Lymphotoxin beta receptor signaling in intestinal epithelial cells orchestrates innate immune responses against mucosal bacterial infection.

PubWeight™: 1.50‹?› | Rank: Top 4%

🔗 View Article (PMC 2878123)

Published in Immunity on March 11, 2010

Authors

Yugang Wang1, Ekaterina P Koroleva, Andrei A Kruglov, Dmitry V Kuprash, Sergei A Nedospasov, Yang-Xin Fu, Alexei V Tumanov

Author Affiliations

1: The University of Chicago, Department of Pathology, Chicago, IL 60637, USA.

Articles citing this

The aryl hydrocarbon receptor regulates gut immunity through modulation of innate lymphoid cells. Immunity (2011) 3.32

Lymphotoxin controls the IL-22 protection pathway in gut innate lymphoid cells during mucosal pathogen challenge. Cell Host Microbe (2011) 2.46

Group 3 innate lymphoid cells inhibit T-cell-mediated intestinal inflammation through aryl hydrocarbon receptor signaling and regulation of microflora. Immunity (2013) 2.01

Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens. Nat Immunol (2013) 1.87

IL-22 bridges the lymphotoxin pathway with the maintenance of colonic lymphoid structures during infection with Citrobacter rodentium. Nat Immunol (2011) 1.78

Epithelial-intrinsic IKKα expression regulates group 3 innate lymphoid cell responses and antibacterial immunity. J Exp Med (2015) 1.47

Mechanistic basis for functional promiscuity in the TNF and TNF receptor superfamilies: structure of the LIGHT:DcR3 assembly. Structure (2014) 1.44

OTUD7B controls non-canonical NF-κB activation through deubiquitination of TRAF3. Nature (2013) 1.21

Regulation of inflammation, autoimmunity, and infection immunity by HVEM-BTLA signaling. J Leukoc Biol (2010) 1.15

Induction of innate lymphoid cell-derived interleukin-22 by the transcription factor STAT3 mediates protection against intestinal infection. Immunity (2014) 1.14

Innate immune responses to systemic Acinetobacter baumannii infection in mice: neutrophils, but not interleukin-17, mediate host resistance. Infect Immun (2011) 1.14

Unique and redundant functions of NKp46+ ILC3s in models of intestinal inflammation. J Exp Med (2015) 1.11

SEF/IL-17R (SEFIR) is not enough: an extended SEFIR domain is required for il-17RA-mediated signal transduction. J Biol Chem (2010) 1.02

AHR and the Transcriptional Regulation of Type-17/22 ILC. Front Immunol (2012) 0.99

An interferon-β-resistant and NLRP3 inflammasome-independent subtype of EAE with neuronal damage. Nat Neurosci (2016) 0.98

A novel bacterial artificial chromosome-transgenic podoplanin-cre mouse targets lymphoid organ stromal cells in vivo. Front Immunol (2011) 0.94

Targeted drug delivery to intestinal macrophages by bioactive nanovesicles released from grapefruit. Mol Ther (2013) 0.91

Lymphotoxin signalling in immune homeostasis and the control of microorganisms. Nat Rev Immunol (2013) 0.90

Innate Lymphoid Cells Control Early Colonization Resistance against Intestinal Pathogens through ID2-Dependent Regulation of the Microbiota. Immunity (2015) 0.89

Tolerogenic properties of lymphatic endothelial cells are controlled by the lymph node microenvironment. PLoS One (2014) 0.88

Aryl hydrocarbon receptor promotes RORγt⁺ group 3 ILCs and controls intestinal immunity and inflammation. Semin Immunopathol (2013) 0.87

A discrete ubiquitin-mediated network regulates the strength of NOD2 signaling. Mol Cell Biol (2012) 0.85

Epithelial expression of the cytosolic retinoid chaperone cellular retinol binding protein II is essential for in vivo imprinting of local gut dendritic cells by lumenal retinoids. Am J Pathol (2012) 0.83

