Published in Curr Biol on September 09, 1999
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas. Nature (2007) 16.95
Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts. Nat Cell Biol (2003) 8.42
The essence of senescence. Genes Dev (2010) 8.21
Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging. Proc Natl Acad Sci U S A (2001) 7.93
The senescence-associated secretory phenotype: the dark side of tumor suppression. Annu Rev Pathol (2010) 7.58
E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis. Genes Dev (2001) 6.13
Replicative senescence of mesenchymal stem cells: a continuous and organized process. PLoS One (2008) 4.37
Control of the replicative life span of human fibroblasts by p16 and the polycomb protein Bmi-1. Mol Cell Biol (2003) 4.05
PML is induced by oncogenic ras and promotes premature senescence. Genes Dev (2000) 3.35
Feedback between p21 and reactive oxygen production is necessary for cell senescence. Mol Syst Biol (2010) 3.27
Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions. Genes Dev (2001) 3.16
Control of the senescence-associated secretory phenotype by NF-κB promotes senescence and enhances chemosensitivity. Genes Dev (2011) 3.05
The role of senescent cells in ageing. Nature (2014) 3.03
Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency. Nat Cell Biol (2008) 2.81
Life extension in Drosophila by feeding a drug. Proc Natl Acad Sci U S A (2002) 2.57
Nutlin-3a activates p53 to both down-regulate inhibitor of growth 2 and up-regulate mir-34a, mir-34b, and mir-34c expression, and induce senescence. Cancer Res (2008) 2.45
Effects of p21Waf1/Cip1/Sdi1 on cellular gene expression: implications for carcinogenesis, senescence, and age-related diseases. Proc Natl Acad Sci U S A (2000) 2.43
Cellular senescence and its effector programs. Genes Dev (2014) 2.37
Role of p14(ARF) in replicative and induced senescence of human fibroblasts. Mol Cell Biol (2001) 2.27
Senescence-specific gene expression fingerprints reveal cell-type-dependent physical clustering of up-regulated chromosomal loci. Proc Natl Acad Sci U S A (2003) 2.18
DNA microarray reveals changes in gene expression of shear stressed human umbilical vein endothelial cells. Proc Natl Acad Sci U S A (2001) 2.16
Loss of HuR is linked to reduced expression of proliferative genes during replicative senescence. Mol Cell Biol (2001) 2.15
Increased MKK4 abundance with replicative senescence is linked to the joint reduction of multiple microRNAs. Sci Signal (2009) 1.97
Cellular senescence and organismal aging. Mech Ageing Dev (2008) 1.92
Circadian clock protein BMAL1 regulates cellular senescence in vivo. Cell Cycle (2011) 1.87
Vascular endothelial senescence: from mechanisms to pathophysiology. J Appl Physiol (1985) (2008) 1.87
Werner syndrome protein limits MYC-induced cellular senescence. Genes Dev (2003) 1.84
Critical pathways in cellular senescence and immortalization revealed by gene expression profiling. Oncogene (2008) 1.81
A highly selective telomerase inhibitor limiting human cancer cell proliferation. EMBO J (2001) 1.79
Longevity regulation in Saccharomyces cerevisiae: linking metabolism, genome stability, and heterochromatin. Microbiol Mol Biol Rev (2003) 1.78
Lamin B1 depletion in senescent cells triggers large-scale changes in gene expression and the chromatin landscape. Genes Dev (2013) 1.78
BRD4 Connects Enhancer Remodeling to Senescence Immune Surveillance. Cancer Discov (2016) 1.54
Oncogene-induced cellular senescence elicits an anti-Warburg effect. Proteomics (2013) 1.50
Adult-onset, short-term dietary restriction reduces cell senescence in mice. Aging (Albany NY) (2010) 1.45
Telomere biology in healthy aging and disease. Pflugers Arch (2009) 1.41
Prohibitin facilitates cellular senescence by recruiting specific corepressors to inhibit E2F target genes. Mol Cell Biol (2006) 1.38
Transcriptional networks and cellular senescence in human mammary fibroblasts. Mol Biol Cell (2004) 1.38
