Published in J Neurosci on April 14, 2010
Wild-type microglia arrest pathology in a mouse model of Rett syndrome. Nature (2012) 3.83
A role for glia in the progression of Rett's syndrome. Nature (2011) 3.18
Synaptic dysfunction in neurodevelopmental disorders associated with autism and intellectual disabilities. Cold Spring Harb Perspect Biol (2012) 2.42
Neuronal maturation defect in induced pluripotent stem cells from patients with Rett syndrome. Proc Natl Acad Sci U S A (2011) 1.63
Methyl-CpG Binding Protein 2 Regulates Microglia and Macrophage Gene Expression in Response to Inflammatory Stimuli. Immunity (2015) 1.61
The "quad-partite" synapse: microglia-synapse interactions in the developing and mature CNS. Glia (2012) 1.59
Complexities of Rett syndrome and MeCP2. J Neurosci (2011) 1.35
Microglia and monocyte-derived macrophages: functionally distinct populations that act in concert in CNS plasticity and repair. Front Cell Neurosci (2013) 1.34
Experimental models of Rett syndrome based on Mecp2 dysfunction. Exp Biol Med (Maywood) (2011) 1.27
Fragile X syndrome and targeted treatment trials. Results Probl Cell Differ (2012) 1.27
MeCP2 is critical for maintaining mature neuronal networks and global brain anatomy during late stages of postnatal brain development and in the mature adult brain. J Neurosci (2012) 1.25
Insulinotropic treatments exacerbate metabolic syndrome in mice lacking MeCP2 function. Hum Mol Genet (2013) 1.15
Rett syndrome: genes, synapses, circuits, and therapeutics. Front Psychiatry (2012) 1.14
Loss of MeCP2 from forebrain excitatory neurons leads to cortical hyperexcitation and seizures. J Neurosci (2014) 1.11
IL-1β and TNF-α induce neurotoxicity through glutamate production: a potential role for neuronal glutaminase. J Neurochem (2013) 1.07
Glutaminase dysregulation in HIV-1-infected human microglia mediates neurotoxicity: relevant to HIV-1-associated neurocognitive disorders. J Neurosci (2011) 1.06
Microglial dynamics and role in the healthy and diseased brain: a paradigm of functional plasticity. Neuroscientist (2014) 1.05
Enhanced asynchronous Ca(2+) oscillations associated with impaired glutamate transport in cortical astrocytes expressing Fmr1 gene premutation expansion. J Biol Chem (2013) 1.04
Connexin and pannexin hemichannels in brain glial cells: properties, pharmacology, and roles. Front Pharmacol (2013) 1.02
Microglia: key elements in neural development, plasticity, and pathology. J Neuroimmune Pharmacol (2013) 1.02
Microglia across the lifespan: from origin to function in brain development, plasticity and cognition. J Physiol (2016) 1.02
Microglial dysregulation in psychiatric disease. Clin Dev Immunol (2013) 1.01
The expression of spinal methyl-CpG-binding protein 2, DNA methyltransferases and histone deacetylases is modulated in persistent pain states. Mol Pain (2012) 1.00
The role of microglia in brain maintenance: implications for Rett syndrome. Trends Immunol (2012) 0.99
X-chromosome inactivation in rett syndrome human induced pluripotent stem cells. Front Psychiatry (2012) 0.97
Chronic exposure to TGFβ1 regulates myeloid cell inflammatory response in an IRF7-dependent manner. EMBO J (2014) 0.96
The evolving landscape of neurotoxicity by unconjugated bilirubin: role of glial cells and inflammation. Front Pharmacol (2012) 0.96
Alterations of gene expression and glutamate clearance in astrocytes derived from an MeCP2-null mouse model of Rett syndrome. PLoS One (2012) 0.96
Interferon-α regulates glutaminase 1 promoter through STAT1 phosphorylation: relevance to HIV-1 associated neurocognitive disorders. PLoS One (2012) 0.94
Oligodendrocyte lineage cells contribute unique features to Rett syndrome neuropathology. J Neurosci (2013) 0.94
