Published in PLoS One on March 10, 2010
Gene balance hypothesis: connecting issues of dosage sensitivity across biological disciplines. Proc Natl Acad Sci U S A (2012) 2.20
Heterosis. Plant Cell (2010) 2.06
Chromosome and gene copy number variation allow major structural change between species and strains of Leishmania. Genome Res (2011) 1.90
Gene duplication as a mechanism of genomic adaptation to a changing environment. Proc Biol Sci (2012) 1.83
Dosage compensation can buffer copy-number variation in wild yeast. Elife (2015) 1.58
Gene copy-number polymorphism in nature. Proc Biol Sci (2010) 1.35
Copy-number variation: the balance between gene dosage and expression in Drosophila melanogaster. Genome Biol Evol (2011) 1.21
A worldwide analysis of beta-defensin copy number variation suggests recent selection of a high-expressing DEFB103 gene copy in East Asia. Hum Mutat (2011) 1.21
Genome-wide mapping of copy number variation in humans: comparative analysis of high resolution array platforms. PLoS One (2011) 1.18
Understanding the impact of 1q21.1 copy number variant. Orphanet J Rare Dis (2011) 1.11
Female behaviour drives expression and evolution of gustatory receptors in butterflies. PLoS Genet (2013) 0.99
Genome-wide analysis of copy number variation in type 1 diabetes. PLoS One (2010) 0.96
Current analysis platforms and methods for detecting copy number variation. Physiol Genomics (2012) 0.94
Microevolution of Duplications and Deletions and Their Impact on Gene Expression in the Nematode Pristionchus pacificus. PLoS One (2015) 0.88
The characterisation of three types of genes that overlie copy number variable regions. PLoS One (2011) 0.86
A genome-wide association study on copy-number variation identifies a 11q11 loss as a candidate susceptibility variant for colorectal cancer. Hum Genet (2013) 0.86
Enzyme recruitment and its role in metabolic expansion. Biochemistry (2014) 0.85
To lyse or not to lyse: transient-mediated stochastic fate determination in cells infected by bacteriophages. PLoS Comput Biol (2011) 0.85
Late-replicating CNVs as a source of new genes. Biol Open (2013) 0.84
Complexity of gene expression evolution after duplication: protein dosage rebalancing. Genet Res Int (2014) 0.84
A comparison of genomic copy number calls by Partek Genomics Suite, Genotyping Console and Birdsuite algorithms to quantitative PCR. BioData Min (2011) 0.83
Impact of constitutional copy number variants on biological pathway evolution. BMC Evol Biol (2013) 0.81
Copy number variations of the extensively amplified Y-linked genes, HSFY and ZNF280BY, in cattle and their association with male reproductive traits in Holstein bulls. BMC Genomics (2014) 0.81
Inducing extra copies of the Hsp70 gene in Drosophila melanogaster increases energetic demand. BMC Evol Biol (2013) 0.80
Association of genetic copy number variations at 11 q14.2 with brain regional volume differences in an alcohol use disorder population. Alcohol (2012) 0.79
hsp90 and hsp47 appear to play an important role in minnow Puntius sophore for surviving in the hot spring run-off aquatic ecosystem. Fish Physiol Biochem (2016) 0.79
Delineating the Hemostaseome as an aid to individualize the analysis of the hereditary basis of thrombotic and bleeding disorders. Hum Genet (2011) 0.78
Subtyping of Gliomaby Combining Gene Expression and CNVs Data Based on a Compressive Sensing Approach. Adv Genet Eng (2012) 0.78
Somatic Mutation Patterns in Hemizygous Genomic Regions Unveil Purifying Selection during Tumor Evolution. PLoS Genet (2016) 0.78
Gene copy number variation analysis reveals dosage-insensitive expression of CYP2E1. Pharmacogenomics J (2015) 0.76
Protein-Protein and Protein-DNA Dosage Balance and Differential Paralog Transcription Factor Retention in Polyploids. Front Plant Sci (2011) 0.76
Effects of Gene Dose, Chromatin, and Network Topology on Expression in Drosophila melanogaster. PLoS Genet (2016) 0.75
Copy Number Variants in Alzheimer's Disease. J Alzheimers Dis (2016) 0.75
No Evidence that MicroRNAs Coevolve with Genes Located in Copy Number Regions. Mol Biol Evol (2015) 0.75
Integrative radiogenomic analysis for multicentric radiophenotype in glioblastoma. Oncotarget (2016) 0.75
Global variation in copy number in the human genome. Nature (2006) 57.50
Detection of large-scale variation in the human genome. Nat Genet (2004) 49.18
A gene atlas of the mouse and human protein-encoding transcriptomes. Proc Natl Acad Sci U S A (2004) 44.81
Towards a proteome-scale map of the human protein-protein interaction network. Nature (2005) 24.76
Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature (2006) 24.29
The evolutionary fate and consequences of duplicate genes. Science (2000) 24.22
Relative impact of nucleotide and copy number variation on gene expression phenotypes. Science (2007) 23.38
A human protein-protein interaction network: a resource for annotating the proteome. Cell (2005) 18.97
The Gene Ontology Annotation (GOA) Database: sharing knowledge in Uniprot with Gene Ontology. Nucleic Acids Res (2004) 18.75
IntAct: an open source molecular interaction database. Nucleic Acids Res (2004) 15.02
Noise in eukaryotic gene expression. Nature (2003) 13.01
Copy-number variation and association studies of human disease. Nat Genet (2007) 8.50
Large-scale mapping of human protein-protein interactions by mass spectrometry. Mol Syst Biol (2007) 8.16
Shotgun sequence assembly and recent segmental duplications within the human genome. Nature (2004) 7.91
The HGNC Database in 2008: a resource for the human genome. Nucleic Acids Res (2007) 7.29
Dosage sensitivity and the evolution of gene families in yeast. Nature (2003) 6.77
Mapping pathways and phenotypes by systematic gene overexpression. Mol Cell (2006) 6.42
Relating whole-genome expression data with protein-protein interactions. Genome Res (2002) 5.78
Selection in the evolution of gene duplications. Genome Biol (2002) 5.58
Mechanisms of haploinsufficiency revealed by genome-wide profiling in yeast. Genetics (2005) 5.08
Global trends of whole-genome duplications revealed by the ciliate Paramecium tetraurelia. Nature (2006) 5.06
Splitting pairs: the diverging fates of duplicated genes. Nat Rev Genet (2002) 4.89
Bias of selection on human copy-number variants. PLoS Genet (2006) 4.44
Mutational and selective effects on copy-number variants in the human genome. Nat Genet (2007) 3.82
Genomic rearrangements and gene copy-number alterations as a cause of nervous system disorders. Neuron (2006) 3.65
Dosage-dependent gene regulation in multicellular eukaryotes: implications for dosage compensation, aneuploid syndromes, and quantitative traits. Dev Biol (2001) 3.51
Development and validation of a CGH microarray for clinical cytogenetic diagnosis. Genet Med (2005) 3.39
CORUM: the comprehensive resource of mammalian protein complexes. Nucleic Acids Res (2007) 3.23
Dosage balance in gene regulation: biological implications. Trends Genet (2005) 3.15
The population genetics of structural variation. Nat Genet (2007) 3.07
Exploring the etiology of haploinsufficiency. Bioessays (2002) 2.88
The genetic basis of dosage compensation of alcohol dehydrogenase-1 in maize. Genetics (1981) 2.72
Structure, function, and evolution of transient and obligate protein-protein interactions. Proc Natl Acad Sci U S A (2005) 2.69
Silence of chromosomal amplifications in colon cancer. Cancer Res (2002) 2.58
The gene balance hypothesis: from classical genetics to modern genomics. Plant Cell (2007) 2.56
A study of enzyme activities in a dosage series of the long arm of chromosome one in maize. Genetics (1979) 2.53
A common framework for understanding the origin of genetic dominance and evolutionary fates of gene duplications. Trends Genet (2004) 2.40
A portrait of copy-number polymorphism in Drosophila melanogaster. Proc Natl Acad Sci U S A (2007) 2.24
Modulation of protein levels in chromosomal dosage series of maize: the biochemical basis of aneuploid syndromes. Genetics (1981) 1.99
Many or most genes in Arabidopsis transposed after the origin of the order Brassicales. Genome Res (2008) 1.90
Organismal complexity, protein complexity, and gene duplicability. Proc Natl Acad Sci U S A (2003) 1.67
A test of Fisher's theory of dominance. Proc Natl Acad Sci U S A (1991) 1.57
Autosomal dosage compensation Drosophila melanogaster strains trisomic for the left arm of chromosome 2. Proc Natl Acad Sci U S A (1982) 1.56
Protein interactions in human genetic diseases. Genome Biol (2008) 1.52
Biological consequences of dosage dependent gene regulatory systems. Biochim Biophys Acta (2007) 1.39
Identification of human haploinsufficient genes and their genomic proximity to segmental duplications. Eur J Hum Genet (2008) 1.29
Confirmation of human protein interaction data by human expression data. BMC Bioinformatics (2005) 1.23
Gene dosage balance: deletions, duplications and dominance. Trends Genet (2005) 1.23
Regulatory evolution across the protein interaction network. Nat Genet (2004) 1.15
