Published in Am J Physiol Endocrinol Metab on February 09, 2010
Excess leucine intake enhances muscle anabolic signaling but not net protein anabolism in young men and women. J Nutr (2010) 1.51
Timing and distribution of protein ingestion during prolonged recovery from resistance exercise alters myofibrillar protein synthesis. J Physiol (2013) 1.49
Supplementation of a suboptimal protein dose with leucine or essential amino acids: effects on myofibrillar protein synthesis at rest and following resistance exercise in men. J Physiol (2012) 1.46
Bed rest impairs skeletal muscle amino acid transporter expression, mTORC1 signaling, and protein synthesis in response to essential amino acids in older adults. Am J Physiol Endocrinol Metab (2012) 1.41
mTor signaling in skeletal muscle during sepsis and inflammation: where does it all go wrong? Physiology (Bethesda) (2011) 1.16
Skeletal muscle amino acid transporter expression is increased in young and older adults following resistance exercise. J Appl Physiol (1985) (2011) 1.11
Role of amino acid transporters in amino acid sensing. Am J Clin Nutr (2013) 1.11
Consilience in sarcopenia of cirrhosis. J Cachexia Sarcopenia Muscle (2012) 1.08
Myocardial oxidative metabolism and protein synthesis during mechanical circulatory support by extracorporeal membrane oxygenation. Am J Physiol Heart Circ Physiol (2012) 1.02
Exercise, amino acids, and aging in the control of human muscle protein synthesis. Med Sci Sports Exerc (2011) 1.00
Age-related differences in lean mass, protein synthesis and skeletal muscle markers of proteolysis after bed rest and exercise rehabilitation. J Physiol (2015) 0.99
Short-term bed rest increases TLR4 and IL-6 expression in skeletal muscle of older adults. Am J Physiol Regul Integr Comp Physiol (2013) 0.99
Increased plasma citrulline in mice marks diet-induced obesity and may predict the development of the metabolic syndrome. PLoS One (2013) 0.98
Membrane transporters for the special amino acid glutamine: structure/function relationships and relevance to human health. Front Chem (2014) 0.96
Nutritional regulation of muscle protein synthesis with resistance exercise: strategies to enhance anabolism. Nutr Metab (Lond) (2012) 0.95
Exercise and amino acid anabolic cell signaling and the regulation of skeletal muscle mass. Nutrients (2012) 0.93
Resistance Exercise Training Alters Mitochondrial Function in Human Skeletal Muscle. Med Sci Sports Exerc (2015) 0.93
The catalytic subunit of the system L1 amino acid transporter (slc7a5) facilitates nutrient signalling in mouse skeletal muscle. PLoS One (2014) 0.92
Aging differentially affects human skeletal muscle amino acid transporter expression when essential amino acids are ingested after exercise. Clin Nutr (2012) 0.91
The SLC38 family of sodium-amino acid co-transporters. Pflugers Arch (2013) 0.91
Survival by self-destruction: a role for autophagy in the placenta? Placenta (2012) 0.90
Dihydrotestosterone stimulates amino acid uptake and the expression of LAT2 in mouse skeletal muscle fibres through an ERK1/2-dependent mechanism. J Physiol (2011) 0.89
Leucine pulses enhance skeletal muscle protein synthesis during continuous feeding in neonatal pigs. Am J Physiol Endocrinol Metab (2013) 0.89
Addition of carbohydrate or alanine to an essential amino acid mixture does not enhance human skeletal muscle protein anabolism. J Nutr (2013) 0.87
Role of Ingested Amino Acids and Protein in the Promotion of Resistance Exercise-Induced Muscle Protein Anabolism. J Nutr (2016) 0.86
Soy-dairy protein blend and whey protein ingestion after resistance exercise increases amino acid transport and transporter expression in human skeletal muscle. J Appl Physiol (1985) (2014) 0.86
Abundance of amino acid transporters involved in mTORC1 activation in skeletal muscle of neonatal pigs is developmentally regulated. Amino Acids (2012) 0.86
Leucine-enriched amino acid ingestion after resistance exercise prolongs myofibrillar protein synthesis and amino acid transporter expression in older men. J Nutr (2014) 0.86
