Published in Nat Chem Biol on January 04, 2009
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Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts. Nature (2010) 10.60
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Targeting androgen receptor in estrogen receptor-negative breast cancer. Cancer Cell (2011) 2.23
Wnt signaling controls the specification of definitive and primitive hematopoiesis from human pluripotent stem cells. Nat Biotechnol (2014) 2.05
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Wnt signaling induces proliferation of sensory precursors in the postnatal mouse cochlea. Proc Natl Acad Sci U S A (2012) 1.54
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Wnt/β-catenin signalling in prostate cancer. Nat Rev Urol (2012) 1.52
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Wnt signaling and colon carcinogenesis: beyond APC. J Carcinog (2011) 1.44
Wnt signalling and the control of cellular metabolism. Biochem J (2010) 1.42
Targeting metabolic remodeling in glioblastoma multiforme. Oncotarget (2010) 1.42
Poised Regeneration of Zebrafish Melanocytes Involves Direct Differentiation and Concurrent Replenishment of Tissue-Resident Progenitor Cells. Dev Cell (2015) 1.38
Targeting protein lipidation in disease. Trends Mol Med (2012) 1.37
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Deletion of mouse Porcn blocks Wnt ligand secretion and reveals an ectodermal etiology of human focal dermal hypoplasia/Goltz syndrome. Proc Natl Acad Sci U S A (2011) 1.35
Wnt secretion is required to maintain high levels of Wnt activity in colon cancer cells. Nat Commun (2013) 1.34
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A diterpenoid derivative 15-oxospiramilactone inhibits Wnt/β-catenin signaling and colon cancer cell tumorigenesis. Cell Res (2011) 1.27
Left-right asymmetry is required for the habenulae to respond to both visual and olfactory stimuli. Curr Biol (2014) 1.27
A dual function for canonical Wnt/β-catenin signaling in the developing mammalian cochlea. Development (2012) 1.25
Regulation of CD133 by HDAC6 promotes β-catenin signaling to suppress cancer cell differentiation. Cell Rep (2012) 1.24
Pyrvinium, a potent small molecule Wnt inhibitor, promotes wound repair and post-MI cardiac remodeling. PLoS One (2010) 1.24
Structure-activity relationship studies of small-molecule inhibitors of Wnt response. Bioorg Med Chem Lett (2009) 1.24
Modulation of β-catenin function maintains mouse epiblast stem cell and human embryonic stem cell self-renewal. Nat Commun (2013) 1.23
Canonical Wnt suppressor, Axin2, promotes colon carcinoma oncogenic activity. Proc Natl Acad Sci U S A (2012) 1.23
Kindlin-1 controls Wnt and TGF-β availability to regulate cutaneous stem cell proliferation. Nat Med (2014) 1.22
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Inhibition of tankyrases induces Axin stabilization and blocks Wnt signalling in breast cancer cells. PLoS One (2012) 1.21
Wnt/beta-catenin signaling in oral tissue development and disease. J Dent Res (2010) 1.20
Wnt/β-catenin and its diverse physiological cell signaling pathways in neurodegenerative and neuropsychiatric disorders. J Neuroimmune Pharmacol (2012) 1.19
A chemical biology approach to myocardial regeneration. J Cardiovasc Transl Res (2011) 1.17
Tankyrase and the canonical Wnt pathway protect lung cancer cells from EGFR inhibition. Cancer Res (2012) 1.16
Spontaneous tumour regression in keratoacanthomas is driven by Wnt/retinoic acid signalling cross-talk. Nat Commun (2014) 1.16
Mechanistic insight into Myc stabilization in breast cancer involving aberrant Axin1 expression. Proc Natl Acad Sci U S A (2011) 1.16
Fluorinated N,N-dialkylaminostilbenes for Wnt pathway inhibition and colon cancer repression. J Med Chem (2011) 1.16
Epicardial spindle orientation controls cell entry into the myocardium. Dev Cell (2010) 1.16
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Small molecule-mediated directed differentiation of human embryonic stem cells toward ventricular cardiomyocytes. Stem Cells Transl Med (2013) 1.13