Genes overexpressed in different human solid cancers exhibit different tissue-specific expression profiles. Proc Natl Acad Sci U S A (2007) 1.02
miRBase: microRNA sequences, targets and gene nomenclature. Nucleic Acids Res (2006) 39.25
The Pfam protein families database. Nucleic Acids Res (2009) 37.98
Pfam: clans, web tools and services. Nucleic Acids Res (2006) 34.83
The Pfam protein families database. Nucleic Acids Res (2011) 33.46
The Pfam protein families database. Nucleic Acids Res (2007) 30.53
Rfam: annotating non-coding RNAs in complete genomes. Nucleic Acids Res (2005) 25.49
InterPro: the integrative protein signature database. Nucleic Acids Res (2008) 25.07
The InterPro Database, 2003 brings increased coverage and new features. Nucleic Acids Res (2003) 24.72
Rfam: an RNA family database. Nucleic Acids Res (2003) 22.93
Pfam: the protein families database. Nucleic Acids Res (2013) 22.48
InterPro, progress and status in 2005. Nucleic Acids Res (2005) 17.53
InterPro in 2011: new developments in the family and domain prediction database. Nucleic Acids Res (2011) 13.45
New developments in the InterPro database. Nucleic Acids Res (2007) 12.49
Rfam: updates to the RNA families database. Nucleic Acids Res (2008) 11.61
QuickTree: building huge Neighbour-Joining trees of protein sequences. Bioinformatics (2002) 9.36
iPfam: visualization of protein-protein interactions in PDB at domain and amino acid resolutions. Bioinformatics (2004) 7.02
Rfam: Wikipedia, clans and the "decimal" release. Nucleic Acids Res (2010) 6.58
Rfam 11.0: 10 years of RNA families. Nucleic Acids Res (2012) 6.14
Enhanced protein domain discovery by using language modeling techniques from speech recognition. Proc Natl Acad Sci U S A (2003) 6.01
MEROPS: the peptidase database. Nucleic Acids Res (2009) 5.33
MEROPS: the database of proteolytic enzymes, their substrates and inhibitors. Nucleic Acids Res (2011) 4.90
The RNA WikiProject: community annotation of RNA families. RNA (2008) 4.83
Predicting active site residue annotations in the Pfam database. BMC Bioinformatics (2007) 3.95
Visualizing profile-profile alignment: pairwise HMM logos. Bioinformatics (2005) 3.52
MEROPS: the database of proteolytic enzymes, their substrates and inhibitors. Nucleic Acids Res (2013) 3.28
Pfam 10 years on: 10,000 families and still growing. Brief Bioinform (2008) 2.79
InterPro: an integrated documentation resource for protein families, domains and functional sites. Brief Bioinform (2002) 2.66
Large-scale screening for novel low-affinity extracellular protein interactions. Genome Res (2008) 2.62
The PASTA domain: a beta-lactam-binding domain. Trends Biochem Sci (2002) 2.40
Identifying protein domains with the Pfam database. Curr Protoc Bioinformatics (2008) 2.24
The Hotdog fold: wrapping up a superfamily of thioesterases and dehydratases. BMC Bioinformatics (2004) 2.16
The systematic functional analysis of Plasmodium protein kinases identifies essential regulators of mosquito transmission. Cell Host Microbe (2010) 2.13
Metazoan Scc4 homologs link sister chromatid cohesion to cell and axon migration guidance. PLoS Biol (2006) 2.08
The tify family previously known as ZIM. Trends Plant Sci (2007) 2.07
Tissue-specific splicing of disordered segments that embed binding motifs rewires protein interaction networks. Mol Cell (2012) 2.02
Towards BioDBcore: a community-defined information specification for biological databases. Nucleic Acids Res (2010) 1.97
Cloud computing. Bioinformatics (2009) 1.94
Challenges in homology search: HMMER3 and convergent evolution of coiled-coil regions. Nucleic Acids Res (2013) 1.83
Enhanced protein domain discovery using taxonomy. BMC Bioinformatics (2004) 1.81
RNAcentral: A vision for an international database of RNA sequences. RNA (2011) 1.73
Genome of Acanthamoeba castellanii highlights extensive lateral gene transfer and early evolution of tyrosine kinase signaling. Genome Biol (2013) 1.62
Alternative splicing of intrinsically disordered regions and rewiring of protein interactions. Curr Opin Struct Biol (2013) 1.61
AntiFam: a tool to help identify spurious ORFs in protein annotation. Database (Oxford) (2012) 1.60
Making your database available through Wikipedia: the pros and cons. Nucleic Acids Res (2011) 1.53
Protein interactions in human genetic diseases. Genome Biol (2008) 1.52
Biocurators and biocuration: surveying the 21st century challenges. Database (Oxford) (2012) 1.46
The ENTH domain. FEBS Lett (2002) 1.45
The evolution of protein domain families. Biochem Soc Trans (2009) 1.44
Ten simple rules for editing Wikipedia. PLoS Comput Biol (2010) 1.36
