Published in Cell Metab on April 07, 2010
The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors. Br J Pharmacol (2013) 5.74
Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human. Nature (2012) 3.41
Cardiovascular biology of the incretin system. Endocr Rev (2012) 2.42
Brain insulin controls adipose tissue lipolysis and lipogenesis. Cell Metab (2011) 1.64
International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands. Pharmacol Rev (2013) 1.60
The cell biology of fat expansion. J Cell Biol (2015) 1.37
G protein-coupled receptors for energy metabolites as new therapeutic targets. Nat Rev Drug Discov (2012) 1.35
Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells. Mol Metab (2013) 1.14
The brown fat secretome: metabolic functions beyond thermogenesis. Trends Endocrinol Metab (2015) 1.05
Neural innervation of white adipose tissue and the control of lipolysis. Front Neuroendocrinol (2014) 1.02
Sympathetic nervous system control of triglyceride metabolism: novel concepts derived from recent studies. J Lipid Res (2013) 0.96
Running forward: new frontiers in endurance exercise biology. Circulation (2014) 0.94
Cell surface lactate receptor GPR81 is crucial for cancer cell survival. Cancer Res (2014) 0.93
Contributions of adipocyte lipid metabolism to body fat content and implications for the treatment of obesity. Curr Opin Pharmacol (2010) 0.90
Lactate transport and signaling in the brain: potential therapeutic targets and roles in body-brain interaction. J Cereb Blood Flow Metab (2014) 0.87
Augmenting energy expenditure by mitochondrial uncoupling: a role of AMP-activated protein kinase. Genes Nutr (2011) 0.86
Hydroxycarboxylic acid receptors are essential for breast cancer cells to control their lipid/fatty acid metabolism. Oncotarget (2015) 0.85
Low affinity GPCRs for metabolic intermediates: challenges for pharmacologists. Front Endocrinol (Lausanne) (2012) 0.84
Type 2 Diabetes Dysregulates Glucose Metabolism in Cardiac Progenitor Cells. J Biol Chem (2016) 0.82
Deficiency in the metabolite receptor SUCNR1 (GPR91) leads to outer retinal lesions. Aging (Albany NY) (2013) 0.82
Adipose tissue lipolysis revisited (again!): lactate involvement in insulin antilipolytic action. Cell Metab (2010) 0.80
Kinome Screen Identifies PFKFB3 and Glucose Metabolism as Important Regulators of the Insulin/Insulin-like Growth Factor (IGF)-1 Signaling Pathway. J Biol Chem (2015) 0.78
Distinct pathways of ERK1/2 activation by hydroxy-carboxylic acid receptor-1. PLoS One (2014) 0.77
Biological roles and therapeutic potential of hydroxy-carboxylic Acid receptors. Front Endocrinol (Lausanne) (2011) 0.76
Naturally occurring HCA1 missense mutations result in loss of function: potential impact on lipid deposition. J Lipid Res (2012) 0.76
Lactate Inhibits the Pro-Inflammatory Response and Metabolic Reprogramming in Murine Macrophages in a GPR81-Independent Manner. PLoS One (2016) 0.76
G-protein-coupled receptor 81 promotes a malignant phenotype in breast cancer through angiogenic factor secretion. Oncotarget (2016) 0.75
Gpr132 sensing of lactate mediates tumor-macrophage interplay to promote breast cancer metastasis. Proc Natl Acad Sci U S A (2017) 0.75
Heat stress increases insulin sensitivity in pigs. Physiol Rep (2015) 0.75
Ischaemic concentrations of lactate increase TREK1 channel activity by interacting with a single histidine residue in the carboxy terminal domain. J Physiol (2015) 0.75
Astrocyte-Neuron Interactions during Learning May Occur by Lactate Signaling Rather than Metabolism. Front Integr Neurosci (2016) 0.75
Induction of triglyceride accumulation and mitochondrial maintenance in muscle cells by lactate. Sci Rep (2016) 0.75