Cellular senescence controls fibrosis in wound healing. Aging (Albany NY) (2010) 1.36
IL1- and TGFβ-Nox4 signaling, oxidative stress and DNA damage response are shared features of replicative, oncogene-induced, and drug-induced paracrine 'bystander senescence'. Aging (Albany NY) (2012) 1.32
SASP reflects senescence. EMBO Rep (2009) 1.27
Uncoupling between phenotypic senescence and cell cycle arrest in aging p21-deficient fibroblasts. Mol Cell Biol (2000) 1.24
Activation of nuclear factor-kappa B signalling promotes cellular senescence. Oncogene (2011) 1.23
Cellular senescence in cancer treatment: friend or foe? J Clin Invest (2004) 1.23
Redistribution of the Lamin B1 genomic binding profile affects rearrangement of heterochromatic domains and SAHF formation during senescence. Genes Dev (2013) 1.23
Beta-catenin expression results in p53-independent DNA damage and oncogene-induced senescence in prelymphomagenic thymocytes in vivo. Mol Cell Biol (2007) 1.21
Human mesenchymal stem cell-replicative senescence and oxidative stress are closely linked to aneuploidy. Cell Death Dis (2013) 1.16
Physiological and pathological consequences of cellular senescence. Cell Mol Life Sci (2014) 1.15
Stem cells, senescence, neosis and self-renewal in cancer. Cancer Cell Int (2006) 1.11
The effects of aging on the molecular and cellular composition of the prostate microenvironment. PLoS One (2010) 1.10
IGFBP-rP1 induces p21 expression through a p53-independent pathway, leading to cellular senescence of MCF-7 breast cancer cells. J Cancer Res Clin Oncol (2012) 1.10
Senescence induction; a possible cancer therapy. Mol Cancer (2009) 1.10
Inflammatory signaling and cellular senescence. Cell Signal (2008) 1.08
Cellular and molecular biology of aging endothelial cells. J Mol Cell Cardiol (2015) 1.07
Use of exogenous hTERT to immortalize primary human cells. Cytotechnology (2004) 1.06
The IGF-1/IGF-1R signaling axis in the skin: a new role for the dermis in aging-associated skin cancer. Oncogene (2009) 1.06
Pak4 induces premature senescence via a pathway requiring p16INK4/p19ARF and mitogen-activated protein kinase signaling. Mol Cell Biol (2005) 1.05
Age-specific variation in immune response in Drosophila melanogaster has a genetic basis. Genetics (2012) 1.05
Epithelial cell senescence impairs repair process and exacerbates inflammation after airway injury. Respir Res (2011) 1.02
Induction of extracellular matrix-remodeling genes by the senescence-associated protein APA-1. Mol Cell Biol (2002) 1.01
Senescent keratinocytes die by autophagic programmed cell death. Am J Pathol (2009) 1.01
Induction of the Cdk inhibitor p21 by LY83583 inhibits tumor cell proliferation in a p53-independent manner. J Clin Invest (2002) 1.00
Nuclear reorganization of mammalian DNA synthesis prior to cell cycle exit. Mol Cell Biol (2004) 0.99
Cellular senescence and cancer chemotherapy resistance. Drug Resist Updat (2012) 0.99
Cellular Senescence - its role in cancer and the response to ionizing radiation. Genome Integr (2011) 0.98
Regulation of senescence in cancer and aging. J Aging Res (2011) 0.98
The PI3K/Akt/mTOR pathway is implicated in the premature senescence of primary human endothelial cells exposed to chronic radiation. PLoS One (2013) 0.97
p35 is required for CDK5 activation in cellular senescence. J Biol Chem (2010) 0.96
Cell autonomous expression of inflammatory genes in biologically aged fibroblasts associated with elevated NF-kappaB activity. Immun Ageing (2008) 0.96
Genome-wide transcriptional reorganization associated with senescence-to-immortality switch during human hepatocellular carcinogenesis. PLoS One (2013) 0.95
Oxidative stress in aging human skin. Biomolecules (2015) 0.94
Immortalized gingival fibroblasts as a cytotoxicity test model for dental materials. J Mater Sci Mater Med (2011) 0.93
Transcriptional control of SV40 T-antigen expression allows a complete reversion of immortalization. Nucleic Acids Res (2004) 0.93
