Published in Curr Opin Mol Ther on April 01, 2010
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Polycomb proteins targeted by a short repeat RNA to the mouse X chromosome. Science (2008) 13.79
The Polycomb group protein EZH2 directly controls DNA methylation. Nature (2005) 13.67
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Divergent transcription from active promoters. Science (2008) 11.03
G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis. Genes Dev (2002) 10.54
Kcnq1ot1 antisense noncoding RNA mediates lineage-specific transcriptional silencing through chromatin-level regulation. Mol Cell (2008) 9.76
Widespread occurrence of antisense transcription in the human genome. Nat Biotechnol (2003) 8.54
The Air noncoding RNA epigenetically silences transcription by targeting G9a to chromatin. Science (2008) 8.45
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The product of the mouse Xist gene is a 15 kb inactive X-specific transcript containing no conserved ORF and located in the nucleus. Cell (1992) 6.26
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Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9. Genes Dev (2005) 5.50
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DNA methyltransferase Dnmt1 associates with histone deacetylase activity. Nat Genet (2000) 5.29
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G9a-mediated irreversible epigenetic inactivation of Oct-3/4 during early embryogenesis. Nat Cell Biol (2006) 5.16
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Different EZH2-containing complexes target methylation of histone H1 or nucleosomal histone H3. Mol Cell (2004) 5.06
Activating gene expression in mammalian cells with promoter-targeted duplex RNAs. Nat Chem Biol (2007) 5.05
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Bidirectional transcription directs both transcriptional gene activation and suppression in human cells. PLoS Genet (2008) 4.45
Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms. Mol Cell (2008) 4.44
The DNA methyltransferases associate with HP1 and the SUV39H1 histone methyltransferase. Nucleic Acids Res (2003) 4.36
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MicroRNA-directed transcriptional gene silencing in mammalian cells. Proc Natl Acad Sci U S A (2008) 4.16
Promoter-associated RNA is required for RNA-directed transcriptional gene silencing in human cells. Proc Natl Acad Sci U S A (2007) 3.99
Regional loss of imprinting and growth deficiency in mice with a targeted deletion of KvDMR1. Nat Genet (2002) 3.88
Polycomb complexes and epigenetic states. Curr Opin Cell Biol (2008) 3.81
A transient heterochromatic state in Xist preempts X inactivation choice without RNA stabilization. Mol Cell (2006) 3.67
Short double-stranded RNA induces transcriptional gene silencing in human cancer cells in the absence of DNA methylation. Nat Genet (2005) 3.66
Involvement of AGO1 and AGO2 in mammalian transcriptional silencing. Nat Struct Mol Biol (2006) 3.46
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Dnmt3a binds deacetylases and is recruited by a sequence-specific repressor to silence transcription. EMBO J (2001) 3.36
Elongation of the Kcnq1ot1 transcript is required for genomic imprinting of neighboring genes. Genes Dev (2006) 3.30
The antisense strand of small interfering RNAs directs histone methylation and transcriptional gene silencing in human cells. RNA (2005) 3.14
G9a/GLP complexes independently mediate H3K9 and DNA methylation to silence transcription. EMBO J (2008) 3.08
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SATB1 defines the developmental context for gene silencing by Xist in lymphoma and embryonic cells. Dev Cell (2009) 2.57
The imprinted Air ncRNA is an atypical RNAPII transcript that evades splicing and escapes nuclear export. EMBO J (2006) 2.55
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An ectopic human XIST gene can induce chromosome inactivation in postdifferentiation human HT-1080 cells. Proc Natl Acad Sci U S A (2002) 2.03
Inhibiting transcription of chromosomal DNA with antigene peptide nucleic acids. Nat Chem Biol (2005) 2.00
Epigenetic changes in cancer. APMIS (2007) 1.96
Regulation of endothelial nitric oxide synthase by small RNA. Proc Natl Acad Sci U S A (2005) 1.85
Mechanisms of transcriptional repression by histone lysine methylation. Int J Dev Biol (2009) 1.82
Promoter targeted small RNAs induce long-term transcriptional gene silencing in human cells. Nucleic Acids Res (2009) 1.79
The third dimension of gene regulation: organization of dynamic chromatin loopscape by SATB1. Curr Opin Genet Dev (2007) 1.75
Long antisense non-coding RNAs function to direct epigenetic complexes that regulate transcription in human cells. Epigenetics (2009) 1.71
Short hairpin RNA-directed cytosine (CpG) methylation of the RASSF1A gene promoter in HeLa cells. Mol Ther (2005) 1.67
Two distinct mechanisms of silencing by the KvDMR1 imprinting control region. EMBO J (2007) 1.59
Prolonged transcriptional silencing and CpG methylation induced by siRNAs targeted to the HIV-1 promoter region. J RNAi Gene Silencing (2005) 1.57
RNA and transcriptional modulation of gene expression. Cell Cycle (2007) 1.56
Promoter-specific transcriptional interference and c-myc gene silencing by siRNAs in human cells. EMBO J (2009) 1.55
