Kaposi's sarcoma-associated herpesvirus ORF57 protein binds and protects a nuclear noncoding RNA from cellular RNA decay pathways.

PubWeight™: 1.18‹?› | Rank: Top 10%

🔗 View Article (PMC 2832700)

Published in PLoS Pathog on March 05, 2010

Authors

Brooke B Sahin1, Denish Patel, Nicholas K Conrad

Author Affiliations

1: Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America.

Articles citing this

Conservation of a triple-helix-forming RNA stability element in noncoding and genomic RNAs of diverse viruses. Cell Rep (2012) 1.34

A viral nuclear noncoding RNA binds re-localized poly(A) binding protein and is required for late KSHV gene expression. PLoS Pathog (2011) 1.17

Nuclear import of cytoplasmic poly(A) binding protein restricts gene expression via hyperadenylation and nuclear retention of mRNA. Mol Cell Biol (2010) 1.17

Regulation of viral and cellular gene expression by Kaposi's sarcoma-associated herpesvirus polyadenylated nuclear RNA. J Virol (2013) 1.09

Stability of a long noncoding viral RNA depends on a 9-nt core element at the RNA 5' end to interact with viral ORF57 and cellular PABPC1. Int J Biol Sci (2011) 1.06

KSHV Rta Promoter Specification and Viral Reactivation. Front Microbiol (2012) 1.04

Kaposi's sarcoma-associated herpesvirus noncoding polyadenylated nuclear RNA interacts with virus- and host cell-encoded proteins and suppresses expression of genes involved in immune modulation. J Virol (2011) 1.03

The human nuclear poly(a)-binding protein promotes RNA hyperadenylation and decay. PLoS Genet (2013) 1.01

An interaction between KSHV ORF57 and UIF provides mRNA-adaptor redundancy in herpesvirus intronless mRNA export. PLoS Pathog (2011) 1.01

Viral noncoding RNAs: more surprises. Genes Dev (2015) 0.99

Viral factors reveal a role for REF/Aly in nuclear RNA stability. Mol Cell Biol (2012) 0.97

Epstein-Barr Virus SM protein utilizes cellular splicing factor SRp20 to mediate alternative splicing. J Virol (2010) 0.96

Delineation of a core RNA element required for Kaposi's sarcoma-associated herpesvirus ORF57 binding and activity. Virology (2011) 0.94

Gammaherpesviral gene expression and virion composition are broadly controlled by accelerated mRNA degradation. PLoS Pathog (2014) 0.91

Binding of cellular export factor REF/Aly by Kaposi's sarcoma-associated herpesvirus (KSHV) ORF57 protein is not required for efficient KSHV lytic replication. J Virol (2012) 0.87

Molecular biology of KSHV lytic reactivation. Viruses (2015) 0.86

NP1 Protein of the Bocaparvovirus Minute Virus of Canines Controls Access to the Viral Capsid Genes via Its Role in RNA Processing. J Virol (2015) 0.85

Strategies for viral RNA stability: live long and prosper. Trends Genet (2011) 0.85

Kaposi's sarcoma-associated herpesvirus ORF57 protein: exploiting all stages of viral mRNA processing. Viruses (2013) 0.84

Mutation of a C-terminal motif affects Kaposi's sarcoma-associated herpesvirus ORF57 RNA binding, nuclear trafficking, and multimerization. J Virol (2011) 0.84

Chromatin immunoprecipitation and microarray analysis suggest functional cooperation between Kaposi's Sarcoma-associated herpesvirus ORF57 and K-bZIP. J Virol (2013) 0.82

KSHV ORF57, a protein of many faces. Viruses (2015) 0.82

Stability of structured Kaposi's sarcoma-associated herpesvirus ORF57 protein is regulated by protein phosphorylation and homodimerization. J Virol (2015) 0.82

Rhesus monkey rhadinovirus ORF57 induces gH and gL glycoprotein expression through posttranscriptional accumulation of target mRNAs. J Virol (2011) 0.81