Regulation of protein synthesis by amino acids in muscle of neonates. Front Biosci (Landmark Ed) (2011) 0.85
Gene expression of carnosine-related enzymes and transporters in skeletal muscle. Eur J Appl Physiol (2012) 0.84
Clinical use of amino acids as dietary supplement: pros and cons. J Cachexia Sarcopenia Muscle (2011) 0.84
Downregulation of E3 ubiquitin ligases and mitophagy-related genes in skeletal muscle of physically inactive, frail older women: a cross-sectional comparison. J Gerontol A Biol Sci Med Sci (2014) 0.84
Dose-dependent increases in p70S6K phosphorylation and intramuscular branched-chain amino acids in older men following resistance exercise and protein intake. Physiol Rep (2014) 0.84
Essential amino acid sensing, signaling, and transport in the regulation of human muscle protein metabolism. Curr Opin Clin Nutr Metab Care (2011) 0.83
Dietary protein considerations to support active aging. Sports Med (2014) 0.81
Sepsis-induced changes in amino acid transporters and leucine signaling via mTOR in skeletal muscle. Amino Acids (2014) 0.81
Anti-1-amino-3-18F-fluorocyclobutane-1-carboxylic acid: physiologic uptake patterns, incidental findings, and variants that may simulate disease. J Nucl Med (2014) 0.80
A soy, whey and caseinate blend extends postprandial skeletal muscle protein synthesis in rats. Clin Nutr (2012) 0.79
Amino acid transporters in the regulation of human skeletal muscle protein metabolism. Curr Opin Clin Nutr Metab Care (2013) 0.79
Whey protein intake after resistance exercise activates mTOR signaling in a dose-dependent manner in human skeletal muscle. Eur J Appl Physiol (2014) 0.79
Bolus ingestion of individual branched-chain amino acids alters plasma amino acid profiles in young healthy men. Springerplus (2014) 0.78
Amino Acid Sensing in Skeletal Muscle. Trends Endocrinol Metab (2016) 0.78
Insulin increases mRNA abundance of the amino acid transporter SLC7A5/LAT1 via an mTORC1-dependent mechanism in skeletal muscle cells. Physiol Rep (2014) 0.77
Effects of Whey, Caseinate, or Milk Protein Ingestion on Muscle Protein Synthesis after Exercise. Nutrients (2016) 0.77
Keeping older muscle “young” through dietary protein and physical activity. Adv Nutr (2014) 0.77
Skeletal muscle Ras-related GTP binding B mRNA and protein expression is increased after essential amino acid ingestion in healthy humans. J Nutr (2014) 0.76
Myosin heavy chain 2A and α-actin expression in human and murine skeletal muscles at feeding; particularly amino acids. J Transl Med (2012) 0.76
Pulsatile delivery of a leucine supplement during long-term continuous enteral feeding enhances lean growth in term neonatal pigs. Am J Physiol Endocrinol Metab (2016) 0.75
High-resolution myogenic lineage mapping by single-cell mass cytometry. Nat Cell Biol (2017) 0.75
Differential effects of military training on fat-free mass and plasma amino acid adaptations in men and women. Nutrients (2012) 0.75
Transcriptome Analysis and Postprandial Expression of Amino Acid Transporter Genes in the Fast Muscles and Gut of Chinese Perch (Siniperca chuatsi). PLoS One (2016) 0.75
Prolonged Calorie Restriction Downregulates Skeletal Muscle mTORC1 Signaling Independent of Dietary Protein Intake and Associated microRNA Expression. Front Physiol (2016) 0.75
Essential amino acid ingestion alters expression of genes associated with amino acid sensing, transport, and mTORC1 regulation in human skeletal muscle. Nutr Metab (Lond) (2017) 0.75
Effect of light-load resistance exercise on postprandial amino acid transporter expression in elderly men. Physiol Rep (2017) 0.75
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods (2001) 414.27
Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol (2002) 82.19
An integrated stress response regulates amino acid metabolism and resistance to oxidative stress. Mol Cell (2003) 15.12
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science (2008) 14.08
Translational regulation of GCN4 and the general amino acid control of yeast. Annu Rev Microbiol (2005) 11.48
