Published in Neuron on March 11, 2010
Chlorzoxazone, an SK-type potassium channel activator used in humans, reduces excessive alcohol intake in rats. Biol Psychiatry (2010) 1.74
Emerging role of the calcium-activated, small conductance, SK3 K+ channel in distal tubule function: regulation by TRPV4. PLoS One (2014) 1.46
Endocytosis promotes rapid dopaminergic signaling. Neuron (2011) 1.35
Cortical activation of accumbens hyperpolarization-active NMDARs mediates aversion-resistant alcohol intake. Nat Neurosci (2013) 1.35
Disruption of alcohol-related memories by mTORC1 inhibition prevents relapse. Nat Neurosci (2013) 1.29
Small conductance calcium-activated potassium type 2 channels regulate alcohol-associated plasticity of glutamatergic synapses. Biol Psychiatry (2010) 1.12
Endothelial small-conductance and intermediate-conductance KCa channels: an update on their pharmacology and usefulness as cardiovascular targets. J Cardiovasc Pharmacol (2013) 1.05
Novel therapeutic strategies for alcohol and drug addiction: focus on GABA, ion channels and transcranial magnetic stimulation. Neuropsychopharmacology (2011) 0.97
The small-conductance calcium-activated potassium channel is a key modulator of firing and long-term depression in the dorsal striatum. Eur J Neurosci (2010) 0.93
Unstructured to structured transition of an intrinsically disordered protein peptide in coupling Ca²⁺-sensing and SK channel activation. Proc Natl Acad Sci U S A (2013) 0.90
Long-lasting alterations in membrane properties, k(+) currents, and glutamatergic synaptic currents of nucleus accumbens medium spiny neurons in a rat model of alcohol dependence. Front Neurosci (2012) 0.86
Increased small conductance calcium-activated potassium type 2 channel-mediated negative feedback on N-methyl-D-aspartate receptors impairs synaptic plasticity following context-dependent sensitization to morphine. Biol Psychiatry (2013) 0.85
KCNN Genes that Encode Small-Conductance Ca2+-Activated K+ Channels Influence Alcohol and Drug Addiction. Neuropsychopharmacology (2015) 0.84
K(Ca)2 channels: novel therapeutic targets for treating alcohol withdrawal and escalation of alcohol consumption. Alcohol (2012) 0.82
Transcriptome analysis of Inbred Long Sleep and Inbred Short Sleep mice. Genes Brain Behav (2013) 0.82
Increased Basolateral Amygdala Pyramidal Cell Excitability May Contribute to the Anxiogenic Phenotype Induced by Chronic Early-Life Stress. J Neurosci (2015) 0.82
K(Ca)2 and k(ca)3 channels in learning and memory processes, and neurodegeneration. Front Pharmacol (2012) 0.82
The therapeutic potential of small-conductance KCa2 channels in neurodegenerative and psychiatric diseases. Expert Opin Ther Targets (2013) 0.82
Chronic Intermittent Ethanol Exposure Enhances the Excitability and Synaptic Plasticity of Lateral Orbitofrontal Cortex Neurons and Induces a Tolerance to the Acute Inhibitory Actions of Ethanol. Neuropsychopharmacology (2015) 0.81
Chronic intermittent ethanol exposure and withdrawal leads to adaptations in nucleus accumbens core postsynaptic density proteome and dendritic spines. Addict Biol (2015) 0.81
Effects of alcohol on the membrane excitability and synaptic transmission of medium spiny neurons in the nucleus accumbens. Alcohol (2012) 0.80
Kv7 channels in the nucleus accumbens are altered by chronic drinking and are targets for reducing alcohol consumption. Addict Biol (2015) 0.79
Novel anticonvulsants for reducing alcohol consumption: A review of evidence from preclinical rodent drinking models. OA Alcohol (2013) 0.79
Molecular overlap in the regulation of SK channels by small molecules and phosphoinositides. Sci Adv (2015) 0.78
MCH and apomorphine in combination enhance action potential firing of nucleus accumbens shell neurons in vitro. PeerJ (2013) 0.77
