Activatable molecular probes for cancer imaging.

Rational chemical design of the next generation of molecular imaging probes based on physics and biology: mixing modalities, colors and signals. Chem Soc Rev (2011) 1.36

Near-infrared fluorescent nanoprobes for cancer molecular imaging: status and challenges. Trends Mol Med (2010) 1.28

Multicolored pH-tunable and activatable fluorescence nanoplatform responsive to physiologic pH stimuli. J Am Chem Soc (2012) 1.13

Nanotheranostics for personalized medicine. Expert Rev Mol Diagn (2013) 0.96

Multiplex imaging of an intracellular proteolytic cascade by using a broad-spectrum nanoquencher. Angew Chem Int Ed Engl (2012) 0.96

Design of "smart" probes for optical imaging of apoptosis. Am J Nucl Med Mol Imaging (2011) 0.94

Hybrid ferritin nanoparticles as activatable probes for tumor imaging. Angew Chem Int Ed Engl (2011) 0.93

In vivo optical imaging of membrane-type matrix metalloproteinase (MT-MMP) activity. Mol Pharm (2011) 0.90

Dual-functional, receptor-targeted fluorogenic probe for in vivo imaging of extracellular protease expressions. Bioconjug Chem (2011) 0.87

Deep tissue imaging: a review from a preclinical cancer research perspective. Histochem Cell Biol (2016) 0.84

Real-time monitoring of caspase cascade activation in living cells. J Control Release (2012) 0.82

Nanoparticle-facilitated functional and molecular imaging for the early detection of cancer. Front Mol Biosci (2014) 0.77

Engineering of radiolabeled iron oxide nanoparticles for dual-modality imaging. Wiley Interdiscip Rev Nanomed Nanobiotechnol (2015) 0.77

Small Molecule Active Site Directed Tools for Studying Human Caspases. Chem Rev (2015) 0.77

Harnessing supramolecular peptide nanotechnology in biomedical applications. Int J Nanomedicine (2017) 0.75

Fluorescent Reporters and Biosensors for Probing the Dynamic Behavior of Protein Kinases. Proteomes (2015) 0.75

Recent Advances of Activatable Molecular Probes Based on Semiconducting Polymer Nanoparticles in Sensing and Imaging. Adv Sci (Weinh) (2017) 0.75

New functions for the matrix metalloproteinases in cancer progression. Nat Rev Cancer (2002) 24.71

A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. Cancer Res (1986) 15.83

In vivo near-infrared fluorescence imaging. Curr Opin Chem Biol (2003) 10.76

Shedding light onto live molecular targets. Nat Med (2003) 8.47

In vivo imaging of tumors with protease-activated near-infrared fluorescent probes. Nat Biotechnol (1999) 8.46

Long-term multiple color imaging of live cells using quantum dot bioconjugates. Nat Biotechnol (2002) 7.19

Molecular mechanisms of caspase regulation during apoptosis. Nat Rev Mol Cell Biol (2004) 6.76

Molecular imaging. Radiology (2001) 5.67

Peptide-labeled near-infrared quantum dots for imaging tumor vasculature in living subjects. Nano Lett (2006) 5.63

Tumor imaging by means of proteolytic activation of cell-penetrating peptides. Proc Natl Acad Sci U S A (2004) 4.95

Self-illuminating quantum dot conjugates for in vivo imaging. Nat Biotechnol (2006) 4.60

In vivo molecular target assessment of matrix metalloproteinase inhibition. Nat Med (2001) 4.30

Self-assembled nanoscale biosensors based on quantum dot FRET donors. Nat Mater (2003) 4.19

Gold nanoparticles in nanomedicine: preparations, imaging, diagnostics, therapies and toxicity. Chem Soc Rev (2009) 4.06

Single-mismatch detection using gold-quenched fluorescent oligonucleotides. Nat Biotechnol (2001) 3.69

Surgery with molecular fluorescence imaging using activatable cell-penetrating peptides decreases residual cancer and improves survival. Proc Natl Acad Sci U S A (2010) 3.41