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Crucial role of antisense transcription across the Xist promoter in Tsix-mediated Xist chromatin modification. Development (2007) 1.50
Mechanistic principles of chromatin remodeling guided by siRNAs and miRNAs. Cell Cycle (2008) 1.50
Closed chromatin architecture is induced by an RNA duplex targeting the HIV-1 promoter region. J Biol Chem (2008) 1.45
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Hematopoietic precursor cells transiently reestablish permissiveness for X inactivation. Mol Cell Biol (2006) 1.34
Non-coding RNAs in polycomb/trithorax regulation. RNA Biol (2009) 1.30
Transcriptional silencing of nonsense codon-containing immunoglobulin minigenes. Mol Cell (2005) 1.24
Mobilization-competent Lentiviral Vector-mediated Sustained Transcriptional Modulation of HIV-1 Expression. Mol Ther (2008) 1.23
Emerging similarities in epigenetic gene silencing by long noncoding RNAs. Mamm Genome (2009) 1.20
Biochemical fractionation reveals association of DNA methyltransferase (Dnmt) 3b with Dnmt1 and that of Dnmt 3a with a histone H3 methyltransferase and Hdac1. J Cell Biochem (2003) 1.17
The plasticity of the mammalian transcriptome. Genomics (2009) 1.07
Xist gene regulation at the onset of X inactivation. Curr Opin Genet Dev (2009) 1.02
Promoter-targeted siRNAs induce gene silencing of simian immunodeficiency virus (SIV) infection in vitro. Mol Ther (2008) 0.99
Studies on the mechanism of RNAi-dependent heterochromatin assembly. Cold Spring Harb Symp Quant Biol (2006) 0.98
Argonaute-1 directs siRNA-mediated transcriptional gene silencing in human cells. Nat Struct Mol Biol (2006) 4.93
Promoter-associated RNA is required for RNA-directed transcriptional gene silencing in human cells. Proc Natl Acad Sci U S A (2007) 3.99
The reality of pervasive transcription. PLoS Biol (2011) 3.41
The antisense strand of small interfering RNAs directs histone methylation and transcriptional gene silencing in human cells. RNA (2005) 3.14
A pseudogene long-noncoding-RNA network regulates PTEN transcription and translation in human cells. Nat Struct Mol Biol (2013) 2.33
Transcriptional regulation of Oct4 by a long non-coding RNA antisense to Oct4-pseudogene 5. Transcription (2010) 1.85
Promoter targeted small RNAs induce long-term transcriptional gene silencing in human cells. Nucleic Acids Res (2009) 1.79
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Profiling microRNA expression with microarrays. Trends Biotechnol (2008) 1.48
Snapshots: chromatin control of viral infection. Virology (2013) 1.39
Mobilization-competent Lentiviral Vector-mediated Sustained Transcriptional Modulation of HIV-1 Expression. Mol Ther (2008) 1.23
An RNA targeted to the HIV-1 LTR promoter modulates indiscriminate off-target gene activation. Nucleic Acids Res (2007) 1.20
Interferon-γ and systemic autoimmunity. Discov Med (2013) 1.13
Controlling transcription with noncoding RNAs in mammalian cells. Biotechniques (2010) 1.03
siRNA induced transcriptional gene silencing in mammalian cells. Cell Cycle (2005) 1.02
The relationship between transcription initiation RNAs and CCCTC-binding factor (CTCF) localization. Epigenetics Chromatin (2011) 0.98
Long non-coding RNA targeting and transcriptional de-repression. Nucleic Acid Ther (2013) 0.98
The efficacy of generating three independent anti-HIV-1 siRNAs from a single U6 RNA Pol III-expressed long hairpin RNA. PLoS One (2008) 0.96
Are viral-encoded microRNAs mediating latent HIV-1 infection? DNA Cell Biol (2006) 0.93
Characterization of an HIV-targeted transcriptional gene-silencing RNA in primary cells. Hum Gene Ther (2012) 0.93
The inhibitory efficacy of RNA POL III-expressed long hairpin RNAs targeted to untranslated regions of the HIV-1 5' long terminal repeat. Oligonucleotides (2007) 0.90
Small RNA-Mediated Epigenetic Myostatin Silencing. Mol Ther Nucleic Acids (2012) 0.89
Non-coding RNA and antisense RNA. Nature's trash or treasure? Biochimie (2011) 0.88
An Algorithm for Generating Small RNAs Capable of Epigenetically Modulating Transcriptional Gene Silencing and Activation in Human Cells. Mol Ther Nucleic Acids (2013) 0.87
Long antisense non-coding RNAs and the epigenetic regulation of gene expression. Biomol Concepts (2013) 0.87
The therapeutic application of CRISPR/Cas9 technologies for HIV. Expert Opin Biol Ther (2015) 0.83
Chromatin, non-coding RNAs, and the expression of HIV. Viruses (2013) 0.83
Epigenetic regulation of gene expression in human cells by noncoding RNAs. Prog Mol Biol Transl Sci (2011) 0.82
Pseudogenes: a novel source of trans-acting antisense RNAs. Methods Mol Biol (2014) 0.81
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MYCNOS functions as an antisense RNA regulating MYCN. RNA Biol (2015) 0.79
A new world order: tailored gene targeting and regulation using CRISPR. Mol Ther (2014) 0.79
Chemically Modified Oligonucleotides Modulate an Epigenetically Varied and Transient Form of Transcription Silencing of HIV-1 in Human Cells. Mol Ther Nucleic Acids (2012) 0.79
Targeted small noncoding RNA-directed gene activation in human cells. Methods Mol Biol (2014) 0.77
Transcriptional Gene Silencing of the Autism-Associated Long Noncoding RNA MSNP1AS in Human Neural Progenitor Cells. Dev Neurosci (2016) 0.76
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In the first post-genomic decade, the ENCODE and FANTOM consortia have revolutionized. Introduction. Curr Top Microbiol Immunol (2016) 0.75