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1
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RTX proteins: a highly diverse family secreted by a common mechanism.
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FEMS Microbiol Rev
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2010
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2.13
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2
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Integrin subunit CD18 Is the T-lymphocyte receptor for the Helicobacter pylori vacuolating cytotoxin.
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Cell Host Microbe
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2008
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1.96
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3
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Transmission of Mycobacterium tuberculosis undetected by tuberculin skin testing.
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Am J Respir Crit Care Med
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2006
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1.72
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4
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An increase in antimycobacterial Th1-cell responses by prime-boost protocols of immunization does not enhance protection against tuberculosis.
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Infect Immun
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2006
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1.51
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5
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Inflammasome activation by adenylate cyclase toxin directs Th17 responses and protection against Bordetella pertussis.
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J Immunol
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2010
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1.48
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6
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Bordetella adenylate cyclase toxin: a swift saboteur of host defense.
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Curr Opin Microbiol
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2006
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1.47
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7
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High frequency of CD4+ T cells specific for the TB10.4 protein correlates with protection against Mycobacterium tuberculosis infection.
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Infect Immun
|
2006
|
1.26
|
|
8
|
Pore-forming and enzymatic activities of Bordetella pertussis adenylate cyclase toxin synergize in promoting lysis of monocytes.
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Infect Immun
|
2006
|
1.25
|
|
9
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Interaction of Bordetella pertussis adenylate cyclase with CD11b/CD18: Role of toxin acylation and identification of the main integrin interaction domain.
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J Biol Chem
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2003
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1.15
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10
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Membrane restructuring by Bordetella pertussis adenylate cyclase toxin, a member of the RTX toxin family.
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J Bacteriol
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2004
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1.13
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11
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A novel "clip-and-link" activity of repeat in toxin (RTX) proteins from gram-negative pathogens. Covalent protein cross-linking by an Asp-Lys isopeptide bond upon calcium-dependent processing at an Asp-Pro bond.
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J Biol Chem
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2004
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1.11
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12
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RTX cytotoxins recognize beta2 integrin receptors through N-linked oligosaccharides.
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Proc Natl Acad Sci U S A
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2008
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1.10
|
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13
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Third activity of Bordetella adenylate cyclase (AC) toxin-hemolysin. Membrane translocation of AC domain polypeptide promotes calcium influx into CD11b+ monocytes independently of the catalytic and hemolytic activities.
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J Biol Chem
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2006
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1.09
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14
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Antigen targeting to CD11b allows efficient presentation of CD4+ and CD8+ T cell epitopes and in vivo Th1-polarized T cell priming.
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J Immunol
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2004
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1.06
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15
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Adenylate cyclase toxin subverts phagocyte function by RhoA inhibition and unproductive ruffling.
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J Immunol
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2008
|
1.06
|
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16
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Characterization of the flexible genome complement of the commensal Escherichia coli strain A0 34/86 (O83 : K24 : H31).
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Microbiology
|
2005
|
1.04
|
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17
|
Bordetella adenylate cyclase toxin mobilizes its beta2 integrin receptor into lipid rafts to accomplish translocation across target cell membrane in two steps.
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PLoS Pathog
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2010
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1.04
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18
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Oligomerization is involved in pore formation by Bordetella adenylate cyclase toxin.
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FASEB J
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2009
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0.99
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19
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Acylation of lysine 860 allows tight binding and cytotoxicity of Bordetella adenylate cyclase on CD11b-expressing cells.
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Biochemistry
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2005
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0.98
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20
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Enhanced ex vivo stimulation of Mycobacterium tuberculosis-specific T cells in human immunodeficiency virus-infected persons via antigen delivery by the Bordetella pertussis adenylate cyclase vector.
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Clin Vaccine Immunol
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2007
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0.98
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21
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The Neisseria meningitidis outer membrane lipoprotein FrpD binds the RTX protein FrpC.
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J Biol Chem
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2004
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0.95
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22
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Efficient Ex vivo stimulation of Mycobacterium tuberculosis-specific T cells by genetically detoxified Bordetella pertussis adenylate cyclase antigen toxoids.
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Infect Immun
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2005
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0.95
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|
23
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Heterologous expression of full-length capsid protein of porcine circovirus 2 in Escherichia coli and its potential use for detection of antibodies.
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J Virol Methods
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2009
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0.95
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24
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Recognition of mycobacterial antigens delivered by genetically detoxified Bordetella pertussis adenylate cyclase by T cells from cattle with bovine tuberculosis.
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Infect Immun
|
2004
|
0.93
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|
25
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Delivery of a MalE CD4(+)-T-cell epitope into the major histocompatibility complex class II antigen presentation pathway by Bordetella pertussis adenylate cyclase.
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Infect Immun
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2002
|
0.92
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26
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Segments crucial for membrane translocation and pore-forming activity of Bordetella adenylate cyclase toxin.
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J Biol Chem
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2007
|
0.92
|
|
27
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Bordetella adenylate cyclase toxin induces a cascade of morphological changes of sheep erythrocytes and localizes into clusters in erythrocyte membranes.
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Microsc Res Tech
|
2006
|
0.91
|
|
28
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Intrinsically disordered enamel matrix protein ameloblastin forms ribbon-like supramolecular structures via an N-terminal segment encoded by exon 5.
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J Biol Chem
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2013
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0.90
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29
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The adenylate cyclase toxin from Bordetella pertussis--a novel promising vehicle for antigen delivery to dendritic cells.