A genome wide analysis of the response to uncapped telomeres in budding yeast reveals a novel role for the NAD+ biosynthetic gene BNA2 in chromosome end protection. Genome Biol (2008) 0.93
The effect of chronological age on the inflammatory response of human fibroblasts. Exp Gerontol (2012) 0.92
Functional genetic screen for genes involved in senescence: role of Tid1, a homologue of the Drosophila tumor suppressor l(2)tid, in senescence and cell survival. Mol Cell Biol (2004) 0.92
Altered cytokine profiles of human retinal pigment epithelium: oxidant injury and replicative senescence. Mol Vis (2013) 0.91
The Mitochondrial-Derived Peptide Humanin Protects RPE Cells From Oxidative Stress, Senescence, and Mitochondrial Dysfunction. Invest Ophthalmol Vis Sci (2016) 0.91
Acute activation of AMP-activated protein kinase prevents H2O2-induced premature senescence in primary human keratinocytes. PLoS One (2012) 0.91
Klotho regulates retinal pigment epithelial functions and protects against oxidative stress. J Neurosci (2013) 0.91
mTOR Signaling from Cellular Senescence to Organismal Aging. Aging Dis (2013) 0.90
Pseudolaric acid B induced cell cycle arrest, autophagy and senescence in murine fibrosarcoma l929 cell. Int J Med Sci (2013) 0.90
The inflammatory network: bridging senescent stroma and epithelial tumorigenesis. Front Biosci (Landmark Ed) (2009) 0.89
From old organisms to new molecules: integrative biology and therapeutic targets in accelerated human ageing. Cell Mol Life Sci (2007) 0.89
Quantitative model of cell cycle arrest and cellular senescence in primary human fibroblasts. PLoS One (2012) 0.88
Low-dose radiation-induced senescent stromal fibroblasts render nearby breast cancer cells radioresistant. Radiat Res (2009) 0.88
Cyclin D1 activity regulates autophagy and senescence in the mammary epithelium. Cancer Res (2012) 0.87
A novel role for the condensin II complex in cellular senescence. Cell Cycle (2015) 0.87
Induction of cellular senescence by doxorubicin is associated with upregulated miR-375 and induction of autophagy in K562 cells. PLoS One (2012) 0.87
Interleukin 1 alpha is a marker of endothelial cellular senescent. Immun Ageing (2006) 0.86
Molecular pathways: involving microenvironment damage responses in cancer therapy resistance. Clin Cancer Res (2012) 0.86
Cell-nonautonomous function of Id1 in the hematopoietic progenitor cell niche. Blood (2009) 0.85
Cellular senescence and protein degradation: breaking down cancer. Cell Cycle (2014) 0.85
Age-related changes in the cellular composition and epithelial organization of the mouse trachea. PLoS One (2014) 0.84
The emerging role of senescent cells in tissue homeostasis and pathophysiology. Pathobiol Aging Age Relat Dis (2015) 0.84
Circulating endothelial progenitor cells: a new approach to anti-aging medicine? J Transl Med (2009) 0.84
Senescence and life span. Pflugers Arch (2009) 0.84
Therapeutic targeting of replicative immortality. Semin Cancer Biol (2015) 0.83
Chemokine-chemokine receptor CCL2-CCR2 and CX3CL1-CX3CR1 axis may play a role in the aggravated inflammation in primary biliary cirrhosis. Dig Dis Sci (2013) 0.83
Senescent vs. non-senescent cells in the human annulus in vivo: cell harvest with laser capture microdissection and gene expression studies with microarray analysis. BMC Biotechnol (2010) 0.83
Induction of cellular senescence by secretory phospholipase A2 in human dermal fibroblasts through an ROS-mediated p53 pathway. J Gerontol A Biol Sci Med Sci (2009) 0.82
The RNA component of human telomerase. Science (1995) 9.86
The product of the tobacco mosaic virus resistance gene N: similarity to toll and the interleukin-1 receptor. Cell (1994) 6.88
Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype. Nat Genet (1999) 3.47
Xeroderma pigmentosum group E cells lack a nuclear factor that binds to damaged DNA. Science (1988) 3.39