Coping with stress: eIF2 kinases and translational control. Biochem Soc Trans (2006) 7.69
Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle. FASEB J (2004) 4.41
The GCN2 eIF2alpha kinase is required for adaptation to amino acid deprivation in mice. Mol Cell Biol (2002) 3.22
Molecular biology of mammalian plasma membrane amino acid transporters. Physiol Rev (1998) 3.10
Resistance exercise increases AMPK activity and reduces 4E-BP1 phosphorylation and protein synthesis in human skeletal muscle. J Physiol (2006) 3.08
Amino acid regulation of TOR complex 1. Am J Physiol Endocrinol Metab (2008) 3.03
Leg blood flow during exercise in man. Clin Sci (1971) 2.97
Leucine stimulates translation initiation in skeletal muscle of postabsorptive rats via a rapamycin-sensitive pathway. J Nutr (2000) 2.93
The response of muscle protein anabolism to combined hyperaminoacidemia and glucose-induced hyperinsulinemia is impaired in the elderly. J Clin Endocrinol Metab (2000) 2.74
Translational control and the unfolded protein response. Antioxid Redox Signal (2007) 2.47
Activating transcription factor 4. Int J Biochem Cell Biol (2007) 2.26
Nutrient signalling in the regulation of human muscle protein synthesis. J Physiol (2007) 2.22
The eIF-2alpha kinases and the control of protein synthesis. FASEB J (1996) 2.19
Recent molecular advances in mammalian glutamine transport. J Nutr (2001) 1.97
ATF4 degradation relies on a phosphorylation-dependent interaction with the SCF(betaTrCP) ubiquitin ligase. Mol Cell Biol (2001) 1.93
Increase in anterior tibialis muscle protein synthesis in healthy man during mixed amino acid infusion: studies of incorporation of [1-13C]leucine. Clin Sci (Lond) (1989) 1.72
Amino acid transceptors: gate keepers of nutrient exchange and regulators of nutrient signaling. Am J Physiol Endocrinol Metab (2009) 1.68
Signaling pathways involved in translational control of protein synthesis in skeletal muscle by leucine. J Nutr (2001) 1.64
Essential amino acids and muscle protein recovery from resistance exercise. Am J Physiol Endocrinol Metab (2002) 1.64
PAT-related amino acid transporters regulate growth via a novel mechanism that does not require bulk transport of amino acids. Development (2005) 1.57
ATF4, the osteoblast accumulation of which is determined post-translationally, can induce osteoblast-specific gene expression in non-osteoblastic cells. J Biol Chem (2004) 1.55
Regulation of muscle protein by amino acids. J Nutr (2002) 1.53
Flooding with L-[1-13C]leucine stimulates human muscle protein incorporation of continuously infused L-[1-13C]valine. Am J Physiol (1992) 1.46
Involvement of transporter recruitment as well as gene expression in the substrate-induced adaptive regulation of amino acid transport system A. Biochim Biophys Acta (2001) 1.43
IL-6 stimulates system A amino acid transporter activity in trophoblast cells through STAT3 and increased expression of SNAT2. Am J Physiol Cell Physiol (2009) 1.37
Role of the transcription factor ATF4 in the anabolic actions of insulin and the anti-anabolic actions of glucocorticoids. J Biol Chem (2007) 1.36
Ceramide down-regulates System A amino acid transport and protein synthesis in rat skeletal muscle cells. FASEB J (2004) 1.30
Transcriptional control of the human sodium-coupled neutral amino acid transporter system A gene by amino acid availability is mediated by an intronic element. J Biol Chem (2003) 1.27
Characterization of the amino acid response element within the human sodium-coupled neutral amino acid transporter 2 (SNAT2) System A transporter gene. Biochem J (2006) 1.25
Amino acids stimulate translation initiation and protein synthesis through an Akt-independent pathway in human skeletal muscle. J Clin Endocrinol Metab (2002) 1.24
Specificity of amino acid regulated gene expression: analysis of genes subjected to either complete or single amino acid deprivation. Amino Acids (2008) 1.23