Postsynaptic adenosine A2A receptors modulate intrinsic excitability of pyramidal cells in the rat basolateral amygdala. Int J Neuropsychopharmacol (2015) 0.77
Targeting the Small- and Intermediate-Conductance Ca-Activated Potassium Channels: The Drug-Binding Pocket at the Channel/Calmodulin Interface. Neurosignals (2014) 0.77
Activators of G-protein signaling 3: a drug addiction molecular gateway. Behav Pharmacol (2010) 0.77
Glutathione and redox signaling in substance abuse. Biomed Pharmacother (2014) 0.76
Differential potassium channel gene regulation in BXD mice reveals novel targets for pharmacogenetic therapies to reduce heavy alcohol drinking. Alcohol (2016) 0.76
Location matters: somatic and dendritic SK channels answer to distinct calcium signals. J Neurophysiol (2014) 0.76
Genome-wide DNA hydroxymethylation identifies potassium channels in the nucleus accumbens as discriminators of methamphetamine addiction and abstinence. Mol Psychiatry (2016) 0.76
Ethanol affects network activity in cultured rat hippocampus: mediation by potassium channels. PLoS One (2013) 0.76
Bidirectional modulation of intrinsic excitability in rat prelimbic cortex neuronal ensembles and non-ensembles following operant learning. J Neurosci (2017) 0.76
Rodent Brain Microinjection to Study Molecular Substrates of Motivated Behavior. J Vis Exp (2015) 0.75
Alcohol and basal ganglia circuitry: Animal models. Neuropharmacology (2017) 0.75
Dnmt3a: addiction's molecular forget-me-not? Nat Neurosci (2010) 0.75
Prefrontal Cortex KCa2 Channels Regulate mGlu5-Dependent Plasticity and Extinction of Alcohol-Seeking Behavior. J Neurosci (2017) 0.75
Nucleus Accumbens Shell and mPFC but Not Insula Orexin-1 Receptors Promote Excessive Alcohol Drinking. Front Neurosci (2016) 0.75
Small K channels: big targets for treating alcoholism? Biol Psychiatry (2011) 0.75
Neural systems of reinforcement for drug addiction: from actions to habits to compulsion. Nat Neurosci (2005) 16.18
Emotion and motivation: the role of the amygdala, ventral striatum, and prefrontal cortex. Neurosci Biobehav Rev (2002) 8.78
From motivation to action: functional interface between the limbic system and the motor system. Prog Neurobiol (1980) 5.46
Evidence for sugar addiction: behavioral and neurochemical effects of intermittent, excessive sugar intake. Neurosci Biobehav Rev (2007) 5.22
Toward a model of drug relapse: an assessment of the validity of the reinstatement procedure. Psychopharmacology (Berl) (2006) 4.23
Ventral striatal control of appetitive motivation: role in ingestive behavior and reward-related learning. Neurosci Biobehav Rev (2004) 4.11
Behavioural assessment of drug reinforcement and addictive features in rodents: an overview. Addict Biol (2006) 3.94
Cocaine seeking habits depend upon dopamine-dependent serial connectivity linking the ventral with the dorsal striatum. Neuron (2008) 3.93
Decreases in the precision of Purkinje cell pacemaking cause cerebellar dysfunction and ataxia. Nat Neurosci (2006) 3.36
Brain circuitry and the reinstatement of cocaine-seeking behavior. Psychopharmacology (Berl) (2003) 3.24
Alcoholism: a systems approach from molecular physiology to addictive behavior. Physiol Rev (2009) 2.82
The alcohol-preferring P rat and animal models of excessive alcohol drinking. Addict Biol (2006) 2.82
Channels underlying neuronal calcium-activated potassium currents. Prog Neurobiol (2002) 2.67
Activator of G protein signaling 3: a gatekeeper of cocaine sensitization and drug seeking. Neuron (2004) 2.57
Neural coding of basic reward terms of animal learning theory, game theory, microeconomics and behavioural ecology. Curr Opin Neurobiol (2004) 2.51
Relapse prevention. An overview of Marlatt's cognitive-behavioral model. Alcohol Res Health (1999) 2.40
