Published in Anal Bioanal Chem on March 19, 2010
A Carbonyl Capture Approach for Profiling Oxidized Metabolites in Cell Extracts. Metabolomics (2012) 0.93
Current Challenges in Volatile Organic Compounds Analysis as Potential Biomarkers of Cancer. J Biomark (2015) 0.87
Mass spectrometry of fatty aldehydes. Biochim Biophys Acta (2011) 0.83
Enhancement by N-hydroxysulfosuccinimide of water-soluble carbodiimide-mediated coupling reactions. Anal Biochem (1986) 4.11
Nucleophilic catalysis of oxime ligation. Angew Chem Int Ed Engl (2006) 2.69
Zero-length crosslinking procedure with the use of active esters. Anal Biochem (1990) 2.63
Oxidative stress in brain aging, neurodegenerative and vascular diseases: an overview. J Chromatogr B Analyt Technol Biomed Life Sci (2005) 1.86
Routes to 4-hydroxynonenal: fundamental issues in the mechanisms of lipid peroxidation. J Biol Chem (2008) 1.76
Enhancement of the LC/MS analysis of fatty acids through derivatization and stable isotope coding. Anal Chem (2007) 1.37
Determination of patterns of biologically relevant aldehydes in exhaled breath condensate of healthy subjects by liquid chromatography/atmospheric chemical ionization tandem mass spectrometry. Rapid Commun Mass Spectrom (2003) 1.31
Enhancement of amino acid detection and quantification by electrospray ionization mass spectrometry. Anal Chem (2006) 1.27
Methods for determination of aldehydic lipid peroxidation products. Free Radic Biol Med (1989) 1.25
Mechanism of amide formation by carbodiimide for bioconjugation in aqueous media. Bioconjug Chem (1995) 1.22
Electrospray mass spectrometry and fragmentation of N-linked carbohydrates derivatized at the reducing terminus. J Am Soc Mass Spectrom (2000) 1.22
Derivatization of neutral steroids to enhance their detection characteristics in liquid chromatography-mass spectrometry. Anal Bioanal Chem (2003) 1.12
Derivatisation for the characterisation of neutral oxosteroids by electrospray and matrix-assisted laser desorption/ionisation tandem mass spectrometry: the Girard P derivative. Rapid Commun Mass Spectrom (2003) 1.07
Derivatization with Girard reagent T combined with LC-MS/MS for the sensitive detection of 5-formyl-2'-deoxyuridine in cellular DNA. Anal Chem (2007) 0.95
Intra-molecular cross-linking of acidic residues for protein structure studies. Eur J Mass Spectrom (Chichester, Eng) (2008) 0.92
Electrospray tandem mass spectrometric study of alkyl 1-methylpyridinium ether derivatives of alcohols. J Mass Spectrom (2001) 0.92
Derivatisation for liquid chromatography/electrospray mass spectrometry: synthesis of pyridinium compounds and their amine and carboxylic acid derivatives. Rapid Commun Mass Spectrom (2003) 0.89
Structure Elucidation of 2,4-Dinitrophenylhydrazone Derivatives of Carbonyl Compounds in Ambient Air by HPLC/MS and Multiple MS/MS Using Atmospheric Chemical Ionization in the Negative Ion Mode. Anal Chem (1998) 0.89
Development of a selective ESI-MS derivatization reagent: synthesis and optimization for the analysis of aldehydes in biological mixtures. Anal Chem (2008) 0.88
A modified Girard derivatizing reagent for universal profiling and trace analysis of aldehydes and ketones by electrospray ionization tandem mass spectrometry. Rapid Commun Mass Spectrom (2007) 0.88
Determination of (22R,S)budesonide in human plasma by automated liquid chromatography/thermospray mass spectrometry. Biol Mass Spectrom (1992) 0.87
Aqueous in situ derivatization of carboxylic acids by an ionic carbodiimide and 2,2,2-trifluoroethylamine for electron-capture detection. J Chromatogr A (2007) 0.87
Analysis of derivatized biogenic aldehydes by LC tandem mass spectrometry. Anal Chem (2005) 0.86
