Published in EMBO J on October 01, 2002
p53 Binding protein 53BP1 is required for DNA damage responses and tumor suppression in mice. Mol Cell Biol (2003) 4.36
Cell cycle kinases as therapeutic targets for cancer. Nat Rev Drug Discov (2009) 4.16
Bmi1 regulates mitochondrial function and the DNA damage response pathway. Nature (2009) 3.90
A selective requirement for 53BP1 in the biological response to genomic instability induced by Brca1 deficiency. Mol Cell (2009) 2.41
G2 checkpoint abrogation and checkpoint kinase-1 targeting in the treatment of cancer. Br J Cancer (2008) 2.33
microRNA-21 negatively regulates Cdc25A and cell cycle progression in colon cancer cells. Cancer Res (2009) 2.32
ATM regulates ATR chromatin loading in response to DNA double-strand breaks. J Exp Med (2006) 2.31
Zinc-finger protein-targeted gene regulation: genomewide single-gene specificity. Proc Natl Acad Sci U S A (2003) 2.24
The effects of deregulated DNA damage signalling on cancer chemotherapy response and resistance. Nat Rev Cancer (2012) 2.20
Swi1 prevents replication fork collapse and controls checkpoint kinase Cds1. Mol Cell Biol (2003) 2.19
Repair of topoisomerase I-mediated DNA damage. Prog Nucleic Acid Res Mol Biol (2006) 2.16
p73 induction after DNA damage is regulated by checkpoint kinases Chk1 and Chk2. Genes Dev (2004) 2.07
Restoration of an absent G1 arrest and protection from apoptosis in embryonic stem cells after ionizing radiation. Proc Natl Acad Sci U S A (2004) 1.96
DNA repair deficiency and neurological disease. Nat Rev Neurosci (2009) 1.91
Taking the time to make important decisions: the checkpoint effector kinases Chk1 and Chk2 and the DNA damage response. DNA Repair (Amst) (2009) 1.89
Essential role for DNA-PKcs in DNA double-strand break repair and apoptosis in ATM-deficient lymphocytes. Mol Cell (2009) 1.86
Loss of ATM/Chk2/p53 pathway components accelerates tumor development and contributes to radiation resistance in gliomas. Cancer Cell (2010) 1.68
Mammalian Rif1 contributes to replication stress survival and homology-directed repair. J Cell Biol (2009) 1.66
Defective apoptosis and B-cell lymphomas in mice with p53 point mutation at Ser 23. EMBO J (2004) 1.63
Chk1 and p21 cooperate to prevent apoptosis during DNA replication fork stress. Mol Biol Cell (2005) 1.60
The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex. Nature (2007) 1.58
The cohesin complex is required for the DNA damage-induced G2/M checkpoint in mammalian cells. EMBO J (2009) 1.58
DNA damage checkpoint kinase Chk2 triggers replicative senescence. EMBO J (2004) 1.58
Apoptosis associated with deregulated E2F activity is dependent on E2F1 and Atm/Nbs1/Chk2. Mol Cell Biol (2004) 1.57
The ATR barrier to replication-born DNA damage. DNA Repair (Amst) (2010) 1.50
p53 C-terminal phosphorylation by CHK1 and CHK2 participates in the regulation of DNA-damage-induced C-terminal acetylation. Mol Biol Cell (2005) 1.46
Pathways for genome integrity in G2 phase of the cell cycle. Biomolecules (2012) 1.44
A role for Chk1 in blocking transcriptional elongation of p21 RNA during the S-phase checkpoint. Genes Dev (2009) 1.42
Death receptor-induced activation of the Chk2- and histone H2AX-associated DNA damage response pathways. Mol Cell Biol (2008) 1.39
ATM-Chk2-p53 activation prevents tumorigenesis at an expense of organ homeostasis upon Brca1 deficiency. EMBO J (2006) 1.38
Differential DNA damage signaling accounts for distinct neural apoptotic responses in ATLD and NBS. Genes Dev (2009) 1.36
Ionizing radiation induces caspase-dependent but Chk2- and p53-independent cell death in Drosophila melanogaster. Proc Natl Acad Sci U S A (2006) 1.31
