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Kinetics and Mechanisms for the Cleavage and Isomerization of the Phosphodiester Bonds of RNA by Brønsted Acids and Bases.
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Chem Rev
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1998
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2.08
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2
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Yersiniophage phiR1-37 is a tailed bacteriophage having a 270 kb DNA genome with thymidine replaced by deoxyuridine.
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Microbiology
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2005
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1.22
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3
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Artificial ribonucleases.
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Org Biomol Chem
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2005
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1.18
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4
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Chemical models for ribozyme action.
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Curr Opin Chem Biol
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2005
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0.91
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5
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68Ga-labeled oligonucleotides for in vivo imaging with PET.
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J Nucl Med
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2004
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0.90
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6
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The reactivity of phosphodiester bonds within linear single-stranded oligoribonucleotides is strongly dependent on the base sequence.
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Nucleic Acids Res
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2002
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0.90
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7
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Synthesis of oligonucleotide glycoconjugates using sequential click and oximation ligations.
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Bioconjug Chem
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2010
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0.83
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8
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Derivatization of phosphopeptides with mercapto- and amino-functionalized conjugate groups by phosphate elimination and subsequent Michael addition.
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Org Biomol Chem
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2005
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0.82
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9
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Hybridization properties of support-bound oligonucleotides: the effect of the site of immobilization on the stability and selectivity of duplex formation.
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Bioconjug Chem
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2003
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0.82
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10
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Utilization of intrachain 4'-C-azidomethylthymidine for preparation of oligodeoxyribonucleotide conjugates by click chemistry in solution and on a solid support.
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Bioconjug Chem
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2008
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0.82
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11
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Solid-supported synthesis and click conjugation of 4'-C-alkyne functionalized oligodeoxyribonucleotides.
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Bioconjug Chem
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2010
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0.82
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12
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Hydrolytic reactions of diribonucleoside 3',5'-(3'-N-phosphoramidates): kinetics and mechanisms for the P-O and P-N bond cleavage of 3'-amino-3'-deoxyuridylyl-3',5'-uridine.
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J Am Chem Soc
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2002
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0.81
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13
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Solid-supported 2'-O-glycoconjugation of oligonucleotides by azidation and click reactions.
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Bioconjug Chem
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2011
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0.81
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14
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Thio effects on the departure of the 3'-linked ribonucleoside from diribonucleoside 3',3'-phosphorodithioate diesters and triribonucleoside 3',3',5'-phosphoromonothioate triesters: implications for ribozyme catalysis.
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Chemistry
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2007
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0.80
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15
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2,6-Bis(functionalized) purines as metal-ion-binding surrogate nucleobases that enhance hybridization with unmodified 2'-O-methyl oligoribonucleotides.
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Org Biomol Chem
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2013
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0.80
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16
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An Orthogonally Protected alpha,alpha-bis(aminomethyl)-beta-alanine building block for the construction of glycoconjugates on a solid support.
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J Org Chem
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2002
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0.80
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17
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Participation of an additional 4'-hydroxymethyl group in the cleavage and isomerization of ribonucleoside 3'-phosphodiesters.
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Org Biomol Chem
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2015
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0.80
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18
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Phosphodiester cleavage of ribonucleoside monophosphates and polyribonucleotides by homo- and heterodinuclear metal complexes of a cyclohexane-based polyamino-polyol ligand.
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Chemistry
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2003
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0.79
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19
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Solid-phase synthesis of multiantennary oligonucleotide glycoconjugates utilizing on-support oximation.
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Bioconjug Chem
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2004
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0.79
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20
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Stabilisation of the transition state of phosphodiester bond cleavage within linear single-stranded oligoribonucleotides.
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Org Biomol Chem
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2003
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0.79
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21
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Di(azacrown) conjugates of 2'-O-methyl oligoribonucleotides as sequence-selective artificial ribonucleases.
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Bioconjug Chem
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2007
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0.79
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22
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Acetylated and methylated β-cyclodextrins as viable soluble supports for the synthesis of short 2′-oligodeoxyribo-nucleotides in solution.
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Molecules
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2012
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0.79
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23
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Simultaneous interaction with base and phosphate moieties modulates the phosphodiester cleavage of dinucleoside 3',5'-monophosphates by dinuclear Zn2+ complexes of di(azacrown) ligands.
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J Am Chem Soc
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2006
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0.78
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24
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Base moiety selectivity in cleavage of short oligoribonucleotides by di- and tri-nuclear Zn(II) complexes of azacrown-derived ligands.