Selective molecular imaging of viable cancer cells with pH-activatable fluorescence probes. Nat Med (2008) 3.15

Dynamic imaging of protease activity with fluorescently quenched activity-based probes. Nat Chem Biol (2005) 2.90

Noninvasive optical imaging of cysteine protease activity using fluorescently quenched activity-based probes. Nat Chem Biol (2007) 2.80

Nanoplatforms for targeted molecular imaging in living subjects. Small (2007) 2.69

Inflammation in atherosclerosis: visualizing matrix metalloproteinase action in macrophages in vivo. Circulation (2006) 2.56

Fluorescence resonance energy transfer (FRET) microscopy imaging of live cell protein localizations. J Cell Biol (2003) 2.55

In vivo molecular imaging of cancer with a quenching near-infrared fluorescent probe using conjugates of monoclonal antibodies and indocyanine green. Cancer Res (2009) 2.51

In vivo characterization of activatable cell penetrating peptides for targeting protease activity in cancer. Integr Biol (Camb) (2009) 2.30

In vivo imaging of proteolytic enzyme activity using a novel molecular reporter. Cancer Res (2000) 2.12

In vivo diagnosis of epidermal growth factor receptor expression using molecular imaging with a cocktail of optically labeled monoclonal antibodies. Clin Cancer Res (2007) 2.01

Caspases: key players in programmed cell death. Curr Opin Struct Biol (2000) 1.93

Noninvasive optical imaging of apoptosis by caspase-targeted activity-based probes. Nat Med (2009) 1.90

Quantum dot-based resonance energy transfer and its growing application in biology. Phys Chem Chem Phys (2008) 1.67

Proteolytic activity monitored by fluorescence resonance energy transfer through quantum-dot-peptide conjugates. Nat Mater (2006) 1.66

Antibodies for molecular imaging of cancer. Cancer J (2008) 1.61

Preparation of a cathepsin D sensitive near-infrared fluorescence probe for imaging. Bioconjug Chem (1999) 1.56

In vivo imaging of protease activity in arthritis: a novel approach for monitoring treatment response. Arthritis Rheum (2004) 1.55

Expression of hyaluronidase by tumor cells induces angiogenesis in vivo. Proc Natl Acad Sci U S A (1996) 1.49

Nanometal surface energy transfer in optical rulers, breaking the FRET barrier. J Am Chem Soc (2005) 1.48

Peptide-based probes for targeted molecular imaging. Biochemistry (2010) 1.43

A near-infrared-fluorescence-quenched gold-nanoparticle imaging probe for in vivo drug screening and protease activity determination. Angew Chem Int Ed Engl (2008) 1.43

Developing a peptide-based near-infrared molecular probe for protease sensing. Bioconjug Chem (2004) 1.42

New approaches and therapeutics targeting apoptosis in disease. Pharmacol Rev (2005) 1.40

Single-cell imaging of retinal ganglion cell apoptosis with a cell-penetrating, activatable peptide probe in an in vivo glaucoma model. Proc Natl Acad Sci U S A (2009) 1.40

Molecular imaging: the vision and opportunity for radiology in the future. Radiology (2007) 1.35

Dual-modality probes for in vivo molecular imaging. Mol Imaging (2009) 1.34

Imaging of differential protease expression in breast cancers for detection of aggressive tumor phenotypes. Radiology (2002) 1.34

An improved cell-penetrating, caspase-activatable, near-infrared fluorescent peptide for apoptosis imaging. Bioconjug Chem (2009) 1.34

Cell-permeable and biocompatible polymeric nanoparticles for apoptosis imaging. J Am Chem Soc (2006) 1.33

Activatable imaging probes with amplified fluorescent signals. Chem Commun (Camb) (2008) 1.32

Polymeric nanoparticle-based activatable near-infrared nanosensor for protease determination in vivo. Nano Lett (2009) 1.29