An intrinsically labile α-helix abutting the BCL9-binding site of β-catenin is required for its inhibition by carnosic acid. Nat Commun (2012) 1.11
Targeting Wnt pathways in disease. Cold Spring Harb Perspect Biol (2012) 1.11
Stage-specific regulation of reprogramming to induced pluripotent stem cells by Wnt signaling and T cell factor proteins. Cell Rep (2013) 1.11
The Wnt inhibitory factor 1 (WIF1) is targeted in glioblastoma and has a tumor suppressing function potentially by induction of senescence. Neuro Oncol (2011) 1.10
Pancreatic cancer-associated retinoblastoma 1 dysfunction enables TGF-β to promote proliferation. J Clin Invest (2013) 1.10
Tankyrase is necessary for canonical Wnt signaling during kidney development. Dev Dyn (2010) 1.09
Stearoyl CoA desaturase is required to produce active, lipid-modified Wnt proteins. Cell Rep (2013) 1.09
LEF1 and B9L shield β-catenin from inactivation by Axin, desensitizing colorectal cancer cells to tankyrase inhibitors. Cancer Res (2014) 1.08
Wnt activation promotes neuronal differentiation of glioblastoma. Cell Death Dis (2013) 1.08
Wnt antagonist SFRP1 functions as a secreted mediator of senescence. Mol Cell Biol (2012) 1.06
Poly(ADP-ribose) polymerase inhibitors as promising cancer therapeutics. Acta Pharmacol Sin (2010) 1.06
Proteasome regulation by ADP-ribosylation. Cell (2013) 1.05
Lymphatic vessels arise from specialized angioblasts within a venous niche. Nature (2015) 1.04
Different APC genotypes in proximal and distal sporadic colorectal cancers suggest distinct WNT/β-catenin signalling thresholds for tumourigenesis. Oncogene (2012) 1.04
The consensus coding sequences of human breast and colorectal cancers. Science (2006) 60.02
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Lessons from hereditary colorectal cancer. Cell (1996) 25.73
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Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4. Nat Genet (1998) 10.51
Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors. Mol Cell Biol (2002) 8.60
Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis. Science (2007) 8.07
The many ways of Wnt in cancer. Curr Opin Genet Dev (2007) 6.29
Augmented Wnt signaling in a mammalian model of accelerated aging. Science (2007) 5.62
Mining the Wnt pathway for cancer therapeutics. Nat Rev Drug Discov (2006) 5.29
Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone. Cell (2008) 5.10
Monounsaturated fatty acid modification of Wnt protein: its role in Wnt secretion. Dev Cell (2006) 4.89
The roles of APC and Axin derived from experimental and theoretical analysis of the Wnt pathway. PLoS Biol (2003) 4.89
Distinct Wnt signaling pathways have opposing roles in appendage regeneration. Development (2006) 4.88
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A zebrafish bmyb mutation causes genome instability and increased cancer susceptibility. Proc Natl Acad Sci U S A (2005) 2.19
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Post-translational palmitoylation and glycosylation of Wnt-5a are necessary for its signalling. Biochem J (2007) 1.95
Palmitoylation and ubiquitination regulate exit of the Wnt signaling protein LRP6 from the endoplasmic reticulum. Proc Natl Acad Sci U S A (2008) 1.64
The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family. Eur J Biochem (2000) 1.40
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A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus. Nat Genet (2013) 6.19
Minimizing the risk of reporting false positives in large-scale RNAi screens. Nat Methods (2006) 5.96
Synthetic lethal screen identification of chemosensitizer loci in cancer cells. Nature (2007) 4.70
Inactivation of Stat5 in mouse mammary epithelium during pregnancy reveals distinct functions in cell proliferation, survival, and differentiation. Mol Cell Biol (2004) 4.45
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BRAF mutations are sufficient to promote nevi formation and cooperate with p53 in the genesis of melanoma. Curr Biol (2005) 3.68
