Published in Crit Care on February 22, 2010
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How does xenon produce anaesthesia? Nature (1998) 1.49
Xenon preconditioning protects against renal ischemic-reperfusion injury via HIF-1alpha activation. J Am Soc Nephrol (2009) 1.43
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Noble gases without anesthetic properties protect myocardium against infarction by activating prosurvival signaling kinases and inhibiting mitochondrial permeability transition in vivo. Anesth Analg (2007) 1.24
Neuroprotection (and lack of neuroprotection) afforded by a series of noble gases in an in vitro model of neuronal injury. Neurosci Lett (2009) 1.22
Neuronal preconditioning by inhalational anesthetics: evidence for the role of plasmalemmal adenosine triphosphate-sensitive potassium channels. Anesthesiology (2009) 1.18
The common chemical motifs within anesthetic binding sites. Anesth Analg (2007) 1.13
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Post-ischemic helium provides neuroprotection in rats subjected to middle cerebral artery occlusion-induced ischemia by producing hypothermia. J Cereb Blood Flow Metab (2009) 0.93
The impact of benzodiazepines on occurrence of pneumonia and mortality from pneumonia: a nested case-control and survival analysis in a population-based cohort. Thorax (2012) 4.40
The alpha2-adrenoceptor agonist dexmedetomidine converges on an endogenous sleep-promoting pathway to exert its sedative effects. Anesthesiology (2003) 3.19
Role of interleukin-1beta in postoperative cognitive dysfunction. Ann Neurol (2010) 3.09
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus. Anesthesiology (2007) 3.02
Postoperative cognitive dysfunction after noncardiac surgery: a systematic review. Anesthesiology (2007) 2.89
Tumor necrosis factor-alpha triggers a cytokine cascade yielding postoperative cognitive decline. Proc Natl Acad Sci U S A (2010) 2.70
Preoperative medical testing in Medicare patients undergoing cataract surgery. N Engl J Med (2015) 2.41
Biologic effects of nitrous oxide: a mechanistic and toxicologic review. Anesthesiology (2008) 2.29
High-mobility group box 1 protein initiates postoperative cognitive decline by engaging bone marrow-derived macrophages. Anesthesiology (2014) 2.24
Dexmedetomidine attenuates isoflurane-induced neurocognitive impairment in neonatal rats. Anesthesiology (2009) 2.24
Isoflurane, a commonly used volatile anesthetic, enhances renal cancer growth and malignant potential via the hypoxia-inducible factor cellular signaling pathway in vitro. Anesthesiology (2013) 2.23
Hypothermia and other treatment options for neonatal encephalopathy: an executive summary of the Eunice Kennedy Shriver NICHD workshop. J Pediatr (2011) 2.22
Bundled payments in total joint arthroplasty: targeting opportunities for quality improvement and cost reduction. Clin Orthop Relat Res (2014) 2.05
Effect of dexmedetomidine versus lorazepam on outcome in patients with sepsis: an a priori-designed analysis of the MENDS randomized controlled trial. Crit Care (2010) 1.97
Competitive inhibition at the glycine site of the N-methyl-D-aspartate receptor by the anesthetics xenon and isoflurane: evidence from molecular modeling and electrophysiology. Anesthesiology (2007) 1.97
Dexmedetomidine for prevention of postoperative delirium in older adults undergoing oesophagectomy with total intravenous anaesthesia: A double-blind, randomised clinical trial. Eur J Anaesthesiol (2021) 1.92
The protective profile of argon, helium, and xenon in a model of neonatal asphyxia in rats. Crit Care Med (2012) 1.85
The neuroprotective effect of xenon administration during transient middle cerebral artery occlusion in mice. Anesthesiology (2003) 1.83
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Xenon mitigates isoflurane-induced neuronal apoptosis in the developing rodent brain. Anesthesiology (2007) 1.80
Perioperative cognitive decline in the aging population. Mayo Clin Proc (2011) 1.66
The role of HMGB1 in inflammation-mediated organ injury. Acta Anaesthesiol Taiwan (2013) 1.60
The impact of IL-1 modulation on the development of lipopolysaccharide-induced cognitive dysfunction. Crit Care (2010) 1.59
Benzodiazepine augmented γ-amino-butyric acid signaling increases mortality from pneumonia in mice. Crit Care Med (2013) 1.56
Dexmedetomidine produces its neuroprotective effect via the alpha 2A-adrenoceptor subtype. Eur J Pharmacol (2004) 1.54
Role of endogenous sleep-wake and analgesic systems in anesthesia. J Comp Neurol (2008) 1.53
A multicenter dose-escalation study of the analgesic and adverse effects of an oral cannabis extract (Cannador) for postoperative pain management. Anesthesiology (2006) 1.52
Feasibility and cardiac safety of inhaled xenon in combination with therapeutic hypothermia following out-of-hospital cardiac arrest. Crit Care Med (2013) 1.45