Biosensing and imaging based on bioluminescence resonance energy transfer. Curr Opin Biotechnol (2009) 1.26

Optical imaging of matrix metalloproteinase-7 activity in vivo using a proteolytic nanobeacon. Mol Imaging (2009) 1.25

Quantum dot/bioluminescence resonance energy transfer based highly sensitive detection of proteases. Angew Chem Int Ed Engl (2007) 1.21

Effect of polymer molecular weight on the tumor targeting characteristics of self-assembled glycol chitosan nanoparticles. J Control Release (2007) 1.18

Synthesis and application of quantum dots FRET-based protease sensors. J Am Chem Soc (2006) 1.15

An azulene dimer as a near-infrared quencher. Angew Chem Int Ed Engl (2002) 1.14

Enzyme-targeted fluorescent imaging probes on a multiple antigenic peptide core. J Med Chem (2006) 1.13

Activatable molecular systems using homologous near-infrared fluorescent probes for monitoring enzyme activities in vitro, in cellulo, and in vivo. Mol Pharm (2009) 1.13

Synthesis and characterization of a small, membrane-permeant, caspase-activatable far-red fluorescent peptide for imaging apoptosis. J Med Chem (2005) 1.11

Activity based probes for proteases: applications to biomarker discovery, molecular imaging and drug screening. Curr Pharm Des (2007) 1.10

Sensing caspase 3 activity with quantum dot-fluorescent protein assemblies. J Am Chem Soc (2009) 1.09

Quantum dots as donors in fluorescence resonance energy transfer for the bioanalysis of nucleic acids, proteins, and other biological molecules. Anal Bioanal Chem (2007) 1.08

Dark quenched matrix metalloproteinase fluorogenic probe for imaging osteoarthritis development in vivo. Bioconjug Chem (2008) 1.06

In vivo imaging of cancer biomarkers using activatable molecular probes. Cancer Biomark (2008) 1.01

Intramolecular dimers: a new design strategy for fluorescence-quenched probes. Chemistry (2003) 0.99

Synthesis, characterization, and in vivo diagnostic applications of hyaluronic acid immobilized gold nanoprobes. Biomaterials (2008) 0.97

Dendrimers: a class of polymers in the nanotechnology for the delivery of active pharmaceuticals. Curr Pharm Des (2009) 0.95

Optimal labeling condition of antibodies available for immunofluorescence endoscopy. J Med Invest (2006) 0.93

In vivo imaging of HIV protease activity in amplicon vector-transduced gliomas. Cancer Res (2004) 0.88

Time gating improves sensitivity in energy transfer assays with terbium chelate/dark quencher oligonucleotide probes. J Am Chem Soc (2004) 0.88

High efficiency synthesis of a bioconjugatable near-infrared fluorochrome. Bioconjug Chem (2003) 0.84

High-thermoelectric performance of nanostructured bismuth antimony telluride bulk alloys. Science (2008) 7.34

In vivo biodistribution and highly efficient tumour targeting of carbon nanotubes in mice. Nat Nanotechnol (2006) 6.93

Carbon nanotubes as photoacoustic molecular imaging agents in living mice. Nat Nanotechnol (2008) 6.41

Peptide-labeled near-infrared quantum dots for imaging tumor vasculature in living subjects. Nano Lett (2006) 5.63

Circulation and long-term fate of functionalized, biocompatible single-walled carbon nanotubes in mice probed by Raman spectroscopy. Proc Natl Acad Sci U S A (2008) 4.89

In vivo visualization of embryonic stem cell survival, proliferation, and migration after cardiac delivery. Circulation (2006) 4.48

Multimodality molecular imaging of tumor angiogenesis. J Nucl Med (2008) 3.99

Drug delivery with carbon nanotubes for in vivo cancer treatment. Cancer Res (2008) 3.47

US imaging of tumor angiogenesis with microbubbles targeted to vascular endothelial growth factor receptor type 2 in mice. Radiology (2008) 3.15

microPET imaging of glioma integrin {alpha}v{beta}3 expression using (64)Cu-labeled tetrameric RGD peptide. J Nucl Med (2005) 2.96

