Striking the target in Wnt-y conditions: intervening in Wnt signaling during cancer progression.

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Published in Biochem Pharmacol on March 06, 2010

Authors

Tura C Camilli1, Ashani T Weeraratna

Author Affiliations

1: Laboratory of Immunology and Research Resources Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.

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Lessons from hereditary colorectal cancer. Cell (1996) 25.73

Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. Science (1997) 24.61

Identification of c-MYC as a target of the APC pathway. Science (1998) 24.25

Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature (1999) 20.34

Wnt signaling and cancer. Genes Dev (2000) 18.53

Cancer regression in patients after transfer of genetically engineered lymphocytes. Science (2006) 16.96

Molecular classification of cutaneous malignant melanoma by gene expression profiling. Nature (2000) 15.53

Identification and characterization of the familial adenomatous polyposis coli gene. Cell (1991) 14.46

beta-catenin is a target for the ubiquitin-proteasome pathway. EMBO J (1997) 12.97

GSK-3: tricks of the trade for a multi-tasking kinase. J Cell Sci (2003) 10.89

Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients. Science (1991) 9.89

APC mutations occur early during colorectal tumorigenesis. Nature (1992) 9.50

Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nat Chem Biol (2009) 9.43

Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome. Cell (1982) 9.29

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling. Nature (2009) 9.15

Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation. Nature (2000) 8.37

Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta. Science (1998) 8.27

Secreted antagonists of the Wnt signalling pathway. J Cell Sci (2003) 8.02

Caught up in a Wnt storm: Wnt signaling in cancer. Biochim Biophys Acta (2003) 7.85

The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3. Genes Dev (1996) 7.78

Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer. Nat Genet (2004) 7.78

Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin. EMBO J (1998) 7.59

The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis. N Engl J Med (2000) 7.54

Suppression of intestinal polyposis in Apc delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2). Cell (1996) 7.46

LDL-receptor-related protein 6 is a receptor for Dickkopf proteins. Nature (2001) 7.44

Rational design and characterization of a Rac GTPase-specific small molecule inhibitor. Proc Natl Acad Sci U S A (2004) 7.24

LDL-receptor-related proteins in Wnt signal transduction. Nature (2000) 6.94

Zebrafish prickle, a modulator of noncanonical Wnt/Fz signaling, regulates gastrulation movements. Curr Biol (2003) 6.60

The many ways of Wnt in cancer. Curr Opin Genet Dev (2007) 6.29

Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6. Curr Biol (2001) 5.95

Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancer. Cancer Res (1998) 5.80

Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta. Curr Biol (1998) 5.78

A genomic screen for genes upregulated by demethylation and histone deacetylase inhibition in human colorectal cancer. Nat Genet (2002) 5.38

Wnt5a signaling directly affects cell motility and invasion of metastatic melanoma. Cancer Cell (2002) 5.23

Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene. Hum Mol Genet (1992) 5.14

Small-molecule antagonists of the oncogenic Tcf/beta-catenin protein complex. Cancer Cell (2004) 4.98

The roles of APC and Axin derived from experimental and theoretical analysis of the Wnt pathway. PLoS Biol (2003) 4.89

Beta-catenin, a novel prognostic marker for breast cancer: its roles in cyclin D1 expression and cancer progression. Proc Natl Acad Sci U S A (2000) 4.71

Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent beta-catenin degradation. J Cell Biol (2003) 4.70

Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2. Nat Rev Cancer (2001) 4.62

Wnt genes. Cell (1992) 4.55

Drosophila Tcf and Groucho interact to repress Wingless signalling activity. Nature (1998) 4.50

Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow. Nat Cell Biol (2001) 4.38

The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway. Genes Cells (2003) 4.11

A functional interaction between the histone deacetylase Rpd3 and the corepressor groucho in Drosophila development. Genes Dev (1999) 3.91

The Wnt/Ca2+ pathway: a new vertebrate Wnt signaling pathway takes shape. Trends Genet (2000) 3.91

The APC tumor suppressor counteracts beta-catenin activation and H3K4 methylation at Wnt target genes. Genes Dev (2006) 3.85

Axin-mediated CKI phosphorylation of beta-catenin at Ser 45: a molecular switch for the Wnt pathway. Genes Dev (2002) 3.80

Microenvironment determines lineage fate in a human model of MLL-AF9 leukemia. Cancer Cell (2008) 3.79

Beta-catenin mutations in cell lines established from human colorectal cancers. Proc Natl Acad Sci U S A (1997) 3.79

The p300/CBP acetyltransferases function as transcriptional coactivators of beta-catenin in vertebrates. EMBO J (2000) 3.77

Control of beta-catenin stability: reconstitution of the cytoplasmic steps of the wnt pathway in Xenopus egg extracts. Mol Cell (2000) 3.65

beta-catenin destruction complex: insights and questions from a structural perspective. Oncogene (2006) 3.43

Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex. Cell (2002) 3.42

Axin, a negative regulator of the wnt signaling pathway, directly interacts with adenomatous polyposis coli and regulates the stabilization of beta-catenin. J Biol Chem (1998) 3.39