Chk2 suppresses the oncogenic potential of DNA replication-associated DNA damage. Mol Cell (2008) 1.30
Differentiation-induced radioresistance in muscle cells. Mol Cell Biol (2004) 1.30
Edd, the murine hyperplastic disc gene, is essential for yolk sac vascularization and chorioallantoic fusion. Mol Cell Biol (2004) 1.28
Thrombospondin-1 and CD47 limit cell and tissue survival of radiation injury. Am J Pathol (2008) 1.26
Global dissociation of HuR-mRNA complexes promotes cell survival after ionizing radiation. EMBO J (2011) 1.21
Reversal of female infertility by Chk2 ablation reveals the oocyte DNA damage checkpoint pathway. Science (2014) 1.21
Collaboration of Brca1 and Chk2 in tumorigenesis. Genes Dev (2004) 1.18
DNA damage during reoxygenation elicits a Chk2-dependent checkpoint response. Mol Cell Biol (2006) 1.13
The regulation of p53 by phosphorylation: a model for how distinct signals integrate into the p53 pathway. Aging (Albany NY) (2009) 1.12
Aberrant topoisomerase-1 DNA lesions are pathogenic in neurodegenerative genome instability syndromes. Nat Neurosci (2014) 1.11
Cellular inhibition of checkpoint kinase 2 (Chk2) and potentiation of camptothecins and radiation by the novel Chk2 inhibitor PV1019 [7-nitro-1H-indole-2-carboxylic acid {4-[1-(guanidinohydrazone)-ethyl]-phenyl}-amide]. J Pharmacol Exp Ther (2009) 1.11
Replication licensing promotes cyclin D1 expression and G1 progression in untransformed human cells. Cell Cycle (2009) 1.11
Genetic and functional analysis of CHEK2 (CHK2) variants in multiethnic cohorts. Int J Cancer (2007) 1.09
CHK2 kinase expression is down-regulated due to promoter methylation in non-small cell lung cancer. Mol Cancer (2004) 1.08
The DNA damage response: Balancing the scale between cancer and ageing. Aging (Albany NY) (2010) 1.08
DNA damage-induced cell cycle regulation and function of novel Chk2 phosphoresidues. Mol Cell Biol (2006) 1.07
CHK2 kinase in the DNA damage response and beyond. J Mol Cell Biol (2014) 1.05
Ubiquitylation, neddylation and the DNA damage response. Open Biol (2015) 1.04
PHD3-dependent hydroxylation of HCLK2 promotes the DNA damage response. J Clin Invest (2012) 1.04
CCT241533 is a potent and selective inhibitor of CHK2 that potentiates the cytotoxicity of PARP inhibitors. Cancer Res (2011) 1.04
Resistance and gain-of-resistance phenotypes in cancers harboring wild-type p53. Biochem Pharmacol (2011) 1.03
Uterus hyperplasia and increased carcinogen-induced tumorigenesis in mice carrying a targeted mutation of the Chk2 phosphorylation site in Brca1. Mol Cell Biol (2004) 1.03
The MDM2 ubiquitination signal in the DNA-binding domain of p53 forms a docking site for calcium calmodulin kinase superfamily members. Mol Cell Biol (2007) 1.01
Allosteric effects mediate CHK2 phosphorylation of the p53 transactivation domain. EMBO Rep (2003) 1.01
Cooperative functions of Chk1 and Chk2 reduce tumour susceptibility in vivo. EMBO J (2010) 1.00
Regulation of Chk2 ubiquitination and signaling through autophosphorylation of serine 379. Mol Cell Biol (2008) 0.98
DNA damage checkpoints and cancer. J Mol Histol (2006) 0.97
Phosphatases in the cellular response to DNA damage. Cell Commun Signal (2010) 0.97
Role of the translocation partner in protection against AID-dependent chromosomal translocations. Proc Natl Acad Sci U S A (2009) 0.96
Genetic modeling of Li-Fraumeni syndrome in zebrafish. Dis Model Mech (2010) 0.95
Activation of checkpoint kinase 2 by 3,3'-diindolylmethane is required for causing G2/M cell cycle arrest in human ovarian cancer cells. Mol Pharmacol (2010) 0.95
The PARP inhibitor PJ34 causes a PARP1-independent, p21 dependent mitotic arrest. DNA Repair (Amst) (2011) 0.94