Prevalence of off-target effects in Drosophila RNA interference screens. Nature (2006) 3.38
Correction of a genetic disease in mouse via use of CRISPR-Cas9. Cell Stem Cell (2013) 3.30
Targeting QseC signaling and virulence for antibiotic development. Science (2008) 3.26
Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3. Cell (2008) 3.15
Top-down control of human visual cortex by frontal and parietal cortex in anticipatory visual spatial attention. J Neurosci (2008) 3.07
Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING. Mol Cell (2013) 2.97
The ihog cell-surface proteins bind Hedgehog and mediate pathway activation. Cell (2006) 2.92
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Discovery of a proneurogenic, neuroprotective chemical. Cell (2010) 2.78
All-trans retinoic acid/As2O3 combination yields a high quality remission and survival in newly diagnosed acute promyelocytic leukemia. Proc Natl Acad Sci U S A (2004) 2.67
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Differently anchored influenza hemagglutinin mutants display distinct interaction dynamics with mutual rafts. J Cell Biol (2003) 2.22
A zebrafish bmyb mutation causes genome instability and increased cancer susceptibility. Proc Natl Acad Sci U S A (2005) 2.19
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Hyperexcitability and epilepsy associated with disruption of the mouse neuronal-specific K-Cl cotransporter gene. Hippocampus (2002) 2.06
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Chinese herbal medicines as adjuvant treatment during chemo- or radio-therapy for cancer. Biosci Trends (2010) 2.01
Common genetic polymorphisms modify the effect of smoking on absolute risk of bladder cancer. Cancer Res (2013) 1.99
Heat- and anesthesia-induced malignant hyperthermia in an RyR1 knock-in mouse. FASEB J (2005) 1.97
Label-free detection of small-molecule-protein interactions by using nanowire nanosensors. Proc Natl Acad Sci U S A (2005) 1.95
Small molecule Wnt inhibitors enhance the efficiency of BMP-4-directed cardiac differentiation of human pluripotent stem cells. J Mol Cell Cardiol (2011) 1.93
Canonical Wnt9b signaling balances progenitor cell expansion and differentiation during kidney development. Development (2011) 1.92
Palmitoylation supports assembly and function of integrin-tetraspanin complexes. J Cell Biol (2004) 1.89
Suberoylanilide hydroxamic acid (vorinostat) up-regulates progranulin transcription: rational therapeutic approach to frontotemporal dementia. J Biol Chem (2011) 1.88
Small molecules that delay S phase suppress a zebrafish bmyb mutant. Nat Chem Biol (2005) 1.87
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A validated tumorgraft model reveals activity of dovitinib against renal cell carcinoma. Sci Transl Med (2012) 1.84
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Removal of FKBP12 enhances mTOR-Raptor interactions, LTP, memory, and perseverative/repetitive behavior. Neuron (2008) 1.80
The liver X receptor ligand T0901317 decreases amyloid beta production in vitro and in a mouse model of Alzheimer's disease. J Biol Chem (2004) 1.75
High-throughput screening for potent and selective inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase. J Biol Chem (2005) 1.73
Draft genome of the kiwifruit Actinidia chinensis. Nat Commun (2013) 1.72
Wnt signaling activation in adipose progenitors promotes insulin-independent muscle glucose uptake. Cell Metab (2012) 1.72
Activation of Hedgehog signaling by loss of GNAS causes heterotopic ossification. Nat Med (2013) 1.66
Stromal-epithelial crosstalk regulates kidney progenitor cell differentiation. Nat Cell Biol (2013) 1.64
Antitumor activity of targeting SRC kinases in endothelial and myeloid cell compartments of the tumor microenvironment. Clin Cancer Res (2010) 1.64
Genome-wide siRNA-based functional genomics of pigmentation identifies novel genes and pathways that impact melanogenesis in human cells. PLoS Genet (2008) 1.64
