Published in Nature on February 19, 2012
A Biological Atlas of Severe Obesity (Biological Tissue Collection) (ABOS) | NCT01129297
The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors. Br J Pharmacol (2013) 5.74
Discovery of a class of endogenous mammalian lipids with anti-diabetic and anti-inflammatory effects. Cell (2014) 3.03
Pleiotropic actions of insulin resistance and inflammation in metabolic homeostasis. Science (2013) 2.85
Nutrient-sensing mechanisms and pathways. Nature (2015) 2.46
The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43. Nat Commun (2013) 2.31
A Gpr120-selective agonist improves insulin resistance and chronic inflammation in obese mice. Nat Med (2014) 1.83
Insulin signaling, resistance, and the metabolic syndrome: insights from mouse models into disease mechanisms. J Endocrinol (2014) 1.76
Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity. Nat Genet (2013) 1.72
International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands. Pharmacol Rev (2013) 1.60
Lipid stimulation of fatty acid sensors in the human duodenum: relationship with gastrointestinal hormones, BMI and diet. Int J Obes (Lond) (2016) 1.39
Functional analysis of free fatty acid receptor GPR120 in human eosinophils: implications in metabolic homeostasis. PLoS One (2015) 1.38
G protein-coupled receptors for energy metabolites as new therapeutic targets. Nat Rev Drug Discov (2012) 1.35
From obesity genetics to the future of personalized obesity therapy. Nat Rev Endocrinol (2013) 1.29
The pharmacology of TUG-891, a potent and selective agonist of the free fatty acid receptor 4 (FFA4/GPR120), demonstrates both potential opportunity and possible challenges to therapeutic agonism. Mol Pharmacol (2013) 1.18
Short-chain free fatty acid receptors FFA2/GPR43 and FFA3/GPR41 as new potential therapeutic targets. Front Endocrinol (Lausanne) (2012) 1.18
Integrated enrichment analysis of variants and pathways in genome-wide association studies indicates central role for IL-2 signaling genes in type 1 diabetes, and cytokine signaling genes in Crohn's disease. PLoS Genet (2013) 1.14
Brown and white adipose tissues: intrinsic differences in gene expression and response to cold exposure in mice. Am J Physiol Endocrinol Metab (2014) 1.12
Neuroinflammatory basis of metabolic syndrome. Mol Metab (2013) 1.10
A potent class of GPR40 full agonists engages the enteroinsular axis to promote glucose control in rodents. PLoS One (2012) 1.08
A point mutation in the human Slo1 channel that impairs its sensitivity to omega-3 docosahexaenoic acid. J Gen Physiol (2013) 1.04
GPR120 (FFAR4) is preferentially expressed in pancreatic delta cells and regulates somatostatin secretion from murine islets of Langerhans. Diabetologia (2014) 1.02
Neural innervation of white adipose tissue and the control of lipolysis. Front Neuroendocrinol (2014) 1.02
Omega 3 fatty acids and GPR120. Cell Metab (2012) 0.99
Role of docosahexaenoic acid treatment in improving liver histology in pediatric nonalcoholic fatty liver disease. PLoS One (2014) 0.98
Metabolic functions of FABPs--mechanisms and therapeutic implications. Nat Rev Endocrinol (2015) 0.94
Activation of the omega-3 fatty acid receptor GPR120 mediates anti-inflammatory actions in immortalized hypothalamic neurons. J Neuroinflammation (2014) 0.93
Gustducin couples fatty acid receptors to GLP-1 release in colon. Am J Physiol Endocrinol Metab (2013) 0.93
Inflammation, metaflammation and immunometabolic disorders. Nature (2017) 0.93
Expression of the fatty acid receptor GPR120 in the gut of diet-induced-obese rats and its role in GLP-1 secretion. PLoS One (2014) 0.92
Unravelling hair follicle-adipocyte communication. Exp Dermatol (2012) 0.91
Chaperoning G protein-coupled receptors: from cell biology to therapeutics. Endocr Rev (2014) 0.91
Sensing of triacylglycerol in the gut: different mechanisms for fatty acids and 2-monoacylglycerol. J Physiol (2015) 0.91
Medium-chain fatty acid-sensing receptor, GPR84, is a proinflammatory receptor. J Biol Chem (2013) 0.91
Regulation of Energy Homeostasis via GPR120. Front Endocrinol (Lausanne) (2014) 0.90