High frequency of acute promyelocytic leukemia among Latinos with acute myeloid leukemia. Blood (1996) 3.24
Human endothelial cell life extension by telomerase expression. J Biol Chem (1999) 2.38
Shk1, a homolog of the Saccharomyces cerevisiae Ste20 and mammalian p65PAK protein kinases, is a component of a Ras/Cdc42 signaling module in the fission yeast Schizosaccharomyces pombe. Proc Natl Acad Sci U S A (1995) 2.33
Telomere shortening is associated with cell division in vitro and in vivo. Exp Cell Res (1995) 2.11
Reconstitution of human telomerase activity and identification of a minimal functional region of the human telomerase RNA. EMBO J (1996) 2.08
Promoter attenuation in gene therapy: interferon-gamma and tumor necrosis factor-alpha inhibit transgene expression. Hum Gene Ther (1997) 2.07
Oncogenic ras triggers the activation of 42-kDa mitogen-activated protein kinase in extracts of quiescent Xenopus oocytes. Proc Natl Acad Sci U S A (1992) 2.02
Transposon tagging of tobacco mosaic virus resistance gene N: its possible role in the TMV-N-mediated signal transduction pathway. Proc Natl Acad Sci U S A (1995) 1.89
Recovery from deep-plane rhytidectomy following unilateral wound treatment with autologous platelet gel: a pilot study. Arch Facial Plast Surg (2001) 1.89
Expansins: ever-expanding numbers and functions. Curr Opin Plant Biol (2001) 1.80
Enhanced detection of intracardiac sources of cerebral emboli by transesophageal echocardiography. Stroke (1991) 1.65
Gut-derived sepsis occurs when the right pathogen with the right virulence genes meets the right host: evidence for in vivo virulence expression in Pseudomonas aeruginosa. Ann Surg (2000) 1.62
Phase II study of accelerated fractionation radiation therapy with carboplatin followed by PCV chemotherapy for the treatment of anaplastic gliomas. Int J Radiat Oncol Biol Phys (2002) 1.61
Heterogeneity of transcriptional activity of mutant p53 proteins and p53 DNA target sequences. Oncogene (1993) 1.59
Congestion of right liver graft in living donor liver transplantation. Transplantation (2001) 1.51
Interleukin-8 and its receptor CXCR2 in the tumour microenvironment promote colon cancer growth, progression and metastasis. Br J Cancer (2012) 1.49
Microstructural characterization of plasma-sprayed hydroxyapatite-10 wt% ZrO2 composite coating on titanium. Biomaterials (1999) 1.49
Neck problems in rheumatoid arthritis--changing disease patterns, surgical treatments and patients' expectations. Rheumatology (Oxford) (2006) 1.45
eNOS activity is reduced in senescent human endothelial cells: Preservation by hTERT immortalization. Circ Res (2001) 1.45
Cervical arthroplasty: the beginning, the middle, the end? Br J Neurosurg (2011) 1.45
Comparison of inflammatory markers and angiographic outcomes after implantation of sirolimus and paclitaxel-eluting stents. Heart (2008) 1.45
TANK2, a new TRF1-associated poly(ADP-ribose) polymerase, causes rapid induction of cell death upon overexpression. J Biol Chem (2001) 1.44
Synaptic innervation density is regulated by neuron-derived BDNF. Neuron (1997) 1.43
Hepatocellular carcinoma treated with percutaneous radio-frequency ablation: evaluation with follow-up multiphase helical CT. Radiology (2001) 1.43
A conserved alternative splice in the von Recklinghausen neurofibromatosis (NF1) gene produces two neurofibromin isoforms, both of which have GTPase-activating protein activity. Mol Cell Biol (1993) 1.43
MAGIC Tool: integrated microarray data analysis. Bioinformatics (2005) 1.42
CASTing for multicomponent DNA-binding complexes. Trends Biochem Sci (1993) 1.41
Intraneural ulnar nerve pressure changes related to operative techniques for cubital tunnel decompression. J Hand Surg Am (1994) 1.40
Cisplatin-resistant cells express increased levels of a factor that recognizes damaged DNA. Proc Natl Acad Sci U S A (1990) 1.39
The T alpha 1 alpha-tubulin promoter specifies gene expression as a function of neuronal growth and regeneration in transgenic mice. J Neurosci (1994) 1.36
