Published in Nat Chem Biol on August 14, 2005
Ebola virus entry requires the cholesterol transporter Niemann-Pick C1. Nature (2011) 5.68
A potent and selective inhibitor of KIAA1363/AADACL1 that impairs prostate cancer pathogenesis. Chem Biol (2011) 1.97
Fluorinated COX-2 inhibitors as agents in PET imaging of inflammation and cancer. Cancer Prev Res (Phila) (2011) 1.68
Peptides and peptide hormones for molecular imaging and disease diagnosis. Chem Rev (2010) 1.63
Peptide-based probes for targeted molecular imaging. Biochemistry (2010) 1.43
Live-cell imaging demonstrates extracellular matrix degradation in association with active cathepsin B in caveolae of endothelial cells during tube formation. Exp Cell Res (2009) 1.35
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Functional imaging of legumain in cancer using a new quenched activity-based probe. J Am Chem Soc (2012) 1.05
Ultra-pH-sensitive nanoprobe library with broad pH tunability and fluorescence emissions. J Am Chem Soc (2014) 1.04
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Cathepsin S is activated during colitis and causes visceral hyperalgesia by a PAR2-dependent mechanism in mice. Gastroenterology (2011) 1.03
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Cathepsin B trafficking in thyroid carcinoma cells. Thyroid Res (2011) 0.93
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Development of activity-based probes for cathepsin X. ACS Chem Biol (2011) 0.87
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Direct measurement of cathepsin B activity in the cytosol of apoptotic cells by an activity-based probe. Chem Biol (2009) 0.86
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A novel cysteine cathepsin inhibitor yields macrophage cell death and mammary tumor regression. Oncogene (2015) 0.84
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Detecting cathepsin activity in human osteoarthritis via activity-based probes. Arthritis Res Ther (2015) 0.83
In vivo magnetic resonance imaging of tumor protease activity. Sci Rep (2014) 0.83
A bright approach to the immunoproteasome: development of LMP2/β1i-specific imaging probes. Bioorg Med Chem (2011) 0.83
Multi-path quenchers: efficient quenching of common fluorophores. Bioconjug Chem (2011) 0.82
3D/4D functional imaging of tumor-associated proteolysis: impact of microenvironment. Methods Enzymol (2012) 0.81
Molecular Imaging of Proteases in Cancer. Cancer Growth Metastasis (2009) 0.81
Peptide length and leaving-group sterics influence potency of peptide phosphonate protease inhibitors. Chem Biol (2011) 0.81
Active cathepsins B, L, and S in murine and human pancreatitis. Am J Physiol Gastrointest Liver Physiol (2012) 0.81
NEAR-INFRARED DYES: Probe Development and Applications in Optical Molecular Imaging. Curr Org Synth (2011) 0.81
In vivo imaging and biochemical characterization of protease function using fluorescent activity-based probes. Curr Protoc Chem Biol (2013) 0.80
Design of Protease Activated Optical Contrast Agents That Exploit a Latent Lysosomotropic Effect for Use in Fluorescence-Guided Surgery. ACS Chem Biol (2015) 0.79
Microscopic detection of quenched activity-based optical imaging probes using an antibody detection system: localizing protease activity. Mol Imaging Biol (2014) 0.78
Systematic optimization of multiplex zymography protocol to detect active cathepsins K, L, S, and V in healthy and diseased tissue: compromise among limits of detection, reduced time, and resources. Mol Biotechnol (2013) 0.78
Photodynamic quenched cathepsin activity based probes for cancer detection and macrophage targeted therapy. Theranostics (2015) 0.77
Applications of small molecule probes in dissecting mechanisms of bacterial virulence and host responses. Biochemistry (2013) 0.77
Molecular tools for cell and systems biology. HFSP J (2007) 0.77
Toward plasmonics-enabled spatiotemporal activity patterns in three-dimensional culture models. Syst Biomed (Austin) (2013) 0.77
Evaluation of alpha,beta-unsaturated ketone-based probes for papain-family cysteine proteases. Bioorg Med Chem (2008) 0.77
Imaging the boundaries-innovative tools for microscopy of living cells and real-time imaging. J Chem Biol (2008) 0.76
CT-based handling and analysis of preclinical multimodality imaging data of bone metastases. Bonekey Rep (2012) 0.76