Mechanisms of omega-3 polyunsaturated fatty acids in prostate cancer prevention. Biomed Res Int (2013) 0.90
Treatment of type 2 diabetes by free Fatty Acid receptor agonists. Front Endocrinol (Lausanne) (2014) 0.89
Obesity genetics in mouse and human: back and forth, and back again. PeerJ (2015) 0.89
Recent findings on the health effects of omega-3 fatty acids and statins, and their interactions: do statins inhibit omega-3? BMC Med (2013) 0.88
Free fatty acid receptors as therapeutic targets for the treatment of diabetes. Front Pharmacol (2014) 0.88
Alteration of the glucagon axis in GPR120 (FFAR4) knockout mice: a role for GPR120 in glucagon secretion. J Biol Chem (2014) 0.88
Comprehensive Map of Molecules Implicated in Obesity. PLoS One (2016) 0.88
Lipid signaling and lipotoxicity in metaflammation: indications for metabolic disease pathogenesis and treatment. J Lipid Res (2016) 0.87
Integration of satiety signals by the central nervous system. Curr Biol (2013) 0.87
Therapeutic role and ligands of medium- to long-chain Fatty Acid receptors. Front Endocrinol (Lausanne) (2014) 0.87
Concomitant action of structural elements and receptor phosphorylation determines arrestin-3 interaction with the free fatty acid receptor FFA4. J Biol Chem (2014) 0.87
The Roles of Adipokines, Proinflammatory Cytokines, and Adipose Tissue Macrophages in Obesity-Associated Insulin Resistance in Modest Obesity and Early Metabolic Dysfunction. PLoS One (2016) 0.87
The molecular basis of ligand interaction at free fatty acid receptor 4 (FFA4/GPR120). J Biol Chem (2014) 0.86
Immunological contributions to adipose tissue homeostasis. Semin Immunol (2015) 0.86
S-nitrosylation regulates mitochondrial quality control via activation of parkin. Sci Rep (2013) 0.86
G protein-coupled receptors and the regulation of autophagy. Trends Endocrinol Metab (2014) 0.85
Mechanisms of homologous and heterologous phosphorylation of FFA receptor 4 (GPR120): GRK6 and PKC mediate phosphorylation of Thr³⁴⁷, Ser³⁵⁰, and Ser³⁵⁷ in the C-terminal tail. Biochem Pharmacol (2014) 0.85
Physiology. Food as a hormone. Science (2013) 0.85
Potential roles of GPR120 and its agonists in the management of diabetes. Drug Des Devel Ther (2014) 0.84
Treatment of intermittent hypoxia increases phosphorylated tau in the hippocampus via biological processes common to aging. Mol Brain (2017) 0.84
Endogenously generated omega-3 fatty acids attenuate vascular inflammation and neointimal hyperplasia by interaction with free fatty acid receptor 4 in mice. J Am Heart Assoc (2015) 0.84
Characterizing pharmacological ligands to study the long-chain fatty acid receptors GPR40/FFA1 and GPR120/FFA4. Br J Pharmacol (2015) 0.83
Dietary fat induces sustained reward response in the human brain without primary taste cortex discrimination. Front Hum Neurosci (2013) 0.83
Drugs or diet?--Developing novel therapeutic strategies targeting the free fatty acid family of GPCRs. Br J Pharmacol (2013) 0.83
Minireview: The effects of species ortholog and SNP variation on receptors for free fatty acids. Mol Endocrinol (2013) 0.83
G protein-coupled receptors as targets for anti-diabetic therapeutics. Nat Rev Drug Discov (2016) 0.83
Understanding the pathophysiological mechanisms in the pediatric non-alcoholic fatty liver disease: The role of genetics. World J Hepatol (2015) 0.83
The beneficial effects of n-3 polyunsaturated fatty acids on diet induced obesity and impaired glucose control do not require Gpr120. PLoS One (2014) 0.82
Omega-3 Fatty Acids and FFAR4. Front Endocrinol (Lausanne) (2014) 0.82
N-3 Polyunsaturated Fatty Acids and Inflammation in Obesity: Local Effect and Systemic Benefit. Biomed Res Int (2015) 0.82
The L-Cell in Nutritional Sensing and the Regulation of Appetite. Front Nutr (2015) 0.81
How does genotype influence disease phenotype in inflammatory bowel disease? Inflamm Bowel Dis (2013) 0.81
Identification of Creb3l4 as an essential negative regulator of adipogenesis. Cell Death Dis (2014) 0.81
Fish Oil Accelerates Diet-Induced Entrainment of the Mouse Peripheral Clock via GPR120. PLoS One (2015) 0.80