Cataloging altered gene expression in young and senescent cells using enhanced differential display. Nucleic Acids Res (1995) 1.36
Optical coherence tomography evaluation of zotarolimus-eluting stents at 9-month follow-up: comparison with sirolimus-eluting stents. Heart (2009) 1.31
Guanine nucleotide binding activity of the src gene product of rat-derived murine sarcoma viruses. Ann N Y Acad Sci (1980) 1.27
Metabolism of 2',2'-difluoro-2'-deoxycytidine and radiation sensitization of human colon carcinoma cells. Cancer Res (1994) 1.25
Transmutation of a heme protein. Proc Natl Acad Sci U S A (1993) 1.25
Identification of the block in targeted retroviral-mediated gene transfer. Proc Natl Acad Sci U S A (1999) 1.25
Mycobacterial diseases and antitumour necrosis factor therapy in USA. Ann Rheum Dis (2012) 1.23
Changes in phases and crystallinity of plasma-sprayed hydroxyapatite coatings under heat treatment: a quantitative study. J Biomed Mater Res (1995) 1.20
Bacteriophages of Clostridium botulinum. Can J Microbiol (1972) 1.20
The mouse telomerase RNA 5"-end lies just upstream of the telomerase template sequence. Nucleic Acids Res (1998) 1.19
Rapid stimulation of 5-lipoxygenase activity in potato by the fungal elicitor arachidonic Acid. Plant Physiol (1992) 1.17
Novel DNA binding of p53 mutants and their role in transcriptional activation. Oncogene (1993) 1.16
Complete cDNA sequence of human preceruloplasmin. Proc Natl Acad Sci U S A (1986) 1.13
Spontaneous reversal of the developmental aging of normal human cells following transcriptional reprogramming. Regen Med (2010) 1.13
Neuronal injury and loss after traumatic brain injury: time course and regional variability. Brain Res (2001) 1.12
Anxiety and depression over the first year of spinal cord injury: a longitudinal study. Paraplegia (1993) 1.12
Telomerase expression prevents replicative senescence but does not fully reset mRNA expression patterns in Werner syndrome cell strains. FASEB J (2001) 1.11
Expression of glycosylated and nonglycosylated human transferrin in mammalian cells. Characterization of the recombinant proteins with comparison to three commercially available transferrins. Biochemistry (1993) 1.10
A self-administered instrument for assessing therapeutic approaches of drug-user treatment counselors. Subst Use Misuse (2001) 1.10
Polymeric gene delivery of ischemia-inducible VEGF significantly attenuates infarct size and apoptosis following myocardial infarct. Gene Ther (2008) 1.09
Efficient production and isolation of recombinant amino-terminal half-molecule of human serum transferrin from baby hamster kidney cells. Protein Expr Purif (1992) 1.09
CT of the bronchus intermedius: frequency and cause of a nodule in the posterior wall on normal scans. AJR Am J Roentgenol (1995) 1.07
Molecular genetic alterations in radiation-induced astrocytomas. Am J Pathol (1999) 1.07
Adjacent segment disease after fusion for cervical spondylosis; myth or reality? Br J Neurosurg (2008) 1.06
A rare case of vomiting: fourth ventricular B-cell lymphoma. J Neurooncol (2008) 1.06
Bone formation and degradation of a highly porous biphasic calcium phosphate ceramic in presence of BMP-7, VEGF and mesenchymal stem cells in an ectopic mouse model. J Craniomaxillofac Surg (2010) 1.05
Intestinal metastases from gastric adenocarcinoma: helical CT findings. J Comput Assist Tomogr (2001) 1.04
Expression and initial characterization of five site-directed mutants of the N-terminal half-molecule of human transferrin. Biochemistry (1991) 1.04
Selective thinning of the perifoveal inner retina as an early sign of hydroxychloroquine retinal toxicity. Eye (Lond) (2010) 1.03
Post-interventional immunosuppressive treatment and vascular restenosis in Takayasu's arteritis. Rheumatology (Oxford) (2005) 1.02
Pathologic findings in Sandhoff disease. Arch Pathol (1973) 1.01
Auricular composite grafting to repair nasal vestibular stenosis. Otolaryngol Head Neck Surg (2000) 1.00