USP28 is recruited to sites of DNA damage by the tandem BRCT domains of 53BP1 but plays a minor role in double-strand break metabolism. Mol Cell Biol (2014) 0.94
Chk1-cyclin A/Cdk1 axis regulates origin firing programs in mammals. Chromosome Res (2010) 0.93
Molecular targets and mechanisms of radiosensitization using DNA damage response pathways. Future Oncol (2013) 0.93
Modulation of ionizing radiation-induced apoptosis by bantam microRNA in Drosophila. Dev Biol (2008) 0.91
DNA damage-induced cell death: lessons from the central nervous system. Cell Res (2008) 0.91
Crystal structure of checkpoint kinase 2 in complex with NSC 109555, a potent and selective inhibitor. Protein Sci (2009) 0.91
Chk2 deficiency in Myc overexpressing lymphoma cells elicits a synergistic lethal response in combination with PARP inhibition. Cell Cycle (2011) 0.90
Phosphatase WIP1 regulates adult neurogenesis and WNT signaling during aging. J Clin Invest (2014) 0.89
Cooperative role of the RNA-binding proteins Hzf and HuR in p53 activation. Mol Cell Biol (2011) 0.89
"The Octet": Eight Protein Kinases that Control Mammalian DNA Replication. Front Physiol (2012) 0.88
The anti-proliferative effects of the CHFR depend on the forkhead associated domain, but not E3 ligase activity mediated by ring finger domain. PLoS One (2008) 0.88
Mice with the CHEK2*1100delC SNP are predisposed to cancer with a strong gender bias. Proc Natl Acad Sci U S A (2009) 0.87
The Role of Wild-Type p53 in Cisplatin-Induced Chk2 Phosphorylation and the Inhibition of Platinum Resistance with a Chk2 Inhibitor. Chemother Res Pract (2010) 0.86
Drosophila Chk2 and p53 proteins induce stage-specific cell death independently during oogenesis. Apoptosis (2010) 0.86
Trial Watch: Targeting ATM-CHK2 and ATR-CHK1 pathways for anticancer therapy. Mol Cell Oncol (2015) 0.86
The ATM signaling cascade promotes recombination-dependent pachytene arrest in mouse spermatocytes. PLoS Genet (2015) 0.85
The cytolethal distending toxin effects on Mammalian cells: a DNA damage perspective. Cells (2014) 0.85
Decoupling of DNA damage response signaling from DNA damages underlies temozolomide resistance in glioblastoma cells. J Biomed Res (2010) 0.84
DNA methylome analysis identifies epigenetic silencing of FHIT as a determining factor for radiosensitivity in oral cancer: an outcome-predicting and treatment-implicating study. Oncotarget (2015) 0.84
Chk2 mediates RITA-induced apoptosis. Cell Death Differ (2011) 0.84
Bimodal regulation of p21(waf1) protein as function of DNA damage levels. Cell Cycle (2014) 0.84
Structural characterization of inhibitor complexes with checkpoint kinase 2 (Chk2), a drug target for cancer therapy. J Struct Biol (2011) 0.84
Mammary tumorigenesis following transgenic expression of a dominant negative CHK2 mutant. Cancer Res (2006) 0.83
Working together and apart: the twisted relationship of the Mre11 complex and Chk2 in apoptosis and tumor suppression. Cell Cycle (2008) 0.83
CHK2: a tumor suppressor or not? Cell Cycle (2003) 0.83
Development of synthetic lethality anticancer therapeutics. J Med Chem (2014) 0.82
Irofulven induces replication-dependent CHK2 activation related to p53 status. Biochem Pharmacol (2006) 0.81
Role of Gadd45a in Wip1-dependent regulation of intestinal tumorigenesis. Cell Death Differ (2012) 0.81
The investigation of a traditional Chinese medicine, Guizhi Fuling Wan (GFW) as an intravesical therapeutic agent for urothelial carcinoma of the bladder. BMC Complement Altern Med (2013) 0.81
Genomic profiling of CHEK2*1100delC-mutated breast carcinomas. BMC Cancer (2015) 0.80
Family cancer syndromes: inherited deficiencies in systems for the maintenance of genomic integrity. Surg Oncol Clin N Am (2009) 0.79