The endocrinology of taste receptors. Nat Rev Endocrinol (2015) 0.80
The oral lipid sensor GPR120 is not indispensable for the orosensory detection of dietary lipids in mice. J Lipid Res (2014) 0.80
Inflammation in sleep apnea: an update. Rev Endocr Metab Disord (2015) 0.80
Nutritional Signaling via Free Fatty Acid Receptors. Int J Mol Sci (2016) 0.79
Expression and localization of the omega-3 fatty acid receptor GPR120 in human term placenta. Placenta (2014) 0.79
Omega-3 fatty acids induce Ca(2+) mobilization responses in human colon epithelial cell lines endogenously expressing FFA4. Acta Pharmacol Sin (2015) 0.79
Lipidome in colorectal cancer. Oncotarget (2016) 0.79
GPR120: A bi-potential mediator to modulate the osteogenic and adipogenic differentiation of BMMSCs. Sci Rep (2015) 0.78
GADD34-deficient mice develop obesity, nonalcoholic fatty liver disease, hepatic carcinoma and insulin resistance. Sci Rep (2015) 0.78
Contribution of common non-synonymous variants in PCSK1 to body mass index variation and risk of obesity: a systematic review and meta-analysis with evidence from up to 331 175 individuals. Hum Mol Genet (2015) 0.78
Disruption of the sugar-sensing receptor T1R2 attenuates metabolic derangements associated with diet-induced obesity. Am J Physiol Endocrinol Metab (2016) 0.78
Jumping on the Train of Personalized Medicine: A Primer for Non- Geneticist Clinicians: Part 3. Clinical Applications in the Personalized Medicine Area. Curr Psychiatry Rev (2014) 0.78
Cross-species comparison of genes related to nutrient sensing mechanisms expressed along the intestine. PLoS One (2014) 0.78
Fish oil and flax seed oil supplemented diets increase FFAR4 expression in the rat colon. Inflamm Res (2015) 0.78
G protein-coupled receptors and adipogenesis: a focus on adenosine receptors. J Cell Physiol (2014) 0.78
Effect of surfactant hydrophobicity on the pathway for unfolding of ubiquitin. J Am Chem Soc (2012) 0.77
Mining microarray datasets in nutrition: expression of the GPR120 (n-3 fatty acid receptor/sensor) gene is down-regulated in human adipocytes by macrophage secretions. J Nutr Sci (2012) 0.77
Cloning and characterization of spliced variants of the porcine G protein coupled receptor 120. Biomed Res Int (2015) 0.77
Functionality of fatty acid chemoreception: a potential factor in the development of obesity? Nutrients (2013) 0.77
Eicosapentaenoic acid attenuates dexamethasome-induced apoptosis by inducing adaptive autophagy via GPR120 in murine bone marrow-derived mesenchymal stem cells. Cell Death Dis (2016) 0.77
Mechanisms Regulating Insulin Response to Intragastric Glucose in Lean and Non-Diabetic Obese Subjects: A Randomized, Double-Blind, Parallel-Group Trial. PLoS One (2016) 0.77
Mercaptoacetate blocks fatty acid-induced GLP-1 secretion in male rats by directly antagonizing GPR40 fatty acid receptors. Am J Physiol Regul Integr Comp Physiol (2016) 0.77
Plasma proteome profiles associated with diet-induced metabolic syndrome and the early onset of metabolic syndrome in a pig model. PLoS One (2013) 0.76
Expression of the long-chain fatty acid receptor GPR120 in the gonadotropes of the mouse anterior pituitary gland. Histochem Cell Biol (2014) 0.76
Dual Roles of Group IID Phospholipase A2 in Inflammation and Cancer. J Biol Chem (2016) 0.76
Oral Fat Sensing and CD36 Gene Polymorphism in Algerian Lean and Obese Teenagers. Nutrients (2015) 0.76
The lipid sensor GPR120 promotes brown fat activation and FGF21 release from adipocytes. Nat Commun (2016) 0.76
EPA, not DHA, prevents fibrosis in pressure overload-induced heart failure: potential role of free fatty acid receptor 4. J Lipid Res (2015) 0.76
Eicosapentaenoic Acid Potentiates Brown Thermogenesis through FFAR4-dependent Up-regulation of miR-30b and miR-378. J Biol Chem (2016) 0.76
Expanding Duplication of Free Fatty Acid Receptor-2 (GPR43) Genes in the Chicken Genome. Genome Biol Evol (2015) 0.75
The effects on weight loss and gene expression in adipose and hepatic tissues of very-low carbohydrate and low-fat isoenergetic diets in diet-induced obese mice. Nutr Metab (Lond) (2016) 0.75
Human non-synonymous SNPs: server and survey. Nucleic Acids Res (2002) 50.45
