Published in Pharmacol Ther on March 20, 2010
Discovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modeling. J Med Chem (2013) 1.10
Management of polyomavirus-associated nephropathy in renal transplant recipients. Nat Rev Nephrol (2012) 1.10
Organic anion and cation SLC22 "drug" transporter (Oat1, Oat3, and Oct1) regulation during development and maturation of the kidney proximal tubule. PLoS One (2012) 0.84
Regulatory pathways for ATP-binding cassette transport proteins in kidney proximal tubules. AAPS J (2012) 0.83
Expression and function of renal and hepatic organic anion transporters in extrahepatic cholestasis. World J Gastroenterol (2012) 0.79
A Human Renal Proximal Tubule Cell Line with Stable Organic Anion Transporter 1 and 3 Expression Predictive for Antiviral-Induced Toxicity. AAPS J (2016) 0.79
Transcriptomic variation of pharmacogenes in multiple human tissues and lymphoblastoid cell lines. Pharmacogenomics J (2016) 0.77
Uremic Solutes in Chronic Kidney Disease and Their Role in Progression. PLoS One (2016) 0.75
Small molecule membrane transporters in the mammalian podocyte: a pathogenic and therapeutic target. Int J Mol Sci (2014) 0.75
Renal Drug Transporters and Drug Interactions. Clin Pharmacokinet (2017) 0.75
The MRP4/ABCC4 gene encodes a novel apical organic anion transporter in human kidney proximal tubules: putative efflux pump for urinary cAMP and cGMP. J Am Soc Nephrol (2002) 1.94
Alkaline phosphatase treatment improves renal function in severe sepsis or septic shock patients. Crit Care Med (2009) 1.93
Intravenously administered short interfering RNA accumulates in the kidney and selectively suppresses gene function in renal proximal tubules. Drug Metab Dispos (2006) 1.71
Potential role for adenosine in the pathogenesis of the vascular complications of hyperhomocysteinemia. Cardiovasc Res (2003) 1.42
Interaction of nonsteroidal anti-inflammatory drugs with multidrug resistance protein (MRP) 2/ABCC2- and MRP4/ABCC4-mediated methotrexate transport. J Pharmacol Exp Ther (2006) 1.41
Gelatin-based plasma expander effectively reduces renal uptake of 111In-octreotide in mice and rats. J Nucl Med (2006) 1.37
Human organic anion transporter MRP4 (ABCC4) is an efflux pump for the purine end metabolite urate with multiple allosteric substrate binding sites. Am J Physiol Renal Physiol (2004) 1.34
Renal uptake of radiolabeled octreotide in human subjects is efficiently inhibited by succinylated gelatin. J Nucl Med (2006) 1.34
The role of ATP binding cassette transporters in tissue defense and organ regeneration. J Pharmacol Exp Ther (2008) 1.27
Upregulation of renal inducible nitric oxide synthase during human endotoxemia and sepsis is associated with proximal tubule injury. Clin J Am Soc Nephrol (2006) 1.17
Multidrug resistance protein 4 (MRP4/ABCC4) regulates cAMP cellular levels and controls human leukemia cell proliferation and differentiation. J Biol Chem (2011) 1.15
Selective iNOS inhibition for the treatment of sepsis-induced acute kidney injury. Nat Rev Nephrol (2009) 1.14
Reducing renal uptake of radiolabeled peptides using albumin fragments. J Nucl Med (2008) 1.05
The kinetic and biological activity of different loaded rhBMP-2 calcium phosphate cement implants in rats. J Biomed Mater Res A (2008) 1.04
Usage patterns of personal care products: important factors for exposure assessment. Food Chem Toxicol (2012) 1.02
Biomarker discovery with SELDI-TOF MS in human urine associated with early renal injury: evaluation with computational analytical tools. Nephrol Dial Transplant (2007) 1.02