Cocaine self-administration selectively abolishes LTD in the core of the nucleus accumbens. Nat Neurosci (2006) 2.23
The nucleus accumbens as part of a basal ganglia action selection circuit. Psychopharmacology (Berl) (2006) 2.14
Differential distribution of three Ca(2+)-activated K(+) channel subunits, SK1, SK2, and SK3, in the adult rat central nervous system. Mol Cell Neurosci (2000) 2.11
Intrinsic membrane properties underlying spontaneous tonic firing in neostriatal cholinergic interneurons. J Neurosci (2000) 1.99
Cocaine-associated stimuli increase cocaine seeking and activate accumbens core neurons after abstinence. J Neurosci (2007) 1.91
Subcortical correlates of craving in recently abstinent alcoholic patients. Am J Psychiatry (2001) 1.84
Differential expression of the small-conductance, calcium-activated potassium channel SK3 is critical for pacemaker control in dopaminergic midbrain neurons. J Neurosci (2001) 1.84
Anatomy and pharmacology of cocaine priming-induced reinstatement of drug seeking. Eur J Pharmacol (2005) 1.65
Comparative immunohistochemical distribution of three small-conductance Ca2+-activated potassium channel subunits, SK1, SK2, and SK3 in mouse brain. Mol Cell Neurosci (2004) 1.61
How to make a rat addicted to cocaine. Prog Neuropsychopharmacol Biol Psychiatry (2007) 1.55
Functional microcircuitry in the accumbens underlying drug addiction: insights from real-time signaling during behavior. Curr Opin Neurobiol (2004) 1.55
Development of an alcohol-deprivation effect in rats. Q J Stud Alcohol (1968) 1.52
Relationships between intracellular calcium and afterhyperpolarizations in neocortical pyramidal neurons. J Neurophysiol (2003) 1.42
Comparative efficacy and safety of skeletal muscle relaxants for spasticity and musculoskeletal conditions: a systematic review. J Pain Symptom Manage (2004) 1.41
Nucleus accumbens AGS3 expression drives ethanol seeking through G betagamma. Proc Natl Acad Sci U S A (2008) 1.41
Withdrawal from intermittent ethanol exposure increases probability of burst firing in VTA neurons in vitro. J Neurophysiol (2007) 1.30
Homeostatic synapse-driven membrane plasticity in nucleus accumbens neurons. J Neurosci (2009) 1.27
Increased ethanol self-administration after a period of imposed ethanol deprivation in rats trained in a limited access paradigm. Alcohol Clin Exp Res (1997) 1.26
D1-like and D2 dopamine receptor antagonists administered into the shell subregion of the rat nucleus accumbens decrease cocaine, but not food, reinforcement. Neuroscience (2005) 1.26
Ethanol-associated olfactory stimuli reinstate ethanol-seeking behavior after extinction and modify extracellular dopamine levels in the nucleus accumbens. Alcohol Clin Exp Res (1999) 1.23
Alcohol-related olfactory cues activate the nucleus accumbens and ventral tegmental area in high-risk drinkers: preliminary findings. Alcohol Clin Exp Res (2004) 1.22
Neuroadaptations in human chronic alcoholics: dysregulation of the NF-kappaB system. PLoS One (2007) 1.19
Activation of the human intermediate-conductance Ca(2+)-activated K(+) channel by 1-ethyl-2-benzimidazolinone is strongly Ca(2+)-dependent. Biochim Biophys Acta (1999) 1.14
Distribution, neuronal colocalization, and 17beta-E2 modulation of small conductance calcium-activated K(+) channel (SK3) mRNA in the guinea pig brain. Endocrinology (2002) 1.13
Modulation of recombinant small-conductance Ca(2+)-activated K(+) channels by the muscle relaxant chlorzoxazone and structurally related compounds. J Pharmacol Exp Ther (2001) 1.10
Focal cerebral blood flow change during craving for alcohol measured by SPECT. J Neuropsychiatry Clin Neurosci (1995) 1.01
Determinants contributing to estrogen-regulated expression of SK3. Biochem Biophys Res Commun (2003) 0.98