Tissue-specific mRNA expression profiles of human solute carrier transporter superfamilies. Drug Metab Pharmacokinet (2008) 1.22
Amino acid-induced stimulation of translation initiation in rat skeletal muscle. Am J Physiol (1999) 1.22
Platelet-derived growth factor stimulates LAT1 gene expression in vascular smooth muscle: role in cell growth. FASEB J (2004) 1.20
p300 modulates ATF4 stability and transcriptional activity independently of its acetyltransferase domain. J Biol Chem (2005) 1.16
Tertiary active transport of amino acids reconstituted by coexpression of System A and L transporters in Xenopus oocytes. Am J Physiol Endocrinol Metab (2009) 1.14
The adaptive regulation of amino acid transport system A is associated to changes in ATA2 expression. FEBS Lett (2001) 1.11
Insulin promotes the cell surface recruitment of the SAT2/ATA2 system A amino acid transporter from an endosomal compartment in skeletal muscle cells. J Biol Chem (2002) 1.06
Amino acid sensing and mTOR regulation: inside or out? Biochem Soc Trans (2009) 1.03
Insulin signaling and the general amino acid control response. Two distinct pathways to amino acid synthesis and uptake. J Biol Chem (2008) 1.00
Impaired system A amino acid transport mimics the catabolic effects of acid in L6 cells. Eur J Clin Invest (2002) 0.93
Amino acid transporters and nutrient-sensing mechanisms: new targets for treating insulin-linked disorders? Biochem Soc Trans (2007) 0.93
Leucine activates system A amino acid transport in L6 rat skeletal muscle cells. Am J Physiol (1995) 0.92
Sequential muscle biopsies during a 6-h tracer infusion do not affect human mixed muscle protein synthesis and muscle phenylalanine kinetics. Am J Physiol Endocrinol Metab (2008) 0.91
Glutamine metabolism and transport in skeletal muscle and heart and their clinical relevance. J Nutr (1996) 0.88
Resistance exercise increases AMPK activity and reduces 4E-BP1 phosphorylation and protein synthesis in human skeletal muscle. J Physiol (2006) 3.08
Rapamycin administration in humans blocks the contraction-induced increase in skeletal muscle protein synthesis. J Physiol (2009) 2.64
Amino acid ingestion improves muscle protein synthesis in the young and elderly. Am J Physiol Endocrinol Metab (2003) 2.41
Leucine-enriched essential amino acid and carbohydrate ingestion following resistance exercise enhances mTOR signaling and protein synthesis in human muscle. Am J Physiol Endocrinol Metab (2007) 2.26
Dietary protein recommendations and the prevention of sarcopenia. Curr Opin Clin Nutr Metab Care (2009) 2.26
Nutrient signalling in the regulation of human muscle protein synthesis. J Physiol (2007) 2.22
Skeletal muscle protein anabolic response to resistance exercise and essential amino acids is delayed with aging. J Appl Physiol (1985) (2008) 2.20
Insulin resistance of muscle protein metabolism in aging. FASEB J (2006) 2.17
Evidence-based recommendations for optimal dietary protein intake in older people: a position paper from the PROT-AGE Study Group. J Am Med Dir Assoc (2013) 1.96
Role of dietary protein in the sarcopenia of aging. Am J Clin Nutr (2008) 1.91
Blood flow restriction during low-intensity resistance exercise increases S6K1 phosphorylation and muscle protein synthesis. J Appl Physiol (1985) (2007) 1.79
Aging impairs contraction-induced human skeletal muscle mTORC1 signaling and protein synthesis. Skelet Muscle (2011) 1.68
Nutritional and contractile regulation of human skeletal muscle protein synthesis and mTORC1 signaling. J Appl Physiol (1985) (2009) 1.65
Mammalian target of rapamycin complex 1 activation is required for the stimulation of human skeletal muscle protein synthesis by essential amino acids. J Nutr (2011) 1.60
Novel noninvasive breath test method for screening individuals at risk for diabetes. Diabetes Care (2008) 1.57
Excess leucine intake enhances muscle anabolic signaling but not net protein anabolism in young men and women. J Nutr (2010) 1.51
The influence of exercise training on inflammatory cytokines and C-reactive protein. Med Sci Sports Exerc (2007) 1.50
