PubRank

Ettore Appella

Author PubWeight™ 176.94‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice. Proc Natl Acad Sci U S A 2003 9.14
2 p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression. Nat Cell Biol 2004 5.82
3 Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice. Cancer Cell 2008 5.11
4 Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK-mediated activation of the p16(Ink4a)-p19(Arf) pathway. Nat Genet 2004 3.89
5 Modulation of p53 function by SET8-mediated methylation at lysine 382. Mol Cell 2007 3.68
6 Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis. Nat Cell Biol 2002 3.55
7 Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription. EMBO J 2002 3.45
8 Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity. Nat Genet 2002 3.32
9 MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation. EMBO J 2002 3.29
10 Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress. Cell Metab 2005 3.15
11 Nutlin-3a activates p53 to both down-regulate inhibitor of growth 2 and up-regulate mir-34a, mir-34b, and mir-34c expression, and induce senescence. Cancer Res 2008 2.45
12 Studying multisite binary and ternary protein interactions by global analysis of isothermal titration calorimetry data in SEDPHAT: application to adaptor protein complexes in cell signaling. Protein Sci 2007 2.44
13 p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity. Cancer Res 2003 2.40
14 Wip1 phosphatase modulates ATM-dependent signaling pathways. Mol Cell 2006 2.39
15 Identification of Plasmodium falciparum antigens by antigenic analysis of genomic and proteomic data. Proc Natl Acad Sci U S A 2003 2.38
16 Alternative p38 activation pathway mediated by T cell receptor-proximal tyrosine kinases. Nat Immunol 2005 2.31
17 Oligomerization of signaling complexes by the multipoint binding of GRB2 to both LAT and SOS1. Nat Struct Mol Biol 2006 2.10
18 Regulation of human Cdc25A stability by Serine 75 phosphorylation is not sufficient to activate a S phase checkpoint. Cell Cycle 2003 2.10
19 Nitric oxide-induced cellular stress and p53 activation in chronic inflammation. Proc Natl Acad Sci U S A 2002 2.04
20 Cell type- and promoter-specific roles of Ser18 phosphorylation in regulating p53 responses. J Biol Chem 2003 2.02
21 A correlation between TCR Valpha docking on MHC and CD8 dependence: implications for T cell selection. Immunity 2003 1.95
22 GSK-3 beta targets Cdc25A for ubiquitin-mediated proteolysis, and GSK-3 beta inactivation correlates with Cdc25A overproduction in human cancers. Cancer Cell 2008 1.91
23 Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1. Nat Struct Mol Biol 2009 1.84
24 Structure of the Tfb1/p53 complex: Insights into the interaction between the p62/Tfb1 subunit of TFIIH and the activation domain of p53. Mol Cell 2006 1.82
25 One percent tenofovir applied topically to humanized BLT mice and used according to the CAPRISA 004 experimental design demonstrates partial protection from vaginal HIV infection, validating the BLT model for evaluation of new microbicide candidates. J Virol 2011 1.77
26 Mutation of mouse p53 Ser23 and the response to DNA damage. Mol Cell Biol 2002 1.65
27 Phosphorylation site interdependence of human p53 post-translational modifications in response to stress. J Biol Chem 2003 1.63
28 Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. J Proteome Res 2006 1.63
29 HIPK2 represses beta-catenin-mediated transcription, epidermal stem cell expansion, and skin tumorigenesis. Proc Natl Acad Sci U S A 2007 1.58
30 Dual phosphorylation controls Cdc25 phosphatases and mitotic entry. Nat Cell Biol 2003 1.58
31 ATM mediates phosphorylation at multiple p53 sites, including Ser(46), in response to ionizing radiation. J Biol Chem 2002 1.56
32 Regulation of ATM/p53-dependent suppression of myc-induced lymphomas by Wip1 phosphatase. J Exp Med 2006 1.53
33 Binding specificity of multiprotein signaling complexes is determined by both cooperative interactions and affinity preferences. Biochemistry 2004 1.52
34 Mice deficient for the wild-type p53-induced phosphatase gene (Wip1) exhibit defects in reproductive organs, immune function, and cell cycle control. Mol Cell Biol 2002 1.46
