Genetic and pharmacologic blockade of central melanocortin signaling attenuates cardiac cachexia in rodent models of heart failure.

PubWeight™: 0.89‹?›

🔗 View Article (PMC 2887273)

Published in J Endocrinol on April 06, 2010

Authors

Jarrad M Scarlett1, Darren D Bowe, Xinxia Zhu, Ayesha K Batra, Wilmon F Grant, Daniel L Marks

Author Affiliations

1: Department of Pediatrics, Oregon Health and Science University, Portland, Oregon 97239, USA.

Articles citing this

Physiological roles of the melanocortin MC₃ receptor. Eur J Pharmacol (2011) 0.94

Melanocortin control of energy balance: evidence from rodent models. Cell Mol Life Sci (2011) 0.94

Meta-analysis of genome-wide association data identifies novel susceptibility loci for obesity. Hum Mol Genet (2013) 0.93

Update on melanocortin interventions for cachexia: progress toward clinical application. Nutrition (2009) 0.89

Highlights of mechanistic and therapeutic cachexia and sarcopenia research 2010 to 2012 and their relevance for cardiology. Arch Med Sci (2013) 0.85

Ghrelin and cachexia: will treatment with GHSR-1a agonists make a difference for patients suffering from chronic wasting syndromes? Mol Cell Endocrinol (2011) 0.84

Neuropeptides in the pathophysiology and treatment of cachexia. Curr Opin Support Palliat Care (2010) 0.82

Hypothalamic signaling in anorexia induced by indispensable amino acid deficiency. Am J Physiol Endocrinol Metab (2012) 0.82

Research on cachexia, sarcopenia and skeletal muscle in cardiology. J Cachexia Sarcopenia Muscle (2012) 0.81

Regulation of lean mass, bone mass, and exercise tolerance by the central melanocortin system. PLoS One (2012) 0.78

Muscle wasting and cachexia in heart failure: mechanisms and therapies. Nat Rev Cardiol (2017) 0.78

Lipopolysaccharide (LPS) and tumor necrosis factor alpha (TNFα) blunt the response of Neuropeptide Y/Agouti-related peptide (NPY/AgRP) glucose inhibited (GI) neurons to decreased glucose. Brain Res (2016) 0.76

Hypothalamic activation is essential for endotoxemia-induced acute muscle wasting. Sci Rep (2016) 0.75

Articles cited by this

Heart disease and stroke statistics--2008 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation (2007) 22.81

Obesity and the risk of heart failure. N Engl J Med (2002) 12.58

Lifetime risk for developing congestive heart failure: the Framingham Heart Study. Circulation (2002) 8.49

Role of melanocortinergic neurons in feeding and the agouti obesity syndrome. Nature (1997) 6.80

Anatomy and regulation of the central melanocortin system. Nat Neurosci (2005) 6.60

Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein. Science (1997) 6.23

The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis. Neuron (2003) 6.05

The obesity paradox: body mass index and outcomes in patients with heart failure. Arch Intern Med (2005) 5.86

Elevated circulating levels of tumor necrosis factor in severe chronic heart failure. N Engl J Med (1990) 5.65

Incidence and aetiology of heart failure; a population-based study. Eur Heart J (1999) 4.56

Biology of cachexia. J Natl Cancer Inst (1997) 4.18

Wasting as independent risk factor for mortality in chronic heart failure. Lancet (1997) 3.37

Evaluation of a quantitative magnetic resonance method for mouse whole body composition analysis. Obes Res (2004) 3.05

The arcuate nucleus as a conduit for diverse signals relevant to energy homeostasis. Int J Obes Relat Metab Disord (2001) 2.08

Role of the central melanocortin system in cachexia. Cancer Res (2001) 1.60

Chronic administration of ghrelin improves left ventricular dysfunction and attenuates development of cardiac cachexia in rats with heart failure. Circulation (2001) 1.58

Central effect of ghrelin, an endogenous growth hormone secretagogue, on hypothalamic peptide gene expression. Endocrinology (2000) 1.51

Regulation of central melanocortin signaling by interleukin-1 beta. Endocrinology (2007) 1.34

The syndrome of cardiac cachexia. Int J Cardiol (2002) 1.33

Acute myocardial infarction induces hypothalamic cytokine synthesis. Am J Physiol Heart Circ Physiol (2004) 1.31

Role of leptin and melanocortin signaling in uremia-associated cachexia. J Clin Invest (2005) 1.30

Heart failure and greater infarct expansion in middle-aged mice: a relevant model for postinfarction failure. Am J Physiol Heart Circ Physiol (2002) 1.20