The co-repressor SMRT delays DNA damage-induced caspase activation by repressing pro-apoptotic genes and modulating the dynamics of checkpoint kinase 2 activation. PLoS One (2013) 0.79
Role of DNA damage response pathways in preventing carcinogenesis caused by intrinsic replication stress. Oncogene (2013) 0.79
Drosophila MOF controls Checkpoint protein2 and regulates genomic stability during early embryogenesis. BMC Mol Biol (2013) 0.78
Recent progress in mouse models for tumor suppressor genes and its implications in human cancer. Clin Med Insights Oncol (2013) 0.78
X-ray structures of checkpoint kinase 2 in complex with inhibitors that target its gatekeeper-dependent hydrophobic pocket. FEBS Lett (2011) 0.77
hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell (2001) 15.97
Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell (2001) 15.05
p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature (1993) 13.46
Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control. Cell (1995) 12.39
Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Science (1998) 11.90
Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint. Genes Dev (2000) 11.49
Enhanced phosphorylation of p53 by ATM in response to DNA damage. Science (1998) 10.89
Thymocyte apoptosis induced by p53-dependent and independent pathways. Nature (1993) 10.72
DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2. Cell (1997) 10.52
Atm-deficient mice: a paradigm of ataxia telangiectasia. Cell (1996) 10.40
Low-penetrance susceptibility to breast cancer due to CHEK2(*)1100delC in noncarriers of BRCA1 or BRCA2 mutations. Nat Genet (2002) 9.71
Radiation-induced cell cycle arrest compromised by p21 deficiency. Nature (1995) 8.53
Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25. Science (1997) 8.24
DNA damage-induced activation of p53 by the checkpoint kinase Chk2. Science (2000) 7.85
Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine. Cancer Res (1999) 7.82
DNA damage activates p53 through a phosphorylation-acetylation cascade. Genes Dev (1998) 7.78
The complexity of p53 modulation: emerging patterns from divergent signals. Genes Dev (1998) 7.46
The p53 pathway. J Pathol (1999) 6.79
Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53. Genes Dev (2000) 5.90
The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites. Genes Dev (2000) 5.72
Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice. Science (1995) 5.65
The many substrates and functions of ATM. Nat Rev Mol Cell Biol (2000) 5.46
Post-translational modifications and activation of p53 by genotoxic stresses. Eur J Biochem (2001) 5.43
Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome. Science (1999) 5.09
p53: death star. Cell (2000) 4.77
Rapid destruction of human Cdc25A in response to DNA damage. Science (2000) 4.74
Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice. Genes Dev (2000) 4.38
Involvement of Brca1 in S-phase and G(2)-phase checkpoints after ionizing irradiation. Mol Cell Biol (2001) 4.35
Two molecularly distinct G(2)/M checkpoints are induced by ionizing irradiation. Mol Cell Biol (2002) 4.27
ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage. Genes Dev (2001) 4.06
Selective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylation. Genes Dev (2001) 3.41
p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2. EMBO J (2001) 3.37
Regulation of p53 function and stability by phosphorylation. Mol Cell Biol (1999) 3.24
Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage. Proc Natl Acad Sci U S A (1999) 3.13
BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage. Nat Genet (2002) 3.11
Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2. EMBO J (1999) 3.00
Phosphorylation of p53 serine 15 increases interaction with CBP. J Biol Chem (1998) 2.97