Comparison of different amino acid derivatives and analysis of rat brain microdialysates by liquid chromatography tandem mass spectrometry. Anal Chim Acta (2008) 0.86
Atmospheric pressure chemical ionization mass spectrometry of aldehydes in biological matrices. Rapid Commun Mass Spectrom (2004) 0.84
Development of an on-line weak-cation exchange liquid chromatography-tandem mass spectrometric method for screening aldehyde products in biological matrices. J Chromatogr B Analyt Technol Biomed Life Sci (2009) 0.83
Liquid chromatography-mass spectrometry method for the determination of aldehydes derivatized by the Hantzsch reaction. J Chromatogr A (1999) 0.81
Derivatization to improve thermospray HPLC/MS sensitivity for the determination of prostaglandins and thromboxane B2. Biomed Environ Mass Spectrom (1987) 0.80
Design of unsymmetrical azo initiators to increase radical generation efficiency in low-density lipoproteins. Free Radic Res (2000) 0.78
Screening and optimization of derivatization in heating block for the determination of aliphatic aldehydes by HPLC. J Biochem Biophys Methods (2006) 0.77
The histamine H3 receptor: from gene cloning to H3 receptor drugs. Nat Rev Drug Discov (2005) 1.67
Analytical separation and detection methods for flavonoids. J Chromatogr A (2006) 1.36
Determination of patterns of biologically relevant aldehydes in exhaled breath condensate of healthy subjects by liquid chromatography/atmospheric chemical ionization tandem mass spectrometry. Rapid Commun Mass Spectrom (2003) 1.31
Diazepam-bound GABAA receptor models identify new benzodiazepine binding-site ligands. Nat Chem Biol (2012) 1.31
Crystal structure-based virtual screening for fragment-like ligands of the human histamine H(1) receptor. J Med Chem (2011) 1.30
Pentameric ligand-gated ion channel ELIC is activated by GABA and modulated by benzodiazepines. Proc Natl Acad Sci U S A (2012) 1.22
Fragment based design of new H4 receptor-ligands with anti-inflammatory properties in vivo. J Med Chem (2008) 1.20
Keynote review: histamine H3 receptor antagonists reach out for the clinic. Drug Discov Today (2005) 1.19
Chemical insights in the concept of hybrid drugs: the antitumor effect of nitric oxide-donating aspirin involves a quinone methide but not nitric oxide nor aspirin. J Med Chem (2007) 1.18
Towards small-molecule CXCR3 ligands with clinical potential. ChemMedChem (2008) 1.11
Use of acetylcholine binding protein in the search for novel alpha7 nicotinic receptor ligands. In silico docking, pharmacological screening, and X-ray analysis. J Med Chem (2009) 1.11
Transforming fragments into candidates: small becomes big in medicinal chemistry. Drug Discov Today (2009) 1.09
Molecular and biochemical pharmacology of the histamine H4 receptor. Br J Pharmacol (2009) 1.06
Biosensor discovery of thyroxine transport disrupting chemicals. Toxicol Appl Pharmacol (2008) 1.04
Antiinflammatory and antinociceptive effects of the selective histamine H4-receptor antagonists JNJ7777120 and VUF6002 in a rat model of carrageenan-induced acute inflammation. Eur J Pharmacol (2007) 1.04
CC12, a high-affinity ligand for [3H]cimetidine binding, is an improgan antagonist. Neuropharmacology (2007) 1.02
Fragment growing induces conformational changes in acetylcholine-binding protein: a structural and thermodynamic analysis. J Am Chem Soc (2011) 1.00
Catechol pyrazolinones as trypanocidals: fragment-based design, synthesis, and pharmacological evaluation of nanomolar inhibitors of trypanosomal phosphodiesterase B1. J Med Chem (2012) 0.99
Noncompetitive antagonism and inverse agonism as mechanism of action of nonpeptidergic antagonists at primate and rodent CXCR3 chemokine receptors. J Pharmacol Exp Ther (2008) 0.99