Identification of the physiological gene targets of the essential lytic replicative Kaposi's sarcoma-associated herpesvirus ORF57 protein. J Virol (2014) 0.81

PAN's Labyrinth: Molecular biology of Kaposi's sarcoma-associated herpesvirus (KSHV) PAN RNA, a multifunctional long noncoding RNA. Viruses (2014) 0.81

Cell-based screening assay for antiviral compounds targeting the ability of herpesvirus posttranscriptional regulatory proteins to stabilize viral mRNAs. J Virol (2013) 0.80

HITS-CLIP analysis uncovers a link between the Kaposi's sarcoma-associated herpesvirus ORF57 protein and host pre-mRNA metabolism. PLoS Pathog (2015) 0.80

Long non-coding RNA and epigenetic gene regulation of KSHV. Viruses (2014) 0.79

New insights into the expression and functions of the Kaposi's sarcoma-associated herpesvirus long noncoding PAN RNA. Virus Res (2015) 0.78

NF-κB activation coordinated by IKKβ and IKKε enables latent infection of Kaposi's sarcoma-associated herpesvirus. J Virol (2013) 0.78

Depletion of REF/Aly alters gene expression and reduces RNA polymerase II occupancy. Nucleic Acids Res (2014) 0.77

Identification and Characterization of the Physiological Gene Targets of the Essential Lytic Replicative Epstein-Barr Virus SM Protein. J Virol (2015) 0.77

Chromatinization of the KSHV Genome During the KSHV Life Cycle. Cancers (Basel) (2015) 0.77

Diverse virus-host interactions influence RNA-based regulation during γ-herpesvirus infection. Curr Opin Microbiol (2012) 0.76

Next-Generation Sequencing in the Understanding of Kaposi's Sarcoma-Associated Herpesvirus (KSHV) Biology. Viruses (2016) 0.75

Articles cited by this

A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res (2001) 124.61

Restricted expression of Kaposi sarcoma-associated herpesvirus (human herpesvirus 8) genes in Kaposi sarcoma. Proc Natl Acad Sci U S A (1996) 6.00

Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon. Cell (2000) 5.54

RNA granules: post-transcriptional and epigenetic modulators of gene expression. Nat Rev Mol Cell Biol (2009) 4.57

Evidence for reassociation of RNA-binding proteins after cell lysis: implications for the interpretation of immunoprecipitation analyses. RNA (2004) 4.23

Global analysis of stress-regulated mRNA turnover by using cDNA arrays. Proc Natl Acad Sci U S A (2002) 3.71

Quality control of mRNA 3'-end processing is linked to the nuclear exosome. Nature (2001) 3.69

The control of mRNA decapping and P-body formation. Mol Cell (2008) 3.58

Kaposi's sarcoma-associated herpesvirus open reading frame 50/Rta protein activates the entire viral lytic cycle in the HH-B2 primary effusion lymphoma cell line. J Virol (2000) 3.50

How introns influence and enhance eukaryotic gene expression. Trends Biochem Sci (2003) 3.47

Intervening sequences increase efficiency of RNA 3' processing and accumulation of cytoplasmic RNA. Nucleic Acids Res (1990) 3.34

Human mRNA export machinery recruited to the 5' end of mRNA. Cell (2006) 3.32

Growth-related changes in phosphorylation of yeast RNA polymerase II. J Biol Chem (1998) 3.24

Recruitment of the human TREX complex to mRNA during splicing. Genes Dev (2005) 3.13

Splicing enhances translation in mammalian cells: an additional function of the exon junction complex. Genes Dev (2004) 3.13

Molecular genetics of Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8) epidemiology and pathogenesis. Microbiol Mol Biol Rev (2003) 2.90

RNA quality control in eukaryotes. Cell (2007) 2.83

A quantitative analysis of intron effects on mammalian gene expression. RNA (2003) 2.80

Polyadenylylated nuclear RNA encoded by Kaposi sarcoma-associated herpesvirus. Proc Natl Acad Sci U S A (1996) 2.76

