Published in Hypertension on March 15, 2010
Inhibition of platelet activation by clopidogrel prevents hypertension-induced cardiac inflammation and fibrosis. Cardiovasc Drugs Ther (2013) 3.32
TGF-β/Smad3 signaling promotes renal fibrosis by inhibiting miR-29. J Am Soc Nephrol (2011) 2.78
Proinflammatory protein CARD9 is essential for infiltration of monocytic fibroblast precursors and cardiac fibrosis caused by Angiotensin II infusion. Am J Hypertens (2011) 1.67
miR-29 inhibits bleomycin-induced pulmonary fibrosis in mice. Mol Ther (2012) 1.56
Autonomic neural regulation of the immune system: implications for hypertension and cardiovascular disease. Hypertension (2012) 1.45
Contribution of microRNA to pathological fibrosis in cardio-renal syndrome: impact of uremic toxins. Physiol Rep (2015) 1.40
Inhibition of miR-29 by TGF-beta-Smad3 signaling through dual mechanisms promotes transdifferentiation of mouse myoblasts into myofibroblasts. PLoS One (2012) 1.30
miR-29b as a therapeutic agent for angiotensin II-induced cardiac fibrosis by targeting TGF-β/Smad3 signaling. Mol Ther (2014) 1.24
Smad7 suppresses renal fibrosis via altering expression of TGF-β/Smad3-regulated microRNAs. Mol Ther (2012) 1.10
Cathepsin S deficiency results in abnormal accumulation of autophagosomes in macrophages and enhances Ang II-induced cardiac inflammation. PLoS One (2012) 1.10
Genetic deficiency of Smad3 protects the kidneys from atrophy and interstitial fibrosis in 2K1C hypertension. Am J Physiol Renal Physiol (2012) 1.05
Disruption of Smad7 promotes ANG II-mediated renal inflammation and fibrosis via Sp1-TGF-β/Smad3-NF.κB-dependent mechanisms in mice. PLoS One (2013) 0.99
Cardiac remodeling in fish: strategies to maintain heart function during temperature Change. PLoS One (2011) 0.98
Reciprocal interaction between macrophages and T cells stimulates IFN-γ and MCP-1 production in Ang II-induced cardiac inflammation and fibrosis. PLoS One (2012) 0.96
TGF-β/Smad3 signalling regulates the transition of bone marrowderived macrophages into myofibroblasts during tissue fibrosis. Oncotarget (2016) 0.94
New take on the role of angiotensin II in cardiac hypertrophy and fibrosis. Hypertension (2011) 0.93
Regulator of G protein signaling 2 is a functionally important negative regulator of angiotensin II-induced cardiac fibroblast responses. Am J Physiol Heart Circ Physiol (2011) 0.90
Up-regulation of BMP-2 antagonizes TGF-β1/ROCK-enhanced cardiac fibrotic signalling through activation of Smurf1/Smad6 complex. J Cell Mol Med (2012) 0.90
Mechanobiology of myofibroblast adhesion in fibrotic cardiac disease. J Cell Sci (2015) 0.88
Smad3 signaling activates bone marrow-derived fibroblasts in renal fibrosis. Lab Invest (2014) 0.87
Fibulin-2 deficiency attenuates angiotensin II-induced cardiac hypertrophy by reducing transforming growth factor-β signalling. Clin Sci (Lond) (2014) 0.87
Is Smad3 the key to inflammation and fibrosis in hypertensive heart disease? Hypertension (2010) 0.86
Long Noncoding RNA Arid2-IR Is a Novel Therapeutic Target for Renal Inflammation. Mol Ther (2015) 0.86
Fibroblast progenitor cells are recruited into the myocardium prior to the development of myocardial fibrosis. Int J Exp Pathol (2012) 0.85
Sp1 Mediates a Therapeutic Role of MiR-7a/b in Angiotensin II-Induced Cardiac Fibrosis via Mechanism Involving the TGF-β and MAPKs Pathways in Cardiac Fibroblasts. PLoS One (2015) 0.85
