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Nitroxyl improves cellular heart function by directly enhancing cardiac sarcoplasmic reticulum Ca2+ cycling.
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The chemistry of nitrosative stress induced by nitric oxide and reactive nitrogen oxide species. Putting perspective on stressful biological situations.
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Thioredoxin reductase-2 is essential for keeping low levels of H(2)O(2) emission from isolated heart mitochondria.
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Nitroxyl increases force development in rat cardiac muscle.
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Nitroxyl affords thiol-sensitive myocardial protective effects akin to early preconditioning.
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16
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Comparison of the NO and HNO donating properties of diazeniumdiolates: primary amine adducts release HNO in Vivo.
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J Med Chem
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2005
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Creatine kinase-mediated improvement of function in failing mouse hearts provides causal evidence the failing heart is energy starved.
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Mechanism of aerobic decomposition of Angeli's salt (sodium trioxodinitrate) at physiological pH.
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2005
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1.22
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2002
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Phospholamban thiols play a central role in activation of the cardiac muscle sarcoplasmic reticulum calcium pump by nitroxyl.
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Biochemistry
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2008
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1.16
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Orthogonal properties of the redox siblings nitroxyl and nitric oxide in the cardiovascular system: a novel redox paradigm.
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Am J Physiol Heart Circ Physiol
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2003
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1.15
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Monoamine oxidases (MAO) in the pathogenesis of heart failure and ischemia/reperfusion injury.
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Biochim Biophys Acta
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1.13
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Glutathione/thioredoxin systems modulate mitochondrial H2O2 emission: an experimental-computational study.
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J Gen Physiol
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1.13
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25
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Peroxynitrite and myocardial contractility: in vivo versus in vitro effects.
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2006
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Playing with cardiac "redox switches": the "HNO way" to modulate cardiac function.
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2011
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1.07
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Monoamine oxidase B prompts mitochondrial and cardiac dysfunction in pressure overloaded hearts.
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2013
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The specificity of nitroxyl chemistry is unique among nitrogen oxides in biological systems.
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2011
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1.04
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Discriminating formation of HNO from other reactive nitrogen oxide species.
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2005
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1.03
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GSH or palmitate preserves mitochondrial energetic/redox balance, preventing mechanical dysfunction in metabolically challenged myocytes/hearts from type 2 diabetic mice.
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Nitroxyl-mediated disulfide bond formation between cardiac myofilament cysteines enhances contractile function.
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1.02
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Comparison of the reactivity of nitric oxide and nitroxyl with heme proteins. A chemical discussion of the differential biological effects of these redox related products of NOS.
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J Inorg Biochem
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Calcitonin gene-related peptide in vivo positive inotropy is attributable to regional sympatho-stimulation and is blunted in congestive heart failure.
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Circ Res
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2004
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0.99
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The emergence of nitroxyl (HNO) as a pharmacological agent.
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Examining nitroxyl in biological systems.
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Inhibiting metalloproteases with PD 166793 in heart failure: impact on cardiac remodeling and beyond.
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0.94
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Acyloxy nitroso compounds inhibit LIF signaling in endothelial cells and cardiac myocytes: evidence that STAT3 signaling is redox-sensitive.
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The chemical dynamics of NO and reactive nitrogen oxides: a practical guide.
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Hydrogen sulfide [corrected] increases survival during sepsis: protective effect of CHOP inhibition.
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Nitroxyl enhances myocyte Ca2+ transients by exclusively targeting SR Ca2+-cycling.
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Mother was right: eat your vegetables and do not spit! When oral nitrate helps with high blood pressure.
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HNO enhances SERCA2a activity and cardiomyocyte function by promoting redox-dependent phospholamban oligomerization.
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Cobalt-Protoporphyrin Improves Heart Function by Blunting Oxidative Stress and Restoring NO Synthase Equilibrium in an Animal Model of Experimental Diabetes.
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β₂-Adrenoceptors, NADPH oxidase, ROS and p38 MAPK: another 'radical' road to heart failure?
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Glutathione oxidation unmasks proarrhythmic vulnerability of chronically hyperglycemic guinea pigs.
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Nitroxyl (HNO): A novel approach for the acute treatment of heart failure.
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Effects of cardioselective KATP channel antagonism on basal, stimulated, and ischaemic myocardial function in in vivo failing canine heart.
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Novel regulation of cardiac force-frequency relation by CREM (cAMP response element modulator).
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Synthesis and chemical and biological comparison of nitroxyl- and nitric oxide-releasing diazeniumdiolate-based aspirin derivatives.
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Reversal of isoflurane-induced depression of myocardial contraction by nitroxyl via myofilament sensitization to Ca2+.
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CCR5 inhibition prevents cardiac dysfunction in the SIV/macaque model of HIV.
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Warburg effect's manifestation in aggressive pheochromocytomas and paragangliomas: insights from a mouse cell model applied to human tumor tissue.
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The shy Angeli and his elusive creature: the HNO route to vasodilation.
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Depletion of cellular glutathione modulates LIF-induced JAK1-STAT3 signaling in cardiac myocytes.
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Endocardial endothelium is a key determinant of force-frequency relationship in rat ventricular myocardium.
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Forever young?: nerve growth factor, sympathetic fibers, and right ventricle pressure overload.
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When the heart sleeps... is the vagus resetting the myocardial 'redox clock'?
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Genes, geography and geometry: the "critical mass" in hypertrophic cardiomyopathy.
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The p75 neurotrophin receptor, semaphorins, and sympathetic traffic in the heart.
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New redox-related arrows in the arsenal of cardiac disease treatment.
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Peroxynitrite like Pan?
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