Published in PLoS One on April 08, 2010
The Mycobacterium tuberculosis stress response factor SigH is required for bacterial burden as well as immunopathology in primate lungs. J Infect Dis (2012) 1.96
Unveiling the mechanisms for decreased glutathione in individuals with HIV infection. Clin Dev Immunol (2011) 1.14
The stress-response factor SigH modulates the interaction between Mycobacterium tuberculosis and host phagocytes. PLoS One (2012) 1.09
Latent tuberculosis infection: myths, models, and molecular mechanisms. Microbiol Mol Biol Rev (2014) 1.06
DNA methylation impacts gene expression and ensures hypoxic survival of Mycobacterium tuberculosis. PLoS Pathog (2013) 1.03
ClpR protein-like regulator specifically recognizes RecA protein-independent promoter motif and broadly regulates expression of DNA damage-inducible genes in mycobacteria. J Biol Chem (2011) 1.00
Structural and functional analysis of the transcriptional regulator Rv3066 of Mycobacterium tuberculosis. Nucleic Acids Res (2012) 1.00
The antipsychotic thioridazine shows promising therapeutic activity in a mouse model of multidrug-resistant tuberculosis. PLoS One (2010) 0.99
Control of Mycobacterium tuberculosis growth by activated natural killer cells. Clin Exp Immunol (2012) 0.97
MprAB regulates the espA operon in Mycobacterium tuberculosis and modulates ESX-1 function and host cytokine response. J Bacteriol (2012) 0.96
Verapamil, and its metabolite norverapamil, inhibit macrophage-induced, bacterial efflux pump-mediated tolerance to multiple anti-tubercular drugs. J Infect Dis (2014) 0.94
Strategies to potentiate antimicrobial photoinactivation by overcoming resistant phenotypes. Photochem Photobiol (2012) 0.94
Quantity and Quality of Inhaled Dose Predicts Immunopathology in Tuberculosis. Front Immunol (2015) 0.91
The Mycobacterium tuberculosis Rv2745c plays an important role in responding to redox stress. PLoS One (2014) 0.89
The HtrA-like serine protease PepD interacts with and modulates the Mycobacterium tuberculosis 35-kDa antigen outer envelope protein. PLoS One (2011) 0.89
Reduced emergence of isoniazid resistance with concurrent use of thioridazine against acute murine tuberculosis. Antimicrob Agents Chemother (2014) 0.87
Thioridazine lacks bactericidal activity in an animal model of extracellular tuberculosis. J Antimicrob Chemother (2013) 0.86
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The role of transport mechanisms in mycobacterium tuberculosis drug resistance and tolerance. Pharmaceuticals (Basel) (2012) 0.85
The Mycobacterium tuberculosis Clp gene regulator is required for in vitro reactivation from hypoxia-induced dormancy. J Biol Chem (2014) 0.82
New Insights in to the Intrinsic and Acquired Drug Resistance Mechanisms in Mycobacteria. Front Microbiol (2017) 0.79
Global analyses of TetR family transcriptional regulators in mycobacteria indicates conservation across species and diversity in regulated functions. BMC Genomics (2015) 0.79
Why and How the Old Neuroleptic Thioridazine Cures the XDR-TB Patient. Pharmaceuticals (Basel) (2012) 0.79
A novel pathway producing dimethylsulphide in bacteria is widespread in soil environments. Nat Commun (2015) 0.79
Rv2744c Is a PspA Ortholog That Regulates Lipid Droplet Homeostasis and Nonreplicating Persistence in Mycobacterium tuberculosis. J Bacteriol (2016) 0.78
Sterilizing activity of thioridazine in combination with the first-line regimen against acute murine tuberculosis. Antimicrob Agents Chemother (2014) 0.78
Mycobacterium tuberculosis Transcription Machinery: Ready To Respond to Host Attacks. J Bacteriol (2016) 0.77
Evidence of significant synergism between antibiotics and the antipsychotic, antimicrobial drug flupenthixol. Eur J Clin Microbiol Infect Dis (2011) 0.77
Hypoxia Sensing and Persistence Genes Are Expressed during the Intragranulomatous Survival of Mycobacterium tuberculosis. Am J Respir Cell Mol Biol (2017) 0.76
DNA, cell wall and general oxidative damage underlie the tellurite/cefotaxime synergistic effect in Escherichia coli. PLoS One (2013) 0.76
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In-Vivo Gene Signatures of Mycobacterium tuberculosis in C3HeB/FeJ Mice. PLoS One (2015) 0.75
Global Transcriptomic Analysis of the Response of Corynebacterium glutamicum to Vanillin. PLoS One (2016) 0.75
Triclosan-induced genes Rv1686c-Rv1687c and Rv3161c are not involved in triclosan resistance in Mycobacterium tuberculosis. Sci Rep (2016) 0.75
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Exploring drug-induced alterations in gene expression in Mycobacterium tuberculosis by microarray hybridization. Proc Natl Acad Sci U S A (1999) 4.33
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Role of the extracytoplasmic-function sigma factor sigma(H) in Mycobacterium tuberculosis global gene expression. Mol Microbiol (2002) 2.73