Neuronal spike activity in the nucleus accumbens of behaving rats during ethanol self-administration. Brain Res (1999) 0.98
Alcohol ingestion inhibits the increased secretion of puberty-related hormones in the developing female rhesus monkey. Endocrinology (2000) 0.96
Calcium-activated potassium currents differentially modulate respiratory rhythm generation. Eur J Neurosci (2008) 0.96
Transcriptional regulation of intronic calcium-activated potassium channel SK2 promoters by nuclear factor-kappa B and glucocorticoids. Mol Cell Biochem (2007) 0.91
Charybdotoxin and apamin sensitivity of the calcium-dependent repolarization and the afterhyperpolarization in neostriatal neurons. J Neurophysiol (1992) 0.87
SK3 K+ channel-deficient mice have enhanced dopamine and serotonin release and altered emotional behaviors. Genes Brain Behav (2008) 0.87
Determination of an estradiol dose-response relationship in the modulation of ethanol intake. Alcohol Clin Exp Res (2004) 0.86
Ca2+-activated outward currents in neostriatal neurons. Neuroscience (1999) 0.86
Learning-induced modulation of SK channels-mediated effect on synaptic transmission. Eur J Neurosci (2007) 0.84
Chlorzoxazone inhibits contraction of rat thoracic aorta. Eur J Pharmacol (2006) 0.80
Modulation of calcium-activated potassium small conductance (SK) current in rat dopamine neurons of the ventral tegmental area. Neurosci Lett (2003) 0.78
Adjuvant trastuzumab in HER2-positive breast cancer. N Engl J Med (2011) 12.52
Phasic firing in dopaminergic neurons is sufficient for behavioral conditioning. Science (2009) 8.76
Drugs of abuse and stress trigger a common synaptic adaptation in dopamine neurons. Neuron (2003) 6.19
Breast cancer subtypes and response to docetaxel in node-positive breast cancer: use of an immunohistochemical definition in the BCIRG 001 trial. J Clin Oncol (2009) 4.66
A genomic predictor of response and survival following taxane-anthracycline chemotherapy for invasive breast cancer. JAMA (2011) 4.63
Excitatory transmission from the amygdala to nucleus accumbens facilitates reward seeking. Nature (2011) 4.58
Orexin A in the VTA is critical for the induction of synaptic plasticity and behavioral sensitization to cocaine. Neuron (2006) 4.39
Results of the CONFIRM phase III trial comparing fulvestrant 250 mg with fulvestrant 500 mg in postmenopausal women with estrogen receptor-positive advanced breast cancer. J Clin Oncol (2010) 3.88
Recombinase-driver rat lines: tools, techniques, and optogenetic application to dopamine-mediated reinforcement. Neuron (2011) 3.49
Dopaminergic terminals in the nucleus accumbens but not the dorsal striatum corelease glutamate. J Neurosci (2010) 3.47
Synaptic and behavioral profile of multiple glutamatergic inputs to the nucleus accumbens. Neuron (2012) 2.91
Reward-predictive cues enhance excitatory synaptic strength onto midbrain dopamine neurons. Science (2008) 2.82
Corticotropin-releasing factor requires CRF binding protein to potentiate NMDA receptors via CRF receptor 2 in dopamine neurons. Neuron (2003) 2.81
A central role of the BK potassium channel in behavioral responses to ethanol in C. elegans. Cell (2003) 2.72
Cocaine but not natural reward self-administration nor passive cocaine infusion produces persistent LTP in the VTA. Neuron (2008) 2.69
The global breast cancer burden: variations in epidemiology and survival. Clin Breast Cancer (2005) 2.69
Docetaxel and doxorubicin compared with doxorubicin and cyclophosphamide as first-line chemotherapy for metastatic breast cancer: results of a randomized, multicenter, phase III trial. J Clin Oncol (2003) 2.69
Acute and chronic cocaine-induced potentiation of synaptic strength in the ventral tegmental area: electrophysiological and behavioral correlates in individual rats. J Neurosci (2004) 2.59