KSHV infection and the pathogenesis of Kaposi's sarcoma. Annu Rev Pathol (2006) 2.61

Splicing of oskar RNA in the nucleus is coupled to its cytoplasmic localization. Nature (2004) 2.58

Exon junction complexes mediate the enhancing effect of splicing on mRNA expression. Proc Natl Acad Sci U S A (2003) 2.52

A block to mRNA nuclear export in S. cerevisiae leads to hyperadenylation of transcripts that accumulate at the site of transcription. Mol Cell (2001) 2.41

Analysis of the stimulatory effect of splicing on mRNA production and utilization in mammalian cells. RNA (2003) 2.40

Transcription activation of polyadenylated nuclear rna by rta in human herpesvirus 8/Kaposi's sarcoma-associated herpesvirus. J Virol (2001) 2.28

P bodies, stress granules, and viral life cycles. Cell Host Microbe (2008) 2.23

Splicing promotes rapid and efficient mRNA export in mammalian cells. Proc Natl Acad Sci U S A (2008) 1.98

Open reading frame 50 protein of Kaposi's sarcoma-associated herpesvirus directly activates the viral PAN and K12 genes by binding to related response elements. J Virol (2002) 1.94

Kaposi's sarcoma-associated herpesvirus open reading frame 57 encodes a posttranscriptional regulator with multiple distinct activities. J Virol (2000) 1.89

An interaction between U2AF 65 and CF I(m) links the splicing and 3' end processing machineries. EMBO J (2006) 1.79

A 5' splice site enhances the recruitment of basal transcription initiation factors in vivo. Mol Cell (2008) 1.74

The evolutionarily conserved Kaposi's sarcoma-associated herpesvirus ORF57 protein interacts with REF protein and acts as an RNA export factor. J Biol Chem (2004) 1.73

Defects in the mRNA export factors Rat7p, Gle1p, Mex67p, and Rat8p cause hyperadenylation during 3'-end formation of nascent transcripts. RNA (2001) 1.71

Specific and global regulation of mRNA stability during osmotic stress in Saccharomyces cerevisiae. RNA (2009) 1.66

Transcriptional pulsing approaches for analysis of mRNA turnover in mammalian cells. Methods (1999) 1.64

Identification of a rapid mammalian deadenylation-dependent decay pathway and its inhibition by a viral RNA element. Mol Cell (2006) 1.59

The role of Kaposi's sarcoma-associated herpesvirus/human herpesvirus-8 regulator of transcription activation (RTA) in control of gene expression. Oncogene (2003) 1.56

The many roles of the regulatory protein ICP27 during herpes simplex virus infection. Front Biosci (2008) 1.48

Guide RNAs with 5' caps and novel box C/D snoRNA-like domains for modification of snRNAs in metazoa. Curr Biol (2004) 1.45

A Kaposi's sarcoma virus RNA element that increases the nuclear abundance of intronless transcripts. EMBO J (2005) 1.45

mRNA decay in prokaryotes and eukaryotes: different approaches to a similar problem. IUBMB Life (2004) 1.38

Recruitment of the complete hTREX complex is required for Kaposi's sarcoma-associated herpesvirus intronless mRNA nuclear export and virus replication. PLoS Pathog (2008) 1.37

Aberrant herpesvirus-induced polyadenylation correlates with cellular messenger RNA destruction. PLoS Biol (2009) 1.36

Targeted disruption of Kaposi's sarcoma-associated herpesvirus ORF57 in the viral genome is detrimental for the expression of ORF59, K8alpha, and K8.1 and the production of infectious virus. J Virol (2006) 1.35

Kaposi's sarcoma-associated herpesvirus lytic gene ORF57 is essential for infectious virion production. J Virol (2006) 1.28

Structural and functional analyses of Kaposi sarcoma-associated herpesvirus ORF57 nuclear localization signals in living cells. J Biol Chem (2006) 1.28

