Published in Regen Med on May 01, 2010
Rejuvenating senescent and centenarian human cells by reprogramming through the pluripotent state. Genes Dev (2011) 1.73
Present state and future perspectives of using pluripotent stem cells in toxicology research. Arch Toxicol (2011) 1.69
Mitochondrial rejuvenation after induced pluripotency. PLoS One (2010) 1.46
Association of telomere length with authentic pluripotency of ES/iPS cells. Cell Res (2011) 1.22
Molecular insights into the heterogeneity of telomere reprogramming in induced pluripotent stem cells. Cell Res (2011) 1.18
Aging and reprogramming: a two-way street. Curr Opin Cell Biol (2012) 1.14
Reprogramming of telomeric regions during the generation of human induced pluripotent stem cells and subsequent differentiation into fibroblast-like derivatives. Epigenetics (2011) 1.08
Biological characteristics of stem cells from foetal, cord blood and extraembryonic tissues. J R Soc Interface (2010) 1.06
Suppression of the imprinted gene NNAT and X-chromosome gene activation in isogenic human iPS cells. PLoS One (2011) 1.01
Transient delivery of modified mRNA encoding TERT rapidly extends telomeres in human cells. FASEB J (2015) 0.99
The aging signature: a hallmark of induced pluripotent stem cells? Aging Cell (2013) 0.96
Telomere dynamics in dyskeratosis congenita: the long and the short of iPS. Cell Res (2011) 0.93
The LARGE principle of cellular reprogramming: lost, acquired and retained gene expression in foreskin and amniotic fluid-derived human iPS cells. PLoS One (2010) 0.92
Stem cell transplantation for motor neuron disease: current approaches and future perspectives. Neurotherapeutics (2011) 0.92
Strigolactone analogues induce apoptosis through activation of p38 and the stress response pathway in cancer cell lines and in conditionally reprogrammed primary prostate cancer cells. Oncotarget (2014) 0.90
Adult Stem Cells and Diseases of Aging. J Clin Med (2014) 0.88
Reprogramming suppresses premature senescence phenotypes of Werner syndrome cells and maintains chromosomal stability over long-term culture. PLoS One (2014) 0.84
The role of telomeres and telomerase reverse transcriptase isoforms in pluripotency induction and maintenance. RNA Biol (2016) 0.84
Telomere reprogramming and maintenance in porcine iPS cells. PLoS One (2013) 0.81
Pluripotent stem cell heterogeneity and the evolving role of proteomic technologies in stem cell biology. Proteomics (2011) 0.80
Blockade of senescence-associated microRNA-195 in aged skeletal muscle cells facilitates reprogramming to produce induced pluripotent stem cells. Aging Cell (2015) 0.77
Specific association of human telomerase activity with immortal cells and cancer. Science (1994) 28.20
Telomerase catalytic subunit homologs from fission yeast and human. Science (1997) 12.35
The RNA component of human telomerase. Science (1995) 9.86
Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT. Nat Genet (1997) 6.69
Plasma fibrinogen level and the risk of major cardiovascular diseases and nonvascular mortality: an individual participant meta-analysis. JAMA (2005) 5.60
Noninvasive diagnosis by Doppler ultrasonography of fetal anemia due to maternal red-cell alloimmunization. Collaborative Group for Doppler Assessment of the Blood Velocity in Anemic Fetuses. N Engl J Med (2000) 4.95
Multiple molecular determinants for retrotransposition in a primer tRNA. Mol Cell Biol (1995) 4.95
Microarray analysis of replicative senescence. Curr Biol (1999) 4.25
An improved method for isolating type II cells in high yield and purity. Am Rev Respir Dis (1986) 3.80
APC mutations in sporadic colorectal tumors: A mutational "hotspot" and interdependence of the "two hits". Proc Natl Acad Sci U S A (2000) 3.41
Malignant urachal lesions. J Urol (1984) 2.99
Shortened telomeres in the expanded CD28-CD8+ cell subset in HIV disease implicate replicative senescence in HIV pathogenesis. AIDS (1996) 2.95
Newborns develop a Th1-type immune response to Mycobacterium bovis bacillus Calmette-Guérin vaccination. J Immunol (1999) 2.94
A multimodal assessment of driving performance in HIV infection. Neurology (2004) 2.81
Telomerase, cell immortality, and cancer. Cold Spring Harb Symp Quant Biol (1994) 2.76
In-vitro production of TNF-alpha in blood samples. Lancet (1990) 2.63
Inactivating mutations in an SH2 domain-encoding gene in X-linked lymphoproliferative syndrome. Proc Natl Acad Sci U S A (1998) 2.46
Nobel laureates' letter to President Bush. Washington Post (2001) 2.43
Long-term outcome in children after antenatal intervention for obstructive uropathies. Lancet (1999) 2.37
Rapid recovery of Escherichia coli from estuarine water. Appl Microbiol (1972) 2.31
Extension of cell life-span and telomere length in animals cloned from senescent somatic cells. Science (2000) 2.25