Secreted transcription factor controls Mycobacterium tuberculosis virulence. Nature (2008) 2.71
The effects of reactive nitrogen intermediates on gene expression in Mycobacterium tuberculosis. Cell Microbiol (2003) 2.20
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Sigma factors and global gene regulation in Mycobacterium tuberculosis. J Bacteriol (2004) 2.05
RseA, the SigE specific anti-sigma factor of Mycobacterium tuberculosis, is inactivated by phosphorylation-dependent ClpC1P2 proteolysis. Mol Microbiol (2009) 2.04
A novel lipase belonging to the hormone-sensitive lipase family induced under starvation to utilize stored triacylglycerol in Mycobacterium tuberculosis. J Biol Chem (2005) 1.99
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Efflux pump-mediated intrinsic drug resistance in Mycobacterium smegmatis. Antimicrob Agents Chemother (2004) 1.63
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Global transcriptional response to vancomycin in Mycobacterium tuberculosis. Microbiology (2009) 1.46
Evidence for complex interactions of stress-associated regulons in an mprAB deletion mutant of Mycobacterium tuberculosis. Microbiology (2007) 1.46
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Virulence of Mycobacterium tuberculosis CDC1551 and H37Rv in rabbits evaluated by Lurie's pulmonary tubercle count method. Infect Immun (1999) 1.46
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Signature gene expression profiles discriminate between isoniazid-, thiolactomycin-, and triclosan-treated Mycobacterium tuberculosis. Antimicrob Agents Chemother (2003) 1.38
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Deletion of Mycobacterium tuberculosis sigma factor E results in delayed time to death with bacterial persistence in the lungs of aerosol-infected mice. Infect Immun (2003) 1.34
The use of microarray analysis to determine the gene expression profiles of Mycobacterium tuberculosis in response to anti-bacterial compounds. Tuberculosis (Edinb) (2004) 1.33
RamA confers multidrug resistance in Salmonella enterica via increased expression of acrB, which is inhibited by chlorpromazine. Antimicrob Agents Chemother (2008) 1.31
Clinical concentrations of thioridazine kill intracellular multidrug-resistant Mycobacterium tuberculosis. Antimicrob Agents Chemother (2003) 1.30
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Roles of SigB and SigF in the Mycobacterium tuberculosis sigma factor network. J Bacteriol (2007) 1.14
The Mycobacterium tuberculosis sigma factor sigmaB is required for full response to cell envelope stress and hypoxia in vitro, but it is dispensable for in vivo growth. J Bacteriol (2009) 1.12
Requirement of the mymA operon for appropriate cell wall ultrastructure and persistence of Mycobacterium tuberculosis in the spleens of guinea pigs. J Bacteriol (2005) 1.11
The new Stop TB Strategy and the Global Plan to Stop TB, 2006-2015. Bull World Health Organ (2007) 1.05
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Differential expression of sigE by Mycobacterium tuberculosis during intracellular growth. Microb Pathog (2001) 1.01
The Mycobacterium tuberculosis TrcR response regulator represses transcription of the intracellularly expressed Rv1057 gene, encoding a seven-bladed beta-propeller. J Bacteriol (2006) 0.99
The curative activity of thioridazine on mice infected with Mycobacterium tuberculosis. In Vivo (2007) 0.98
Reversal of methicillin resistance in Staphylococcus aureus by thioridazine. J Antimicrob Chemother (2008) 0.98
An integrated regulatory network including two positive feedback loops to modulate the activity of sigma(E) in mycobacteria. Mol Microbiol (2009) 0.92
Reversal of resistance in microorganisms by help of non-antibiotics. J Antimicrob Chemother (2007) 0.90
Promising therapy of XDR-TB/MDR-TB with thioridazine an inhibitor of bacterial efflux pumps. Curr Drug Targets (2008) 0.88
In-vitro and intracellular antimycobacterial activity of trifluoperazine. J Antimicrob Chemother (1996) 0.84
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Activity of diclofenac used alone and in combination with streptomycin against Mycobacterium tuberculosis in mice. Int J Antimicrob Agents (2007) 0.83
Synthesis and antitubercular activity of quaternized promazine and promethazine derivatives. Bioorg Med Chem Lett (2006) 0.80
Activity of the phenothiazine methdilazine alone or in combination with isoniazid or streptomycin against Mycobacterium tuberculosis in mice. J Med Microbiol (2009) 0.78
Microarray analysis of pneumococcal gene expression during invasive disease. Infect Immun (2004) 2.38
Identification of a Candidate Streptococcus pneumoniae core genome and regions of diversity correlated with invasive pneumococcal disease. Infect Immun (2006) 2.33
Long-term in vitro expansion alters the biology of adult mesenchymal stem cells. Cancer Res (2008) 2.02