Tumor necrosis factor superfamily in innate immunity and inflammation. Cold Spring Harb Perspect Biol (2014) 0.82

Stimulus-selective crosstalk via the NF-κB signaling system reinforces innate immune response to alleviate gut infection. Elife (2015) 0.82

Innate lymphoid cells facilitate NK cell development through a lymphotoxin-mediated stromal microenvironment. J Exp Med (2014) 0.80

Lymphotoxin beta receptor signaling limits mucosal damage through driving IL-23 production by epithelial cells. Mucosal Immunol (2014) 0.80

LIGHT/TNFSR14 can regulate hepatic lipase expression by hepatocytes independent of T cells and Kupffer cells. PLoS One (2013) 0.79

The Lymphotoxin Network: orchestrating a type I interferon response to optimize adaptive immunity. Cytokine Growth Factor Rev (2014) 0.79

Mixing Signals: Molecular Turn Ons and Turn Offs for Innate γδ T-Cells. Front Immunol (2014) 0.78

Phenotype-dependent alteration of pathways and networks reveals a pure synergistic mechanism for compounds treating mouse cerebral ischemia. Acta Pharmacol Sin (2015) 0.78

Lymphotoxin organizes contributions to host defense and metabolic illness from innate lymphoid cells. Cytokine Growth Factor Rev (2013) 0.78

Development and Function of Secondary and Tertiary Lymphoid Organs in the Small Intestine and the Colon. Front Immunol (2016) 0.76

Linking the microbiota and metabolic disease with lymphotoxin. Int Immunol (2013) 0.76

Lymphotoxin in physiology of lymphoid tissues - Implication for antiviral defense. Cytokine (2016) 0.76

Proinflammatory IL-17 induces iBALT development. Cell Mol Immunol (2011) 0.76

The non-canonical NF-κB pathway in immunity and inflammation. Nat Rev Immunol (2017) 0.75

Lessons Learned From Trials Targeting Cytokine Pathways in Patients With Inflammatory Bowel Diseases. Gastroenterology (2016) 0.75

Epithelial LTβR signaling controls the population size of the progenitors of medullary thymic epithelial cells in neonatal mice. Sci Rep (2017) 0.75

Emerging Roles for Noncanonical NF-κB Signaling in the Modulation of Inflammatory Bowel Disease Pathobiology. Inflamm Bowel Dis (2016) 0.75

LTβR controls thymic portal endothelial cells for haematopoietic progenitor cell homing and T-cell regeneration. Nat Commun (2016) 0.75

An attenuated duck plague virus (DPV) vaccine induces both systemic and mucosal immune responses to protect ducks against virulent DPV infection. Clin Vaccine Immunol (2014) 0.75

RORγt, a multitask nuclear receptor at mucosal surfaces. Mucosal Immunol (2016) 0.75

Steroid Receptor Coactivator 3 Contributes to Host Defense against Enteric Bacteria by Recruiting Neutrophils via Upregulation of CXCL2 Expression. J Immunol (2017) 0.75

Intestinal helminth infection impacts the systemic distribution and function of the naive lymphocyte pool. Mucosal Immunol (2017) 0.75

Articles cited by this

The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell (2006) 33.94

Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell (2004) 29.32

Conditional gene targeting in macrophages and granulocytes using LysMcre mice. Transgenic Res (1999) 12.83

Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens. Nat Med (2008) 12.68

An essential function for the nuclear receptor RORgamma(t) in the generation of fetal lymphoid tissue inducer cells. Nat Immunol (2003) 8.23

A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity. Nature (2008) 8.22

Cis elements of the villin gene control expression in restricted domains of the vertical (crypt) and horizontal (duodenum, cecum) axes of the intestine. J Biol Chem (2002) 7.74

Microbial flora drives interleukin 22 production in intestinal NKp46+ cells that provide innate mucosal immune defense. Immunity (2008) 6.49