Mobile phone technology in the management of asthma. J Telemed Telecare (2005) 2.15
Catheter-induced ablation of the atrioventricular junction to control refractory supraventricular arrhythmias. JAMA (1982) 2.08
Reconstitution of human telomerase activity and identification of a minimal functional region of the human telomerase RNA. EMBO J (1996) 2.08
Effect sizes and p values: what should be reported and what should be replicated? Psychophysiology (1996) 2.07
Microbial hazards associated with bean sprouting. J Assoc Off Anal Chem (1982) 2.03
Monoclonal antibodies specific to apical surfaces of rat alveolar type I cells bind to surfaces of cultured, but not freshly isolated, type II cells. Biochim Biophys Acta (1988) 2.01
Highly water-permeable type I alveolar epithelial cells confer high water permeability between the airspace and vasculature in rat lung. Proc Natl Acad Sci U S A (1998) 1.85
Rapid detection of methicillin-resistant staphylococci by multiplex PCR. J Hosp Infect (1999) 1.84
Pulmonary surfactant and its components inhibit secretion of phosphatidylcholine from cultured rat alveolar type II cells. Proc Natl Acad Sci U S A (1987) 1.79
The ethical validity of using nuclear transfer in human transplantation. JAMA (2000) 1.77
Nonintubated Anderson-Hynes repair of ureteropelvic junction obstruction in 60 patients. J Urol (1989) 1.76
Prevalence of human respiratory viruses in adults with acute respiratory tract infections in Beijing, 2005-2007. Clin Microbiol Infect (2009) 1.76
The two major xylanases from Trichoderma reesei: characterization of both enzymes and genes. Biotechnology (N Y) (1992) 1.76
Telomerase reverse transcriptase genes identified in Tetrahymena thermophila and Oxytricha trifallax. Proc Natl Acad Sci U S A (1998) 1.74
Investigation of under-ascertainment in epidemiological studies based in general practice. Int J Epidemiol (1999) 1.73
Rapid serogroup identification of Neisseria meningitidis by using antiserum agar: Prevalence of serotypes in a disease-free military population. J Clin Microbiol (1979) 1.71
Neurogenic bladder dysfunction in children: review of pathophysiology and current management. J Pediatr (1994) 1.68
Beta-galactosidase histochemistry and telomere loss in senescent retinal pigment epithelial cells. Invest Ophthalmol Vis Sci (1999) 1.67
The efficacy and safety of the dorzolamide-timolol combination versus the concomitant administration of its components. Dorzolamide-Timolol Study Group. Ophthalmology (1998) 1.67
Radiofrequency catheter ablation as a cure for idiopathic tachycardia of both left and right ventricular origin. J Am Coll Cardiol (1994) 1.60
Heterogeneity of transcriptional activity of mutant p53 proteins and p53 DNA target sequences. Oncogene (1993) 1.59
Procedural experience and comfort level in internal medicine trainees. J Gen Intern Med (2000) 1.56
Engineering a homo-ethanol pathway in Escherichia coli: increased glycolytic flux and levels of expression of glycolytic genes during xylose fermentation. J Bacteriol (2001) 1.55
Presence of tumor DNA in plasma of breast cancer patients: clinicopathological correlations. Cancer Res (1999) 1.55
Usefulness of the stomacher in a microbiological regulatory laboratory. Appl Environ Microbiol (1978) 1.53
Goodpasture's syndrome with normal renal function. Nephrol Dial Transplant (1996) 1.51
Effect of neoadjuvant chemotherapy on circumferential margin positivity and its impact on prognosis in patients with resectable oesophageal cancer. Br J Surg (2008) 1.50
A comparative study of the diagnostic performance of amniotic fluid glucose, white blood cell count, interleukin-6, and gram stain in the detection of microbial invasion in patients with preterm premature rupture of membranes. Am J Obstet Gynecol (1993) 1.49
The role of laparoscopy in preoperative staging of esophageal cancer. Surg Endosc (2000) 1.49
Steroid sulfation by expressed human cytosolic sulfotransferases. J Steroid Biochem Mol Biol (1994) 1.47
Extracranial vertebral artery pseudoaneurysm presenting as subarachnoid hemorrhage. Stroke (1993) 1.47
Idiopathic anterior urethritis in prepubertal and pubertal boys: pathology and clues to etiology. Urology (1998) 1.47
Emergency intracardiac defibrillation for refractory ventricular fibrillation during routine electrophysiologic study. J Am Coll Cardiol (1991) 1.46
The study of infectious intestinal disease in England: socio-economic impact. Epidemiol Infect (2003) 1.45
A putative poststreptococcal case of OCD with chronic tic disorder, not otherwise specified. J Am Acad Child Adolesc Psychiatry (1996) 1.45
Timing of the endometrial biopsy may be critical for the accurate diagnosis of luteal phase deficiency. Fertil Steril (1994) 1.44
TANK2, a new TRF1-associated poly(ADP-ribose) polymerase, causes rapid induction of cell death upon overexpression. J Biol Chem (2001) 1.44