Aerobic exercise overcomes the age-related insulin resistance of muscle protein metabolism by improving endothelial function and Akt/mammalian target of rapamycin signaling. Diabetes (2007) 1.50
Blood flow restriction exercise stimulates mTORC1 signaling and muscle protein synthesis in older men. J Appl Physiol (1985) (2010) 1.47
Effect of insulin on human skeletal muscle protein synthesis is modulated by insulin-induced changes in muscle blood flow and amino acid availability. Am J Physiol Endocrinol Metab (2006) 1.46
Aging differentially affects human skeletal muscle microRNA expression at rest and after an anabolic stimulus of resistance exercise and essential amino acids. Am J Physiol Endocrinol Metab (2008) 1.45
Aging and microRNA expression in human skeletal muscle: a microarray and bioinformatics analysis. Physiol Genomics (2010) 1.43
Bed rest impairs skeletal muscle amino acid transporter expression, mTORC1 signaling, and protein synthesis in response to essential amino acids in older adults. Am J Physiol Endocrinol Metab (2012) 1.41
Leucine-enriched nutrients and the regulation of mammalian target of rapamycin signalling and human skeletal muscle protein synthesis. Curr Opin Clin Nutr Metab Care (2008) 1.34
Pulsatile portal vein insulin delivery enhances hepatic insulin action and signaling. Diabetes (2012) 1.32
Human muscle gene expression following resistance exercise and blood flow restriction. Med Sci Sports Exerc (2008) 1.32
Malonyl coenzyme A and the regulation of functional carnitine palmitoyltransferase-1 activity and fat oxidation in human skeletal muscle. J Clin Invest (2002) 1.31
Satellite cell depletion does not inhibit adult skeletal muscle regrowth following unloading-induced atrophy. Am J Physiol Cell Physiol (2012) 1.29
Insulin stimulates human skeletal muscle protein synthesis via an indirect mechanism involving endothelial-dependent vasodilation and mammalian target of rapamycin complex 1 signaling. J Clin Endocrinol Metab (2010) 1.24
Essential amino acid and carbohydrate ingestion before resistance exercise does not enhance postexercise muscle protein synthesis. J Appl Physiol (1985) (2008) 1.22
Essential amino acids increase microRNA-499, -208b, and -23a and downregulate myostatin and myocyte enhancer factor 2C mRNA expression in human skeletal muscle. J Nutr (2009) 1.20
Expression of growth-related genes in young and older human skeletal muscle following an acute stimulation of protein synthesis. J Appl Physiol (1985) (2008) 1.20
Muscle protein breakdown has a minor role in the protein anabolic response to essential amino acid and carbohydrate intake following resistance exercise. Am J Physiol Regul Integr Comp Physiol (2010) 1.20
Basal muscle intracellular amino acid kinetics in women and men. Am J Physiol Endocrinol Metab (2006) 1.18
Influence of exercise training and age on CD14+ cell-surface expression of toll-like receptor 2 and 4. Brain Behav Immun (2005) 1.16
Short-term insulin and nutritional energy provision do not stimulate muscle protein synthesis if blood amino acid availability decreases. Am J Physiol Endocrinol Metab (2005) 1.14
Pharmacological vasodilation improves insulin-stimulated muscle protein anabolism but not glucose utilization in older adults. Diabetes (2010) 1.13
Physical activity status, but not age, influences inflammatory biomarkers and toll-like receptor 4. J Gerontol A Biol Sci Med Sci (2006) 1.13
Skeletal muscle amino acid transporter expression is increased in young and older adults following resistance exercise. J Appl Physiol (1985) (2011) 1.11
TLR4 is lower in resistance-trained older women and related to inflammatory cytokines. Med Sci Sports Exerc (2004) 1.11
Skeletal muscle autophagy and protein breakdown following resistance exercise are similar in younger and older adults. J Gerontol A Biol Sci Med Sci (2012) 1.09
Amino acids are necessary for the insulin-induced activation of mTOR/S6K1 signaling and protein synthesis in healthy and insulin resistant human skeletal muscle. Clin Nutr (2008) 1.08