Published in Tumori on March 08, 2010
Methylated eyes absent 4 (EYA4) gene promotor in non-neoplastic mucosa of ulcerative colitis patients with colorectal cancer: evidence for a field effect. Inflamm Bowel Dis (2013) 0.78
Discovery of genes from feces correlated with colorectal cancer progression. Oncol Lett (2016) 0.75
Presence of Salmonella AvrA in colorectal tumor and its precursor lesions in mouse intestine and human specimens. Oncotarget (2017) 0.75
EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib. Proc Natl Acad Sci U S A (2004) 33.85
Erlotinib in lung cancer - molecular and clinical predictors of outcome. N Engl J Med (2005) 13.01
Epidermal growth factor receptor gene and protein and gefitinib sensitivity in non-small-cell lung cancer. J Natl Cancer Inst (2005) 9.10
Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon. Nat Genet (1994) 8.34
Gene copy number for epidermal growth factor receptor (EGFR) and clinical response to antiEGFR treatment in colorectal cancer: a cohort study. Lancet Oncol (2005) 7.43
Bronchioloalveolar pathologic subtype and smoking history predict sensitivity to gefitinib in advanced non-small-cell lung cancer. J Clin Oncol (2004) 4.77
Cigarette smoking and adenomatous polyps: a meta-analysis. Gastroenterology (2007) 3.73
Smoking and colorectal cancer: a meta-analysis. JAMA (2008) 3.19
Asia Pacific consensus recommendations for colorectal cancer screening. Gut (2008) 3.19
Accelerated age-related CpG island methylation in ulcerative colitis. Cancer Res (2001) 3.02
Smoking history and epidermal growth factor receptor expression as predictors of survival benefit from erlotinib for patients with non-small-cell lung cancer in the National Cancer Institute of Canada Clinical Trials Group study BR.21. Clin Lung Cancer (2006) 2.14
Successful application of microarray technology to microdissected formalin-fixed, paraffin-embedded tissue. J Mol Diagn (2007) 2.04
Effects of dietary folate and alcohol intake on promoter methylation in sporadic colorectal cancer: the Netherlands cohort study on diet and cancer. Cancer Res (2003) 2.03
Smoke exposure, histologic type and geography-related differences in the methylation profiles of non-small cell lung cancer. Int J Cancer (2003) 2.01
Improved fecal DNA test for colorectal cancer screening. Clin Gastroenterol Hepatol (2006) 1.99
Fecal collection, ambient preservation, and DNA extraction for PCR amplification of bacterial and human markers from human feces. J Microbiol Methods (2007) 1.77
Stool screening for colorectal cancer: molecular approaches. Gastroenterology (2005) 1.61
Molecular determinants of cetuximab efficacy. J Clin Oncol (2005) 1.56
Increased rectal cell proliferation following alcohol abuse. Gut (2001) 1.49
EGF receptor in neoplasia and metastasis. Cancer Metastasis Rev (1993) 1.43
Patterns of EGFR, HER2, TP53, and KRAS mutations of p14arf expression in non-small cell lung cancers in relation to smoking history. Cancer Res (2007) 1.41
A simplified, noninvasive stool DNA test for colorectal cancer detection. Am J Gastroenterol (2008) 1.40
Aberrant methylation of multiple genes in the upper aerodigestive tract epithelium of heavy smokers. Int J Cancer (2003) 1.39
DNA hypermethylation in the normal colonic mucosa of patients with colorectal cancer. Br J Cancer (2006) 1.36
Mutations within the tyrosine kinase domain of EGFR gene specifically occur in lung adenocarcinoma patients with a low exposure of tobacco smoking. Br J Cancer (2006) 1.29
Potential usefulness of detecting cyclooxygenase 2 messenger RNA in feces for colorectal cancer screening. Gastroenterology (2004) 1.27
Clinicopathologic features and prognostic implications of epidermal growth factor receptor (EGFR) gene copy number and protein expression in non-small cell lung cancer. Lung Cancer (2006) 1.25
Detection of hypermethylated DNA or cyclooxygenase-2 messenger RNA in fecal samples of patients with colorectal cancer or polyps. Am J Gastroenterol (2007) 1.21
The EGFR mutation and its correlation with response of gefitinib in previously treated Chinese patients with advanced non-small-cell lung cancer. Ann Oncol (2005) 1.20