Treatment of renal fibrosis by rebalancing TGF-β/Smad signaling with the combination of asiatic acid and naringenin. Oncotarget (2015) 0.84
Dynamic reorganization of the AC16 cardiomyocyte transcriptome in response to TNFα signaling revealed by integrated genomic analyses. BMC Genomics (2014) 0.84
Deficiency of Smad7 enhances cardiac remodeling induced by angiotensin II infusion in a mouse model of hypertension. PLoS One (2013) 0.81
Smad3 deficiency protects mice from obesity-induced podocyte injury that precedes insulin resistance. Kidney Int (2015) 0.80
Endothelial dysfunction exacerbates renal interstitial fibrosis through enhancing fibroblast Smad3 linker phosphorylation in the mouse obstructed kidney. PLoS One (2013) 0.80
Smad7 protects against chronic aristolochic acid nephropathy in mice. Oncotarget (2015) 0.79
Losartan Attenuates Myocardial Endothelial-To-Mesenchymal Transition in Spontaneous Hypertensive Rats via Inhibiting TGF-β/Smad Signaling. PLoS One (2016) 0.79
Measurement of multiple biomarkers in advanced stage heart failure patients treated with pulmonary artery catheter guided therapy. Crit Care (2012) 0.78
Role of Bone Marrow-Derived Fibroblasts in Renal Fibrosis. Front Physiol (2016) 0.76
Identification of Genes Associated with Smad3-dependent Renal Injury by RNA-seq-based Transcriptome Analysis. Sci Rep (2015) 0.76
Inflammatory macrophages can transdifferentiate into myofibroblasts during renal fibrosis. Cell Death Dis (2016) 0.75
Deletion of Smad3 improves cardiac allograft rejection in mice. Oncotarget (2015) 0.75
Heat shock transcription factor 1 protects against pressure overload-induced cardiac fibrosis via Smad3. J Mol Med (Berl) (2017) 0.75
Fibulin-2 is essential for angiotensin II-induced myocardial fibrosis mediated by transforming growth factor (TGF)-β. Lab Invest (2016) 0.75
P‑selectin increases angiotensin II‑induced cardiac inflammation and fibrosis via platelet activation. Mol Med Rep (2016) 0.75
Achievement of a target dose of bisoprolol may not be a preferred option for attenuating pressure overload-induced cardiac hypertrophy and fibrosis. Exp Ther Med (2016) 0.75
Targeting c-fms kinase attenuates chronic aristolochic acid nephropathy in mice. Oncotarget (2016) 0.75
Gualou Xiebai decoction inhibits cardiac dysfunction and inflammation in cardiac fibrosis rats. BMC Complement Altern Med (2016) 0.75
Gallic acid prevents isoproterenol-induced cardiac hypertrophy and fibrosis through regulation of JNK2 signaling and Smad3 binding activity. Sci Rep (2016) 0.75
The Histone Methyltransferase Mixed Lineage Leukemia (MLL) 3 May Play a Potential Role on Clinical Dilated Cardiomyopathy. Mol Med (2017) 0.75
Prevalence, awareness, treatment, and control of hypertension among United States adults 1999-2004. Hypertension (2006) 11.68
Genomic instability in laminopathy-based premature aging. Nat Med (2005) 4.54
Identification of microRNA-181 by genome-wide screening as a critical player in EpCAM-positive hepatic cancer stem cells. Hepatology (2009) 3.92
TGF-β and BMP signaling in osteoblast differentiation and bone formation. Int J Biol Sci (2012) 3.49
A subpopulation of CD26+ cancer stem cells with metastatic capacity in human colorectal cancer. Cell Stem Cell (2010) 3.43
Uric acid stimulates monocyte chemoattractant protein-1 production in vascular smooth muscle cells via mitogen-activated protein kinase and cyclooxygenase-2. Hypertension (2003) 3.39
Hyperuricemia induces a primary renal arteriolopathy in rats by a blood pressure-independent mechanism. Am J Physiol Renal Physiol (2002) 3.37