Mammalian G proteins and their cell type specific functions. Physiol Rev (2005) 4.40
G12-G13-LARG-mediated signaling in vascular smooth muscle is required for salt-induced hypertension. Nat Med (2007) 4.26
Platelet-derived nucleotides promote tumor-cell transendothelial migration and metastasis via P2Y2 receptor. Cancer Cell (2013) 3.74
PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect. Nat Med (2003) 2.97
Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphology. Neuron (2002) 2.59
Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis. Nature (2016) 2.24
The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition. Proc Natl Acad Sci U S A (2014) 2.22
Rho/Rho-kinase mediated signaling in physiology and pathophysiology. J Mol Med (Berl) (2002) 2.03
Achalasia--a disease of unknown cause that is often diagnosed too late. Dtsch Arztebl Int (2012) 2.01
MicroRNAs are necessary for vascular smooth muscle growth, differentiation, and function. Arterioscler Thromb Vasc Biol (2010) 2.00
(D)-beta-Hydroxybutyrate inhibits adipocyte lipolysis via the nicotinic acid receptor PUMA-G. J Biol Chem (2005) 1.99
GPR41/FFAR3 and GPR43/FFAR2 as cosensors for short-chain fatty acids in enteroendocrine cells vs FFAR3 in enteric neurons and FFAR2 in enteric leukocytes. Endocrinology (2013) 1.89
Megakaryocyte-specific RhoA deficiency causes macrothrombocytopenia and defective platelet activation in hemostasis and thrombosis. Blood (2011) 1.88
GPR109A (PUMA-G/HM74A) mediates nicotinic acid-induced flushing. J Clin Invest (2005) 1.88
G13 is an essential mediator of platelet activation in hemostasis and thrombosis. Nat Med (2003) 1.77
Conditional gene deletion in primary nociceptive neurons of trigeminal ganglia and dorsal root ganglia. Genesis (2004) 1.75
Nicotinic acid- and monomethyl fumarate-induced flushing involves GPR109A expressed by keratinocytes and COX-2-dependent prostanoid formation in mice. J Clin Invest (2010) 1.64
Members of a large retroposon family are determinants of post-transcriptional gene expression in Leishmania. PLoS Pathog (2007) 1.59
Receptor-dependent RhoA activation in G12/G13-deficient cells: genetic evidence for an involvement of Gq/G11. J Biol Chem (2003) 1.57
Nicotinic acid: pharmacological effects and mechanisms of action. Annu Rev Pharmacol Toxicol (2008) 1.55
Galpha12/13 is essential for directed cell migration and localized Rho-Dia1 function. J Biol Chem (2005) 1.51
Nicotinic acid inhibits progression of atherosclerosis in mice through its receptor GPR109A expressed by immune cells. J Clin Invest (2011) 1.46
Endothelial cation channel PIEZO1 controls blood pressure by mediating flow-induced ATP release. J Clin Invest (2016) 1.45
Tgfbr2 disruption in postnatal smooth muscle impairs aortic wall homeostasis. J Clin Invest (2014) 1.40
Nicotinic acid-induced flushing is mediated by activation of epidermal langerhans cells. Mol Pharmacol (2006) 1.39
ErbB-2 and met reciprocally regulate cellular signaling via plexin-B1. J Biol Chem (2007) 1.38
G(12)/G(13)-mediated signalling in mammalian physiology and disease. Trends Pharmacol Sci (2008) 1.36
G protein-coupled receptors for energy metabolites as new therapeutic targets. Nat Rev Drug Discov (2012) 1.35
Plexin-B1/RhoGEF-mediated RhoA activation involves the receptor tyrosine kinase ErbB-2. J Cell Biol (2004) 1.33
Smooth muscle miRNAs are critical for post-natal regulation of blood pressure and vascular function. PLoS One (2011) 1.33
Parathyroid-specific double knockout of Gq and G11 alpha-subunits leads to a phenotype resembling germline knockout of the extracellular Ca2+ -sensing receptor. Mol Endocrinol (2006) 1.31