35 Cooperative interactions at the SLP-76 complex are critical for actin polymerization. EMBO J 2010 1.45
36 The Epstein-Barr virus immediate-early protein BZLF1 regulates p53 function through multiple mechanisms. J Virol 2002 1.45
37 Acetylation of mouse p53 at lysine 317 negatively regulates p53 apoptotic activities after DNA damage. Mol Cell Biol 2006 1.45
38 Pillars article: Characterization of peptides bound to the class I MHC molecule HLA-A2.1 by mass spectrometry. Science 1992. 255: 1261-1263. J Immunol 2007 1.39
39 Role for 53BP1 Tudor domain recognition of p53 dimethylated at lysine 382 in DNA damage signaling. J Biol Chem 2008 1.38
40 Wip1 phosphatase regulates p53-dependent apoptosis of stem cells and tumorigenesis in the mouse intestine. Cell Stem Cell 2007 1.37
41 The p53-induced oncogenic phosphatase PPM1D interacts with uracil DNA glycosylase and suppresses base excision repair. Mol Cell 2004 1.36
42 Downstream E-box-mediated regulation of the human telomerase reverse transcriptase (hTERT) gene transcription: evidence for an endogenous mechanism of transcriptional repression. Mol Biol Cell 2002 1.36
43 ING2 regulates the onset of replicative senescence by induction of p300-dependent p53 acetylation. Mol Cell Biol 2005 1.31
44 Proteomic analysis of early melanosomes: identification of novel melanosomal proteins. J Proteome Res 2003 1.31
45 Structural basis for p300 Taz2-p53 TAD1 binding and modulation by phosphorylation. Structure 2009 1.28
46 Regulation of tyrosinase processing and trafficking by organellar pH and by proteasome activity. J Biol Chem 2003 1.27
47 Regulation of the Wip1 phosphatase and its effects on the stress response. Front Biosci (Landmark Ed) 2012 1.24
48 Substrate specificity of the human protein phosphatase 2Cdelta, Wip1. Biochemistry 2005 1.23
49 The processing of Holliday junctions by BLM and WRN helicases is regulated by p53. J Biol Chem 2002 1.22
50 p53 isoforms regulate aging- and tumor-associated replicative senescence in T lymphocytes. J Clin Invest 2013 1.21
51 Sorting of Pmel17 to melanosomes through the plasma membrane by AP1 and AP2: evidence for the polarized nature of melanocytes. J Cell Sci 2006 1.20
52 A rational strategy to design multiepitope immunogens based on multiple Th lymphocyte epitopes. J Immunol 2002 1.19
53 Impairment of p53 acetylation, stability and function by an oncogenic transcription factor. EMBO J 2004 1.16
54 Multiepitope Trojan antigen peptide vaccines for the induction of antitumor CTL and Th immune responses. J Immunol 2004 1.15
55 Positive feedback between p53 and TRF2 during telomere-damage signalling and cellular senescence. Nat Cell Biol 2010 1.14
56 The MBT repeats of L3MBTL1 link SET8-mediated p53 methylation at lysine 382 to target gene repression. J Biol Chem 2010 1.13
57 A decaepitope polypeptide primes for multiple CD8+ IFN-gamma and Th lymphocyte responses: evaluation of multiepitope polypeptides as a mode for vaccine delivery. J Immunol 2002 1.13
58 Disruption of estrogen receptor DNA-binding domain and related intramolecular communication restores tamoxifen sensitivity in resistant breast cancer. Cancer Cell 2006 1.12
59 Multiple Chlamydia pneumoniae antigens prime CD8+ Tc1 responses that inhibit intracellular growth of this vacuolar pathogen. J Immunol 2002 1.11
60 Frequencies of tetramer+ T cells specific for the wild-type sequence p53(264-272) peptide in the circulation of patients with head and neck cancer. Cancer Res 2002 1.09
61 Human apurinic/apyrimidinic endonuclease (Ape1) and its N-terminal truncated form (AN34) are involved in DNA fragmentation during apoptosis. J Biol Chem 2003 1.08
62 Development of a substrate-based cyclic phosphopeptide inhibitor of protein phosphatase 2Cdelta, Wip1. Biochemistry 2006 1.06
63 p53 N-terminal phosphorylation: a defining layer of complex regulation. Carcinogenesis 2012 1.06
64 Hormone-dependent nuclear export of estradiol receptor and DNA synthesis in breast cancer cells. J Cell Biol 2008 1.05
65 Two distinct motifs within the p53 transactivation domain bind to the Taz2 domain of p300 and are differentially affected by phosphorylation. Biochemistry 2009 1.05
66 The Wip1 phosphatase PPM1D dephosphorylates SQ/TQ motifs in checkpoint substrates phosphorylated by PI3K-like kinases. Biochemistry 2007 1.04