Evolutionarily conserved elements in vertebrate, insect, worm, and yeast genomes. Genome Res (2005) 44.08
Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm. Nat Protoc (2009) 38.62
affy--analysis of Affymetrix GeneChip data at the probe level. Bioinformatics (2004) 32.08
PANTHER: a library of protein families and subfamilies indexed by function. Genome Res (2003) 21.64
Prediction of deleterious human alleles. Hum Mol Genet (2001) 21.00
SNAP predicts effect of mutations on protein function. Bioinformatics (2008) 15.39
PMUT: a web-based tool for the annotation of pathological mutations on proteins. Bioinformatics (2005) 9.88
Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43. Nature (2009) 8.71
GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects. Cell (2010) 8.69
Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism. Cell (2008) 7.37
Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40. Nature (2003) 6.87
Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations. Nat Genet (2009) 6.39
Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120. Nat Med (2004) 6.16
Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity. Proc Natl Acad Sci U S A (2002) 6.00
Body Mass Index variations: centiles from birth to 87 years. Eur J Clin Nutr (1991) 4.60
Islet beta cell expression of constitutively active Akt1/PKB alpha induces striking hypertrophy, hyperplasia, and hyperinsulinemia. J Clin Invest (2001) 3.29
Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2. J Clin Invest (2000) 3.01
The FFA receptor GPR40 links hyperinsulinemia, hepatic steatosis, and impaired glucose homeostasis in mouse. Cell Metab (2005) 2.71
Critical role of stearoyl-CoA desaturase-1 (SCD1) in the onset of diet-induced hepatic insulin resistance. J Clin Invest (2006) 2.13
Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41). Proc Natl Acad Sci U S A (2011) 1.97
Medium-chain fatty acids as ligands for orphan G protein-coupled receptor GPR84. J Biol Chem (2006) 1.95
Inflammation is associated with a decrease of lipogenic factors in omental fat in women. Am J Physiol Regul Integr Comp Physiol (2008) 1.88
[An epidemiologic survey from a network of French Health Examination Centres, (D.E.S.I.R.): epidemiologic data on the insulin resistance syndrome]. Rev Epidemiol Sante Publique (1996) 1.86
Ecological and individual predictors of birthweight in a northern Finland birth cohort 1986. Paediatr Perinat Epidemiol (1997) 1.85
Variants in the FTO gene are associated with common obesity in the Belgian population. Mol Genet Metab (2007) 1.82
An autocrine lactate loop mediates insulin-dependent inhibition of lipolysis through GPR81. Cell Metab (2010) 1.81
Defining childhood obesity: the relative body mass index (BMI). European Childhood Obesity group. Acta Paediatr (1995) 1.66
The regulation of adipogenesis through GPR120. Biochem Biophys Res Commun (2007) 1.55
Free fatty acids induce cholecystokinin secretion through GPR120. Naunyn Schmiedebergs Arch Pharmacol (2007) 1.52
Free fatty acid receptors act as nutrient sensors to regulate energy homeostasis. Prostaglandins Other Lipid Mediat (2009) 1.45
R125W coding variant in TBC1D1 confers risk for familial obesity and contributes to linkage on chromosome 4p14 in the French population. Hum Mol Genet (2008) 1.44
Novel common copy number variation for early onset extreme obesity on chromosome 11q11 identified by a genome-wide analysis. Hum Mol Genet (2010) 1.40
Novel selective ligands for free fatty acid receptors GPR120 and GPR40. Naunyn Schmiedebergs Arch Pharmacol (2009) 1.38
Dok1 mediates high-fat diet-induced adipocyte hypertrophy and obesity through modulation of PPAR-gamma phosphorylation. Nat Med (2008) 1.27
MicroRNA-34a inhibits cell proliferation by repressing mitogen-activated protein kinase kinase 1 during megakaryocytic differentiation of K562 cells. Mol Pharmacol (2010) 1.26
Pleiotropic effects of fatty acids on pancreatic beta-cells. J Cell Physiol (2003) 1.21
Free fatty acid receptors FFAR1 and GPR120 as novel therapeutic targets for metabolic disorders. J Pharm Sci (2011) 1.20