Contribution of multidrug resistance protein 2 (MRP2/ABCC2) to the renal excretion of p-aminohippurate (PAH) and identification of MRP4 (ABCC4) as a novel PAH transporter. J Am Soc Nephrol (2004) 1.02
The ABCs of multidrug resistance in malaria. Trends Parasitol (2010) 1.01
Mass spectrometry analysis of hepcidin peptides in experimental mouse models. PLoS One (2011) 1.00
Uremic toxins inhibit transport by breast cancer resistance protein and multidrug resistance protein 4 at clinically relevant concentrations. PLoS One (2011) 0.99
Mechanisms of renal anionic drug transport. Eur J Pharmacol (2008) 0.96
Hyperuricemia influences tryptophan metabolism via inhibition of multidrug resistance protein 4 (MRP4) and breast cancer resistance protein (BCRP). Biochim Biophys Acta (2013) 0.95
Involvement of VDAC, Bax and ceramides in the efflux of AIF from mitochondria during curcumin-induced apoptosis. PLoS One (2009) 0.94
HMOX1 promoter polymorphism modulates the relationship between disease activity and joint damage in rheumatoid arthritis. Arthritis Rheum (2008) 0.92
Impaired renal secretion of substrates for the multidrug resistance protein 2 in mutant transport-deficient (TR-) rats. J Am Soc Nephrol (2003) 0.92
Localization of breast cancer resistance protein (Bcrp) in endocrine organs and inhibition of its transport activity by steroid hormones. Cell Tissue Res (2012) 0.92
Functional role of arginine 375 in transmembrane helix 6 of multidrug resistance protein 4 (MRP4/ABCC4). Mol Pharmacol (2008) 0.91
Interaction of immunosuppressive drugs with human organic anion transporter (OAT) 1 and OAT3, and multidrug resistance-associated protein (MRP) 2 and MRP4. Transl Res (2013) 0.90
Biomarkers for methotrexate-induced liver injury: urinary protein profiling of psoriasis patients. Toxicol Lett (2013) 0.90
Na,K-ATPase activity modulates Src activation: a role for ATP/ADP ratio. Biochim Biophys Acta (2012) 0.89
Effect of drugs on renal development. Clin J Am Soc Nephrol (2010) 0.89
Nitric oxide differentially regulates renal ATP-binding cassette transporters during endotoxemia. Pflugers Arch (2007) 0.89
Endocrine disruptors differentially target ATP-binding cassette transporters in the blood-testis barrier and affect Leydig cell testosterone secretion in vitro. Toxicol Sci (2013) 0.89
AMAP, the alleged non-toxic isomer of acetaminophen, is toxic in rat and human liver. Arch Toxicol (2012) 0.89
Localization of the ATP-binding cassette (ABC) transport proteins PfMRP1, PfMRP2, and PfMDR5 at the Plasmodium falciparum plasma membrane. Malar J (2009) 0.87
Breast cancer resistance protein (Bcrp1/Abcg2) limits net intestinal uptake of quercetin in rats by facilitating apical efflux of glucuronides. Mol Pharmacol (2005) 0.86
Characterization of P-glycoprotein and multidrug resistance proteins in rat kidney and intestinal cell lines. Eur J Pharm Sci (2006) 0.86
Cannabinoid type 1 receptor antagonists modulate transport activity of multidrug resistance-associated proteins MRP1, MRP2, MRP3, and MRP4. Drug Metab Dispos (2011) 0.86
Insights into the role of bone marrow-derived stem cells in renal repair. Kidney Blood Press Res (2008) 0.86
Short report: Severe Plasmodium falciparum malaria in Cameroon: associated with the glutathione S-transferase M1 null genotype. Am J Trop Med Hyg (2006) 0.86
In silico identification of potential cholestasis-inducing agents via modeling of Na(+)-dependent taurocholate cotransporting polypeptide substrate specificity. Toxicol Sci (2012) 0.86