Requirement for RORgamma in thymocyte survival and lymphoid organ development. Science (2000) 5.78

Thymic origin of intestinal alphabeta T cells revealed by fate mapping of RORgammat+ cells. Science (2004) 5.66

Lymphoid tissue inducer-like cells are an innate source of IL-17 and IL-22. J Exp Med (2008) 4.95

Human fetal lymphoid tissue-inducer cells are interleukin 17-producing precursors to RORC+ CD127+ natural killer-like cells. Nat Immunol (2008) 4.94

Influence of the transcription factor RORgammat on the development of NKp46+ cell populations in gut and skin. Nat Immunol (2008) 4.78

Citrobacter rodentium of mice and man. Cell Microbiol (2005) 4.76

The lymphotoxin beta receptor controls organogenesis and affinity maturation in peripheral lymphoid tissues. Immunity (1998) 4.56

Development and maturation of secondary lymphoid tissues. Annu Rev Immunol (1999) 3.69

Requirement for lymphoid tissue-inducer cells in isolated follicle formation and T cell-independent immunoglobulin A generation in the gut. Immunity (2008) 3.64

Network communications: lymphotoxins, LIGHT, and TNF. Annu Rev Immunol (2005) 3.02

Targeted depletion of lymphotoxin-alpha-expressing TH1 and TH17 cells inhibits autoimmune disease. Nat Med (2009) 2.42

Abnormal development of secondary lymphoid tissues in lymphotoxin beta-deficient mice. Proc Natl Acad Sci U S A (1997) 2.37

Clearance of Citrobacter rodentium requires B cells but not secretory immunoglobulin A (IgA) or IgM antibodies. Infect Immun (2004) 2.32

B lymphocytes induce the formation of follicular dendritic cell clusters in a lymphotoxin alpha-dependent fashion. J Exp Med (1998) 2.32

TLR signaling mediated by MyD88 is required for a protective innate immune response by neutrophils to Citrobacter rodentium. J Immunol (2007) 2.27

Host susceptibility to the attaching and effacing bacterial pathogen Citrobacter rodentium. Infect Immun (2003) 2.17

Interleukin-22-producing innate immune cells: new players in mucosal immunity and tissue repair? Nat Rev Immunol (2009) 2.04

Critical role of T cell-dependent serum antibody, but not the gut-associated lymphoid tissue, for surviving acute mucosal infection with Citrobacter rodentium, an attaching and effacing pathogen. J Immunol (2004) 2.02

The sequential role of lymphotoxin and B cells in the development of splenic follicles. J Exp Med (1998) 1.72

Toll-like receptor 2 plays a critical role in maintaining mucosal integrity during Citrobacter rodentium-induced colitis. Cell Microbiol (2007) 1.59

Distinct role of surface lymphotoxin expressed by B cells in the organization of secondary lymphoid tissues. Immunity (2002) 1.49

MIP-2 secreted by epithelial cells increases neutrophil and lymphocyte recruitment in the mouse intestine. Gut (2001) 1.46

Inhibition of the lymphotoxin pathway as a therapy for autoimmune disease. Immunol Rev (2008) 1.42

Neutrophils and intracellular pathogens: beyond phagocytosis and killing. Trends Microbiol (2006) 1.30

Vaccine-induced protection against gastrointestinal bacterial infections in the absence of secretory antibodies. Eur J Immunol (2005) 1.29

Dysregulated LIGHT expression on T cells mediates intestinal inflammation and contributes to IgA nephropathy. J Clin Invest (2004) 1.28

Visualization of lymphotoxin-beta and lymphotoxin-beta receptor expression in mouse embryos. J Immunol (2002) 1.24

CXCR2-dependent mucosal neutrophil influx protects against colitis-associated diarrhea caused by an attaching/effacing lesion-forming bacterial pathogen. J Immunol (2009) 1.24

Dissecting the role of lymphotoxin in lymphoid organs by conditional targeting. Immunol Rev (2003) 1.21