67 Comparative Bioinformatics Analyses and Profiling of Lysosome-Related Organelle Proteomes. Int J Mass Spectrom 2007 1.04
68 T cell receptor-mediated activation of p38{alpha} by mono-phosphorylation of the activation loop results in altered substrate specificity. J Biol Chem 2009 1.04
69 Wip1 phosphatase-deficient mice exhibit defective T cell maturation due to sustained p53 activation. J Immunol 2006 1.03
70 Specificity of acyl transfer from 2-mercaptobenzamide thioesters to the HIV-1 nucleocapsid protein. J Am Chem Soc 2007 1.03
71 Sialylated core 1 O-glycans influence the sorting of Pmel17/gp100 and determine its capacity to form fibrils. J Biol Chem 2007 1.03
72 Gamma interferon triggers interaction between ICSBP (IRF-8) and TEL, recruiting the histone deacetylase HDAC3 to the interferon-responsive element. Mol Cell Biol 2002 1.03
73 Structural insight into p53 recognition by the 53BP1 tandem Tudor domain. J Mol Biol 2010 1.03
74 Optimization of unique, uncharged thioesters as inhibitors of HIV replication. Bioorg Med Chem 2004 1.02
75 The isoflavonoids genistein and quercetin activate different stress signaling pathways as shown by analysis of site-specific phosphorylation of ATM, p53 and histone H2AX. DNA Repair (Amst) 2004 1.01
76 Induction of PPM1D following DNA-damaging treatments through a conserved p53 response element coincides with a shift in the use of transcription initiation sites. Nucleic Acids Res 2008 1.01
77 Cooperative functions of Chk1 and Chk2 reduce tumour susceptibility in vivo. EMBO J 2010 1.00
78 Charge modification at multiple C-terminal lysine residues regulates p53 oligomerization and its nucleus-cytoplasm trafficking. J Biol Chem 2005 1.00
79 The ability of variant peptides to reverse the nonresponsiveness of T lymphocytes to the wild-type sequence p53(264-272) epitope. J Immunol 2002 1.00
80 Epitope mapping of the melanosomal matrix protein gp100 (PMEL17): rapid processing in the endoplasmic reticulum and glycosylation in the early Golgi compartment. J Biol Chem 2004 1.00
81 p53 binding to nucleosomal DNA depends on the rotational positioning of DNA response element. J Biol Chem 2009 0.99
82 Delay of simian human immunodeficiency virus infection and control of viral replication in vaccinated macaques challenged in the presence of a topical microbicide. AIDS 2011 0.99
83 Inhibition of estradiol receptor/Src association and cell growth by an estradiol receptor alpha tyrosine-phosphorylated peptide. Mol Cancer Res 2007 0.99
84 Unfolding, aggregation, and amyloid formation by the tetramerization domain from mutant p53 associated with lung cancer. Biochemistry 2006 0.98
85 Small-molecule inactivation of HIV-1 NCp7 by repetitive intracellular acyl transfer. Nat Chem Biol 2010 0.96
86 Suppression of breast cancer by chemical modulation of vulnerable zinc fingers in estrogen receptor. Nat Med 2003 0.96
87 High affinity xenoreactive TCR:MHC interaction recruits CD8 in absence of binding to MHC. J Immunol 2003 0.95
88 Human immunodeficiency virus type 1 nucleocapsid inhibitors impede trans infection in cellular and explant models and protect nonhuman primates from infection. J Virol 2009 0.95
89 Wip1 promotes RUNX2-dependent apoptosis in p53-negative tumors and protects normal tissues during treatment with anticancer agents. Proc Natl Acad Sci U S A 2011 0.95
90 Studies on the mechanism of inactivation of the HIV-1 nucleocapsid protein NCp7 with 2-mercaptobenzamide thioesters. J Med Chem 2005 0.92
91 P53(110-124)-specific human CD4+ T-helper cells enhance in vitro generation and antitumor function of tumor-reactive CD8+ T cells. Cancer Res 2003 0.92
92 Control of p53 multimerization by Ubc13 is JNK-regulated. Proc Natl Acad Sci U S A 2009 0.91
93 In vivo antiviral activity of novel human immunodeficiency virus type 1 nucleocapsid p7 zinc finger inhibitors in a transgenic murine model. AIDS Res Hum Retroviruses 2003 0.90
94 Defective p53 post-translational modification required for wild type p53 inactivation in malignant epithelial cells with mdm2 gene amplification. J Biol Chem 2003 0.90
95 Single MHC mutation eliminates enthalpy associated with T cell receptor binding. J Mol Biol 2007 0.90