Involvement of guanylyl cyclase and cGMP in the regulation of Mrp2-mediated transport in the proximal tubule. Am J Physiol Renal Physiol (2004) 0.85
Modeling mitochondrial dysfunctions in the brain: from mice to men. J Inherit Metab Dis (2011) 0.84
Role of NO in endothelin-regulated drug transport in the renal proximal tubule. Am J Physiol Renal Physiol (2002) 0.84
Glibenclamide depletes ATP in renal proximal tubular cells by interfering with mitochondrial metabolism. Br J Pharmacol (2005) 0.84
Short-term beneficial effects of methylene blue on kidney damage in septic shock patients. Intensive Care Med (2007) 0.84
Short- and long-term influences of heavy metals on anionic drug efflux from renal proximal tubule. J Pharmacol Exp Ther (2002) 0.84
Vitamin A equivalency and apparent absorption of beta-carotene in ileostomy subjects using a dual-isotope dilution technique. Br J Nutr (2010) 0.84
Interaction of fluvastatin with the liver-specific Na+ -dependent taurocholate cotransporting polypeptide (NTCP). Eur J Pharm Sci (2011) 0.83
Regulatory pathways for ATP-binding cassette transport proteins in kidney proximal tubules. AAPS J (2012) 0.83
Function and regulation of multidrug resistance proteins (MRPs) in the renal elimination of organic anions. Drug Metab Rev (2005) 0.83
First reported use of elvitegravir and cobicistat during pregnancy. AIDS (2016) 0.82
Short-term exposure of renal proximal tubules to gentamicin increases long-term multidrug resistance protein 2 (Abcc2) transport function and reduces nephrotoxicant sensitivity. J Pharmacol Exp Ther (2005) 0.82
Hypothermia causes a marked injury to rat proximal tubular cells that is aggravated by all currently used preservation solutions. Cryobiology (2003) 0.82
Heme Oxygenase-1 and breast cancer resistance protein protect against heme-induced toxicity. Curr Pharm Des (2013) 0.81
The feline bile salt export pump: a structural and functional comparison with canine and human Bsep/BSEP. BMC Vet Res (2013) 0.81
Bromide as a marker to measure adherence to drug therapy. Eur J Clin Pharmacol (2006) 0.81
The heme-heme oxygenase system in wound healing; implications for scar formation. Curr Drug Targets (2010) 0.81
Interaction of digitalis-like compounds with liver uptake transporters NTCP, OATP1B1, and OATP1B3. Mol Pharm (2014) 0.81
Differential effects of sulfonylurea derivatives on vascular ATP-sensitive potassium channels. Eur J Pharmacol (2012) 0.81
Increased apical insertion of the multidrug resistance protein 2 (MRP2/ABCC2) in renal proximal tubules following gentamicin exposure. J Pharmacol Exp Ther (2006) 0.81
Sensitive method for quantification of octamethylcyclotetrasiloxane (D4) and decamethylcyclopentasiloxane (D5) in end-exhaled air by thermal desorption gas chromatography mass spectrometry. Anal Chem (2014) 0.81
Only weak vasorelaxant properties of loop diuretics in isolated resistance arteries from man, rat and guinea pig. Eur J Pharmacol (2003) 0.80
Regulation of P-glycoprotein in renal proximal tubule epithelial cells by LPS and TNF-alpha. J Biomed Biotechnol (2010) 0.80
Phenylalanine 368 of multidrug resistance-associated protein 4 (MRP4/ABCC4) plays a crucial role in substrate-specific transport activity. Biochem Pharmacol (2012) 0.80
Modulatory effects of hormones, drugs, and toxic events on renal organic anion transport. Biochem Pharmacol (2003) 0.79
Na(+),K(+)-ATPase isoform selectivity for digitalis-like compounds is determined by two amino acids in the first extracellular loop. Chem Res Toxicol (2014) 0.79