New knowledge from old: in silico discovery of novel protein domains in Streptomyces coelicolor. BMC Microbiol (2003) 1.33
Quantifying the mechanisms of domain gain in animal proteins. Genome Biol (2010) 1.32
The challenge of increasing Pfam coverage of the human proteome. Database (Oxford) (2013) 1.30
TreeFam v9: a new website, more species and orthology-on-the-fly. Nucleic Acids Res (2013) 1.29
Asparagine peptide lyases: a seventh catalytic type of proteolytic enzymes. J Biol Chem (2011) 1.26
A comparison of dense transposon insertion libraries in the Salmonella serovars Typhi and Typhimurium. Nucleic Acids Res (2013) 1.26
iPfam: a database of protein family and domain interactions found in the Protein Data Bank. Nucleic Acids Res (2013) 1.26
Towards BioDBcore: a community-defined information specification for biological databases. Database (Oxford) (2011) 1.24
The COMBREX project: design, methodology, and initial results. PLoS Biol (2013) 1.24
Membrane-bound progesterone receptors contain a cytochrome b5-like ligand-binding domain. Genome Biol (2002) 1.20
Reuse of structural domain-domain interactions in protein networks. BMC Bioinformatics (2007) 1.19
Identifying protein domains with the Pfam database. Curr Protoc Bioinformatics (2003) 1.18
Curators of the world unite: the International Society of Biocuration. Bioinformatics (2010) 1.16
Databases, data tombs and dust in the wind. Bioinformatics (2008) 1.12
The BON domain: a putative membrane-binding domain. Trends Biochem Sci (2003) 1.10
RNIE: genome-wide prediction of bacterial intrinsic terminators. Nucleic Acids Res (2011) 1.09
The use of structure information to increase alignment accuracy does not aid homologue detection with profile HMMs. Bioinformatics (2002) 1.07
The PepSY domain: a regulator of peptidase activity in the microbial environment? Trends Biochem Sci (2004) 1.01
Bioimage informatics: a new category in Bioinformatics. Bioinformatics (2012) 0.96
Novel protein domains and motifs in the marine planctomycete Rhodopirellula baltica. FEMS Microbiol Lett (2004) 0.96
The structure of Jann_2411 (DUF1470) from Jannaschia sp. at 1.45 Å resolution reveals a new fold (the ABATE domain) and suggests its possible role as a transcription regulator. Acta Crystallogr Sect F Struct Biol Cryst Commun (2009) 0.94
SnoPatrol: how many snoRNA genes are there? J Biol (2010) 0.93
Bioinformatics for next generation sequencing. Bioinformatics (2009) 0.93
Time to underpin Wikipedia wisdom. Nature (2010) 0.90
Recent advances in biocuration: meeting report from the Fifth International Biocuration Conference. Database (Oxford) (2012) 0.89
Pepsin homologues in bacteria. BMC Genomics (2009) 0.86
The characterisation of three types of genes that overlie copy number variable regions. PLoS One (2011) 0.86
Structural genomics meets computational biology. Bioinformatics (2006) 0.85
An introduction to hidden Markov models. Curr Protoc Bioinformatics (2007) 0.85
Bacterial pleckstrin homology domains: a prokaryotic origin for the PH domain. J Mol Biol (2009) 0.85
Filling out the structural map of the NTF2-like superfamily. BMC Bioinformatics (2013) 0.85
Using the MEROPS Database for Proteolytic Enzymes and Their Inhibitors and Substrates. Curr Protoc Bioinformatics (2014) 0.85
Ten simple rules for chairing a scientific session. PLoS Comput Biol (2009) 0.82
A comparison of Pfam and MEROPS: two databases, one comprehensive, and one specialised. BMC Bioinformatics (2003) 0.81
The rise and fall of supervised machine learning techniques. Bioinformatics (2011) 0.79
The YARHG domain: an extracellular domain in search of a function. PLoS One (2012) 0.79
Two Pfam protein families characterized by a crystal structure of protein lpg2210 from Legionella pneumophila. BMC Bioinformatics (2013) 0.76
Structure and computational analysis of a novel protein with metallopeptidase-like and circularly permuted winged-helix-turn-helix domains reveals a possible role in modified polysaccharide biosynthesis. BMC Bioinformatics (2014) 0.76
LUD, a new protein domain associated with lactate utilization. BMC Bioinformatics (2013) 0.76
The SHOCT domain: a widespread domain under-represented in model organisms. PLoS One (2013) 0.75
The structure of pyogenecin immunity protein, a novel bacteriocin-like immunity protein from Streptococcus pyogenes. BMC Struct Biol (2009) 0.75
DATABASE, The Journal of Biological Databases and Curation, is now the official journal of the International Society for Biocuration. Database (Oxford) (2013) 0.75