The Mycobacterium tuberculosis stress response factor SigH is required for bacterial burden as well as immunopathology in primate lungs. J Infect Dis (2012) 1.96
General nature of the STAT3-activated anti-inflammatory response. J Immunol (2006) 1.90
Genetic requirements for the survival of tubercle bacilli in primates. J Infect Dis (2010) 1.69
The DosR Regulon Modulates Adaptive Immunity and Is Essential for Mycobacterium tuberculosis Persistence. Am J Respir Crit Care Med (2015) 1.63
CXCR5⁺ T helper cells mediate protective immunity against tuberculosis. J Clin Invest (2013) 1.55
Transcriptional reprogramming in nonhuman primate (rhesus macaque) tuberculosis granulomas. PLoS One (2010) 1.53
Reactivation of latent tuberculosis in rhesus macaques by coinfection with simian immunodeficiency virus. J Med Primatol (2011) 1.47
Attenuation of late-stage disease in mice infected by the Mycobacterium tuberculosis mutant lacking the SigF alternate sigma factor and identification of SigF-dependent genes by microarray analysis. Infect Immun (2004) 1.41
Platelet-activating factor receptor and innate immunity: uptake of gram-positive bacterial cell wall into host cells and cell-specific pathophysiology. J Immunol (2006) 1.37
Functional genomics reveals extended roles of the Mycobacterium tuberculosis stress response factor sigmaH. J Bacteriol (2009) 1.29
S100A8/A9 proteins mediate neutrophilic inflammation and lung pathology during tuberculosis. Am J Respir Crit Care Med (2013) 1.23
Interaction of the Lyme disease spirochete Borrelia burgdorferi with brain parenchyma elicits inflammatory mediators from glial cells as well as glial and neuronal apoptosis. Am J Pathol (2008) 1.19
Granuloma correlates of protection against tuberculosis and mechanisms of immune modulation by Mycobacterium tuberculosis. J Infect Dis (2012) 1.15
Increased expression of P-glycoprotein and doxorubicin chemoresistance of metastatic breast cancer is regulated by miR-298. Am J Pathol (2012) 1.15
The stress-response factor SigH modulates the interaction between Mycobacterium tuberculosis and host phagocytes. PLoS One (2012) 1.09
MicroRNA profiling reveals age-dependent differential expression of nuclear factor κB and mitogen-activated protein kinase in adipose and bone marrow-derived human mesenchymal stem cells. Stem Cell Res Ther (2011) 1.06
Role of interleukin 6 in innate immunity to Mycobacterium tuberculosis infection. J Infect Dis (2013) 1.05
Vancomycin stress response in a sensitive and a tolerant strain of Streptococcus pneumoniae. J Bacteriol (2005) 1.04
Mycobacterium tuberculosis MT2816 encodes a key stress-response regulator. J Infect Dis (2010) 1.01
Revising the role of the pneumococcal vex-vncRS locus in vancomycin tolerance. J Bacteriol (2004) 0.99
Evaluation of IFN-gamma effects on apoptosis and gene expression in neuroblastoma--preclinical studies. Biochim Biophys Acta (2006) 0.98
Transient acidification and subsequent proinflammatory cytokine stimulation of astrocytes induce distinct activation phenotypes. J Cell Physiol (2013) 0.97
The antibiotics doxycycline and minocycline inhibit the inflammatory responses to the Lyme disease spirochete Borrelia burgdorferi. J Infect Dis (2009) 0.95
Interleukin-10 alters effector functions of multiple genes induced by Borrelia burgdorferi in macrophages to regulate Lyme disease inflammation. Infect Immun (2011) 0.94
Crystal structure of the 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase•dihydropteroate synthase bifunctional enzyme from Francisella tularensis. PLoS One (2010) 0.94
Microglia are mediators of Borrelia burgdorferi-induced apoptosis in SH-SY5Y neuronal cells. PLoS Pathog (2009) 0.94
Closing the phenotypic gap between transformed neuronal cell lines in culture and untransformed neurons. J Neurosci Methods (2008) 0.91
Focused examination of the intestinal lamina propria yields greater molecular insight into mechanisms underlying SIV induced immune dysfunction. PLoS One (2012) 0.88
DosS Is required for the complete virulence of mycobacterium tuberculosis in mice with classical granulomatous lesions. Am J Respir Cell Mol Biol (2015) 0.83
Improved xenobiotic metabolism and reduced susceptibility to cancer in gluten-sensitive macaques upon introduction of a gluten-free diet. PLoS One (2011) 0.82
Expression levels of 10 candidate genes in lung tissue of vaccinated and TB-infected cynomolgus macaques. J Med Primatol (2013) 0.81
Aerosolized gentamicin reduces the burden of tuberculosis in a murine model. Antimicrob Agents Chemother (2011) 0.79
A novel approach for the analysis of T-cell reconstitution by using a T-cell receptor beta-based oligonucleotide microarray in hematopoietic stem cell transplantation. Exp Hematol (2007) 0.78
How well do you know your monkeys? J Med Primatol (2013) 0.77
Eicosanoids, prostaglandins, and the progression of tuberculosis. J Infect Dis (2012) 0.75
Microdissection approaches in tuberculosis research. J Med Primatol (2014) 0.75