DNA stabilization is critical for maximizing performance of fecal DNA-based colorectal cancer tests. Diagn Mol Pathol (2005) 1.20
EGFR, ERBB2, and KRAS mutations in Korean non-small cell lung cancer patients. Cancer Genet Cytogenet (2007) 1.20
A sensitive method to quantify human long DNA in stool: relevance to colorectal cancer screening. Cancer Epidemiol Biomarkers Prev (2006) 1.14
Techniques used in studies of epigenome dysregulation due to aberrant DNA methylation: an emphasis on fetal-based adult diseases. Reprod Toxicol (2007) 1.13
Pro- and anti-inflammatory gene expression in the murine small intestine and liver after chronic exposure to alcohol. Alcohol Clin Exp Res (2001) 1.02
Differential activation of total and EGF receptor (EGF-R) tyrosine kinase (tyr-k) in the rectal mucosa in patients with adenomatous polyps, ulcerative colitis and colon cancer. Hepatogastroenterology (1997) 1.02
The study of p16 and p15 gene methylation in head and neck squamous cell carcinoma and their quantitative evaluation in plasma by real-time PCR. Eur J Cancer (2003) 1.02
Modification of breast cancer risk in young women by a polymorphic sequence in the egfr gene. Cancer Res (2004) 0.99
Methods for detecting DNA methylation in tumors: from bench to bedside. Cancer Lett (2006) 0.99
Human stools as a source of viable colonic epithelial cells. FASEB J (1991) 0.97
Exfoliated cells in stool: a source for reverse transcription-PCR-based analysis of biomarkers of gastrointestinal cancer. Cancer Epidemiol Biomarkers Prev (2008) 0.93
Lectin binding to human colonocytes is predictive of colonic neoplasia. Am J Gastroenterol (1999) 0.90
Modulation by celecoxib and difluoromethylornithine of the methylation of DNA and the estrogen receptor-alpha gene in rat colon tumors. Carcinogenesis (2004) 0.87
EGFRvIII mutation in lung cancer correlates with increased EGFR copy number. Oncol Rep (2007) 0.86
The survival outcomes of patients with resected non-small cell lung cancer differ according to EGFR mutations and the P21 expression. Lung Cancer (2007) 0.86
Accuracy of self-reported family history of cancer in a large case-control study of ovarian cancer. Cancer Causes Control (2008) 0.84
Use of exfoliated cells from target tissues to predict responses to bioactive food components. J Nutr (2003) 0.80
Inhibition of alcohol-associated colonic hyperregeneration by alpha-tocopherol in the rat. Alcohol Clin Exp Res (2003) 0.79
Small tumor size and limited smoking history predicts activated epidermal growth factor receptor in early-stage non-small cell lung cancer. Chest (2005) 0.79
The intestinal epithelial cell modulates the effect of alcohol on neutrophil inflammatory potential. J Trauma (2007) 0.77
Spontaneous rupture of the diaphragm: case report and comprehensive review of the world literature. J Thorac Cardiovasc Surg (2010) 2.84
Distinct subsets of microRNAs are expressed differentially in the human placentas of patients with preeclampsia. Am J Obstet Gynecol (2007) 2.78
Machine learning and its applications to biology. PLoS Comput Biol (2007) 2.57
Membrane transporters and folate homeostasis: intestinal absorption and transport into systemic compartments and tissues. Expert Rev Mol Med (2009) 2.33
Onto-Tools: new additions and improvements in 2006. Nucleic Acids Res (2007) 2.33
The composition and stability of the vaginal microbiota of normal pregnant women is different from that of non-pregnant women. Microbiome (2014) 2.24
Amyand hernia: what lies beneath--a proposed classification scheme to determine management. Am Surg (2007) 1.91
Cryptic lineages of the genus Escherichia. Appl Environ Microbiol (2009) 1.81
Fecal collection, ambient preservation, and DNA extraction for PCR amplification of bacterial and human markers from human feces. J Microbiol Methods (2007) 1.77
Sciatic hernia: a comprehensive review of the world literature (1900-2008). Am J Surg (2010) 1.65