Requirement for Atm in ionizing radiation-induced cell death in the developing central nervous system. Science (1998) 2.88
CHK2 kinase--a busy messenger. Nat Rev Mol Cell Biol (2001) 2.68
Retracted BRCA1 required for transcription-coupled repair of oxidative DNA damage. Science (1998) 2.48
Damage-mediated phosphorylation of human p53 threonine 18 through a cascade mediated by a casein 1-like kinase. Effect on Mdm2 binding. J Biol Chem (2000) 2.08
ATM: a mediator of multiple responses to genotoxic stress. Oncogene (1999) 2.06
Phosphorylation of murine p53 at ser-18 regulates the p53 responses to DNA damage. Proc Natl Acad Sci U S A (2000) 1.80
Atm selectively regulates distinct p53-dependent cell-cycle checkpoint and apoptotic pathways. Nat Genet (1997) 1.76
Mutation of mouse p53 Ser23 and the response to DNA damage. Mol Cell Biol (2002) 1.65
Regulation of p53 localization. Eur J Biochem (2001) 1.57
Ataxia telangiectasia mutated-dependent apoptosis after genotoxic stress in the developing nervous system is determined by cellular differentiation status. J Neurosci (2001) 1.45
Hydrocephalus, situs inversus, chronic sinusitis, and male infertility in DNA polymerase lambda-deficient mice: possible implication for the pathogenesis of immotile cilia syndrome. Mol Cell Biol (2002) 1.40
Reactive oxygen species-induced phosphorylation of p53 on serine 20 is mediated in part by polo-like kinase-3. J Biol Chem (2001) 1.39
Loss of atm radiosensitizes multiple p53 null tissues. Cancer Res (1998) 1.20
Critical roles for the serine 20, but not the serine 15, phosphorylation site and for the polyproline domain in regulating p53 turnover. Biochem J (2001) 1.14
Histological type-selective, tumor-predominant expression of a novel CHK1 isoform and infrequent in vivo somatic CHK2 mutation in small cell lung cancer. Cancer Res (2000) 1.11
Adenovirus-mediated transfer of p53-related genes induces apoptosis of human cancer cells. Jpn J Cancer Res (2000) 0.88
In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses. Nature (2009) 14.59
Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice. Proc Natl Acad Sci U S A (2003) 9.14
Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells. Nat Med (2006) 7.62
Heterozygous TGFBR2 mutations in Marfan syndrome. Nat Genet (2004) 6.15
Enhanced virulence of influenza A viruses with the haemagglutinin of the 1918 pandemic virus. Nature (2004) 6.11
Foxo3a is essential for maintenance of the hematopoietic stem cell pool. Cell Stem Cell (2007) 5.94
DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1. Nat Cell Biol (2002) 5.85
p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression. Nat Cell Biol (2004) 5.82
Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice. Cancer Cell (2008) 5.11
Targeted ablation of osteocytes induces osteoporosis with defective mechanotransduction. Cell Metab (2007) 4.64
RANKL maintains bone homeostasis through c-Fos-dependent induction of interferon-beta. Nature (2002) 4.44
Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK-mediated activation of the p16(Ink4a)-p19(Arf) pathway. Nat Genet (2004) 3.89
Activity of Rho-family GTPases during cell division as visualized with FRET-based probes. J Cell Biol (2003) 3.85
A requirement for PARP-1 for the assembly or stability of XRCC1 nuclear foci at sites of oxidative DNA damage. Nucleic Acids Res (2003) 3.85
Modulation of p53 function by SET8-mediated methylation at lysine 382. Mol Cell (2007) 3.68
Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis. Nat Cell Biol (2002) 3.55
LPA3-mediated lysophosphatidic acid signalling in embryo implantation and spacing. Nature (2005) 3.35
Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity. Nat Genet (2002) 3.32
MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation. EMBO J (2002) 3.29
Loop-mediated isothermal amplification for detection of African trypanosomes. J Clin Microbiol (2003) 3.23
Transgenic expression of Helicobacter pylori CagA induces gastrointestinal and hematopoietic neoplasms in mouse. Proc Natl Acad Sci U S A (2008) 3.17
Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress. Cell Metab (2005) 3.15
TGF-beta-FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia. Nature (2010) 3.12
Hemoprotein Bach1 regulates enhancer availability of heme oxygenase-1 gene. EMBO J (2002) 3.06
Haploinsufficiency of NSD1 causes Sotos syndrome. Nat Genet (2002) 2.96
Different anti-HCV profiles of statins and their potential for combination therapy with interferon. Hepatology (2006) 2.87
Deletion of LOX-1 reduces atherogenesis in LDLR knockout mice fed high cholesterol diet. Circ Res (2007) 2.87
Thymus-derived leukemia-lymphoma in mice transgenic for the Tax gene of human T-lymphotropic virus type I. Nat Med (2006) 2.81
CT of internal hernias. Radiographics (2005) 2.75
Abnormal angiogenesis in Foxo1 (Fkhr)-deficient mice. J Biol Chem (2004) 2.73
Atg7 modulates p53 activity to regulate cell cycle and survival during metabolic stress. Science (2012) 2.56
Implications of the aquaporin-4 structure on array formation and cell adhesion. J Mol Biol (2005) 2.50
Nutlin-3a activates p53 to both down-regulate inhibitor of growth 2 and up-regulate mir-34a, mir-34b, and mir-34c expression, and induce senescence. Cancer Res (2008) 2.45
Studying multisite binary and ternary protein interactions by global analysis of isothermal titration calorimetry data in SEDPHAT: application to adaptor protein complexes in cell signaling. Protein Sci (2007) 2.44
In vivo imaging of C. elegans ASH neurons: cellular response and adaptation to chemical repellents. EMBO J (2004) 2.43
p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity. Cancer Res (2003) 2.40
Wip1 phosphatase modulates ATM-dependent signaling pathways. Mol Cell (2006) 2.39
Identification of Plasmodium falciparum antigens by antigenic analysis of genomic and proteomic data. Proc Natl Acad Sci U S A (2003) 2.38
Multi-detector row CT imaging of vertebral microstructure for evaluation of fracture risk. J Bone Miner Res (2005) 2.36
Role of Jhdm2a in regulating metabolic gene expression and obesity resistance. Nature (2009) 2.35
Posttranslational modification of p53: cooperative integrators of function. Cold Spring Harb Perspect Biol (2009) 2.34
Alternative p38 activation pathway mediated by T cell receptor-proximal tyrosine kinases. Nat Immunol (2005) 2.31
Common defects of ABCG2, a high-capacity urate exporter, cause gout: a function-based genetic analysis in a Japanese population. Sci Transl Med (2009) 2.25
Chk1 is a histone H3 threonine 11 kinase that regulates DNA damage-induced transcriptional repression. Cell (2008) 2.17
The insulin/PI 3-kinase pathway regulates salt chemotaxis learning in Caenorhabditis elegans. Neuron (2006) 2.14
Regulation of human Cdc25A stability by Serine 75 phosphorylation is not sufficient to activate a S phase checkpoint. Cell Cycle (2003) 2.10
Oligomerization of signaling complexes by the multipoint binding of GRB2 to both LAT and SOS1. Nat Struct Mol Biol (2006) 2.10
FOXO transcription factors in cell-cycle regulation and the response to oxidative stress. Antioxid Redox Signal (2005) 2.06
Activated macrophages promote Wnt signalling through tumour necrosis factor-alpha in gastric tumour cells. EMBO J (2008) 2.05
DNA damage checkpoints in mammals. Mutagenesis (2005) 2.05
Nitric oxide-induced cellular stress and p53 activation in chronic inflammation. Proc Natl Acad Sci U S A (2002) 2.04