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Org Biomol Chem
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2009
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0.78
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25
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Bisphosphonate derivatives of nucleoside antimetabolites: hydrolytic stability and hydroxyapatite adsorption of 5'-beta,gamma-methylene and 5'-beta,gamma-(1-hydroxyethylidene) triphosphates of 5-fluorouridine and ara-cytidine.
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J Org Chem
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2008
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0.78
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26
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The base sequence dependent flexibility of linear single-stranded oligoribonucleotides correlates with the reactivity of the phosphodiester bond.
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Org Biomol Chem
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2003
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0.78
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27
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Solid-supported NOTA and DOTA chelators useful for the synthesis of 3'-radiometalated oligonucleotides.
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Bioconjug Chem
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2012
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0.78
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28
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Solid-supported synthesis of cryptand-like macrobicyclic peptides.
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J Org Chem
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2003
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0.77
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29
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Zn2+ complexes of di- and tri-nucleating azacrown ligands as base-moiety-selective cleaving agents of RNA 3',5'-phosphodiester bonds: binding to guanine base.
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Chembiochem
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2008
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0.77
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30
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Reactions of 9-substituted guanines with bromomalondialdehyde in aqueous solution predominantly yield glyoxal-derived adducts.
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Org Biomol Chem
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2004
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0.76
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31
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Preparation of azacrown-functionalized 2'-O-methyl oligoribonucleotides, potential artificial RNases.
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Bioconjug Chem
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2004
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0.76
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32
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Biodegradable protections for nucleoside 5'-monophosphates: comparative study on the removal of O-acetyl and O-acetyloxymethyl protected 3-hydroxy-2,2-bis(ethoxycarbonyl)propyl groups.
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J Org Chem
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2009
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0.76
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33
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Phosphoester Hydrolysis and Intramolecular Transesterification of Ribonucleoside 2'- and 3'-Phosphoromonothioate Triesters: Kinetics and Mechanisms for the Reactions of 5'-O-Methyluridine 2'- and 3'-Dimethylphosphoromonothioates.
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J Org Chem
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1997
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0.76
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34
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Pentaerythrityltetramine scaffolds for solid-phase combinatorial chemistry.
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J Org Chem
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2004
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0.76
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35
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Synthesis and enzymatic deprotection of fully protected 2'-5' oligoadenylates (2-5A): towards a prodrug strategy for short 2-5A.
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Chem Biodivers
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2012
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0.76
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36
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Hydrolytic reactions of thymidine 5'-o-phenyl-N-alkylphosphoramidates, models of nucleoside 5'-monophosphate prodrugs.
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Chemistry
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2007
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0.75
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37
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2,2-Disubstituted 4-acylthio-3-oxobutyl groups as esterase- and thermolabile protecting groups of phosphodiesters.
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J Org Chem
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2013
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0.75
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38
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3-Acetyloxy-2-cyano-2-(alkylaminocarbamoyl)propyl groups as biodegradable protecting groups of nucleoside 5´-mono-phosphates.
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Molecules
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2011
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0.75
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39
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Chemical and enzymatic stability of amino acid derived phosphoramidates of antiviral nucleoside 5'-monophosphates bearing a biodegradable protecting group.
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Org Biomol Chem
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2010
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0.75
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40
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A promising approach for treatment of tumor-induced bone diseases: utilizing bisphosphonate derivatives of nucleoside antimetabolites.
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Bone
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2010
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0.75
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41
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Preparation of hexaaza and heptaaza macrocycles functionalized with a single aminoalkyl pendant arm.
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Org Biomol Chem
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2003
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0.75
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42
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A mixed-phase immunoassay based on simultaneous binding of fluorescently tagged and PNA-conjugated peptide epitopes on antibodies: quantification on PNA-coated microparticles.
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Bioconjug Chem
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2006
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0.75
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43
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Solid-phase synthesis of 4(5),1',5'-trisubstituted 2,4'-biimidazoles.
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J Org Chem
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2009
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0.75
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44
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Metal ion promoted cleavage of RNA phosphodiester bonds: from Zn(II) aqua ion to artificial ribonucleases.
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Nucleic Acids Symp Ser (Oxf)
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2007
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0.75
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45
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Macrocyclic amines as catalysts of the hydrolysis of the triphosphate bridge of the mRNA 5'-cap structure.
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Org Biomol Chem
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2003
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0.75
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46
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Orthogonally protected cyclo-beta-tetrapeptides as solid-supported scaffolds for the synthesis of glycoclusters.
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J Org Chem
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2006
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0.75
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47
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The Zn(2+) complex of 1,4,7,10-tetraazacyclododecane as an artificial nucleobase.