Cutting edge: selective impairment of CD8+ T cell function in mice lacking the TNF superfamily member LIGHT. J Immunol (2002) 1.20

Expression of lymphotoxin-alphabeta on antigen-specific T cells is required for DC function. J Exp Med (2007) 1.17

The lymphotoxin-beta receptor is critical for control of murine Citrobacter rodentium-induced colitis. Gastroenterology (2004) 1.15

Contribution of the lymphotoxin beta receptor to liver regeneration. J Immunol (2005) 1.10

Host defences to Citrobacter rodentium. Int J Med Microbiol (2003) 1.10

Expression of lymphotoxin beta governs immunity at two distinct levels. Eur J Immunol (2006) 1.05

Immunoregulation by tumor necrosis factor superfamily member LIGHT. Immunol Rev (2009) 0.98

Gene profiling approach in the analysis of lymphotoxin and TNF deficiencies. J Leukoc Biol (2000) 0.85

Articles by these authors

Innate and adaptive immune cells in the tumor microenvironment. Nat Immunol (2013) 5.43

Therapeutic effects of ablative radiation on local tumor require CD8+ T cells: changing strategies for cancer treatment. Blood (2009) 5.21

Priming of naive T cells inside tumors leads to eradication of established tumors. Nat Immunol (2004) 3.95

The therapeutic effect of anti-HER2/neu antibody depends on both innate and adaptive immunity. Cancer Cell (2010) 3.52

Adaptive immune cells temper initial innate responses. Nat Med (2007) 3.37

Tumor necrosis factor-induced nonapoptotic cell death requires receptor-interacting protein-mediated cellular reactive oxygen species accumulation. J Biol Chem (2003) 3.35

The aryl hydrocarbon receptor regulates gut immunity through modulation of innate lymphoid cells. Immunity (2011) 3.32

Induced sensitization of tumor stroma leads to eradication of established cancer by T cells. J Exp Med (2007) 3.15

Irradiation and anti-PD-L1 treatment synergistically promote antitumor immunity in mice. J Clin Invest (2014) 3.06

Intratumor depletion of CD4+ cells unmasks tumor immunogenicity leading to the rejection of late-stage tumors. J Exp Med (2005) 3.01

Recognition of host immune activation by Pseudomonas aeruginosa. Science (2005) 2.84

A lymphotoxin-driven pathway to hepatocellular carcinoma. Cancer Cell (2009) 2.64

The efficacy of radiotherapy relies upon induction of type i interferon-dependent innate and adaptive immunity. Cancer Res (2011) 2.60

Lymphotoxin controls the IL-22 protection pathway in gut innate lymphoid cells during mucosal pathogen challenge. Cell Host Microbe (2011) 2.46

Circulating and liver resident CD4+CD25+ regulatory T cells actively influence the antiviral immune response and disease progression in patients with hepatitis B. J Immunol (2006) 2.44

CD95 promotes tumour growth. Nature (2010) 2.42

Lymphotoxin-mediated crosstalk between B cells and splenic stroma promotes the initial type I interferon response to cytomegalovirus. Cell Host Microbe (2008) 2.40

Distinct and nonredundant in vivo functions of TNF produced by t cells and macrophages/neutrophils: protective and deleterious effects. Immunity (2005) 2.35

Costimulatory molecule-targeted antibody therapy of a spontaneous autoimmune disease. Nat Med (2002) 2.23

Antigen persistence and the control of local T cell memory by migrant respiratory dendritic cells after acute virus infection. J Exp Med (2010) 2.22

Lymphotoxin beta receptor signaling promotes tertiary lymphoid organogenesis in the aorta adventitia of aged ApoE-/- mice. J Exp Med (2009) 2.12

Lymphotoxin beta receptor-dependent control of lipid homeostasis. Science (2007) 2.06

Nonredundant function of soluble LTα3 produced by innate lymphoid cells in intestinal homeostasis. Science (2013) 2.03