Docking of axonal mitochondria by syntaphilin controls their mobility and affects short-term facilitation. Cell (2008) 2.93
A critical role for beta cell M3 muscarinic acetylcholine receptors in regulating insulin release and blood glucose homeostasis in vivo. Cell Metab (2006) 2.82
TGF-β/Smad3 signaling promotes renal fibrosis by inhibiting miR-29. J Am Soc Nephrol (2011) 2.78
Smad3-mediated upregulation of miR-21 promotes renal fibrosis. J Am Soc Nephrol (2011) 2.71
Smad4 signalling in T cells is required for suppression of gastrointestinal cancer. Nature (2006) 2.60
Essential role of Smad3 in angiotensin II-induced vascular fibrosis. Circ Res (2006) 2.59
miR-192 mediates TGF-beta/Smad3-driven renal fibrosis. J Am Soc Nephrol (2010) 2.51
Transforming growth factor-beta and Smad signalling in kidney diseases. Nephrology (Carlton) (2005) 2.23
Mice lacking Smad3 are protected against cutaneous injury induced by ionizing radiation. Am J Pathol (2002) 2.23
Chymase is upregulated in diabetic nephropathy: implications for an alternative pathway of angiotensin II-mediated diabetic renal and vascular disease. J Am Soc Nephrol (2003) 2.20
Impairment of tubuloglomerular feedback regulation of GFR in ecto-5'-nucleotidase/CD73-deficient mice. J Clin Invest (2004) 2.12
Peripheral disruption of the Grb10 gene enhances insulin signaling and sensitivity in vivo. Mol Cell Biol (2007) 2.08
Atrial fibrillation. Lancet (2011) 2.05
A beta-catenin gradient links the clock and wavefront systems in mouse embryo segmentation. Nat Cell Biol (2007) 2.01
TGF-beta induces proangiogenic and antiangiogenic factors via parallel but distinct Smad pathways. Kidney Int (2004) 1.95
Smad4 loss in mice causes spontaneous head and neck cancer with increased genomic instability and inflammation. J Clin Invest (2009) 1.95
Advanced glycation end products activate Smad signaling via TGF-beta-dependent and independent mechanisms: implications for diabetic renal and vascular disease. FASEB J (2003) 1.93
A small-molecule macrophage migration inhibitory factor antagonist protects against glomerulonephritis in lupus-prone NZB/NZW F1 and MRL/lpr mice. J Immunol (2010) 1.91
Smad2 protects against TGF-beta/Smad3-mediated renal fibrosis. J Am Soc Nephrol (2010) 1.89
Tbx5 is essential for forelimb bud initiation following patterning of the limb field in the mouse embryo. Development (2003) 1.88
Smad7 inhibits fibrotic effect of TGF-Beta on renal tubular epithelial cells by blocking Smad2 activation. J Am Soc Nephrol (2002) 1.86
C-reactive protein promotes cardiac fibrosis and inflammation in angiotensin II-induced hypertensive cardiac disease. Hypertension (2010) 1.85
Angiotensin II induces connective tissue growth factor and collagen I expression via transforming growth factor-beta-dependent and -independent Smad pathways: the role of Smad3. Hypertension (2009) 1.85
Adult neurogenesis requires Smad4-mediated bone morphogenic protein signaling in stem cells. J Neurosci (2008) 1.81
Retracted BRCA1 phosphorylation by Aurora-A in the regulation of G2 to M transition. J Biol Chem (2004) 1.77
Functional abnormalities in patients with permanent right ventricular pacing: the effect of sites of electrical stimulation. J Am Coll Cardiol (2002) 1.76
The microRNA miR-433 promotes renal fibrosis by amplifying the TGF-β/Smad3-Azin1 pathway. Kidney Int (2013) 1.72
The protective role of Smad7 in diabetic kidney disease: mechanism and therapeutic potential. Diabetes (2010) 1.68