Cathepsin Activity-Based Probes and Inhibitor for Preclinical Atherosclerosis Imaging and Macrophage Depletion. PLoS One (2016) 0.75
Rapid visualization of nonmelanoma skin cancer. J Am Acad Dermatol (2016) 0.75
Investigation of endosome and lysosome biology by ultra pH-sensitive nanoprobes. Adv Drug Deliv Rev (2016) 0.75
Intraoperative Fluorescence Imaging for Personalized Brain Tumor Resection: Current State and Future Directions. Front Surg (2016) 0.75
Dual-Modality Activity-Based Probes as Molecular Imaging Agents for Vascular Inflammation. J Nucl Med (2016) 0.75
A chemical strategy for the cell-based detection of HDAC activity. ACS Chem Biol (2014) 0.75
Detecting the active conformation of calpain with calpastatin-based reagents. Biochim Biophys Acta (2008) 0.75
Ligand-directed dibromophenyl benzoate chemistry for rapid and selective acylation of intracellular natural proteins. Chem Sci (2015) 0.75
Cysteine cathepsins: multifunctional enzymes in cancer. Nat Rev Cancer (2006) 5.06
Cathepsin cysteine proteases are effectors of invasive growth and angiogenesis during multistage tumorigenesis. Cancer Cell (2004) 4.38
Joint Commission and Regulatory Fatigue/Weakness/Overabundance/Distraction: Clinical Context Matters. Anesth Analg (2015) 3.98
The Future of Anesthesiology: Should the Perioperative Surgical Home Redefine Us? Anesth Analg (2015) 3.84
Bicarbonate increases tumor pH and inhibits spontaneous metastases. Cancer Res (2009) 3.40
Identification of proteases that regulate erythrocyte rupture by the malaria parasite Plasmodium falciparum. Nat Chem Biol (2008) 3.16
Noninvasive optical imaging of cysteine protease activity using fluorescently quenched activity-based probes. Nat Chem Biol (2007) 2.80
Acidity generated by the tumor microenvironment drives local invasion. Cancer Res (2013) 2.63
A cathepsin L isoform that is devoid of a signal peptide localizes to the nucleus in S phase and processes the CDP/Cux transcription factor. Mol Cell (2004) 2.44
Myosin II contributes to cell-scale actin network treadmilling through network disassembly. Nature (2010) 2.37
Activity-based probes that target diverse cysteine protease families. Nat Chem Biol (2005) 2.21
Tumor cell-derived and macrophage-derived cathepsin B promotes progression and lung metastasis of mammary cancer. Cancer Res (2006) 2.20
A role for the protease falcipain 1 in host cell invasion by the human malaria parasite. Science (2002) 2.20
Substrate profiling of cysteine proteases using a combinatorial peptide library identifies functionally unique specificities. J Biol Chem (2006) 2.05
The shape of motile cells. Curr Biol (2009) 2.00
Nucleic acid recognition by Toll-like receptors is coupled to stepwise processing by cathepsins and asparagine endopeptidase. J Exp Med (2011) 1.93
Cysteine cathepsins in human cancer. Biol Chem (2004) 1.91
Noninvasive optical imaging of apoptosis by caspase-targeted activity-based probes. Nat Med (2009) 1.90
An adhesion-dependent switch between mechanisms that determine motile cell shape. PLoS Biol (2011) 1.90
Cathepsin B inhibition limits bone metastasis in breast cancer. Cancer Res (2012) 1.89
Cathepsin L in secretory vesicles functions as a prohormone-processing enzyme for production of the enkephalin peptide neurotransmitter. Proc Natl Acad Sci U S A (2003) 1.83
Fine-scale time-lapse analysis of the biphasic, dynamic behaviour of the two Vibrio cholerae chromosomes. Mol Microbiol (2006) 1.79
Chemical approaches for functionally probing the proteome. Mol Cell Proteomics (2002) 1.78
Tagging and detection strategies for activity-based proteomics. Curr Opin Chem Biol (2006) 1.70
Pericellular cathepsin B and malignant progression. Cancer Metastasis Rev (2003) 1.68
Small molecule-induced allosteric activation of the Vibrio cholerae RTX cysteine protease domain. Science (2008) 1.67
Autophagic degradation of the BCR-ABL oncoprotein and generation of antileukemic responses by arsenic trioxide. Blood (2012) 1.66
Rational design of inhibitors and activity-based probes targeting Clostridium difficile virulence factor TcdB. Chem Biol (2010) 1.60
Prevention of airway fires: do not overlook the expired oxygen concentration. Anesth Analg (2013) 1.54
Proteases, extracellular matrix, and cancer: a workshop of the path B study section. Am J Pathol (2004) 1.52
Rab35 controls actin bundling by recruiting fascin as an effector protein. Science (2009) 1.51