Group 3 innate lymphoid cells inhibit T-cell-mediated intestinal inflammation through aryl hydrocarbon receptor signaling and regulation of microflora. Immunity (2013) 2.01

Clinical experiences with anti-CD137 and anti-PD1 therapeutic antibodies. Semin Oncol (2010) 2.00

Coordinated epithelial NHE3 inhibition and barrier dysfunction are required for TNF-mediated diarrhea in vivo. J Clin Invest (2006) 2.00

Lymphotoxin regulates commensal responses to enable diet-induced obesity. Nat Immunol (2012) 1.99

Tumor masses support naive T cell infiltration, activation, and differentiation into effectors. J Exp Med (2010) 1.97

B7DC/PDL2 promotes tumor immunity by a PD-1-independent mechanism. J Exp Med (2003) 1.92

p53 is a suppressor of inflammatory response in mice. FASEB J (2005) 1.91

Dynamic programmed death 1 expression by virus-specific CD8 T cells correlates with the outcome of acute hepatitis B. Gastroenterology (2008) 1.84

The role of herpesvirus entry mediator as a negative regulator of T cell-mediated responses. J Clin Invest (2005) 1.82

Lymphotoxin pathway directs thymic Aire expression. Nat Immunol (2003) 1.79

Signaling via the MyD88 adaptor protein in B cells suppresses protective immunity during Salmonella typhimurium infection. Immunity (2010) 1.75

Local expression of B7-H1 promotes organ-specific autoimmunity and transplant rejection. J Clin Invest (2004) 1.71

B cell maintenance of subcapsular sinus macrophages protects against a fatal viral infection independent of adaptive immunity. Immunity (2012) 1.70

LIGHT signals directly to intestinal epithelia to cause barrier dysfunction via cytoskeletal and endocytic mechanisms. Gastroenterology (2007) 1.70

Route of immunization with peptide-pulsed dendritic cells controls the distribution of memory and effector T cells in lymphoid tissues and determines the pattern of regional tumor control. J Exp Med (2003) 1.68

The human BCL6 transgene promotes the development of lymphomas in the mouse. Proc Natl Acad Sci U S A (2004) 1.63

B and T lymphocyte attenuator regulates CD8+ T cell-intrinsic homeostasis and memory cell generation. Nat Immunol (2007) 1.61

Targeting the primary tumor to generate CTL for the effective eradication of spontaneous metastases. J Immunol (2007) 1.60

Type I interferon response and innate immune sensing of cancer. Trends Immunol (2012) 1.59

Crosstalk between the canonical NF-κB and Notch signaling pathways inhibits Pparγ expression and promotes pancreatic cancer progression in mice. J Clin Invest (2011) 1.58

Interaction of mature CD3+CD4+ T cells with dendritic cells triggers the development of tertiary lymphoid structures in the thyroid. J Clin Invest (2006) 1.57

The role of stroma in immune recognition and destruction of well-established solid tumors. Curr Opin Immunol (2006) 1.56

Tumor-infiltrating T lymphocytes: friends or foes? Lab Invest (2006) 1.56

Positioning of follicular dendritic cells within the spleen controls prion neuroinvasion. Nature (2003) 1.51

Complementary role of CD4+ T cells and secondary lymphoid tissues for cross-presentation of tumor antigen to CD8+ T cells. J Exp Med (2003) 1.49

Administration of agonistic anti-4-1BB monoclonal antibody leads to the amelioration of experimental autoimmune encephalomyelitis. J Immunol (2002) 1.45

Radiation-induced equilibrium is a balance between tumor cell proliferation and T cell-mediated killing. J Immunol (2013) 1.44

OX40 signaling favors the induction of T(H)9 cells and airway inflammation. Nat Immunol (2012) 1.43

NK-cell activation by LIGHT triggers tumor-specific CD8+ T-cell immunity to reject established tumors. Blood (2005) 1.43

