Published in J Neurosci on September 09, 2009
The tempted brain eats: pleasure and desire circuits in obesity and eating disorders. Brain Res (2010) 2.68
Brain reactivity to smoking cues prior to smoking cessation predicts ability to maintain tobacco abstinence. Biol Psychiatry (2010) 2.45
Caloric restriction experience reprograms stress and orexigenic pathways and promotes binge eating. J Neurosci (2010) 1.77
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Hypocretin 1/orexin A in the ventral tegmental area enhances dopamine responses to cocaine and promotes cocaine self-administration. Psychopharmacology (Berl) (2010) 1.17
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Orexin signaling in the paraventricular thalamic nucleus modulates mesolimbic dopamine and hedonic feeding in the rat. Neuroscience (2012) 1.05
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Nicotine self-administration in the rat: effects of hypocretin antagonists and changes in hypocretin mRNA. Psychopharmacology (Berl) (2010) 1.01
Role of orexin in modulating arousal, feeding, and motivation. Front Behav Neurosci (2013) 1.01
Orexin / hypocretin 1 receptor antagonist reduces heroin self-administration and cue-induced heroin seeking. Eur J Neurosci (2012) 0.99
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An orexin hotspot in ventral pallidum amplifies hedonic 'liking' for sweetness. Neuropsychopharmacology (2013) 0.98
Orexin-1 receptor mediation of cocaine seeking in male and female rats. J Pharmacol Exp Ther (2011) 0.96
Forebrain networks and the control of feeding by environmental learned cues. Physiol Behav (2013) 0.96
Hypocretin/orexin regulation of dopamine signaling: implications for reward and reinforcement mechanisms. Front Behav Neurosci (2012) 0.93
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Local hypocretin-1 modulates terminal dopamine concentration in the nucleus accumbens shell. Front Behav Neurosci (2012) 0.92
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Optogenetic examination identifies a context-specific role for orexins/hypocretins in anxiety-related behavior. Physiol Behav (2013) 0.91
Regulation of the ventral tegmental area by the bed nucleus of the stria terminalis is required for expression of cocaine preference. Eur J Neurosci (2012) 0.91
Involvement of the orexin/hypocretin system in ethanol conditioned place preference. Psychopharmacology (Berl) (2010) 0.90
Hindbrain orexin 1 receptors influence palatable food intake, operant responding for food, and food-conditioned place preference in rats. Psychopharmacology (Berl) (2013) 0.90
The paraventricular nucleus of the thalamus is recruited by both natural rewards and drugs of abuse: recent evidence of a pivotal role for orexin/hypocretin signaling in this thalamic nucleus in drug-seeking behavior. Front Behav Neurosci (2014) 0.89
Tobacco dependence, the insular cortex and the hypocretin connection. Pharmacol Biochem Behav (2010) 0.89
Lateral thinking about leptin: a review of leptin action via the lateral hypothalamus. Physiol Behav (2011) 0.88
Hypocretin-1 receptors regulate the reinforcing and reward-enhancing effects of cocaine: pharmacological and behavioral genetics evidence. Front Behav Neurosci (2012) 0.88
GOAT induced ghrelin acylation regulates hedonic feeding. Horm Behav (2012) 0.88
Hypocretins and the neurobiology of sleep-wake mechanisms. Prog Brain Res (2012) 0.87
The dual orexin/hypocretin receptor antagonist, almorexant, in the ventral tegmental area attenuates ethanol self-administration. PLoS One (2012) 0.87
Selective Fos induction in hypothalamic orexin/hypocretin, but not melanin-concentrating hormone neurons, by a learned food-cue that stimulates feeding in sated rats. Neuroscience (2012) 0.86
Lateral hypothalamic orexin/hypocretin neurons that project to ventral tegmental area are differentially activated with morphine preference. J Neurosci (2012) 0.86
To ingest or rest? Specialized roles of lateral hypothalamic area neurons in coordinating energy balance. Front Syst Neurosci (2015) 0.85
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Acute high fat diet consumption activates the mesolimbic circuit and requires orexin signaling in a mouse model. PLoS One (2014) 0.84
Cocaine potentiates excitatory drive in the perifornical/lateral hypothalamus. J Physiol (2012) 0.84
Hypocretin/Orexin regulation of dopamine signaling and cocaine self-administration is mediated predominantly by hypocretin receptor 1. ACS Chem Neurosci (2014) 0.84
The role of orexins/hypocretins in alcohol use and abuse: an appetitive-reward relationship. Front Behav Neurosci (2012) 0.83