Cytokines and neurohormones relating to body composition alterations in the wasting syndrome of chronic heart failure. Eur Heart J (1999) 1.20

Involvement of the arcuate nucleus of the hypothalamus in interleukin-1-induced anorexia. J Neurosci (2002) 1.16

Effects of chronic central nervous system administration of agouti-related protein in pair-fed animals. Diabetes (2001) 1.15

Cardiac cachexia. Ann Med (2004) 1.14

Regulation of agouti-related protein messenger ribonucleic acid transcription and peptide secretion by acute and chronic inflammation. Endocrinology (2008) 1.13

Leptin sensitive neurons in the hypothalamus. Horm Metab Res (1999) 1.09

Assessment of cardiac function with the pressure-volume conductance system following myocardial infarction in mice. Am J Physiol Heart Circ Physiol (2007) 1.08

Cardiac magnetic resonance imaging in small animal models of human heart failure. Med Image Anal (2003) 1.07

Anorexia induced by chronic central administration of cytokines at estimated pathophysiological concentrations. Physiol Behav (1996) 1.06

Muscular levels of proinflammatory cytokines correlate with a reduced expression of insulinlike growth factor-I in chronic heart failure. Basic Res Cardiol (2003) 1.04

Sex-related changes in cardiac function following myocardial infarction in mice. Am J Physiol Regul Integr Comp Physiol (2008) 1.00

MyD88 is a key mediator of anorexia, but not weight loss, induced by lipopolysaccharide and interleukin-1 beta. Endocrinology (2006) 0.99

Evidence that lipopolysaccharide-induced anorexia depends upon central, rather than peripheral, inflammatory signals. Endocrinology (2007) 0.99

Transgenic mice and cytokine actions in the brain: bridging the gap between structural and functional neuropathology. Brain Res Brain Res Rev (1998) 0.94

Cytokines and feeding. Int J Obes Relat Metab Disord (2001) 0.94

Melanocortin-4 receptor messenger ribonucleic acid expression in rat cardiorespiratory, musculoskeletal, and integumentary systems. Endocrinology (2003) 0.93

Central infusion of the melanocortin receptor antagonist agouti-related peptide (AgRP(83-132)) prevents cachexia-related symptoms induced by radiation and colon-26 tumors in mice. Peptides (2007) 0.92

Central administration of peptide and small molecule MC4 receptor antagonists induce hyperphagia in mice and attenuate cytokine-induced anorexia. Peptides (2005) 0.87

Tumour necrosis factor alpha in severe congestive cardiac failure. Br Heart J (1993) 0.87

Further evidence that melanocortins prevent myocardial reperfusion injury by activating melanocortin MC3 receptors. Eur J Pharmacol (2003) 0.86

MC-3 receptor and the inflammatory mechanisms activated in acute myocardial infarct. J Leukoc Biol (2004) 0.84

Body weight regulation by selective MC4 receptor agonists and antagonists. Ann N Y Acad Sci (2003) 0.82

Aortic banding in rat as a model to investigate malnutrition associated with heart failure. Am J Physiol Regul Integr Comp Physiol (2005) 0.78

Articles by these authors

Activity-dependent dendritic arborization mediated by CaM-kinase I activation and enhanced CREB-dependent transcription of Wnt-2. Neuron (2006) 4.10

Optical coherence tomography: a review of clinical development from bench to bedside. J Biomed Opt (2007) 3.18

Chronic treatment with a melanocortin-4 receptor agonist causes weight loss, reduces insulin resistance, and improves cardiovascular function in diet-induced obese rhesus macaques. Diabetes (2012) 1.91

Engineered microsphere contrast agents for optical coherence tomography. Opt Lett (2003) 1.91

Effect of Agouti-related protein in regulation of the hypothalamic-pituitary-thyroid axis in the melanocortin 4 receptor knockout mouse. Endocrinology (2004) 1.71

Therapy insight: Use of melanocortin antagonists in the treatment of cachexia in chronic disease. Nat Clin Pract Endocrinol Metab (2006) 1.70

Optical probes and techniques for molecular contrast enhancement in coherence imaging. J Biomed Opt (2005) 1.67

Compressive holography. Opt Express (2009) 1.66

Optical coherence tomography: feasibility for basic research and image-guided surgery of breast cancer. Breast Cancer Res Treat (2004) 1.62

Arcuate nucleus proopiomelanocortin neurons mediate the acute anorectic actions of leukemia inhibitory factor via gp130. Endocrinology (2009) 1.58

Regulation of axonal extension and growth cone motility by calmodulin-dependent protein kinase I. J Neurosci (2004) 1.57