Synthesis and discovery of high affinity folate receptor-specific glycinamide ribonucleotide formyltransferase inhibitors with antitumor activity. J Med Chem (2008) 1.54
Association between prenatal pesticide exposures and the generation of leukemia-associated T(8;21). Pediatr Blood Cancer (2007) 1.54
Rodent intestinal folate transporters (SLC46A1): secondary structure, functional properties, and response to dietary folate restriction. Am J Physiol Cell Physiol (2007) 1.52
Gene expression profiles predict survival and progression of pleural mesothelioma. Clin Cancer Res (2004) 1.51
FAK association with multiple signal proteins mediates pressure-induced colon cancer cell adhesion via a Src-dependent PI3K/Akt pathway. FASEB J (2007) 1.51
Differential gene expression, GATA1 target genes, and the chemotherapy sensitivity of Down syndrome megakaryocytic leukemia. Blood (2005) 1.51
Racial differences in the association between SNPs on 15q25.1, smoking behavior, and risk of non-small cell lung cancer. J Thorac Oncol (2009) 1.49
Genetic and vascular modifiers of age-sensitive cognitive skills: effects of COMT, BDNF, ApoE, and hypertension. Neuropsychology (2009) 1.48
Ogilvie syndrome and herpes zoster: case report and review of the literature. J Emerg Med (2009) 1.45
GATA1, cytidine deaminase, and the high cure rate of Down syndrome children with acute megakaryocytic leukemia. J Natl Cancer Inst (2005) 1.41
Impact of objectively assessing surgeons' teaching on effective perioperative instructional behaviors. JAMA Surg (2013) 1.39
Patient misunderstanding of the academic hierarchy is prevalent and predictable. J Surg Res (2010) 1.38
The transcriptome of the fetal inflammatory response syndrome. Am J Reprod Immunol (2010) 1.37
Autoantibody approach for serum-based detection of head and neck cancer. Cancer Epidemiol Biomarkers Prev (2007) 1.35
Genes associated with prostate cancer are differentially expressed in African American and European American men. Cancer Epidemiol Biomarkers Prev (2013) 1.32
Volume of white matter hyperintensities in healthy adults: contribution of age, vascular risk factors, and inflammation-related genetic variants. Biochim Biophys Acta (2011) 1.29
Microarray analysis and RNA silencing link fra-1 to cd44 and c-met expression in mesothelioma. Cancer Res (2003) 1.27
Acute T-cell leukemias remain dependent on Notch signaling despite PTEN and INK4A/ARF loss. Blood (2009) 1.23
RUNX1 regulates phosphoinositide 3-kinase/AKT pathway: role in chemotherapy sensitivity in acute megakaryocytic leukemia. Blood (2009) 1.22
Targeting the proton-coupled folate transporter for selective delivery of 6-substituted pyrrolo[2,3-d]pyrimidine antifolate inhibitors of de novo purine biosynthesis in the chemotherapy of solid tumors. Mol Pharmacol (2010) 1.21
The human reduced folate carrier gene is ubiquitously and differentially expressed in normal human tissues: identification of seven non-coding exons and characterization of a novel promoter. Biochem J (2002) 1.21
The phosphatase MKP1 is a transcriptional target of p53 involved in cell cycle regulation. J Biol Chem (2003) 1.20
Suppression of sphingomyelin synthase 1 by small interference RNA is associated with enhanced ceramide production and apoptosis after photodamage. Exp Cell Res (2008) 1.19
Activity of dendrimer-methotrexate conjugates on methotrexate-sensitive and -resistant cell lines. Bioconjug Chem (2006) 1.19
Mutational spectrum at GATA1 provides insights into mutagenesis and leukemogenesis in Down syndrome. Blood (2009) 1.18
Repetitive deformation activates focal adhesion kinase and ERK mitogenic signals in human Caco-2 intestinal epithelial cells through Src and Rac1. J Biol Chem (2006) 1.18
Schlafen 3, a novel gene, regulates colonic mucosal growth during aging. Am J Physiol Gastrointest Liver Physiol (2009) 1.17
The human proton-coupled folate transporter: Biology and therapeutic applications to cancer. Cancer Biol Ther (2012) 1.16
Pressure activates colon cancer cell adhesion by inside-out focal adhesion complex and actin cytoskeletal signaling. Gastroenterology (2004) 1.15
