of protein export via the Tat pathway. J Bacteriol (2004) 1.34
Highly active and selective endopeptidases with programmed substrate specificities. Nat Chem Biol (2008) 1.33
An engineered pathway for the formation of protein disulfide bonds. Science (2004) 1.29
Automated selection of aptamers against protein targets translated in vitro: from gene to aptamer. Nucleic Acids Res (2002) 1.29
Export pathway selectivity of Escherichia coli twin arginine translocation signal peptides. J Biol Chem (2007) 1.28
Revisiting the role of glycosylation in the structure of human IgG Fc. ACS Chem Biol (2012) 1.28
Passive protection against anthrax by using a high-affinity antitoxin antibody fragment lacking an Fc region. Infect Immun (2005) 1.28
Molecular deconvolution of the monoclonal antibodies that comprise the polyclonal serum response. Proc Natl Acad Sci U S A (2013) 1.26
Differential modulation of E. coli mRNA abundance by inhibitory proteins that alter the composition of the degradosome. Mol Microbiol (2006) 1.26
Surface-immobilized aptamers for cancer cell isolation and microscopic cytology. Cancer Res (2010) 1.26
Micromechanical detection of proteins using aptamer-based receptor molecules. Anal Chem (2004) 1.24
Substrate specificity of the Escherichia coli outer membrane protease OmpT. J Bacteriol (2004) 1.23
AANT: the Amino Acid-Nucleotide Interaction Database. Nucleic Acids Res (2004) 1.22
Functional plasticity of a peroxidase allows evolution of diverse disulfide-reducing pathways. Proc Natl Acad Sci U S A (2008) 1.22
Group I aptazymes as genetic regulatory switches. BMC Biotechnol (2002) 1.20
Structure-based design of supercharged, highly thermoresistant antibodies. Chem Biol (2012) 1.19
Replacing Mn(2+) with Co(2+) in human arginase i enhances cytotoxicity toward l-arginine auxotrophic cancer cell lines. ACS Chem Biol (2010) 1.19
Recursive genomewide recombination and sequencing reveals a key refinement step in the evolution of a metabolic innovation in Escherichia coli. Proc Natl Acad Sci U S A (2013) 1.19
Therapeutic enzyme deimmunization by combinatorial T-cell epitope removal using neutral drift. Proc Natl Acad Sci U S A (2011) 1.18
Technical and biological issues relevant to cell typing with aptamers. J Proteome Res (2009) 1.17
The robustness of naturally and artificially selected nucleic acid secondary structures. J Mol Evol (2004) 1.17
Aglycosylated IgG variants expressed in bacteria that selectively bind FcgammaRI potentiate tumor cell killing by monocyte-dendritic cells. Proc Natl Acad Sci U S A (2009) 1.17
Construction and selection of bead-bound combinatorial oligonucleoside phosphorothioate and phosphorodithioate aptamer libraries designed for rapid PCR-based sequencing. Nucleic Acids Res (2002) 1.16
Production and processing of aptamer microarrays. Methods (2005) 1.16
Systematic profiling of cellular phenotypes with spotted cell microarrays reveals mating-pheromone response genes. Genome Biol (2006) 1.16
Using a deoxyribozyme ligase and rolling circle amplification to detect a non-nucleic acid analyte, ATP. J Am Chem Soc (2005) 1.16
Synthetic antibody libraries focused towards peptide ligands. J Mol Biol (2008) 1.15
A CMOS Electrochemical Impedance Spectroscopy (EIS) Biosensor Array. IEEE Trans Biomed Circuits Syst (2010) 1.15
Simultaneous detection of diverse analytes with an aptazyme ligase array. Anal Biochem (2003) 1.15
Dynamic reorganization of metabolic enzymes into intracellular bodies. Annu Rev Cell Dev Biol (2012) 1.15
Optimization of aptamer microarray technology for multiple protein targets. Anal Chim Acta (2006) 1.14
Shaping up nucleic acid computation. Curr Opin Biotechnol (2010) 1.14
Tuning the specificity of a synthetic receptor using a selected nucleic acid receptor. J Am Chem Soc (2004) 1.13
Evolution of phage with chemically ambiguous proteomes. BMC Evol Biol (2003) 1.11
Cell-Surface display of heterologous proteins: From high-throughput screening to environmental applications. Biotechnol Bioeng (2002) 1.11
Abiotic self-replication. Acc Chem Res (2012) 1.11
Quantum-dot aptamer beacons for the detection of proteins. Chembiochem (2005) 1.10
The human asparaginase-like protein 1 hASRGL1 is an Ntn hydrolase with beta-aspartyl peptidase activity. Biochemistry (2009) 1.10
Antibody repertoires in humanized NOD-scid-IL2Rγ(null) mice and human B cells reveals human-like diversification and tolerance checkpoints in the mouse. PLoS One (2012) 1.09
Directed evolution of gold nanoparticle delivery to cells. Chem Commun (Camb) (2009) 1.09
Disulfide bond formation by exported glutaredoxin indicates glutathione's presence in the E. coli periplasm. Proc Natl Acad Sci U S A (2009) 1.08
Real-time detection of isothermal amplification reactions with thermostable catalytic hairpin assembly. J Am Chem Soc (2013) 1.08