Signaling mechanism of TGF-beta1 in prevention of renal inflammation: role of Smad7. J Am Soc Nephrol (2005) 1.67
Genetic inhibition of fibroblast growth factor receptor 1 in knee cartilage attenuates the degeneration of articular cartilage in adult mice. Arthritis Rheum (2012) 1.66
Ultrasound-microbubble-mediated gene transfer of inducible Smad7 blocks transforming growth factor-beta signaling and fibrosis in rat remnant kidney. Am J Pathol (2005) 1.63
Ectodermal Smad4 and p38 MAPK are functionally redundant in mediating TGF-beta/BMP signaling during tooth and palate development. Dev Cell (2008) 1.61
Overexpression of HCN-encoded pacemaker current silences bioartificial pacemakers. Heart Rhythm (2008) 1.61
Alternative Gnas gene products have opposite effects on glucose and lipid metabolism. Proc Natl Acad Sci U S A (2005) 1.59
Advanced glycation end products induce tubular epithelial-myofibroblast transition through the RAGE-ERK1/2 MAP kinase signaling pathway. Am J Pathol (2004) 1.58
miR-29 inhibits bleomycin-induced pulmonary fibrosis in mice. Mol Ther (2012) 1.56
Disruption of the Smad7 gene promotes renal fibrosis and inflammation in unilateral ureteral obstruction (UUO) in mice. Nephrol Dial Transplant (2008) 1.56
Left ventricular dysfunction assessed by speckle-tracking strain analysis in patients with systemic sclerosis: relationship to functional capacity and ventricular arrhythmias. Arthritis Rheum (2011) 1.54
Olfactomedin 4 down-regulates innate immunity against Helicobacter pylori infection. Proc Natl Acad Sci U S A (2010) 1.49
Histone H2AX is integral to hypoxia-driven neovascularization. Nat Med (2009) 1.48
Effects of cyclosporine in osteopontin null mice. Kidney Int (2002) 1.47
Treatment of atrial fibrillation with an implantable atrial defibrillator--long term results. Eur Heart J (2003) 1.46
Angiotensin II up-regulates angiotensin I-converting enzyme (ACE), but down-regulates ACE2 via the AT1-ERK/p38 MAP kinase pathway. Am J Pathol (2008) 1.46
Advanced glycation end-products induce tubular CTGF via TGF-beta-independent Smad3 signaling. J Am Soc Nephrol (2009) 1.45
Defective lysosomal targeting of activated fibroblast growth factor receptor 3 in achondroplasia. Proc Natl Acad Sci U S A (2003) 1.44
Identification of the control region for tissue-specific imprinting of the stimulatory G protein alpha-subunit. Proc Natl Acad Sci U S A (2005) 1.43
Development of diabetes in Chinese with the metabolic syndrome: a 6-year prospective study. Diabetes Care (2007) 1.43
FGF signaling acts upstream of the NOTCH and WNT signaling pathways to control segmentation clock oscillations in mouse somitogenesis. Development (2007) 1.40
Role of the TGF-β/BMP-7/Smad pathways in renal diseases. Clin Sci (Lond) (2013) 1.40
Ewing sarcoma gene EWS is essential for meiosis and B lymphocyte development. J Clin Invest (2007) 1.39
Paclitaxel-eluting stent long-term outcomes in percutaneous saphenous vein graft interventions (PELOPS) study. Am J Cardiol (2008) 1.37
Critical role of macrophage migration inhibitory factor activity in experimental autoimmune diabetes. Endocrinology (2005) 1.36
Anti-inflammatory and renal protective actions of stanniocalcin-1 in a model of anti-glomerular basement membrane glomerulonephritis. Am J Pathol (2009) 1.35
Resveratrol inhibits mTOR signaling by promoting the interaction between mTOR and DEPTOR. J Biol Chem (2010) 1.35
Lack of huntingtin-associated protein-1 causes neuronal death resembling hypothalamic degeneration in Huntington's disease. J Neurosci (2003) 1.35