Prenatal origin of GATA1 mutations may be an initiating step in the development of megakaryocytic leukemia in Down syndrome. Blood (2004) 1.13
Therapeutic targeting of a novel 6-substituted pyrrolo [2,3-d]pyrimidine thienoyl antifolate to human solid tumors based on selective uptake by the proton-coupled folate transporter. Mol Pharmacol (2011) 1.12
Mechanisms of synergistic antileukemic interactions between valproic acid and cytarabine in pediatric acute myeloid leukemia. Clin Cancer Res (2010) 1.11
The learning curve with single-port cholecystectomy. JSLS (2009) 1.11
Structure and regulation of the murine reduced folate carrier gene: identification of four noncoding exons and promoters and regulation by dietary folates. J Biol Chem (2004) 1.11
Influence of maternal-fetal histocompatibility and MHC zygosity on maternal microchimerism. J Immunol (2005) 1.10
Cytokine SNPs: Comparison of allele frequencies by race and implications for future studies. Cytokine (2009) 1.09
Haploinsufficiency in DNA polymerase beta increases cancer risk with age and alters mortality rate. Cancer Res (2006) 1.08
New insights into Notch1 regulation of the PI3K-AKT-mTOR1 signaling axis: targeted therapy of γ-secretase inhibitor resistant T-cell acute lymphoblastic leukemia. Cell Signal (2013) 1.07
Alpha-actinin-1 phosphorylation modulates pressure-induced colon cancer cell adhesion through regulation of focal adhesion kinase-Src interaction. Am J Physiol Cell Physiol (2007) 1.07
The role of cytidine deaminase and GATA1 mutations in the increased cytosine arabinoside sensitivity of Down syndrome myeloblasts and leukemia cell lines. Cancer Res (2004) 1.07
Src and focal adhesion kinase mediate mechanical strain-induced proliferation and ERK1/2 phosphorylation in human H441 pulmonary epithelial cells. Am J Physiol Cell Physiol (2007) 1.07
Genetic analysis of polymorphisms in biologically relevant candidate genes in patients with abdominal aortic aneurysms. J Vasc Surg (2005) 1.07
miR-210 targets iron-sulfur cluster scaffold homologue in human trophoblast cell lines: siderosis of interstitial trophoblasts as a novel pathology of preterm preeclampsia and small-for-gestational-age pregnancies. Am J Pathol (2011) 1.06
New Onto-Tools: Promoter-Express, nsSNPCounter and Onto-Translate. Nucleic Acids Res (2006) 1.06
Intestinal mucosal atrophy and adaptation. World J Gastroenterol (2012) 1.06
Differential expression of microRNAs with progression of gestation and inflammation in the human chorioamniotic membranes. Am J Obstet Gynecol (2007) 1.06
High frequency of leukemic clones in newborn screening blood samples of children with B-precursor acute lymphoblastic leukemia. Blood (2002) 1.05
A primate subfamily of galectins expressed at the maternal-fetal interface that promote immune cell death. Proc Natl Acad Sci U S A (2009) 1.04
Localization of a substrate binding domain of the human reduced folate carrier to transmembrane domain 11 by radioaffinity labeling and cysteine-substituted accessibility methods. J Biol Chem (2005) 1.03
Cytokine and cytokine receptor single-nucleotide polymorphisms predict risk for non-small cell lung cancer among women. Cancer Epidemiol Biomarkers Prev (2009) 1.02
The motogenic effects of cyclic mechanical strain on intestinal epithelial monolayer wound closure are matrix dependent. Gastroenterology (2006) 1.02
The human reduced folate carrier gene is regulated by the AP2 and sp1 transcription factor families and a functional 61-base pair polymorphism. J Biol Chem (2002) 1.01
Protection of NRK-52E cells, a rat renal proximal tubular cell line, from chemical-induced apoptosis by overexpression of a mitochondrial glutathione transporter. J Pharmacol Exp Ther (2002) 1.01
Schlafen 3 induction by cyclic strain regulates intestinal epithelial differentiation. Am J Physiol Gastrointest Liver Physiol (2010) 1.01
Regulation of the intestinal epithelial response to cyclic strain by extracellular matrix proteins. FASEB J (2003) 1.00
Transforming growth factor-beta stimulates intestinal epithelial focal adhesion kinase synthesis via Smad- and p38-dependent mechanisms. Am J Pathol (2008) 1.00