p21-Activated kinase 1 coordinates aberrant cell survival and pericellular proteolysis in a three-dimensional culture model for premalignant progression of human breast cancer. Neoplasia (2008) 1.48
Regulation of collagenase activities of human cathepsins by glycosaminoglycans. J Biol Chem (2003) 1.46
Activity-based protein profiling: applications to biomarker discovery, in vivo imaging and drug discovery. Am J Pharmacogenomics (2004) 1.45
A substrate-inspired probe monitors translocation, activation, and subcellular targeting of bacterial type III effector protease AvrPphB. Chem Biol (2013) 1.44
Identification of early intermediates of caspase activation using selective inhibitors and activity-based probes. Mol Cell (2006) 1.43
Caveolin-1 mediates the expression and localization of cathepsin B, pro-urokinase plasminogen activator and their cell-surface receptors in human colorectal carcinoma cells. J Cell Sci (2005) 1.43
Small molecule affinity fingerprinting. A tool for enzyme family subclassification, target identification, and inhibitor design. Chem Biol (2002) 1.42
Fibroblast hepatocyte growth factor promotes invasion of human mammary ductal carcinoma in situ. Cancer Res (2009) 1.41
Ferri-liposomes as an MRI-visible drug-delivery system for targeting tumours and their microenvironment. Nat Nanotechnol (2011) 1.41
Membrane tension in rapidly moving cells is determined by cytoskeletal forces. Curr Biol (2013) 1.41
Chronic autophagy is a cellular adaptation to tumor acidic pH microenvironments. Cancer Res (2012) 1.38
Mechanistic and structural insights into the proteolytic activation of Vibrio cholerae MARTX toxin. Nat Chem Biol (2009) 1.36
Activity profiling of papain-like cysteine proteases in plants. Plant Physiol (2004) 1.36
Cathepsin B and its role(s) in cancer progression. Biochem Soc Symp (2003) 1.36
Live-cell imaging demonstrates extracellular matrix degradation in association with active cathepsin B in caveolae of endothelial cells during tube formation. Exp Cell Res (2009) 1.35
Phase II trial of single agent Val-boroPro (Talabostat) inhibiting Fibroblast Activation Protein in patients with metastatic colorectal cancer. Cancer Biol Ther (2007) 1.35
Functional expression and characterization of Schistosoma mansoni cathepsin B and its trans-activation by an endogenous asparaginyl endopeptidase. Mol Biochem Parasitol (2003) 1.34
A mild chemically cleavable linker system for functional proteomic applications. Angew Chem Int Ed Engl (2007) 1.33
Aminopeptidase fingerprints, an integrated approach for identification of good substrates and optimal inhibitors. J Biol Chem (2009) 1.33
Matrix metalloproteinase activity and osteoclasts in experimental prostate cancer bone metastasis tissue. Am J Pathol (2005) 1.32
Tissue inhibitor of metalloproteinase-1 protects human breast epithelial cells from extrinsic cell death: a potential oncogenic activity of tissue inhibitor of metalloproteinase-1. Cancer Res (2005) 1.32
VEGF-A induces angiogenesis by perturbing the cathepsin-cysteine protease inhibitor balance in venules, causing basement membrane degradation and mother vessel formation. Cancer Res (2009) 1.32
Functional imaging of proteases: recent advances in the design and application of substrate-based and activity-based probes. Curr Opin Chem Biol (2011) 1.31
Caspase-8 association with the focal adhesion complex promotes tumor cell migration and metastasis. Cancer Res (2009) 1.30
Functional imaging of proteolysis: stromal and inflammatory cells increase tumor proteolysis. Mol Imaging (2003) 1.29
Sequential autolytic processing activates the zymogen of Arg-gingipain. J Biol Chem (2003) 1.27
A nonpeptidic cathepsin S activity-based probe for noninvasive optical imaging of tumor-associated macrophages. Chem Biol (2012) 1.27
Visualizing protease activity in living cells: from two dimensions to four dimensions. Curr Protoc Cell Biol (2008) 1.26
Analysis of host- and tumor-derived proteinases using a custom dual species microarray reveals a protective role for stromal matrix metalloproteinase-12 in non-small cell lung cancer. Cancer Res (2006) 1.26
Activity-based probes as a tool for functional proteomic analysis of proteases. Expert Rev Proteomics (2008) 1.26
Molecular regulation of human cathepsin B: implication in pathologies. Biol Chem (2003) 1.26