Xenon preconditioning protects against renal ischemic-reperfusion injury via HIF-1alpha activation. J Am Soc Nephrol (2009) 1.43
Transient regional hypothermia applied to a traumatic limb attenuates distant lung injury following blast limb trauma. Crit Care Med (2014) 1.43
Dexmedetomidine provides renoprotection against ischemia-reperfusion injury in mice. Crit Care (2011) 1.40
Expansion of gas bubbles by nitrous oxide and xenon. Anesthesiology (2006) 1.40
The "Friday effect": Can epidemiology tell us when to operate? Can J Anaesth (2015) 1.38
The involvement of hypothalamic sleep pathways in general anesthesia: testing the hypothesis using the GABAA receptor beta3N265M knock-in mouse. J Neurosci (2009) 1.37
Cognitive decline following major surgery is associated with gliosis, β-amyloid accumulation, and τ phosphorylation in old mice. Crit Care Med (2010) 1.35
Dexmedetomidine: another arrow for the clinician's quiver. Anesthesiology (2004) 1.28
Xenon and hypothermia combine to provide neuroprotection from neonatal asphyxia. Ann Neurol (2005) 1.27
Attentional effects of noradrenaline vary with arousal level: selective activation of thalamic pulvinar in humans. Neuroimage (2004) 1.22
Neuroprotection (and lack of neuroprotection) afforded by a series of noble gases in an in vitro model of neuronal injury. Neurosci Lett (2009) 1.22
Sedation & immunomodulation. Crit Care Clin (2009) 1.21
Retinal nerve fiber layer structure abnormalities in early Alzheimer's disease: evidence in optical coherence tomography. Neurosci Lett (2010) 1.21
Xenon preconditioning reduces brain damage from neonatal asphyxia in rats. J Cereb Blood Flow Metab (2006) 1.21
Comparative analgesic and mental effects of increasing plasma concentrations of dexmedetomidine and alfentanil in humans. Anesthesiology (2004) 1.20
Cancer recurrence after surgery: direct and indirect effects of anesthetic agents. Int J Cancer (2011) 1.18
Neuronal preconditioning by inhalational anesthetics: evidence for the role of plasmalemmal adenosine triphosphate-sensitive potassium channels. Anesthesiology (2009) 1.18
alpha2-Adrenoceptor agonists: shedding light on neuroprotection? Br Med Bull (2005) 1.17
Anticipating and managing postoperative delirium and cognitive decline in adults. BMJ (2011) 1.16
Xenon augmented hypothermia reduces early lactate/N-acetylaspartate and cell death in perinatal asphyxia. Ann Neurol (2011) 1.13
Effect of noble gases on oxygen and glucose deprived injury in human tubular kidney cells. Exp Biol Med (Maywood) (2010) 1.13
Nociceptive stimuli enhance anesthetic-induced neuroapoptosis in the rat developing brain. Neurobiol Dis (2011) 1.11
General anesthetics induce apoptotic neurodegeneration in the neonatal rat spinal cord. Anesth Analg (2008) 1.09
Sedation improves early outcome in severely septic Sprague Dawley rats. Crit Care (2009) 1.07
Predicting perioperative risk and informed consent. Ann Surg (2015) 1.07
Depletion of bone marrow-derived macrophages perturbs the innate immune response to surgery and reduces postoperative memory dysfunction. Anesthesiology (2013) 1.07
Xenon pretreatment attenuates anesthetic-induced apoptosis in the developing brain in comparison with nitrous oxide and hypoxia. Anesthesiology (2010) 1.05
Molecular mechanisms transducing the anesthetic, analgesic, and organ-protective actions of xenon. Anesthesiology (2006) 1.05
Isoflurane and nociception: spinal alpha2A adrenoceptors mediate antinociception while supraspinal alpha1 adrenoceptors mediate pronociception. Anesthesiology (2002) 1.04
Effects of xenon on in vitro and in vivo models of neuronal injury. Anesthesiology (2002) 1.04
Systemic inflammation enhances surgery-induced cognitive dysfunction in mice. Neurosci Lett (2011) 1.04
Dysfunction of inflammation-resolving pathways is associated with exaggerated postoperative cognitive decline in a rat model of the metabolic syndrome. Mol Med (2013) 1.03
Surgery results in exaggerated and persistent cognitive decline in a rat model of the Metabolic Syndrome. Anesthesiology (2013) 1.03
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Polymorphisms in the MAOA, MAOB, and COMT genes and aggressive behavior in schizophrenia. Am J Med Genet B Neuropsychiatr Genet (2004) 1.03
The neuroinflammatory response of postoperative cognitive decline. Br Med Bull (2013) 1.01
Central nervous system inflammation in disease related conditions: mechanistic prospects. Brain Res (2012) 1.01
Xenon attenuates cardiopulmonary bypass-induced neurologic and neurocognitive dysfunction in the rat. Anesthesiology (2003) 1.00
Preconditioning and postinsult therapies for perinatal hypoxic-ischemic injury at term. Anesthesiology (2010) 0.97
Statins: the role in the treatment and prevention of Alzheimer's neurodegeneration. J Alzheimers Dis (2011) 0.97