Regulation of central melanocortin signaling by interleukin-1 beta. Endocrinology (2007) 1.34

Three-dimensional optical coherence tomography of the embryonic murine cardiovascular system. J Biomed Opt (2006) 1.33

Stabilization of continuum generation from normally dispersive nonlinear optical fibers for a tunable broad bandwidth source for optical coherence tomography. Opt Lett (2007) 1.32

Inverse scattering for optical coherence tomography. J Opt Soc Am A Opt Image Sci Vis (2006) 1.32

Role of leptin and melanocortin signaling in uremia-associated cachexia. J Clin Invest (2005) 1.30

Activity-dependent release of tissue plasminogen activator from the dendritic spines of hippocampal neurons revealed by live-cell imaging. J Neurobiol (2006) 1.29

Projected index computed tomography. Opt Lett (2003) 1.29

Nonparaxial vector-field modeling of optical coherence tomography and interferometric synthetic aperture microscopy. J Opt Soc Am A Opt Image Sci Vis (2007) 1.25

Ghrelin treatment causes increased food intake and retention of lean body mass in a rat model of cancer cachexia. Endocrinology (2007) 1.25

Obesity-induced inflammation in white adipose tissue is attenuated by loss of melanocortin-3 receptor signaling. Endocrinology (2007) 1.24

Ghrelin treatment of chronic kidney disease: improvements in lean body mass and cytokine profile. Endocrinology (2007) 1.23

Near-infrared dyes as contrast-enhancing agents for spectroscopic optical coherence tomography. Opt Lett (2004) 1.23

Systemic inflammation and insulin sensitivity in obese IFN-γ knockout mice. Metabolism (2012) 1.22

Localized waveguide formation in germanosilicate fiber transmitting femtosecond IR pulses. J Opt Soc Am B (2008) 1.22

Inflammation-induced lethargy is mediated by suppression of orexin neuron activity. J Neurosci (2011) 1.22

Neural control of the anorexia-cachexia syndrome. Am J Physiol Endocrinol Metab (2008) 1.18

Optical biopsy of lymph node morphology using optical coherence tomography. Technol Cancer Res Treat (2005) 1.16

Functional optical coherence tomography for detecting neural activity through scattering changes. Opt Lett (2003) 1.15

Central nervous system inflammation induces muscle atrophy via activation of the hypothalamic-pituitary-adrenal axis. J Exp Med (2011) 1.15

Design and scaling of monocentric multiscale imagers. Appl Opt (2012) 1.15

High-spectral-resolution coherent anti-Stokes Raman scattering with interferometrically detected broadband chirped pulses. Opt Lett (2006) 1.13

Maternal high fat diet is associated with decreased plasma n-3 fatty acids and fetal hepatic apoptosis in nonhuman primates. PLoS One (2011) 1.13

Regulation of agouti-related protein messenger ribonucleic acid transcription and peptide secretion by acute and chronic inflammation. Endocrinology (2008) 1.13

Molecular histopathology by spectrally reconstructed nonlinear interferometric vibrational imaging. Cancer Res (2010) 1.09

Spatial light interference tomography (SLIT). Opt Express (2011) 1.09

Inverse scattering for high-resolution interferometric microscopy. Opt Lett (2006) 1.09

Real-time interferometric synthetic aperture microscopy. Opt Express (2008) 1.08

Study of an ultrahigh-numerical-aperture fiber continuum generation source for optical coherence tomography. Opt Lett (2002) 1.07

Real-time digital signal processing-based optical coherence tomography and Doppler optical coherence tomography. IEEE Trans Biomed Eng (2004) 1.07

Emergence of self-organized long-period fiber gratings in supercontinuum-generating optical fibers. Opt Lett (2009) 1.06

Molecularly sensitive optical coherence tomography. Opt Lett (2005) 1.05

Deconvolution methods for mitigation of transverse blurring in optical coherence tomography. IEEE Trans Image Process (2005) 1.04

Hypothalamic mechanisms in cachexia. Physiol Behav (2010) 1.04

Metamaterial apertures for coherent computational imaging on the physical layer. J Opt Soc Am A Opt Image Sci Vis (2013) 1.02

Cross-validation of interferometric synthetic aperture microscopy and optical coherence tomography. Opt Lett (2010) 1.02

Peripheral administration of the melanocortin-4 receptor antagonist NBI-12i ameliorates uremia-associated cachexia in mice. J Am Soc Nephrol (2007) 1.02

Needle-based reflection refractometry of scattering samples using coherence-gated detection. Opt Express (2007) 1.00

Design of a spherical focal surface using close-packed relay optics. Opt Express (2011) 0.99