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Towards patient-based cancer therapeutics. Nat Biotechnol (2010) 1.63
Diminishing catalyst concentration in atom transfer radical polymerization with reducing agents. Proc Natl Acad Sci U S A (2006) 1.61
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An indole-3-acetic acid carboxyl methyltransferase regulates Arabidopsis leaf development. Plant Cell (2005) 1.53
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Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of Parkinson disease. Proc Natl Acad Sci U S A (2012) 1.45
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In vivo Wnt signaling tracing through a transgenic biosensor fish reveals novel activity domains. Dev Biol (2012) 1.43
Systematic review of high-dose and standard-dose chemotherapies in the treatment of primary well-differentiated osteosarcoma. Tumour Biol (2014) 1.40
IFNL4-ΔG genotype is associated with slower viral clearance in hepatitis C, genotype-1 patients treated with sofosbuvir and ribavirin. J Infect Dis (2013) 1.39
CoSi particles on silica support as a highly active and selective catalyst for naphthalene hydrogenation. Chem Commun (Camb) (2009) 1.39
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Transgenic indica rice plants harboring a synthetic cry2A* gene of Bacillus thuringiensis exhibit enhanced resistance against lepidopteran rice pests. Theor Appl Genet (2005) 1.37
Functional variants in the promoter region of Chitinase 3-like 1 (CHI3L1) and susceptibility to schizophrenia. Am J Hum Genet (2006) 1.37
p53 ancestry: gazing through an evolutionary lens. Nat Rev Cancer (2009) 1.37
Complete genome analysis of the C4 subgenotype strains of enterovirus 71: predominant recombination C4 viruses persistently circulating in China for 14 years. PLoS One (2013) 1.36
A genome-wide association study of bladder cancer identifies a new susceptibility locus within SLC14A1, a urea transporter gene on chromosome 18q12.3. Hum Mol Genet (2011) 1.36
Common genetic variants in the PSCA gene influence gene expression and bladder cancer risk. Proc Natl Acad Sci U S A (2012) 1.36
Spinophilin regulates Ca2+ signalling by binding the N-terminal domain of RGS2 and the third intracellular loop of G-protein-coupled receptors. Nat Cell Biol (2005) 1.36
Atf4 regulates obesity, glucose homeostasis, and energy expenditure. Diabetes (2009) 1.34
Genome-wide association study identifies multiple loci associated with bladder cancer risk. Hum Mol Genet (2013) 1.34
Development of proneurogenic, neuroprotective small molecules. J Am Chem Soc (2011) 1.33
Diverse chemical scaffolds support direct inhibition of the membrane-bound O-acyltransferase porcupine. J Biol Chem (2012) 1.33
A mouse model of rhabdomyosarcoma originating from the adipocyte lineage. Cancer Cell (2012) 1.32
Anti-hepatitis B virus activity of chlorogenic acid, quinic acid and caffeic acid in vivo and in vitro. Antiviral Res (2009) 1.32
Evidence for a critical role of the tumor necrosis factor alpha convertase (TACE) in ectodomain shedding of the p75 neurotrophin receptor (p75NTR). J Biol Chem (2003) 1.32
High-resolution array CGH identifies common mechanisms that drive embryonal rhabdomyosarcoma pathogenesis. Genes Chromosomes Cancer (2011) 1.31
Effects of S-glutathionylation and S-nitrosylation on calmodulin binding to triads and FKBP12 binding to type 1 calcium release channels. Antioxid Redox Signal (2005) 1.29
ARNO and ARF6 regulate axonal elongation and branching through downstream activation of phosphatidylinositol 4-phosphate 5-kinase alpha. Mol Biol Cell (2003) 1.29
Bufalin and cinobufagin induce apoptosis of human hepatocellular carcinoma cells via Fas- and mitochondria-mediated pathways. Cancer Sci (2011) 1.28
Reduced miR-128 in breast tumor-initiating cells induces chemotherapeutic resistance via Bmi-1 and ABCC5. Clin Cancer Res (2011) 1.28
Fighting fat with fat: the expanding field of adipose stem cells. Cell Stem Cell (2009) 1.25