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Nucleosides Nucleotides Nucleic Acids
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2011
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0.75
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48
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Effective anomerisation of 2'-deoxyadenosine derivatives during disaccharide nucleoside synthesis.
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Nucleosides Nucleotides Nucleic Acids
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2004
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0.75
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49
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Synthesis of phosphate-branched oligonucleotides.
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Bioconjug Chem
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2004
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0.75
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50
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Selective circular oligonucleotide probes improve detection of point mutations in DNA.
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Chem Biodivers
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2004
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0.75
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51
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Synthesis of modified nucleosides for incorporation of formyletheno and carboxyetheno adducts of adenine nucleosides into oligonucleotides.
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Nucleosides Nucleotides Nucleic Acids
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2007
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0.75
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52
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Synthesis of an oligonucleotide analogue of ethenoadenosine.
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Nucleosides Nucleotides Nucleic Acids
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2003
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0.75
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53
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Metal ion complexes of macrocyclic polyamines enhance both the phosphate hydrolysis and imidazole ring opening of RNA 5'-cap structure.
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Chem Biodivers
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2005
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0.75
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54
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Polyazacyclophanes incorporating two pyridine units and a heteroaromatic pendant group as potential cleaving agents of mRNA 5'-cap structure.
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Chem Biodivers
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2005
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0.75
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55
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Synthesis and cellular uptake of fluorescently labeled multivalent hyaluronan disaccharide conjugates of oligonucleotide phosphorothioates.
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Bioconjug Chem
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2008
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0.75
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56
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Bimetallic complexes of spiro-azacrown ligands as catalysts of phosphoester and phosphoric anhydride cleavage.
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Chem Biodivers
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2004
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0.75
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57
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Mixed-phase hybridization of short oligodeoxyribonucleotides on microscopic polymer particles: effect of one-base mismatches on duplex stability.
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Bioconjug Chem
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2002
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0.75
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58
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An aminooxy-functionalized non-nucleosidic phosphoramidite for the construction of multiantennary oligonucleotide glycoconjugates on a solid support.
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Curr Protoc Nucleic Acid Chem
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2005
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0.75
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59
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Sequence-selective cleavage of oligoribonucleotides by 3d transition metal complexes of 1,5,9-triazacyclododecane-functionalized 2'-O-methyl oligoribonucleotides.
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Bioconjug Chem
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2004
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0.75
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60
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Synthesis and enzymatic deprotection of biodegradably protected dinucleoside-2',5'-monophosphates: 3-(acetyloxy)-2,2-bis(ethoxycarbonyl)propyl phosphoesters of 3'-O-(acyloxymethyl)adenylyl-2',5'-adenosines.
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Chem Biodivers
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2011
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0.75
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61
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The cleavage of the triphosphate bridge of a model for the 5'-cap mRNA promoted by dinuclear bicyclic complexes with metal ions.
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Nucleosides Nucleotides Nucleic Acids
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2003
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0.75
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62
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Phosphodiester cleavage of guanylyl-(3',3')-(2'-amino-2'-deoxyuridine): rate acceleration by the 2'-amino function.
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J Am Chem Soc
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2005
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0.75
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63
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Intramolecular participation of amino groups in the cleavage and isomerization of ribonucleoside 3'-phosphodiesters: the role in stabilization of the phosphorane intermediate.
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Chemistry
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2013
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0.75
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64
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2,2-Bis(ethoxycarbonyl)- and 2-(alkylaminocarbonyl)-2-cyano-substituted 3-(pivaloyloxy)propyl groups as biodegradable phosphate protections of oligonucleotides.
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Bioconjug Chem
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2005
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0.75
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65
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Hydrolysis of a mRNA 5'-cap model substrate, 5',5'-ApppA by di- and trinuclear zinc(II) complexes of a polyamino-polyol ligand.
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J Inorg Biochem
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2005
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0.75
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66
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Solid-phase synthesis of 7-substituted 3H-imidazo[2,1-i]purines.
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Org Biomol Chem
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2006
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0.75
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67
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Solid-phase synthesis of oligonucleotide glycoconjugates bearing three different glycosyl groups: orthogonally protected bis(hydroxymethyl)-N,N'-bis(3-hydroxypropyl)malondiamide phosphoramidite as key building block.
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J Org Chem
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2004
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0.75
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68
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Quantification of mixed-phase hybridization on polymer microparticles by europium(III) ion fluorescence.
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Methods Mol Biol
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2007
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0.75
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69
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A comparative study on the cleavage of stereoisomeric uridylyl(3',5')uridines [D,D-, D,L- and L,D-UpU] by acid, base and metal ion catalysts.
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Orig Life Evol Biosph
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2002
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0.75
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