Complementary roles of glycoprotein VI and alpha2beta1 integrin in collagen-induced thrombus formation in flowing whole blood ex vivo. FASEB J (2003) 1.28
GPR109A, GPR109B and GPR81, a family of hydroxy-carboxylic acid receptors. Trends Pharmacol Sci (2009) 1.28
SDF-1α induction in mature smooth muscle cells by inactivation of PTEN is a critical mediator of exacerbated injury-induced neointima formation. Arterioscler Thromb Vasc Biol (2011) 1.27
Interaction of G alpha(12) with G alpha(13) and G alpha(q) signaling pathways. Proc Natl Acad Sci U S A (2002) 1.27
Association of axon guidance factor semaphorin 3A with poor outcome in pancreatic cancer. Int J Cancer (2007) 1.26
Niacin stimulates adiponectin secretion through the GPR109A receptor. Am J Physiol Endocrinol Metab (2009) 1.25
Activation of TRPC6 channels is essential for lung ischaemia-reperfusion induced oedema in mice. Nat Commun (2012) 1.25
A combined proteomic and transcriptomic approach to the study of stage differentiation in Leishmania infantum. Proteomics (2006) 1.24
Distinct 3'-untranslated region elements regulate stage-specific mRNA accumulation and translation in Leishmania. J Biol Chem (2005) 1.24
Hydroxycarboxylic acid receptor 2 mediates dimethyl fumarate's protective effect in EAE. J Clin Invest (2014) 1.24
Structural basis for the inhibition of mammalian membrane adenylyl cyclase by 2 '(3')-O-(N-Methylanthraniloyl)-guanosine 5 '-triphosphate. J Biol Chem (2004) 1.23
Broad specificity of mammalian adenylyl cyclase for interaction with 2',3'-substituted purine- and pyrimidine nucleotide inhibitors. Mol Pharmacol (2006) 1.20
Blockade of dendritic cell development by bacterial fermentation products butyrate and propionate through a transporter (Slc5a8)-dependent inhibition of histone deacetylases. J Biol Chem (2010) 1.18
Anaphylactic shock depends on endothelial Gq/G11. J Exp Med (2009) 1.16
Radial construction of an arterial wall. Dev Cell (2012) 1.16
Thyrocyte-specific Gq/G11 deficiency impairs thyroid function and prevents goiter development. J Clin Invest (2007) 1.15
Labeling of human mesenchymal stromal cells with superparamagnetic iron oxide leads to a decrease in migration capacity and colony formation ability. Cytotherapy (2009) 1.14
Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells. Mol Metab (2013) 1.14
[Total trans-oral endoscopic thyroidectomy and cervical lymphadenectomy: a human cadavers surgery study]. Zhonghua Wai Ke Za Zhi (2013) 1.13
Thrombin protease-activated receptor-1 signals through Gq- and G13-initiated MAPK cascades regulating c-Jun expression to induce cell transformation. J Biol Chem (2003) 1.13
Characterization of determinants of ligand binding to the nicotinic acid receptor GPR109A (HM74A/PUMA-G). Mol Pharmacol (2005) 1.13
Inhibitors of membranous adenylyl cyclases. Trends Pharmacol Sci (2011) 1.12
Identification of geographically distributed sub-populations of Leishmania (Leishmania) major by microsatellite analysis. BMC Evol Biol (2008) 1.11
The Gq/G11-mediated signaling pathway is critical for autocrine potentiation of insulin secretion in mice. J Clin Invest (2010) 1.10
Increased cGMP promotes healthy expansion and browning of white adipose tissue. FASEB J (2013) 1.09
Novel formulation of a reconstituted high-density lipoprotein (CSL112) dramatically enhances ABCA1-dependent cholesterol efflux. Arterioscler Thromb Vasc Biol (2013) 1.09
Thromboxane, prostacyclin and isoprostanes: therapeutic targets in atherogenesis. Trends Pharmacol Sci (2005) 1.09
PRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα12. Nat Cell Biol (2012) 1.08