Casein kinase I transduces Wnt signals. Nature (1999) 3.38

The human F box protein beta-Trcp associates with the Cul1/Skp1 complex and regulates the stability of beta-catenin. Oncogene (1999) 3.36

The APC gene product in normal and tumor cells. Proc Natl Acad Sci U S A (1993) 3.25

The Wnt5A/protein kinase C pathway mediates motility in melanoma cells via the inhibition of metastasis suppressors and initiation of an epithelial to mesenchymal transition. J Biol Chem (2007) 3.24

Mechanism and function of signal transduction by the Wnt/beta-catenin and Wnt/Ca2+ pathways. Oncogene (1999) 3.24

Wnt5A/CaMKII signaling contributes to the inflammatory response of macrophages and is a target for the antiinflammatory action of activated protein C and interleukin-10. Arterioscler Thromb Vasc Biol (2008) 3.13

The transcriptional coactivator CBP interacts with beta-catenin to activate gene expression. J Cell Biol (2000) 3.13

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Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta. Genes Dev (2004) 2.94

The Wnts. Genome Biol (2001) 2.90

Ca(2+)/calmodulin-dependent protein kinase II is stimulated by Wnt and Frizzled homologs and promotes ventral cell fates in Xenopus. J Biol Chem (2000) 2.90

Cthrc1 selectively activates the planar cell polarity pathway of Wnt signaling by stabilizing the Wnt-receptor complex. Dev Cell (2008) 2.89

The chromatin remodelling factor Brg-1 interacts with beta-catenin to promote target gene activation. EMBO J (2001) 2.87

Expression of Wnt-5a is correlated with aggressiveness of gastric cancer by stimulating cell migration and invasion. Cancer Res (2006) 2.86

Wnt5a functions in planar cell polarity regulation in mice. Dev Biol (2007) 2.85

Transformation by Wnt family proteins correlates with regulation of beta-catenin. Cell Growth Differ (1997) 2.74

Epigenetic inactivation of the Wnt antagonist DICKKOPF-1 (DKK-1) gene in human colorectal cancer. Oncogene (2006) 2.69

beta-Trcp couples beta-catenin phosphorylation-degradation and regulates Xenopus axis formation. Proc Natl Acad Sci U S A (1999) 2.66

Bridging of beta-catenin and glycogen synthase kinase-3beta by axin and inhibition of beta-catenin-mediated transcription. Proc Natl Acad Sci U S A (1998) 2.66

Wnt 5a signaling is critical for macrophage-induced invasion of breast cancer cell lines. Proc Natl Acad Sci U S A (2006) 2.60

Wnt5a inhibits B cell proliferation and functions as a tumor suppressor in hematopoietic tissue. Cancer Cell (2003) 2.49

Axis determination in Xenopus involves biochemical interactions of axin, glycogen synthase kinase 3 and beta-catenin. Curr Biol (1998) 2.48

Parafibromin/Hyrax activates Wnt/Wg target gene transcription by direct association with beta-catenin/Armadillo. Cell (2006) 2.47

Activated Wnt/beta-catenin signaling in melanoma is associated with decreased proliferation in patient tumors and a murine melanoma model. Proc Natl Acad Sci U S A (2009) 2.41

Beta-catenin mutations in human prostate cancer. Cancer Res (1998) 2.37

Sporadic medulloblastomas contain oncogenic beta-catenin mutations. Cancer Res (1998) 2.33

A retrovirus vector expressing the putative mammary oncogene int-1 causes partial transformation of a mammary epithelial cell line. Cell (1986) 2.32

WIF1, a component of the Wnt pathway, is down-regulated in prostate, breast, lung, and bladder cancer. J Pathol (2003) 2.30

Prickle 1 regulates cell movements during gastrulation and neuronal migration in zebrafish. Development (2003) 2.26

A new nuclear component of the Wnt signalling pathway. Nat Cell Biol (2002) 2.23

Wnt5a control of cell polarity and directional movement by polarized redistribution of adhesion receptors. Science (2008) 2.22

Wnt signaling and breast cancer. Cancer Biol Ther (2004) 2.22

Oncogene-induced liver neoplasia in transgenic mice. Oncogene (1989) 2.20

WNT/PCP signaling pathway and human cancer (review). Oncol Rep (2005) 2.17

beta-Catenin mutation and overexpression in hepatocellular carcinoma: clinicopathologic and prognostic significance. Cancer (2001) 2.17

Role of glycogen synthase kinase-3 in TNF-alpha-induced NF-kappaB activation and apoptosis in hepatocytes. Am J Physiol Gastrointest Liver Physiol (2002) 2.17

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Wnt-5a has tumor suppressor activity in thyroid carcinoma. Oncogene (2005) 2.11

Pygopus, a nuclear PHD-finger protein required for Wingless signaling in Drosophila. Development (2002) 2.11

Transcription under the control of nuclear Arm/beta-catenin. Curr Biol (2006) 2.11

Myeloid cell leukemia-1 inversely correlates with glycogen synthase kinase-3beta activity and associates with poor prognosis in human breast cancer. Cancer Res (2007) 2.10

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