Epstein-Barr virus (EBV) SM protein induces and recruits cellular Sp110b to stabilize mRNAs and enhance EBV lytic gene expression. J Virol (2004) 1.27

Gene structure and expression of Kaposi's sarcoma-associated herpesvirus ORF56, ORF57, ORF58, and ORF59. J Virol (2006) 1.27

Mutational analysis of a viral RNA element that counteracts rapid RNA decay by interaction with the polyadenylate tail. Proc Natl Acad Sci U S A (2007) 1.26

The human herpesvirus-8 ORF 57 gene and its properties. J Gen Virol (1999) 1.25

Viral RNAs: lessons from the enemy. Cell (2009) 1.25

Regulation of KSHV lytic gene expression. Curr Top Microbiol Immunol (2007) 1.24

The human herpesvirus 8 homolog of Epstein-Barr virus SM protein (KS-SM) is a posttranscriptional activator of gene expression. J Virol (2000) 1.24

An essential role for hGle1 nucleocytoplasmic shuttling in mRNA export. J Cell Biol (2003) 1.22

The human cytomegalovirus regulatory protein UL69 and its effect on mRNA export. Front Biosci (2008) 1.21

RNA turnover: unexpected consequences of being tailed. Curr Biol (2005) 1.21

The Rta/Orf50 transactivator proteins of the gamma-herpesviridae. Curr Top Microbiol Immunol (2007) 1.20

Kaposi's sarcoma-associated herpesvirus ORF57 protein enhances mRNA accumulation independently of effects on nuclear RNA export. J Virol (2007) 1.19

Functional co-operation between the Kaposi's sarcoma-associated herpesvirus ORF57 and ORF50 regulatory proteins. J Gen Virol (2004) 1.16

Kaposi's sarcoma-associated herpesvirus ORF57 functions as a viral splicing factor and promotes expression of intron-containing viral lytic genes in spliceosome-mediated RNA splicing. J Virol (2008) 1.13

Kaposi's sarcoma-associated herpesvirus ORF57 in viral RNA processing. Front Biosci (Landmark Ed) (2009) 1.13

Introns regulate the rate of unstable mRNA decay. J Biol Chem (2007) 1.11

Relationship between mRNA stability and intron presence. Biochem Biophys Res Commun (2007) 1.10

Promoter- and cell-specific transcriptional transactivation by the Kaposi's sarcoma-associated herpesvirus ORF57/Mta protein. J Virol (2007) 1.07

Split genes and their expression in Kaposi's sarcoma-associated herpesvirus. Rev Med Virol (2003) 1.06

Post-transcriptional gene regulation by gamma herpesviruses. J Cell Biochem (2005) 1.03

Assembly of an export-competent mRNP is needed for efficient release of the 3'-end processing complex after polyadenylation. Mol Cell Biol (2009) 1.01

Human herpesvirus 8-encoded proteins with potential roles in virus-associated neoplasia. Front Biosci (2007) 0.98

Herpes simplex virus ICP27 is required for virus-induced stabilization of the ARE-containing IEX-1 mRNA encoded by the human IER3 gene. J Virol (2006) 0.97

Epstein-Barr virus SM protein functions as an alternative splicing factor. J Virol (2008) 0.95

Tethered function assays using 3' untranslated regions. Methods (2002) 0.93

gamma-2 Herpes virus post-transcriptional gene regulation. Clin Microbiol Infect (2006) 0.92

A posttranscriptional regulator of Kaposi's sarcoma-associated herpesvirus interacts with RNA-binding protein PCBP1 and controls gene expression through the IRES. Virology (2004) 0.90

Chapter 15. Co-immunoprecipitation techniques for assessing RNA-protein interactions in vivo. Methods Enzymol (2008) 0.90

Posttranscriptional gene regulation in Kaposi's sarcoma-associated herpesvirus. Adv Appl Microbiol (2009) 0.89

Computational prediction of SEG (single exon gene) function in humans. Front Biosci (2005) 0.89

Viruses: overturning RNA turnover. RNA Biol (2006) 0.79