Alteration of topoisomerase II-alpha gene in human breast cancer: association with responsiveness to anthracycline-based chemotherapy. J Clin Oncol (2010) 2.48
Rapid strengthening of thalamo-amygdala synapses mediates cue-reward learning. Nature (2008) 2.47
Role of NMDA receptors in dopamine neurons for plasticity and addictive behaviors. Neuron (2008) 2.41
Optogenetic interrogation of dopaminergic modulation of the multiple phases of reward-seeking behavior. J Neurosci (2011) 2.37
The type 1 equilibrative nucleoside transporter regulates ethanol intoxication and preference. Nat Neurosci (2004) 2.33
Cocaine self-administration selectively abolishes LTD in the core of the nucleus accumbens. Nat Neurosci (2006) 2.23
Kappa-opioid agonists directly inhibit midbrain dopaminergic neurons. J Neurosci (2003) 2.21
Genetic markers of toxicity from capecitabine and other fluorouracil-based regimens: investigation in the QUASAR2 study, systematic review, and meta-analysis. J Clin Oncol (2014) 2.17
Rescuing cocaine-induced prefrontal cortex hypoactivity prevents compulsive cocaine seeking. Nature (2013) 2.15
Mechanism and time course of cocaine-induced long-term potentiation in the ventral tegmental area. J Neurosci (2008) 2.15
Mechanisms of scent-tracking in humans. Nat Neurosci (2006) 2.07
Orexin A/hypocretin-1 selectively promotes motivation for positive reinforcers. J Neurosci (2009) 2.02
Phase II clinical trial of ixabepilone (BMS-247550), an epothilone B analog, in patients with taxane-resistant metastatic breast cancer. J Clin Oncol (2007) 1.93
Inhibition of orexin-1/hypocretin-1 receptors inhibits yohimbine-induced reinstatement of ethanol and sucrose seeking in Long-Evans rats. Psychopharmacology (Berl) (2008) 1.89
Evaluation of a 30-gene paclitaxel, fluorouracil, doxorubicin, and cyclophosphamide chemotherapy response predictor in a multicenter randomized trial in breast cancer. Clin Cancer Res (2010) 1.81
Transient stimulation of distinct subpopulations of striatal neurons mimics changes in action value. Nat Neurosci (2012) 1.79
Adjuvant lapatinib for women with early-stage HER2-positive breast cancer: a randomised, controlled, phase 3 trial. Lancet Oncol (2012) 1.75
Chlorzoxazone, an SK-type potassium channel activator used in humans, reduces excessive alcohol intake in rats. Biol Psychiatry (2010) 1.74
Synaptic plasticity and drug addiction. Curr Opin Pharmacol (2005) 1.73
AMPA receptor synaptic plasticity induced by psychostimulants: the past, present, and therapeutic future. Neuron (2010) 1.68
Long-lasting potentiation of GABAergic synapses in dopamine neurons after a single in vivo ethanol exposure. J Neurosci (2002) 1.66
Cocaine enhances NMDA receptor-mediated currents in ventral tegmental area cells via dopamine D5 receptor-dependent redistribution of NMDA receptors. J Neurosci (2006) 1.63
Both kappa and mu opioid agonists inhibit glutamatergic input to ventral tegmental area neurons. J Neurophysiol (2004) 1.62
NMDA receptor function is regulated by the inhibitory scaffolding protein, RACK1. Proc Natl Acad Sci U S A (2002) 1.59
A polymorphism in the cytidine deaminase promoter predicts severe capecitabine-induced hand-foot syndrome. Clin Cancer Res (2011) 1.58
Adjuvant docetaxel, doxorubicin, and cyclophosphamide in node-positive breast cancer: 10-year follow-up of the phase 3 randomised BCIRG 001 trial. Lancet Oncol (2012) 1.55
Dopamine responsiveness is regulated by targeted sorting of D2 receptors. Proc Natl Acad Sci U S A (2005) 1.55
Accumbens neurochemical adaptations produced by binge-like alcohol consumption. Psychopharmacology (Berl) (2007) 1.50
Phase III randomized trial of sunitinib versus capecitabine in patients with previously treated HER2-negative advanced breast cancer. Breast Cancer Res Treat (2010) 1.47