Genetic control of postnatal human brain growth. Curr Opin Neurol (2016) 0.91
Glia and neurodevelopment: focus on fetal alcohol spectrum disorders. Front Pediatr (2014) 0.91
Astrocytes conspire with neurons during progression of neurological disease. Curr Opin Neurobiol (2012) 0.90
Expression profiling of autism candidate genes during human brain development implicates central immune signaling pathways. PLoS One (2011) 0.89
Microglial control of neuronal activity. Front Cell Neurosci (2013) 0.89
GABA and glutamate pathways are spatially and developmentally affected in the brain of Mecp2-deficient mice. PLoS One (2014) 0.88
Microglia: an active player in the regulation of synaptic activity. Neural Plast (2013) 0.88
Altered glial marker expression in autistic post-mortem prefrontal cortex and cerebellum. Mol Autism (2014) 0.88
Impaired CO2 sensitivity of astrocytes in a mouse model of Rett syndrome. J Physiol (2015) 0.87
MeCP2 as a genome-wide modulator: the renewal of an old story. Front Genet (2012) 0.87
Deficiency of GABAergic synaptic inhibition in the Kölliker-Fuse area underlies respiratory dysrhythmia in a mouse model of Rett syndrome. J Physiol (2015) 0.87
DNA methylation reader MECP2: cell type- and differentiation stage-specific protein distribution. Epigenetics Chromatin (2014) 0.86
In sickness and in health: the role of methyl-CpG binding protein 2 in the central nervous system. Eur J Neurosci (2011) 0.86
System xC- is a mediator of microglial function and its deletion slows symptoms in amyotrophic lateral sclerosis mice. Brain (2014) 0.86
Microglia contribute to circuit defects in Mecp2 null mice independent of microglia-specific loss of Mecp2 expression. Elife (2016) 0.86
WONOEP appraisal: new genetic approaches to study epilepsy. Epilepsia (2014) 0.85
The role of microglia in human disease: therapeutic tool or target? Acta Neuropathol (2014) 0.85
Targeting Mitochondria by Olesoxime or Complement 1q Binding Protein as a Novel Management for Autism: A Hypothesis. Mol Syndromol (2011) 0.85
Dysregulation of glutamine transporter SNAT1 in Rett syndrome microglia: a mechanism for mitochondrial dysfunction and neurotoxicity. J Neurosci (2015) 0.85
Does microglial dysfunction play a role in autism and Rett syndrome? Neuron Glia Biol (2012) 0.84
Deficiency of GRP94 in the hematopoietic system alters proliferation regulators in hematopoietic stem cells. Stem Cells Dev (2013) 0.84
The Use of Induced Pluripotent Stem Cell Technology to Advance Autism Research and Treatment. Neurotherapeutics (2015) 0.84
Microglia as a critical player in both developmental and late-life CNS pathologies. Acta Neuropathol (2014) 0.84
Central nervous system myeloid cells as drug targets: current status and translational challenges. Nat Rev Drug Discov (2015) 0.83
Novel alterations in the epigenetic signature of MeCP2-targeted promoters in lymphocytes of Rett syndrome patients. Epigenetics (2013) 0.83
The Interaction between the Immune System and Epigenetics in the Etiology of Autism Spectrum Disorders. Front Neurosci (2016) 0.82
Rescue of Methyl-CpG Binding Protein 2 Dysfunction-induced Defects in Newborn Neurons by Pentobarbital. Neurotherapeutics (2015) 0.82
Developmental Dynamics of Rett Syndrome. Neural Plast (2016) 0.82
MeCP2 dependent heterochromatin reorganization during neural differentiation of a novel Mecp2-deficient embryonic stem cell reporter line. PLoS One (2012) 0.82
Microglia contact induces synapse formation in developing somatosensory cortex. Nat Commun (2016) 0.81
Beyond Widespread Mecp2 Deletions to Model Rett Syndrome: Conditional Spatio-Temporal Knockout, Single-Point Mutations and Transgenic Rescue Mice. Autism Open Access (2012) 0.81