Exploiting transport activity of p-glycoprotein at the blood-brain barrier for the development of peripheral cannabinoid type 1 receptor antagonists. Mol Pharm (2012) 0.79
Nitric oxide down-regulates the expression of organic cation transporters (OCT) 1 and 2 in rat kidney during endotoxemia. Eur J Pharmacol (2008) 0.79
Rapid, nongenomic stimulation of multidrug resistance protein 2 (Mrp2) activity by glucocorticoids in renal proximal tubule. J Pharmacol Exp Ther (2011) 0.79
Atovaquone and quinine anti-malarials inhibit ATP binding cassette transporter activity. Malar J (2014) 0.79
In silico identification and in vitro validation of potential cholestatic compounds through 3D ligand-based pharmacophore modeling of BSEP inhibitors. Chem Res Toxicol (2014) 0.79
Transport of the coumarin metabolite 7-hydroxycoumarin glucuronide is mediated via multidrug resistance-associated proteins 3 and 4. Drug Metab Dispos (2012) 0.79
Common genotypic polymorphisms in glutathione S-transferases in mild and severe falciparum malaria in Tanzanian children. Am J Trop Med Hyg (2009) 0.78
Semi-mechanistic physiologically-based pharmacokinetic modeling of clinical glibenclamide pharmacokinetics and drug-drug-interactions. Eur J Pharm Sci (2013) 0.78
Deficiency of either P-glycoprotein or breast cancer resistance protein protect against acute kidney injury. Cell Transplant (2010) 0.78
Regulation and expression of endothelin-1 (ET-1) and ET-receptors in rat epithelial cells of renal and intestinal origin. Pharmacol Res (2006) 0.78
Identification of novel translational urinary biomarkers for acetaminophen-induced acute liver injury using proteomic profiling in mice. PLoS One (2012) 0.78
Interaction of digitalis-like compounds with p-glycoprotein. Toxicol Sci (2012) 0.78
Glutathione status and the renal elimination of inorganic mercury in the Mrp2(-/-) mouse. PLoS One (2013) 0.78
Acute acetaminophen intoxication leads to hepatic iron loading by decreased hepcidin synthesis. Toxicol Sci (2012) 0.77
Stress susceptibility as a determinant of endothelium-dependent vascular reactivity in rat mesenteric arteries. J Cardiovasc Pharmacol (2003) 0.77
Stress susceptibility as a determinant of the response to adrenergic stimuli in mesenteric resistance arteries of the rat. J Cardiovasc Pharmacol (2002) 0.77
Familial hemiplegic migraine mutations affect Na,K-ATPase domain interactions. Biochim Biophys Acta (2013) 0.76
Proteomic profiling in incubation medium of mouse, rat and human precision-cut liver slices for biomarker detection regarding acute drug-induced liver injury. J Appl Toxicol (2013) 0.76
Delayed cutaneous wound closure in HO-2 deficient mice despite normal HO-1 expression. J Cell Mol Med (2014) 0.76
Vitamin A equivalency of beta-carotene in healthy adults: limitation of the extrinsic dual-isotope dilution technique to measure matrix effect. Br J Nutr (2008) 0.76
Preserved vascular reactivity of rat renal arteries after cold storage. Cryobiology (2004) 0.75
Application of urine proteomics for biomarker discovery in drug-induced liver injury. Crit Rev Toxicol (2014) 0.75
Urinary proteomic profiling reveals diclofenac-induced renal injury and hepatic regeneration in mice. Toxicol Appl Pharmacol (2013) 0.75
Substantially lowered dolutegravir exposure in a treatment-experienced perinatally HIV-1-infected pregnant woman. AIDS (2016) 0.75
Iron chelators do not reduce cold-induced cell injury in the isolated perfused rat kidney model. Nephrol Dial Transplant (2005) 0.75
Impaired KATP channel function in the fetoplacental circulation of patients with type 1 diabetes mellitus. Am J Obstet Gynecol (2005) 0.75