Plexin-B family members demonstrate non-redundant expression patterns in the developing mouse nervous system: an anatomical basis for morphogenetic effects of Sema4D during development. Eur J Neurosci (2004) 1.07
Conserved MIP receptor-ligand pair regulates Platynereis larval settlement. Proc Natl Acad Sci U S A (2013) 1.05
A functional role for semaphorin 4D/plexin B1 interactions in epithelial branching morphogenesis during organogenesis. Development (2008) 1.05
Inducible knockout mutagenesis reveals compensatory mechanisms elicited by constitutive BK channel deficiency in overactive murine bladder. FEBS J (2008) 1.04
Molecular analysis of the interaction of anthrax adenylyl cyclase toxin, edema factor, with 2'(3')-O-(N-(methyl)anthraniloyl)-substituted purine and pyrimidine nucleotides. Mol Pharmacol (2008) 1.04
Costimulation of Gi- and G12/G13-mediated signaling pathways induces integrin alpha IIbbeta 3 activation in platelets. J Biol Chem (2002) 1.04
Coxibs and cardiovascular side-effects: from light to shadow. Curr Pharm Des (2006) 1.03
Guanine nucleotide-binding proteins of the G12 family shape immune functions by controlling CD4+ T cell adhesiveness and motility. Immunity (2009) 1.03
Forebrain-specific inactivation of Gq/G11 family G proteins results in age-dependent epilepsy and impaired endocannabinoid formation. Mol Cell Biol (2006) 1.02
Castor oil induces laxation and uterus contraction via ricinoleic acid activating prostaglandin EP3 receptors. Proc Natl Acad Sci U S A (2012) 1.02
ErbB-2 signals through Plexin-B1 to promote breast cancer metastasis. J Clin Invest (2012) 1.01
Recombinase-mediated cassette exchange reveals the selective use of Gq/G11-dependent and -independent endothelin 1/endothelin type A receptor signaling in pharyngeal arch development. Development (2008) 1.01
From the design to the clinical application of thromboxane modulators. Curr Pharm Des (2006) 1.01
Functional specificity of G alpha q and G alpha 11 in the cholinergic and glutamatergic modulation of potassium currents and excitability in hippocampal neurons. J Neurosci (2002) 1.01
Real-time visualization of heterotrimeric G protein Gq activation in living cells. BMC Biol (2011) 1.00
Deletion of the last five C-terminal amino acid residues of connexin43 leads to lethal ventricular arrhythmias in mice without affecting coupling via gap junction channels. Basic Res Cardiol (2013) 1.00
Characterization of mouse heart adenylyl cyclase. J Pharmacol Exp Ther (2009) 0.99
Plexin-B2, but not Plexin-B1, critically modulates neuronal migration and patterning of the developing nervous system in vivo. J Neurosci (2007) 0.99
A novel class of developmentally regulated noncoding RNAs in Leishmania. Eukaryot Cell (2006) 0.98
Anti-glycoprotein VI treatment severely compromises hemostasis in mice with reduced alpha2beta1 levels or concomitant aspirin therapy. Circulation (2004) 0.98
Role of vascular extracellular superoxide dismutase in hypertension. Hypertension (2011) 0.98
G13 controls angiogenesis through regulation of VEGFR-2 expression. Dev Cell (2013) 0.97
Heterotrimeric G proteins of the Gq/11 family are crucial for the induction of maternal behavior in mice. Mol Cell Biol (2004) 0.96
Unresponsiveness of platelets lacking both Galpha(q) and Galpha(13). Implications for collagen-induced platelet activation. J Biol Chem (2004) 0.95
Deorphanization of GPR109B as a receptor for the beta-oxidation intermediate 3-OH-octanoic acid and its role in the regulation of lipolysis. J Biol Chem (2009) 0.95
Mouse models to study G-protein-mediated signaling. Pharmacol Ther (2004) 0.95
Nicotinic acid (niacin): new lipid-independent mechanisms of action and therapeutic potentials. Trends Pharmacol Sci (2011) 0.94