Nanoparticle-based theranostic agents. Adv Drug Deliv Rev (2010) 2.86

Dual-function probe for PET and near-infrared fluorescence imaging of tumor vasculature. J Nucl Med (2007) 2.86

PET/MRI dual-modality tumor imaging using arginine-glycine-aspartic (RGD)-conjugated radiolabeled iron oxide nanoparticles. J Nucl Med (2008) 2.77

microPET-based biodistribution of quantum dots in living mice. J Nucl Med (2007) 2.76

Nanoplatforms for targeted molecular imaging in living subjects. Small (2007) 2.69

Quantitative PET imaging of tumor integrin alphavbeta3 expression with 18F-FRGD2. J Nucl Med (2006) 2.65

Particle size, surface coating, and PEGylation influence the biodistribution of quantum dots in living mice. Small (2009) 2.59

(64)Cu-labeled tetrameric and octameric RGD peptides for small-animal PET of tumor alpha(v)beta(3) integrin expression. J Nucl Med (2007) 2.50

PET/NIRF/MRI triple functional iron oxide nanoparticles. Biomaterials (2010) 2.31

Quantitative PET of EGFR expression in xenograft-bearing mice using 64Cu-labeled cetuximab, a chimeric anti-EGFR monoclonal antibody. Eur J Nucl Med Mol Imaging (2007) 2.31

PET imaging of colorectal cancer in xenograft-bearing mice by use of an 18F-labeled T84.66 anti-carcinoembryonic antigen diabody. J Nucl Med (2007) 2.28

PET of vascular endothelial growth factor receptor expression. J Nucl Med (2006) 2.18

Diabetes does not alter mortality or hemostatic and inflammatory responses in patients with severe sepsis. Crit Care Med (2010) 2.11

In vitro and in vivo characterization of 64Cu-labeled Abegrin, a humanized monoclonal antibody against integrin alpha v beta 3. Cancer Res (2006) 2.09

Imaging of integrins as biomarkers for tumor angiogenesis. Curr Pharm Des (2008) 2.04

Solution structures of chemoenzymatically synthesized heparin and its precursors. J Am Chem Soc (2008) 2.02

Near-infrared fluorescent RGD peptides for optical imaging of integrin alphavbeta3 expression in living mice. Bioconjug Chem (2005) 2.01

Ultrahigh sensitivity carbon nanotube agents for photoacoustic molecular imaging in living mice. Nano Lett (2010) 2.00

(68)Ga-labeled multimeric RGD peptides for microPET imaging of integrin alpha(v)beta (3) expression. Eur J Nucl Med Mol Imaging (2008) 1.91

18F-labeled galacto and PEGylated RGD dimers for PET imaging of αvβ3 integrin expression. Mol Imaging Biol (2009) 1.90

Ultrasmall c(RGDyK)-coated Fe3O4 nanoparticles and their specific targeting to integrin alpha(v)beta3-rich tumor cells. J Am Chem Soc (2008) 1.89

Preparation of peptide-conjugated quantum dots for tumor vasculature-targeted imaging. Nat Protoc (2008) 1.87

A thiol-reactive 18F-labeling agent, N-[2-(4-18F-fluorobenzamido)ethyl]maleimide, and synthesis of RGD peptide-based tracer for PET imaging of alpha v beta 3 integrin expression. J Nucl Med (2006) 1.83

How molecular imaging is speeding up antiangiogenic drug development. Mol Cancer Ther (2006) 1.81

Pulse accumulation, radial heat conduction, and anisotropic thermal conductivity in pump-probe transient thermoreflectance. Rev Sci Instrum (2008) 1.80

64Cu-labeled alpha-melanocyte-stimulating hormone analog for microPET imaging of melanocortin 1 receptor expression. Bioconjug Chem (2007) 1.79

Unusual magnetic properties of one-dimensional molecule-based magnets associated with a structural phase transition. Inorg Chem (2002) 1.78