Acute pain and a motivational pathway in adult rats: influence of early life pain experience. PLoS One (2012) 0.83
The selective orexin receptor 1 antagonist ACT-335827 in a rat model of diet-induced obesity associated with metabolic syndrome. Front Pharmacol (2013) 0.83
Orexin-1 receptor signaling increases motivation for cocaine-associated cues. Eur J Neurosci (2015) 0.83
Blockade of hypocretin receptor-1 preferentially prevents cocaine seeking: comparison with natural reward seeking. Neuroreport (2014) 0.82
Cannabinoid-hypocretin cross-talk in the central nervous system: what we know so far. Front Neurosci (2013) 0.82
Attenuation of saccharin-seeking in rats by orexin/hypocretin receptor 1 antagonist. Psychopharmacology (Berl) (2013) 0.82
Individual differences in orexin-I receptor modulation of motivation for the opioid remifentanil. Addict Biol (2015) 0.81
Conflation of cocaine seeking and cocaine taking responses in IV self-administration experiments in rats: methodological and interpretational considerations. Neurosci Biobehav Rev (2013) 0.81
Role of orexin/hypocretin in conditioned sucrose-seeking in female rats. Neuropharmacology (2014) 0.80
Hypocretin receptor 1 blockade preferentially reduces high effort responding for cocaine without promoting sleep. Behav Brain Res (2015) 0.80
Organization of connections between the amygdala, medial prefrontal cortex, and lateral hypothalamus: a single and double retrograde tracing study in rats. Brain Struct Funct (2015) 0.79
Hubs and spokes of the lateral hypothalamus: cell types, circuits and behaviour. J Physiol (2016) 0.79
Orexin regulates bone remodeling via a dominant positive central action and a subordinate negative peripheral action. Cell Metab (2014) 0.79
Orexin-1 receptor antagonism does not reduce the rewarding potency of cocaine in Swiss-Webster mice. Brain Res (2011) 0.79
Effects of individual glucose levels on the neuronal correlates of emotions. Front Hum Neurosci (2013) 0.79
Repeated orexin 1 receptor antagonism effects on cocaine seeking in rats. Neuropharmacology (2012) 0.78
Neural plasticity in hypocretin neurons: the basis of hypocretinergic regulation of physiological and behavioral functions in animals. Front Syst Neurosci (2015) 0.78
The role of the lateral hypothalamus and orexin in ingestive behavior: a model for the translation of past experience and sensed deficits into motivated behaviors. Front Syst Neurosci (2014) 0.78
The highly selective orexin/hypocretin 1 receptor antagonist GSK1059865 potently reduces ethanol drinking in ethanol dependent mice. Brain Res (2016) 0.78
Orexin/hypocretin neuron activation is correlated with alcohol seeking and preference in a topographically specific manner. Eur J Neurosci (2016) 0.77
Orexin/Hypocretin-1 Receptor Antagonism Selectively Reduces Cue-Induced Feeding in Sated Rats and Recruits Medial Prefrontal Cortex and Thalamus. Sci Rep (2015) 0.77
Hypocretin/orexin involvement in reward and reinforcement. Vitam Horm (2012) 0.77
Integration of reward signalling and appetite regulating peptide systems in the control of food-cue responses. Br J Pharmacol (2015) 0.77
Opposing roles of cotransmission of dynorphin and hypocretin on reward and motivation. Proc Natl Acad Sci U S A (2014) 0.77
Orexin/hypocretin receptor 1 signaling mediates Pavlovian cue-food conditioning and extinction. Physiol Behav (2016) 0.76
Smoking, Alcohol, Drug Use, Abuse and Dependence in Narcolepsy and Idiopathic Hypersomnia: A Case-Control Study. Sleep (2016) 0.76
Orexin/hypocretin-1 receptor antagonism reduces ethanol self-administration and reinstatement selectively in highly-motivated rats. Brain Res (2016) 0.76
A relationship between reduced nucleus accumbens shell and enhanced lateral hypothalamic orexin neuronal activation in long-term fructose bingeing behavior. PLoS One (2014) 0.76
Hypocretin Neurotransmission Within the Central Amygdala Mediates Escalated Cocaine Self-Administration and Stress-Induced Reinstatement in Rats. Biol Psychiatry (2016) 0.76
Orexin Neurons Respond Differentially to Auditory Cues Associated with Appetitive versus Aversive Outcomes. J Neurosci (2016) 0.76
Hypocretin/orexin knock-out mice display disrupted behavioral and dopamine responses to cocaine. Addict Biol (2016) 0.76
Suvorexant, an orexin/hypocretin receptor antagonist, attenuates motivational and hedonic properties of cocaine. Addict Biol (2017) 0.76
Orexin-1 receptor blockade suppresses compulsive-like alcohol drinking in mice. Neuropharmacology (2016) 0.75
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