Evidence-based tool for triggering school closures during influenza outbreaks, Japan. Emerg Infect Dis (2009) 2.02
Cell type- and promoter-specific roles of Ser18 phosphorylation in regulating p53 responses. J Biol Chem (2003) 2.02
Transcription factor Nrf2 is required for the constitutive and inducible expression of multidrug resistance-associated protein 1 in mouse embryo fibroblasts. Biochem Biophys Res Commun (2003) 2.01
Distinct p53 genomic binding patterns in normal and cancer-derived human cells. Cell Cycle (2011) 2.01
Interleukin 15-mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1. Nat Immunol (2007) 1.97
A correlation between TCR Valpha docking on MHC and CD8 dependence: implications for T cell selection. Immunity (2003) 1.95
DNA damage tumor suppressor genes and genomic instability. Curr Opin Genet Dev (2004) 1.94
Activin-Nodal signaling is involved in propagation of mouse embryonic stem cells. J Cell Sci (2007) 1.94
GSK-3 beta targets Cdc25A for ubiquitin-mediated proteolysis, and GSK-3 beta inactivation correlates with Cdc25A overproduction in human cancers. Cancer Cell (2008) 1.91
A thin polymer membrane, nano-suit, enhancing survival across the continuum between air and high vacuum. Proc Natl Acad Sci U S A (2013) 1.88
Specific role of Chk1 phosphorylations in cell survival and checkpoint activation. Mol Cell Biol (2007) 1.87
Efficient replication of a full-length hepatitis C virus genome, strain O, in cell culture, and development of a luciferase reporter system. Biochem Biophys Res Commun (2005) 1.84
Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1. Nat Struct Mol Biol (2009) 1.84
Role of Lkb1, the causative gene of Peutz-Jegher's syndrome, in embryogenesis and polyposis. Proc Natl Acad Sci U S A (2002) 1.83
Structure of the Tfb1/p53 complex: Insights into the interaction between the p62/Tfb1 subunit of TFIIH and the activation domain of p53. Mol Cell (2006) 1.82
FOXO forkhead transcription factors induce G(2)-M checkpoint in response to oxidative stress. J Biol Chem (2002) 1.76
Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes: consequences for pravastatin pharmacokinetics. Clin Pharmacol Ther (2003) 1.74
SIRT1 is critical regulator of FOXO-mediated transcription in response to oxidative stress. Int J Mol Med (2005) 1.73
Coordination of PGC-1beta and iron uptake in mitochondrial biogenesis and osteoclast activation. Nat Med (2009) 1.72
Early changes in KCC2 phosphorylation in response to neuronal stress result in functional downregulation. J Neurosci (2007) 1.72
Osteoclast-secreted CTHRC1 in the coupling of bone resorption to formation. J Clin Invest (2013) 1.70
Long-term clinical outcome after intramuscular implantation of bone marrow mononuclear cells (Therapeutic Angiogenesis by Cell Transplantation [TACT] trial) in patients with chronic limb ischemia. Am Heart J (2008) 1.70
Prolonged treatment with bicalutamide induces androgen receptor overexpression and androgen hypersensitivity. Prostate (2010) 1.70
Narrowing candidate region for monosomy 9p syndrome to a 4.7-Mb segment at 9p22.2-p23. Am J Med Genet A (2006) 1.70
Epidemiology of influenza in Hanoi, Vietnam, from 2001 to 2003. J Infect (2007) 1.69
Osteocytes regulate primary lymphoid organs and fat metabolism. Cell Metab (2013) 1.68
Synthetic double-stranded RNA poly(I:C) combined with mucosal vaccine protects against influenza virus infection. J Virol (2005) 1.67
Inter-regional contribution of enhanced activity of the primary somatosensory cortex to the anterior cingulate cortex accelerates chronic pain behavior. J Neurosci (2011) 1.67
Mutation of mouse p53 Ser23 and the response to DNA damage. Mol Cell Biol (2002) 1.65