Activation of dopamine neurons is critical for aversive conditioning and prevention of generalized anxiety. Nat Neurosci (2011) 1.46
Nucleus accumbens AGS3 expression drives ethanol seeking through G betagamma. Proc Natl Acad Sci U S A (2008) 1.41
Cooperative activation of dopamine D1 and D2 receptors increases spike firing of nucleus accumbens neurons via G-protein betagamma subunits. J Neurosci (2003) 1.38
Endocytosis promotes rapid dopaminergic signaling. Neuron (2011) 1.35
Cortical activation of accumbens hyperpolarization-active NMDARs mediates aversion-resistant alcohol intake. Nat Neurosci (2013) 1.35
Endogenous hydrogen peroxide regulates the excitability of midbrain dopamine neurons via ATP-sensitive potassium channels. J Neurosci (2005) 1.33
Acute cocaine exposure alters spine density and long-term potentiation in the ventral tegmental area. Eur J Neurosci (2007) 1.33
Estrogen receptor expression and efficacy of docetaxel-containing adjuvant chemotherapy in patients with node-positive breast cancer: results from a pooled analysis. J Clin Oncol (2008) 1.33
Glutamate-dependent inhibition of dopamine release in striatum is mediated by a new diffusible messenger, H2O2. J Neurosci (2003) 1.33
C57BL/6N mutation in cytoplasmic FMRP interacting protein 2 regulates cocaine response. Science (2013) 1.31
Dynamic interaction between sigma-1 receptor and Kv1.2 shapes neuronal and behavioral responses to cocaine. Cell (2013) 1.31
Withdrawal from intermittent ethanol exposure increases probability of burst firing in VTA neurons in vitro. J Neurophysiol (2007) 1.30
The melanin-concentrating hormone system modulates cocaine reward. Proc Natl Acad Sci U S A (2009) 1.30
Similar roles of substantia nigra and ventral tegmental dopamine neurons in reward and aversion. J Neurosci (2014) 1.30
Dual control of dopamine synthesis and release by presynaptic and postsynaptic dopamine D2 receptors. J Neurosci (2012) 1.29
Voluntary ethanol intake enhances excitatory synaptic strength in the ventral tegmental area. Alcohol Clin Exp Res (2008) 1.29
Docetaxel-related side effects and their management. Eur J Oncol Nurs (2009) 1.29
Final overall survival: fulvestrant 500 mg vs 250 mg in the randomized CONFIRM trial. J Natl Cancer Inst (2013) 1.28
Synaptic plasticity in the mesolimbic system: therapeutic implications for substance abuse. Ann N Y Acad Sci (2010) 1.28
Analysis of Fcγ receptor IIIa and IIa polymorphisms: lack of correlation with outcome in trastuzumab-treated breast cancer patients. Clin Cancer Res (2012) 1.27
Hypothalamic neurotensin projections promote reward by enhancing glutamate transmission in the VTA. J Neurosci (2013) 1.26
Motivation for alcohol becomes resistant to quinine adulteration after 3 to 4 months of intermittent alcohol self-administration. Alcohol Clin Exp Res (2010) 1.23
The sigma-1 receptor: roles in neuronal plasticity and disease. Trends Neurosci (2012) 1.22
Phase III multicenter clinical trial of the sialyl-TN (STn)-keyhole limpet hemocyanin (KLH) vaccine for metastatic breast cancer. Oncologist (2011) 1.21
Effects of stress and aversion on dopamine neurons: implications for addiction. Neurosci Biobehav Rev (2010) 1.21
Ethanol alters trafficking and functional N-methyl-D-aspartate receptor NR2 subunit ratio via H-Ras. J Biol Chem (2005) 1.18
Cancer therapy-induced cardiac toxicity in early breast cancer: addressing the unresolved issues. Circulation (2012) 1.14
Chronic cocaine enhances corticotropin-releasing factor-dependent potentiation of excitatory transmission in ventral tegmental area dopamine neurons. J Neurosci (2009) 1.11
Transient activation of specific neurons in mice by selective expression of the capsaicin receptor. Nat Commun (2012) 1.10
CRF acts in the midbrain to attenuate accumbens dopamine release to rewards but not their predictors. Nat Neurosci (2013) 1.09