Recruitment and activation of naive T cells in the islets by lymphotoxin beta receptor-dependent tertiary lymphoid structure. Immunity (2006) 1.40

Equilibrium between host and cancer caused by effector T cells killing tumor stroma. Cancer Res (2008) 1.39

Signaling via LTbetaR on the lamina propria stromal cells of the gut is required for IgA production. Nat Immunol (2002) 1.36

Coordination between NF-kappaB family members p50 and p52 is essential for mediating LTbetaR signals in the development and organization of secondary lymphoid tissues. Blood (2005) 1.35

Hyper innate responses in neonates lead to increased morbidity and mortality after infection. Proc Natl Acad Sci U S A (2008) 1.33

Tumor necrosis factor family members and inflammatory bowel disease. Immunol Rev (2005) 1.29

NF-kappaB2 is required for the establishment of central tolerance through an Aire-dependent pathway. J Clin Invest (2006) 1.29

Targeting CD137 enhances the efficacy of cetuximab. J Clin Invest (2014) 1.29

Dysregulated LIGHT expression on T cells mediates intestinal inflammation and contributes to IgA nephropathy. J Clin Invest (2004) 1.28

Differential regulation of CCL21 in lymphoid/nonlymphoid tissues for effectively attracting T cells to peripheral tissues. J Clin Invest (2003) 1.27

Cetuximab-mediated tumor regression depends on innate and adaptive immune responses. Mol Ther (2012) 1.24

TNFR2 activates MLCK-dependent tight junction dysregulation to cause apoptosis-mediated barrier loss and experimental colitis. Gastroenterology (2013) 1.24

Gadd45beta promotes hepatocyte survival during liver regeneration in mice by modulating JNK signaling. J Clin Invest (2008) 1.23

The inhibitory HVEM-BTLA pathway counter regulates lymphotoxin receptor signaling to achieve homeostasis of dendritic cells. J Immunol (2008) 1.23

Crosstalk between keratinocytes and adaptive immune cells in an IkappaBalpha protein-mediated inflammatory disease of the skin. Immunity (2007) 1.21

Dissecting the role of lymphotoxin in lymphoid organs by conditional targeting. Immunol Rev (2003) 1.21

OTUD7B controls non-canonical NF-κB activation through deubiquitination of TRAF3. Nature (2013) 1.21

B and T lymphocyte attenuator tempers early infection immunity. J Immunol (2009) 1.18

The role of tumor-associated macrophages in breast cancer progression (review). Int J Oncol (2013) 1.16

Protein kinase C alpha-mediated chemotaxis of neutrophils requires NF-kappa B activity but is independent of TNF alpha signaling in mouse skin in vivo. J Immunol (2005) 1.16

Negative regulation of CD40-mediated B cell responses by E3 ubiquitin ligase Casitas-B-lineage lymphoma protein-B. J Immunol (2007) 1.16

The critical role of LIGHT in promoting intestinal inflammation and Crohn's disease. J Immunol (2005) 1.14

Intracellular signals and events activated by cytokines of the tumor necrosis factor superfamily: From simple paradigms to complex mechanisms. Int Rev Cytol (2006) 1.12

Stimulating lymphotoxin beta receptor on the dendritic cells is critical for their homeostasis and expansion. J Immunol (2005) 1.10

Contribution of the lymphotoxin beta receptor to liver regeneration. J Immunol (2005) 1.10

Cellular source and molecular form of TNF specify its distinct functions in organization of secondary lymphoid organs. Blood (2010) 1.10

Prominent role for T cell-derived tumour necrosis factor for sustained control of Mycobacterium tuberculosis infection. Sci Rep (2013) 1.10

Physiological functions of tumor necrosis factor and the consequences of its pathologic overexpression or blockade: mouse models. Cytokine Growth Factor Rev (2008) 1.09

Novel tumor necrosis factor-knockout mice that lack Peyer's patches. Eur J Immunol (2005) 1.09