96 A CD8+ T cell heptaepitope minigene vaccine induces protective immunity against Chlamydia pneumoniae. J Immunol 2005 0.89
97 Optimization of a cyclic peptide inhibitor of Ser/Thr phosphatase PPM1D (Wip1). Biochemistry 2011 0.89
98 Topical microbicides: a promising approach for controlling the AIDS pandemic via retroviral zinc finger inhibitors. Adv Pharmacol 2008 0.89
99 Toward the development of multi-epitope p53 cancer vaccines: an in vitro assessment of CD8(+) T cell responses to HLA class I-restricted wild-type sequence p53 peptides. Clin Immunol 2007 0.88
100 Wip1 sensitizes p53-negative tumors to apoptosis by regulating the Bax/Bcl-xL ratio. Cell Cycle 2012 0.88
101 UV-induced histone H2AX phosphorylation and DNA damage related proteins accumulate and persist in nucleotide excision repair-deficient XP-B cells. DNA Repair (Amst) 2010 0.88
102 Multipoint binding of the SLP-76 SH2 domain to ADAP is critical for oligomerization of SLP-76 signaling complexes in stimulated T cells. Mol Cell Biol 2013 0.88
103 Benzamide-based thiolcarbamates: a new class of HIV-1 NCp7 inhibitors. Bioorg Med Chem Lett 2002 0.87
104 Genetic variants and mutations of PPM1D control the response to DNA damage. Cell Cycle 2013 0.86
105 Tumor susceptibility and apoptosis defect in a mouse strain expressing a human p53 transgene. Cancer Res 2006 0.86
106 The wild-type sequence (wt) p53(25-35) peptide induces HLA-DR7 and HLA-DR11-restricted CD4+ Th cells capable of enhancing the ex vivo expansion and function of anti-wt p53(264-272) peptide CD8+ T cells. J Immunol 2006 0.85
107 Homeostatic regulation of base excision repair by a p53-induced phosphatase: linking stress response pathways with DNA repair proteins. Cell Cycle 2004 0.83
108 Inhibition of multidrug resistance-linked P-glycoprotein (ABCB1) function by 5'-fluorosulfonylbenzoyl 5'-adenosine: evidence for an ATP analogue that interacts with both drug-substrate-and nucleotide-binding sites. Biochemistry 2011 0.83
109 Immunological characterization of missense mutations occurring within cytotoxic T cell-defined p53 epitopes in HLA-A*0201+ squamous cell carcinomas of the head and neck. Int J Cancer 2007 0.83
110 Comparison of the specificity of interaction of cellular and viral zinc-binding domains with 2-mercaptobenzamide thioesters. J Am Chem Soc 2006 0.83
111 Preclinical evaluation of a zinc finger inhibitor targeting lentivirus nucleocapsid protein in SIV-infected monkeys. Curr HIV Res 2006 0.83
112 Synthesis and biological properties of amino acid amide ligand-based pyridinioalkanoyl thioesters as anti-HIV agents. Bioorg Med Chem 2002 0.82
113 A small molecular scaffold for selective inhibition of Wip1 phosphatase. ChemMedChem 2008 0.81
114 Identification of a 17beta-hydroxysteroid dehydrogenase type 12 pseudogene as the source of a highly restricted BALB/c Meth A tumor rejection peptide. Cancer Immunol Immunother 2009 0.80
115 Targeting androgen receptor/Src complex impairs the aggressive phenotype of human fibrosarcoma cells. PLoS One 2013 0.79
116 Selectivity and mechanism of action of a growth factor receptor-bound protein 2 SRC homology 2 domain binding antagonist. J Med Chem 2008 0.79
117 The alkylating carcinogen N-methyl-N'-nitro-N-nitrosoguanidine activates the plasminogen activator inhibitor-1 gene through sequential phosphorylation of p53 by ATM and ATR kinases. Thromb Haemost 2005 0.78
118 Binding of a third metal ion by the human phosphatases PP2Cα and Wip1 is required for phosphatase activity. Biochemistry 2013 0.78
119 Quantitative proteomics analysis of the effects of ionizing radiation in wild type and p53 K317R knock-in mouse thymocytes. Mol Cell Proteomics 2008 0.78
120 Polyproline and Tat transduction peptides in the study of the rapid actions of steroid receptors. Steroids 2012 0.77
121 Radioprobing the conformation of DNA in a p53-DNA complex. Int J Radiat Biol 2012 0.75
122 Fmoc-based chemical synthesis and selective binding to supercoiled DNA of the p53 C-terminal segment and its phosphorylated and acetylated derivatives. J Pept Sci 2004 0.75
123 Conformational Changes in Active and Inactive States of Human PP2Cα Characterized by Hydrogen/Deuterium Exchange - Mass Spectrometry. Biochemistry 2017 0.75