A Postnatal Pax7 Progenitor Gives Rise to Pituitary Adenomas. Genes Cancer (2010) 0.99

Genetic dissection of the functions of the melanocortin-3 receptor, a seven-transmembrane G-protein-coupled receptor, suggests roles for central and peripheral receptors in energy homeostasis. J Biol Chem (2011) 0.98

Increased maternal fat consumption during pregnancy alters body composition in neonatal mice. Am J Physiol Endocrinol Metab (2011) 0.98

Interferometric Synthetic Aperture Microscopy: Computed Imaging for Scanned Coherent Microscopy. Sensors (Basel) (2008) 0.95

Pathophysiology and treatment of inflammatory anorexia in chronic disease. J Cachexia Sarcopenia Muscle (2010) 0.95

Combined effects of ghrelin and higher food intake enhance skeletal muscle mitochondrial oxidative capacity and AKT phosphorylation in rats with chronic kidney disease. Kidney Int (2010) 0.93

Autocorrelation artifacts in optical coherence tomography and interferometric synthetic aperture microscopy. Opt Lett (2007) 0.92

The regulation of feeding and metabolic rate and the prevention of murine cancer cachexia with a small-molecule melanocortin-4 receptor antagonist. Endocrinology (2005) 0.92

Cancer- and endotoxin-induced cachexia require intact glucocorticoid signaling in skeletal muscle. FASEB J (2013) 0.91

Structural and functional imaging of 3D microfluidic mixers using optical coherence tomography. Proc Natl Acad Sci U S A (2004) 0.91

Mechanisms of disease: Cytokine and adipokine signaling in uremic cachexia. Nat Clin Pract Nephrol (2006) 0.90

Administration of IL-1beta to the 4th ventricle causes anorexia that is blocked by agouti-related peptide and that coincides with activation of tyrosine-hydroxylase neurons in the nucleus of the solitary tract. Peptides (2008) 0.90

Orexigenic and anorexigenic mechanisms in the control of nutrition in chronic kidney disease. Pediatr Nephrol (2005) 0.90

High-Speed Nonlinear Interferometric Vibrational Imaging of Biological Tissue With Comparison to Raman Microscopy. IEEE J Quantum Electron (2009) 0.90

P-selectin genotype is associated with the development of cancer cachexia. EMBO Mol Med (2012) 0.89

Fast-Fourier-domain delay line for in vivo optical coherence tomography with a polygonal scanner. Appl Opt (2003) 0.89

High-speed processing architecture for spectral-domain optical coherence microscopy. J Biomed Opt (2008) 0.88

Perinatal exposure to a high-fat diet is associated with reduced hepatic sympathetic innervation in one-year old male Japanese macaques. PLoS One (2012) 0.87

Prostacyclin signaling regulates circulating ghrelin during acute inflammation. J Endocrinol (2008) 0.87

Variable penetrance of metabolic phenotypes and development of high-fat diet-induced adiposity in NEIL1-deficient mice. Am J Physiol Endocrinol Metab (2011) 0.86

Role of soluble epoxide hydrolase in exacerbation of stroke by streptozotocin-induced type 1 diabetes mellitus. J Cereb Blood Flow Metab (2013) 0.86

Hyperglycemia slows embryonic growth and suppresses cell cycle via cyclin D1 and p21. Diabetes (2012) 0.86

Cachexia: lessons from melanocortin antagonism. Trends Endocrinol Metab (2006) 0.85

The use of melanocortin antagonists in cachexia of chronic disease. Expert Opin Investig Drugs (2005) 0.84

Adipose tissue NK cells manifest an activated phenotype in human obesity. Metabolism (2013) 0.83

Hypothalamic signaling in anorexia induced by indispensable amino acid deficiency. Am J Physiol Endocrinol Metab (2012) 0.82

Neuropeptides in the pathophysiology and treatment of cachexia. Curr Opin Support Palliat Care (2010) 0.82

Expression of myeloid differentiation factor 88 in neurons is not requisite for the induction of sickness behavior by interleukin-1β. J Neuroinflammation (2012) 0.81

Coding for compressive focal tomography. Appl Opt (2011) 0.81

Hypothalamic regulation of muscle metabolism. Curr Opin Clin Nutr Metab Care (2011) 0.81

Optomechanical design of multiscale gigapixel digital camera. Appl Opt (2013) 0.81

Spatially resolving antenna arrays using frequency diversity. J Opt Soc Am A Opt Image Sci Vis (2016) 0.81

Hexosamine biosynthesis is a possible mechanism underlying hypoxia's effects on lipid metabolism in human adipocytes. PLoS One (2013) 0.81