Inhibition of cysteine cathepsin protease activity enhances chemotherapy regimens by decreasing tumor growth and invasiveness in a mouse model of multistage cancer. Cancer Res (2007) 1.24
FAP-overexpressing fibroblasts produce an extracellular matrix that enhances invasive velocity and directionality of pancreatic cancer cells. BMC Cancer (2011) 1.24
Cathepsin V, a novel and potent elastolytic activity expressed in activated macrophages. J Biol Chem (2004) 1.24
Commonly used caspase inhibitors designed based on substrate specificity profiles lack selectivity. Cell Res (2006) 1.22
Functional studies of Plasmodium falciparum dipeptidyl aminopeptidase I using small molecule inhibitors and active site probes. Chem Biol (2010) 1.20
Lysosomal cathepsin B participates in the podosome-mediated extracellular matrix degradation and invasion via secreted lysosomes in v-Src fibroblasts. Cancer Res (2008) 1.20
Targeted disruption of Plasmodium falciparum cysteine protease, falcipain 1, reduces oocyst production, not erythrocytic stage growth. Mol Microbiol (2004) 1.19
Simplified, enhanced protein purification using an inducible, autoprocessing enzyme tag. PLoS One (2009) 1.19
Increased expression and activity of nuclear cathepsin L in cancer cells suggests a novel mechanism of cell transformation. Mol Cancer Res (2007) 1.18
Hemoglobin digestion in blood-feeding ticks: mapping a multipeptidase pathway by functional proteomics. Chem Biol (2009) 1.17
Application of activity-based probes to the study of enzymes involved in cancer progression. Curr Opin Genet Dev (2008) 1.17
Inhibition of cathepsin B reduces beta-amyloid production in regulated secretory vesicles of neuronal chromaffin cells: evidence for cathepsin B as a candidate beta-secretase of Alzheimer's disease. Biol Chem (2005) 1.16
Challenges to glycemic measurement in the perioperative and critically ill patient: a review. J Diabetes Sci Technol (2009) 1.15
Falstatin, a cysteine protease inhibitor of Plasmodium falciparum, facilitates erythrocyte invasion. PLoS Pathog (2006) 1.15
Cathepsin B: a potential prognostic marker for inflammatory breast cancer. J Transl Med (2011) 1.15
Proteomic analysis of fractionated Toxoplasma oocysts reveals clues to their environmental resistance. PLoS One (2012) 1.15
Engineered hybrid dimers: tracking the activation pathway of caspase-7. Mol Cell (2006) 1.14
Using small molecules to dissect mechanisms of microbial pathogenesis. ACS Chem Biol (2009) 1.14
Improved quenched fluorescent probe for imaging of cysteine cathepsin activity. J Am Chem Soc (2013) 1.14
Development of near-infrared fluorophore (NIRF)-labeled activity-based probes for in vivo imaging of legumain. ACS Chem Biol (2010) 1.13
Bone microenvironment modulates expression and activity of cathepsin B in prostate cancer. Neoplasia (2005) 1.11
New approaches for dissecting protease functions to improve probe development and drug discovery. Nat Struct Mol Biol (2012) 1.11
Activity-based profiling of proteases. Annu Rev Biochem (2014) 1.10
Topical application of activity-based probes for visualization of brain tumor tissue. PLoS One (2012) 1.10
Coupling protein engineering with probe design to inhibit and image matrix metalloproteinases with controlled specificity. J Am Chem Soc (2013) 1.10
Activity based probes for proteases: applications to biomarker discovery, molecular imaging and drug screening. Curr Pharm Des (2007) 1.10
Cystatin m: a novel candidate tumor suppressor gene for breast cancer. Cancer Res (2004) 1.10
Actin disassembly clock determines shape and speed of lamellipodial fragments. Proc Natl Acad Sci U S A (2011) 1.09
Differential susceptibilities of murine hepatoma 1c1c7 and Tao cells to the lysosomal photosensitizer NPe6: influence of aryl hydrocarbon receptor on lysosomal fragility and protease contents. Mol Pharmacol (2004) 1.09
Is there an apparent reason for these cancer recurrence data? Anesth Analg (2013) 1.09
A coupled protein and probe engineering approach for selective inhibition and activity-based probe labeling of the caspases. J Am Chem Soc (2013) 1.09
A selective activity-based probe for the papain family cysteine protease dipeptidyl peptidase I/cathepsin C. J Am Chem Soc (2006) 1.09
Validation of the proteasome as a therapeutic target in Plasmodium using an epoxyketone inhibitor with parasite-specific toxicity. Chem Biol (2012) 1.09