Persistence of herpes simplex virus type 1 DNA in chronic conjunctival and eyelid lesions of mice. J Virol (1998) 0.99
Identification of binding sites for bepridil and trifluoperazine on cardiac troponin C. J Biol Chem (1998) 0.99
Conspicuity of hepatocellular nodular lesions in cirrhotic livers at ferumoxides-enhanced MR imaging: importance of Kupffer cell number. Radiology (2001) 0.99
The shear strength and the failure mode of plasma-sprayed hydroxyapatite coating to bone: the effect of coating thickness. J Biomed Mater Res (1993) 0.98
An allelic association implicates myeloperoxidase in the etiology of acute promyelocytic leukemia. Blood (1997) 0.98
Program factors and treatment outcomes in drug dependence treatment: an examination using meta-analysis. Subst Use Misuse (2001) 0.98
Recombinant human erythrocyte cytochrome b5. Biochemistry (1994) 0.97
Membrane-limited expression and regulation of Na+-H+ exchanger isoforms by P2 receptors in the rat submandibular gland duct. J Physiol (1998) 0.96
Biotic and abiotic stress-related expression of 1-aminocyclopropane-1-carboxylate oxidase gene family in Nicotiana glutinosa L. Plant Cell Physiol (1998) 0.95
CHRK1, a chitinase-related receptor-like kinase in tobacco. Plant Physiol (2000) 0.93
Small vectors for expression based on dominant drug resistance with direct multicopy selection. Methods Mol Biol (1998) 0.92
Rituximab for treatment of ocular inflammatory disease: a series of four cases. Br J Ophthalmol (2009) 0.91
Comparative gene mapping in the domestic cat (Felis catus). J Hered (1997) 0.91
Influence of residual stress on bonding strength and fracture of plasma-sprayed hydroxyapatite coatings on Ti-6Al-4V substrate. Biomaterials (2001) 0.90
An adult-to-adult living donor liver transplant using dual left lobe grafts. Surgery (2001) 0.90
Idiopathic polyhydramnios and perinatal outcome. Am J Obstet Gynecol (1999) 0.90
Phosphatidate phosphohydrolases in liver, heart and adipose tissue of the JCR:LA corpulent rat and the lean genotypes: implications for glycerolipid synthesis and signal transduction. Int J Obes Relat Metab Disord (1992) 0.90
p53, secreted by K-Ras-Snail pathway, is endocytosed by K-Ras-mutated cells; implication of target-specific drug delivery and early diagnostic marker. Oncogene (2009) 0.90
The reduction half cell in biomaterials corrosion: oxygen diffusion profiles near and cell response to polarized titanium surfaces. J Biomed Mater Res (1998) 0.90
T-cell vaccines that elicit effective immune responses against HCV in chimpanzees may create greater immune pressure for viral mutation. Vaccine (2009) 0.90
Skin punch biopsies and lymphocytes in the diagnosis of lipidoses. Can J Neurol Sci (1975) 0.90
Laparoscopic fenestration and modified marsupialization of posttraumatic splenic cysts using a harmonic scalpel. Surg Endosc (2001) 0.89
Multiple hormones regulate angiotensinogen messenger ribonucleic acid levels in a rat hepatoma cell line. Endocrinology (1987) 0.89
Cancer clusters: the importance of monitoring multiple geographic scales. Soc Sci Med (1993) 0.89
Left ventricular diastolic functional reserve during exercise in patients with impaired myocardial relaxation at rest. Heart (2008) 0.89
Retinoic acid receptor-beta as a prognostic indicator in stage I non-small-cell lung cancer. J Clin Oncol (2000) 0.88
Characterization of wild-type and an active-site mutant in Escherichia coli of short-chain acyl-CoA dehydrogenase from Megasphaera elsdenii. Biochemistry (1993) 0.88
The serpin-enzyme complex receptor recognizes soluble, nontoxic amyloid-beta peptide but not aggregated, cytotoxic amyloid-beta peptide. J Biol Chem (1996) 0.88
Fine structure of cutaneous nerves in ganglioside storage disease. J Neurol Neurosurg Psychiatry (1977) 0.88
Molecular cloning of a novel pathogen-inducible cDNA encoding a putative acyl-CoA synthetase from Capsicum annuum L. Plant Mol Biol (2001) 0.88