Protein digestion: an overview of the available techniques and recent developments. J Proteome Res (2013) 0.98
Discovery of quinazolines as histamine H4 receptor inverse agonists using a scaffold hopping approach. J Med Chem (2008) 0.98
Sex- and histamine-dependent long-term cognitive effects of methamphetamine exposure. Neuropsychopharmacology (2006) 0.96
Synthesis and structure-activity relationship of the first nonpeptidergic inverse agonists for the human cytomegalovirus encoded chemokine receptor US28. J Med Chem (2005) 0.96
Online fluorescence enhancement assay for the acetylcholine binding protein with parallel mass spectrometric identification. J Med Chem (2010) 0.96
Antinociceptive activity of chemical congeners of improgan: optimization of side chain length leads to the discovery of a new, potent, non-opioid analgesic. Neuropharmacology (2006) 0.96
Rapid dereplication of estrogenic compounds in pomegranate (Punica granatum) using on-line biochemical detection coupled to mass spectrometry. Phytochemistry (2004) 0.95
Molecular determinants of ligand binding to H4R species variants. Mol Pharmacol (2010) 0.93
Bioanalytical LC-MS/MS of protein-based biopharmaceuticals. J Chromatogr B Analyt Technol Biomed Life Sci (2013) 0.92
Phenylalanine 169 in the second extracellular loop of the human histamine H4 receptor is responsible for the difference in agonist binding between human and mouse H4 receptors. J Pharmacol Exp Ther (2008) 0.92
Recent Advancements in the LC- and GC-Based Analysis of Malondialdehyde (MDA): A Brief Overview. Chromatographia (2012) 0.92
Discovery of novel Trypanosoma brucei phosphodiesterase B1 inhibitors by virtual screening against the unliganded TbrPDEB1 crystal structure. J Med Chem (2013) 0.91
Identification and analysis of products formed from phospholipids in the free radical oxidation of human low density lipoproteins. J Lipid Res (2004) 0.91
Determining acetylcholinesterase inhibitory activity in plant extracts using a fluorimetric flow assay. Phytochem Anal (2003) 0.90
Identification of a novel scaffold for allosteric inhibition of wild type and drug resistant HIV-1 reverse transcriptase by fragment library screening. J Med Chem (2011) 0.89
On-line coupling of high-performance liquid chromatography to a continuous-flow enzyme assay based on electrospray ionization mass spectrometry. Anal Chem (2004) 0.89
Discovery of S-(2-guanidylethyl)-isothiourea (VUF 8430) as a potent nonimidazole histamine H4 receptor agonist. J Med Chem (2006) 0.88
Studying protein-protein affinity and immobilized ligand-protein affinity interactions using MS-based methods. Anal Bioanal Chem (2011) 0.88
KLIFS: a knowledge-based structural database to navigate kinase-ligand interaction space. J Med Chem (2013) 0.88
Development of a selective ESI-MS derivatization reagent: synthesis and optimization for the analysis of aldehydes in biological mixtures. Anal Chem (2008) 0.88
Acetylcholine binding protein (AChBP) as template for hierarchical in silico screening procedures to identify structurally novel ligands for the nicotinic receptors. Bioorg Med Chem (2011) 0.87
Development of an online p38α mitogen-activated protein kinase binding assay and integration of LC-HR-MS. Anal Bioanal Chem (2010) 0.87
Determination and identification of estrogenic compounds generated with biosynthetic enzymes using hyphenated screening assays, high resolution mass spectrometry and off-line NMR. J Chromatogr B Analyt Technol Biomed Life Sci (2010) 0.87
Recent developments in protein-ligand affinity mass spectrometry. Anal Bioanal Chem (2010) 0.87