Efficient drug screening and gene correction for treating liver disease using patient-specific stem cells. Hepatology (2013) 1.34
Latent TGF-beta1 protects against crescentic glomerulonephritis. J Am Soc Nephrol (2008) 1.33
Chemokines in renal injury. J Am Soc Nephrol (2011) 1.30
Role of TGF-beta signaling in extracellular matrix production under high glucose conditions. Kidney Int (2003) 1.29
A member of the Pyrin family, IFI16, is a novel BRCA1-associated protein involved in the p53-mediated apoptosis pathway. Oncogene (2003) 1.29
Signaling mechanism of renal fibrosis in unilateral ureteral obstructive kidney disease in ROCK1 knockout mice. J Am Soc Nephrol (2006) 1.28
HBsAg and HBx knocked into the p21 locus causes hepatocellular carcinoma in mice. Hepatology (2004) 1.28
Conditional inactivation of Fgfr1 in mouse defines its role in limb bud establishment, outgrowth and digit patterning. Development (2005) 1.27
Blockade of NFkappaB activation and renal inflammation by ultrasound-mediated gene transfer of Smad7 in rat remnant kidney. Kidney Int Suppl (2005) 1.26
Mechanism of chronic aristolochic acid nephropathy: role of Smad3. Am J Physiol Renal Physiol (2010) 1.24
Activation of p53 promotes renal injury in acute aristolochic acid nephropathy. J Am Soc Nephrol (2009) 1.24
Essential role for Smad3 in angiotensin II-induced tubular epithelial-mesenchymal transition. J Pathol (2010) 1.20
The role of Snapin in neurosecretion: snapin knock-out mice exhibit impaired calcium-dependent exocytosis of large dense-core vesicles in chromaffin cells. J Neurosci (2005) 1.20
Disruption of Smad4 impairs TGF-β/Smad3 and Smad7 transcriptional regulation during renal inflammation and fibrosis in vivo and in vitro. Kidney Int (2011) 1.20
Smad signaling in the neural crest regulates cardiac outflow tract remodeling through cell autonomous and non-cell autonomous effects. Dev Biol (2007) 1.18
Macrophage migration inhibitory factor induces MMP-9 expression in macrophages via the MEK-ERK MAP kinase pathway. J Interferon Cytokine Res (2007) 1.18
Smad4 is required to regulate the fate of cranial neural crest cells. Dev Biol (2007) 1.18
Association of genetic variants in the adiponectin gene with adiponectin level and hypertension in Hong Kong Chinese. Eur J Endocrinol (2010) 1.17
Transforming growth factor-β and Smads. Contrib Nephrol (2011) 1.17
Dietary restriction: standing up for sirtuins. Science (2010) 1.17
Conditional knockout of the Smad1 gene. Genesis (2002) 1.16
Absence of the full-length breast cancer-associated gene-1 leads to increased expression of insulin-like growth factor signaling axis members. Cancer Res (2006) 1.15
BMP signaling regulates sympathetic nervous system development through Smad4-dependent and -independent pathways. Development (2009) 1.15
Cell-nonautonomous induction of ovarian and uterine serous cystadenomas in mice lacking a functional Brca1 in ovarian granulosa cells. Curr Biol (2005) 1.14
Comparison of free fructose and glucose to sucrose in the ability to cause fatty liver. Eur J Nutr (2009) 1.12
Smad7 suppresses renal fibrosis via altering expression of TGF-β/Smad3-regulated microRNAs. Mol Ther (2012) 1.10
Integrated miRNA and mRNA expression profiling of mouse mammary tumor models identifies miRNA signatures associated with mammary tumor lineage. Genome Biol (2011) 1.09
Smad3 mediates ANG II-induced hypertensive kidney disease in mice. Am J Physiol Renal Physiol (2012) 1.09