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Int J Med Microbiol
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2004
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0.90
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30
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Complete protection against P. berghei malaria upon heterologous prime/boost immunization against circumsporozoite protein employing Salmonella type III secretion system and Bordetella adenylate cyclase toxoid.
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Vaccine
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2008
|
0.89
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31
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Neisseria meningitidis RTX proteins are not required for virulence in infant rats.
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Infect Immun
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2003
|
0.88
|
|
32
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Adenylate cyclase toxin translocates across target cell membrane without forming a pore.
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Mol Microbiol
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2010
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0.88
|
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33
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The iron-regulated transcriptome and proteome of Neisseria meningitidis serogroup C.
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Proteomics
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2006
|
0.87
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34
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Differences in purinergic amplification of osmotic cell lysis by the pore-forming RTX toxins Bordetella pertussis CyaA and Actinobacillus pleuropneumoniae ApxIA: the role of pore size.
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Infect Immun
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2013
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0.86
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35
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Novel high-affinity binders of human interferon gamma derived from albumin-binding domain of protein G.
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Proteins
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2011
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0.86
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36
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Prime/boost immunotherapy of HPV16-induced tumors with E7 protein delivered by Bordetella adenylate cyclase and modified vaccinia virus Ankara.
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Cancer Immunol Immunother
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2005
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0.86
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37
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Human interleukin-23 receptor antagonists derived from an albumin-binding domain scaffold inhibit IL-23-dependent ex vivo expansion of IL-17-producing T-cells.
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Proteins
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2013
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0.86
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38
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Single-step affinity purification of recombinant proteins using a self-excising module from Neisseria meningitidis FrpC.
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Protein Sci
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2008
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0.86
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39
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Immunization with a circumsporozoite epitope fused to Bordetella pertussis adenylate cyclase in conjunction with cytotoxic T-lymphocyte-associated antigen 4 blockade confers protection against Plasmodium berghei liver-stage malaria.
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Infect Immun
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2006
|
0.85
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40
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Gliadin fragments promote migration of dendritic cells.
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J Cell Mol Med
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2011
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0.85
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41
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Calcium influx rescues adenylate cyclase-hemolysin from rapid cell membrane removal and enables phagocyte permeabilization by toxin pores.
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PLoS Pathog
|
2012
|
0.85
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|
42
|
Channel formation in model membranes by the adenylate cyclase toxin of Bordetella pertussis: effect of calcium.
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Biochemistry
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2003
|
0.83
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43
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The RNA chaperone Hfq is required for virulence of Bordetella pertussis.
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Infect Immun
|
2013
|
0.82
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|
44
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Filamentous hemagglutinin of Bordetella pertussis: a key adhesin with immunomodulatory properties?
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Future Microbiol
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2014
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0.82
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45
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Heterosubtypic protection against influenza A induced by adenylate cyclase toxoids delivering conserved HA2 subunit of hemagglutinin.
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Antiviral Res
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2012
|
0.82
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46
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Nematode-induced interference with the anti-Plasmodium CD8+ T-cell response can be overcome by optimizing antigen administration.
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Eur J Immunol
|
2012
|
0.82
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47
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Pore formation by the Bordetella adenylate cyclase toxin in lipid bilayer membranes: role of voltage and pH.
|
Biochim Biophys Acta
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2007
|
0.81
|
|
48
|
Different structural requirements for adenylate cyclase toxin interactions with erythrocyte and liposome membranes.
|
Biochim Biophys Acta
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2004
|
0.80
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49
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Meningococcal adhesion suppresses proapoptotic gene expression and promotes expression of genes supporting early embryonic and cytoprotective signaling of human endothelial cells.
|
FEMS Microbiol Lett
|
2006
|
0.80
|
|
50
|
Type IV fimbrial subunit protein ApfA contributes to protection against porcine pleuropneumonia.
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Vet Res
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2012
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0.80
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51
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Detection of immune cell response to M. tuberculosis-specific antigens by quantitative polymerase chain reaction.
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Diagn Microbiol Infect Dis
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2011
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0.80
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52
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Delivery of large heterologous polypeptides across the cytoplasmic membrane of antigen-presenting cells by the Bordetella RTX hemolysin moiety lacking the adenylyl cyclase domain.
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Infect Immun
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2012
|
0.79
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53
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Crystallization and preliminary crystallographic characterization of the iron-regulated outer membrane lipoprotein FrpD from Neisseria meningitidis.
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Acta Crystallogr Sect F Struct Biol Cryst Commun
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2010
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0.79
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54
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Plasmodium berghei sporozoite challenge of vaccinated BALB/c mice leads to the induction of humoral immunity and improved function of CD8(+) memory T cells.
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Eur J Immunol
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2013
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0.78
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55
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HlyA knock out yields a safer Escherichia coli A0 34/86 variant with unaffected colonization capacity in piglets.
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FEMS Immunol Med Microbiol
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2006
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0.78
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56
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Complexes of streptavidin-fused antigens with biotinylated antibodies targeting receptors on dendritic cell surface: a novel tool for induction of specific T-cell immune responses.
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Mol Biotechnol
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2012
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0.78
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57
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The Bordetella pertussis type III secretion system tip complex protein Bsp22 is not a protective antigen and fails to elicit serum antibody responses during infection of humans and mice.
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Infect Immun
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2013
|
0.77
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58
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Specific regions of genome plasticity and genetic diversity of the commensal Escherichia coli A0 34/86.
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Int J Med Microbiol
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2006
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0.76
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