Near-infrared fluorescent deoxyglucose analogue for tumor optical imaging in cell culture and living mice. Bioconjug Chem (2006) 1.75

(68)Ga-labeled cyclic RGD dimers with Gly3 and PEG4 linkers: promising agents for tumor integrin alphavbeta3 PET imaging. Eur J Nucl Med Mol Imaging (2009) 1.69

Surface-engineered magnetic nanoparticle platforms for cancer imaging and therapy. Acc Chem Res (2011) 1.69

Synthesis and stabilization of monodisperse Fe nanoparticles. J Am Chem Soc (2006) 1.68

Upconversion nanoparticles: design, nanochemistry, and applications in theranostics. Chem Rev (2014) 1.68

Au-Fe3O4 dumbbell nanoparticles as dual-functional probes. Angew Chem Int Ed Engl (2008) 1.64

Click chemistry for (18)F-labeling of RGD peptides and microPET imaging of tumor integrin alphavbeta3 expression. Bioconjug Chem (2007) 1.64

Anti-angiogenic cancer therapy based on integrin alphavbeta3 antagonism. Anticancer Agents Med Chem (2006) 1.64

Peptides and peptide hormones for molecular imaging and disease diagnosis. Chem Rev (2010) 1.63

Why integrin as a primary target for imaging and therapy. Theranostics (2011) 1.61

High-affinity peptide against MT1-MMP for in vivo tumor imaging. J Control Release (2011) 1.59

Pilot pharmacokinetic and dosimetric studies of (18)F-FPPRGD2: a PET radiopharmaceutical agent for imaging α(v)β(3) integrin levels. Radiology (2011) 1.59

Trafficking mesenchymal stem cell engraftment and differentiation in tumor-bearing mice by bioluminescence imaging. Stem Cells (2009) 1.58

Comparison study of [18F]FAl-NOTA-PRGD2, [18F]FPPRGD2, and [68Ga]Ga-NOTA-PRGD2 for PET imaging of U87MG tumors in mice. Bioconjug Chem (2011) 1.56

Oxorhenium(V) complexes containing tridentate Schiff-base and monothiol coligands. Inorganica Chim Acta (2000) 1.56

Light-triggered theranostics based on photosensitizer-conjugated carbon dots for simultaneous enhanced-fluorescence imaging and photodynamic therapy. Adv Mater (2012) 1.56

Dual-modality optical and positron emission tomography imaging of vascular endothelial growth factor receptor on tumor vasculature using quantum dots. Eur J Nucl Med Mol Imaging (2008) 1.55

Intracellular delivery of an anionic antisense oligonucleotide via receptor-mediated endocytosis. Nucleic Acids Res (2008) 1.49

Characterizing breast cancer xenograft epidermal growth factor receptor expression by using near-infrared optical imaging. Acta Radiol (2009) 1.49

Integrin targeting for tumor optical imaging. Theranostics (2011) 1.47

Association of interleukin-13 SNP rs20541 with allergic rhinitis risk: a meta-analysis. Gene (2013) 1.47

Glycomics of proteoglycan biosynthesis in murine embryonic stem cell differentiation. J Proteome Res (2007) 1.46

Effects of nanoparticle size on cellular uptake and liver MRI with polyvinylpyrrolidone-coated iron oxide nanoparticles. ACS Nano (2010) 1.46

microPET of tumor integrin alphavbeta3 expression using 18F-labeled PEGylated tetrameric RGD peptide (18F-FPRGD4). J Nucl Med (2007) 1.46

Near-infrared fluorescence imaging of tumor integrin alpha v beta 3 expression with Cy7-labeled RGD multimers. Mol Imaging Biol (2006) 1.46

Quantification of heparan sulfate disaccharides using ion-pairing reversed-phase microflow high-performance liquid chromatography with electrospray ionization trap mass spectrometry. Anal Chem (2009) 1.45