The role of the cytoskeleton in differentially regulating pressure-mediated effects on malignant colonocyte focal adhesion signaling and cell adhesion. Carcinogenesis (2005) 1.00
Signature pathways identified from gene expression profiles in the human uterine cervix before and after spontaneous term parturition. Am J Obstet Gynecol (2007) 1.00
Characterization of the myometrial transcriptome and biological pathways of spontaneous human labor at term. J Perinat Med (2010) 1.00
Modulation of expression of rat mitochondrial 2-oxoglutarate carrier in NRK-52E cells alters mitochondrial transport and accumulation of glutathione and susceptibility to chemically induced apoptosis. J Pharmacol Exp Ther (2005) 0.99
Effects of age, genes, and pulse pressure on executive functions in healthy adults. Neurobiol Aging (2009) 0.98
Region-specific gene expression profiling: novel evidence for biological heterogeneity of the human amnion. Biol Reprod (2008) 0.97
Identification and functional impact of homo-oligomers of the human proton-coupled folate transporter. J Biol Chem (2011) 0.97
MicroRNA expression profiling of the human uterine cervix after term labor and delivery. Am J Obstet Gynecol (2009) 0.96
Placental protein 13 (galectin-13) has decreased placental expression but increased shedding and maternal serum concentrations in patients presenting with preterm pre-eclampsia and HELLP syndrome. Virchows Arch (2008) 0.96
Dynamic gene expression in the human cerebral cortex distinguishes children from adults. PLoS One (2012) 0.96
The effects of mechanical forces on intestinal physiology and pathology. Cell Signal (2009) 0.95
Activation of p38 MAPKalpha by extracellular pressure mediates the stimulation of macrophage phagocytosis by pressure. Am J Physiol Cell Physiol (2004) 0.95
Akt directly regulates focal adhesion kinase through association and serine phosphorylation: implication for pressure-induced colon cancer metastasis. Am J Physiol Cell Physiol (2011) 0.95
An imbalance between angiogenic and anti-angiogenic factors precedes fetal death in a subset of patients: results of a longitudinal study. J Matern Fetal Neonatal Med (2010) 0.95
Analysis of membrane topology of the human reduced folate carrier protein by hemagglutinin epitope insertion and scanning glycosylation insertion mutagenesis. Biochim Biophys Acta (2002) 0.95
Akt2, but not Akt1 or Akt3 mediates pressure-stimulated serum-opsonized latex bead phagocytosis through activating mTOR and p70 S6 kinase. J Cell Biochem (2007) 0.95
Colchicine inhibits pressure-induced tumor cell implantation within surgical wounds and enhances tumor-free survival in mice. J Clin Invest (2008) 0.94
Intronic non-CG DNA hydroxymethylation and alternative mRNA splicing in honey bees. BMC Genomics (2013) 0.94
Transcriptional regulation of the cystathionine-beta -synthase gene in Down syndrome and non-Down syndrome megakaryocytic leukemia cell lines. Blood (2002) 0.94
p130cas but not paxillin is essential for Caco-2 intestinal epithelial cell spreading and migration on collagen IV. J Biol Chem (2005) 0.94
Roles of USF, Ikaros and Sp proteins in the transcriptional regulation of the human reduced folate carrier B promoter. Biochem J (2004) 0.94
Functional loss of the reduced folate carrier enhances the antitumor activities of novel antifolates with selective uptake by the proton-coupled folate transporter. Mol Pharmacol (2012) 0.94
The transcriptome of cervical ripening in human pregnancy before the onset of labor at term: identification of novel molecular functions involved in this process. J Matern Fetal Neonatal Med (2009) 0.93
A role for mannose-binding lectin, a component of the innate immune system in pre-eclampsia. Am J Reprod Immunol (2008) 0.93
Colon cancer cell adhesion in response to Src kinase activation and actin-cytoskeleton by non-laminar shear stress. J Cell Biochem (2004) 0.93
Paxillin modulates squamous cancer cell adhesion and is important in pressure-augmented adhesion. J Cell Biochem (2006) 0.93