Bacterial growth kinetics on diphenylmethane and naphthalene-heptamethylnonane mixtures. Appl Environ Microbiol (1977) 1.43
Newer strategies for effective evaluation of primary melanoma and treatment of stage III and IV disease. J Am Acad Dermatol (2000) 1.43
Reye's syndrome associated with acute myocarditis and fatal circulatory failure. Pediatr Emerg Care (1991) 1.41
The moroccan food snail, Helix aspersa, as a source of Salmonella. Appl Microbiol (1975) 1.41
Pericytes as a supplementary source of osteoblasts in periosteal osteogenesis. Clin Orthop Relat Res (1992) 1.41
CASTing for multicomponent DNA-binding complexes. Trends Biochem Sci (1993) 1.41
Yeast lariat debranching enzyme. Substrate and sequence specificity. J Biol Chem (1994) 1.39
Maximal and explosive force production capacity and balance performance in men of different ages. Eur J Appl Physiol Occup Physiol (1999) 1.39
The GATA factor AreA is essential for chromatin remodelling in a eukaryotic bidirectional promoter. EMBO J (1999) 1.37
Cataloging altered gene expression in young and senescent cells using enhanced differential display. Nucleic Acids Res (1995) 1.36
Are factors originating from serum, plasma, or cultured cells involved in the growth-promoting effect of the extracellular matrix produced by cultured bovine corneal endothelial cells? J Cell Physiol (1983) 1.35
Administration of autologous bone marrow stem cells into spinal cord injury patients via multiple routes is safe and improves their quality of life: comprehensive case studies. Cell Transplant (2008) 1.34
Autophosphorylation activates the soluble cytoplasmic domain of the insulin receptor in an intermolecular reaction. J Biol Chem (1989) 1.30
Pasteurella multocida. Osteomyelitis following dog bites. Am J Dis Child (1981) 1.28
Oxidation of a specific methionine in thrombomodulin by activated neutrophil products blocks cofactor activity. A potential rapid mechanism for modulation of coagulation. J Clin Invest (1992) 1.27
Evidence for tissue diffusion limitation of VO2max in normal humans. J Appl Physiol (1985) (1989) 1.27
The value of urodynamic testing in the management of neonates with myelodysplasia: a prospective study. J Urol (1986) 1.26
Transmutation of a heme protein. Proc Natl Acad Sci U S A (1993) 1.25
Rapid PCR-based detection of Streptococcus pneumoniae DNA in cerebrospinal fluid. J Clin Microbiol (1999) 1.25
Sacral metastasis in a patient with endometrial cancer: case report and review of the literature. Gynecol Oncol (2008) 1.24
Sequence of the FRA3B common fragile region: implications for the mechanism of FHIT deletion. Proc Natl Acad Sci U S A (1997) 1.24
The bgl1 gene of Trichoderma reesei QM 9414 encodes an extracellular, cellulose-inducible beta-glucosidase involved in cellulase induction by sophorose. Mol Microbiol (1995) 1.24
Closed-chest electrode-catheter technique for His bundle ablation in dogs. Am J Physiol (1981) 1.24
Improvement of in-rumen digestibility of alfalfa forage by genetic manipulation of lignin O-methyltransferases. Transgenic Res (2001) 1.24
Infection and labor. VIII. Microbial invasion of the amniotic cavity in patients with suspected cervical incompetence: prevalence and clinical significance. Am J Obstet Gynecol (1992) 1.23
Diverticula of the male urethra. J Urol (1980) 1.22
Allelic loss of the PTEN region (10q23) in breast carcinomas of poor pathophenotype. Breast Cancer Res Treat (1999) 1.22
Observations on a cell line producing mammary tumor virus. J Natl Cancer Inst (1968) 1.22
Prune belly syndrome in females: a triad of abdominal musculature deficiency and anomalies of the urinary and genital systems. J Pediatr (1991) 1.21
Prune belly syndrome: clinicopathologic study of 29 cases. Pediatr Pathol (1989) 1.20
Metastatic tumor cells adhere preferentially to the extracellular matrix underlying vascular endothelial cells. Int J Cancer (1980) 1.20
The mouse telomerase RNA 5"-end lies just upstream of the telomerase template sequence. Nucleic Acids Res (1998) 1.19
Influence of methodology upon apparent concentrations of antibiotics in tissue. Antimicrob Agents Chemother (1973) 1.19
Preparative elution of proteins from nitrocellulose membranes after separation by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Anal Biochem (1985) 1.17
Deletion of the unique gene encoding a typical histone H1 has no apparent phenotype in Aspergillus nidulans. Mol Microbiol (2000) 1.16
The efficacy of a prophylactic knee brace to reduce knee injuries in football. A prospective, randomized study at West Point. Am J Sports Med (1990) 1.16
Novel DNA binding of p53 mutants and their role in transcriptional activation. Oncogene (1993) 1.16
A sympathetic reflex elicited by distension of the mesenteric venous bed. J Physiol (1972) 1.15