First experience of 18F-alfatide in lung cancer patients using a new lyophilized kit for rapid radiofluorination. J Nucl Med (2013) 1.44

Supramolecular stacking of doxorubicin on carbon nanotubes for in vivo cancer therapy. Angew Chem Int Ed Engl (2009) 1.44

Photosensitizer-loaded gold vesicles with strong plasmonic coupling effect for imaging-guided photothermal/photodynamic therapy. ACS Nano (2013) 1.44

Peptide-based probes for targeted molecular imaging. Biochemistry (2010) 1.43

A new PET tracer specific for vascular endothelial growth factor receptor 2. Eur J Nucl Med Mol Imaging (2007) 1.43

Triblock copolymer coated iron oxide nanoparticle conjugate for tumor integrin targeting. Biomaterials (2009) 1.42

A strategy for the proliferation of Ulva prolifera, main causative species of green tides, with formation of sporangia by fragmentation. PLoS One (2010) 1.42

Integrin targeted delivery of chemotherapeutics. Theranostics (2011) 1.42

Improving tumor-targeting capability and pharmacokinetics of (99m)Tc-labeled cyclic RGD dimers with PEG(4) linkers. Mol Pharm (2009) 1.41

Octanuclear metallocyclic Ni4Fc4 compound: synthesis, crystal structure, and electrochemical sensing for Mg2+. Inorg Chem (2004) 1.40

Evaluation of a (99m)Tc-labeled cyclic RGD tetramer for noninvasive imaging integrin alpha(v)beta3-positive breast cancer. Bioconjug Chem (2007) 1.39

Ultrasmall near-infrared non-cadmium quantum dots for in vivo tumor imaging. Small (2010) 1.38

Structural analysis of bikunin glycosaminoglycan. J Am Chem Soc (2008) 1.37

18F-labeled bombesin analogs for targeting GRP receptor-expressing prostate cancer. J Nucl Med (2006) 1.37

Protease-activated drug development. Theranostics (2012) 1.36

Improving tumor uptake and pharmacokinetics of (64)Cu-labeled cyclic RGD peptide dimers with Gly(3) and PEG(4) linkers. Bioconjug Chem (2009) 1.36

PET of EGFR antibody distribution in head and neck squamous cell carcinoma models. J Nucl Med (2009) 1.36

Noninvasive imaging of tumor integrin expression using (18)F-labeled RGD dimer peptide with PEG (4) linkers. Eur J Nucl Med Mol Imaging (2009) 1.35

Short hairpin RNA interference therapy for ischemic heart disease. Circulation (2008) 1.34

Dual-modality probes for in vivo molecular imaging. Mol Imaging (2009) 1.34

Unusual magnetic property associated with dimerization within a nickel tetramer. Inorg Chem (2002) 1.33

Multimodality imaging of vascular endothelial growth factor and vascular endothelial growth factor receptor expression. Front Biosci (2007) 1.33

Single continuous wave laser induced photodynamic/plasmonic photothermal therapy using photosensitizer-functionalized gold nanostars. Adv Mater (2013) 1.31

Monitoring therapeutic response of human ovarian cancer to 17-DMAG by noninvasive PET imaging with (64)Cu-DOTA-trastuzumab. Eur J Nucl Med Mol Imaging (2009) 1.30

Are quantum dots ready for in vivo imaging in human subjects? Nanoscale Res Lett (2007) 1.30

Cetuximab-based immunotherapy and radioimmunotherapy of head and neck squamous cell carcinoma. Clin Cancer Res (2010) 1.29

18F-labeled BBN-RGD heterodimer for prostate cancer imaging. J Nucl Med (2008) 1.29

Small-animal PET of tumors with (64)Cu-labeled RGD-bombesin heterodimer. J Nucl Med (2009) 1.29

Polymeric nanoparticle-based activatable near-infrared nanosensor for protease determination in vivo. Nano Lett (2009) 1.29

Noninvasive de novo imaging of human embryonic stem cell-derived teratoma formation. Cancer Res (2009) 1.28