Pharmacological characterization of the new histamine H4 receptor agonist VUF 8430. Br J Pharmacol (2009) 0.87
Development of a countergradient parking system for gradient liquid chromatography with online biochemical detection of serine protease inhibitors. Anal Chem (2008) 0.87
A microfluidic-based enzymatic assay for bioactivity screening combined with capillary liquid chromatography and mass spectrometry. Lab Chip (2005) 0.86
Advances in mass spectrometry-based post-column bioaffinity profiling of mixtures. Anal Bioanal Chem (2010) 0.86
Fragment library screening reveals remarkable similarities between the G protein-coupled receptor histamine H₄ and the ion channel serotonin 5-HT₃A. Bioorg Med Chem Lett (2011) 0.86
From heptahelical bundle to hits from the Haystack: structure-based virtual screening for GPCR ligands. Methods Enzymol (2013) 0.86
Online biochemical detection of glutathione-S-transferase P1-specific inhibitors in complex mixtures. J Biomol Screen (2007) 0.86
Rapid on-line profiling of estrogen receptor binding metabolites of tamoxifen. J Med Chem (2006) 0.86
Design, synthesis, and structure-activity relationships of highly potent 5-HT₃ receptor ligands. J Med Chem (2012) 0.85
Major advances in the development of histamine H4 receptor ligands. Drug Discov Today (2009) 0.85
Fragmentation pathways of drugs of abuse and their metabolites based on QTOF MS/MS and MS(E) accurate-mass spectra. J Mass Spectrom (2011) 0.85
En route to new blockbuster anti-histamines: surveying the offspring of the expanding histamine receptor family. Trends Pharmacol Sci (2011) 0.85
Delineation of agonist binding to the human histamine H4 receptor using mutational analysis, homology modeling, and ab initio calculations. J Chem Inf Model (2008) 0.85
Development of a simplified method for the simultaneous determination of retinol, alpha-tocopherol, and beta-carotene in serum by liquid chromatography-tandem mass spectrometry with atmospheric pressure chemical ionization. Anal Bioanal Chem (2003) 0.85
Identification of overlapping but differential binding sites for the high-affinity CXCR3 antagonists NBI-74330 and VUF11211. Mol Pharmacol (2013) 0.85
Synthesis and pharmacological characterization of novel inverse agonists acting on the viral-encoded chemokine receptor US28. Bioorg Med Chem (2006) 0.85
Metabolic profiling of endocrine-disrupting compounds by on-line cytochrome p450 bioreaction coupled to on-line receptor affinity screening. Chem Res Toxicol (2007) 0.84
Target immobilization as a strategy for NMR-based fragment screening: comparison of TINS, STD, and SPR for fragment hit identification. J Biomol Screen (2010) 0.84
Virtual fragment screening: discovery of histamine H3 receptor ligands using ligand-based and protein-based molecular fingerprints. J Chem Inf Model (2012) 0.84
N-substituted piperidinyl alkyl imidazoles: discovery of methimepip as a potent and selective histamine H3 receptor agonist. J Med Chem (2005) 0.84
Fragment based lead discovery of small molecule inhibitors for the EPHA4 receptor tyrosine kinase. Eur J Med Chem (2011) 0.84
Assembly of a π-π stack of ligands in the binding site of an acetylcholine-binding protein. Nat Commun (2013) 0.84
Characterization of the histamine H4 receptor binding site. Part 1. Synthesis and pharmacological evaluation of dibenzodiazepine derivatives. J Med Chem (2006) 0.84
Fatty acid profiling of raw human plasma and whole blood using direct thermal desorption combined with gas chromatography-mass spectrometry. J Chromatogr A (2007) 0.84
A high-throughput sample preparation method for cellular proteomics using 96-well filter plates. Proteomics (2013) 0.84