Adult height distribution in subjects born small for gestational age. Horm Res (2004) 1.14
Structure-activity relationships of GPR120 agonists based on a docking simulation. Mol Pharmacol (2010) 1.11
Distribution and regulation of protein expression of the free fatty acid receptor GPR120. Naunyn Schmiedebergs Arch Pharmacol (2009) 1.04
Fatty acid desaturation index correlates with body mass and adiposity indices of obesity in Wistar NIN obese mutant rat strains WNIN/Ob and WNIN/GR-Ob. Nutr Metab (Lond) (2009) 1.00
Successful multi-intervention treatment of severe obesity: a 7-year prospective study with 96% follow-up. Obes Surg (2008) 0.98
Combined therapy of dietary fish oil and stearoyl-CoA desaturase 1 inhibition prevents the metabolic syndrome and atherosclerosis. Arterioscler Thromb Vasc Biol (2009) 0.94
PPAR-gamma2 Pro12Ala variant is associated with greater insulin sensitivity in childhood obesity. Pediatr Res (2004) 0.89
Biological complexity is under the 'strange attraction' of non-esterified fatty acids. Prostaglandins Leukot Essent Fatty Acids (1997) 0.85
Association between BBS6/MKKS gene polymorphisms, obesity and metabolic syndrome in the Greek population. Int J Obes (Lond) (2008) 0.84
The Q121 variant of ENPP1 may protect from childhood overweight/obesity in the Italian population. Obesity (Silver Spring) (2008) 0.82
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science (2007) 37.88
A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature (2007) 35.08
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet (2008) 22.35
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet (2010) 16.96
Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet (2008) 15.94
A common genetic variant is associated with adult and childhood obesity. Science (2006) 14.95
Variation in FTO contributes to childhood obesity and severe adult obesity. Nat Genet (2007) 13.62
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25
Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet (2009) 12.44
Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. Nat Genet (2008) 12.32
Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. Nat Genet (2008) 12.07
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat Genet (2012) 11.09
Variants in MTNR1B influence fasting glucose levels. Nat Genet (2008) 10.85
A signature pattern of stress-responsive microRNAs that can evoke cardiac hypertrophy and heart failure. Proc Natl Acad Sci U S A (2006) 10.09
Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature (2003) 9.79
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet (2010) 7.94
Effects of liraglutide in the treatment of obesity: a randomised, double-blind, placebo-controlled study. Lancet (2009) 7.24
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nat Genet (2010) 6.66
Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior. Nat Genet (2010) 6.49
Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations. Nat Genet (2009) 6.39
Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120. Nat Med (2004) 6.16
Genome-wide scan identifies variation in MLXIPL associated with plasma triglycerides. Nat Genet (2008) 6.06
FCGR3B copy number variation is associated with susceptibility to systemic, but not organ-specific, autoimmunity. Nat Genet (2007) 5.93
Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions. Nat Med (2007) 5.89
Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution. Nat Genet (2007) 5.88
Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution. PLoS Genet (2009) 5.81
Effect of lower sodium intake on health: systematic review and meta-analyses. BMJ (2013) 5.78
Aircraft noise and cardiovascular disease near Heathrow airport in London: small area study. BMJ (2013) 5.74
Use of HbA1c in predicting progression to diabetes in French men and women: data from an Epidemiological Study on the Insulin Resistance Syndrome (DESIR). Diabetes Care (2006) 5.56
Common genetic variation near MC4R is associated with waist circumference and insulin resistance. Nat Genet (2008) 5.55
A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk. Nat Genet (2008) 5.49