Genotype-specific effects of Mecp2 loss-of-function on morphology of Layer V pyramidal neurons in heterozygous female Rett syndrome model mice. Front Cell Neurosci (2015) 0.81
A model for the induction of autism in the ecosystem of the human body: the anatomy of a modern pandemic? Microb Ecol Health Dis (2015) 0.81
Evaluation of current pharmacological treatment options in the management of Rett syndrome: from the present to future therapeutic alternatives. Curr Clin Pharmacol (2013) 0.80
Potential primary roles of glial cells in the mechanisms of psychiatric disorders. Front Cell Neurosci (2015) 0.79
Bioanalysis of 6-diazo-5-oxo-l-norleucine in plasma and brain by ultra-performance liquid chromatography mass spectrometry. Anal Biochem (2015) 0.79
Is autism a member of a family of diseases resulting from genetic/cultural mismatches? Implications for treatment and prevention. Autism Res Treat (2012) 0.79
Twenty-four hour quantitative-EEG and in-vivo glutamate biosensor detects activity and circadian rhythm dependent biomarkers of pathogenesis in Mecp2 null mice. Front Syst Neurosci (2014) 0.78
Recent advances in understanding synaptic abnormalities in Rett syndrome. F1000Res (2015) 0.78
Normal mitral cell dendritic development in the setting of Mecp2 mutation. Neuroscience (2011) 0.78
Glycine enhances microglial intracellular calcium signaling. A role for sodium-coupled neutral amino acid transporters. Pflugers Arch (2011) 0.78
MeCP2 is required for activity-dependent refinement of olfactory circuits. Mol Cell Neurosci (2014) 0.77
Advancements in the Underlying Pathogenesis of Schizophrenia: Implications of DNA Methylation in Glial Cells. Front Cell Neurosci (2015) 0.77
Missing and Possible Link between Neuroendocrine Factors, Neuropsychiatric Disorders, and Microglia. Front Integr Neurosci (2013) 0.77
Unexpected cellular players in Rett syndrome pathology. Neurobiol Dis (2015) 0.77
A review of Rett syndrome (RTT) with induced pluripotent stem cells. Stem Cell Investig (2016) 0.76
Beta-lactam antibiotics as a possible novel therapy for managing epilepsy and autism, a case report and review of literature. Iran J Child Neurol (2015) 0.76
Neurological and psychiatric disorders as a neuroglial failure. (2014) 0.76
Astrocytes and Microglia and Their Potential Link with Autism Spectrum Disorders. Front Cell Neurosci (2016) 0.76
Astrocyte-specific regulation of hMeCP2 expression in Drosophila. Biol Open (2014) 0.76
Physiological function of microglia. Neuron Glia Biol (2011) 0.75
Glia-neuron interactions in neurological diseases: Testing non-cell autonomy in a dish. Brain Res (2016) 0.75
Deletion of the Fractalkine Receptor, CX3CR1, Improves Endogenous Repair, Axon Sprouting, and Synaptogenesis after Spinal Cord Injury in Mice. J Neurosci (2017) 0.75
Imbalance between Glutamate and GABA in Fmr1 Knockout Astrocytes Influences Neuronal Development. Genes (Basel) (2016) 0.75
The Indispensable Roles of Microglia and Astrocytes during Brain Development. Front Hum Neurosci (2016) 0.75
Connexins and Pannexins: New Insights into Microglial Functions and Dysfunctions. Front Mol Neurosci (2016) 0.75
Immature Neurons and Radial Glia, But Not Astrocytes or Microglia, Are Altered in Adult Cntnap2 and Shank3 Mice, Models of Autism. eNeuro (2016) 0.75
MeCP2-Related Diseases and Animal Models. Diseases (2014) 0.75
Microglial Dysregulation in OCD, Tourette Syndrome, and PANDAS. J Immunol Res (2016) 0.75
Clinical and Neurobiological Relevance of Current Animal Models of Autism Spectrum Disorders. Biomol Ther (Seoul) (2016) 0.75
Influenza A induces dysfunctional immunity and death in MeCP2-overexpressing mice. JCI Insight (2017) 0.75
Effects of Mecp2 loss of function in embryonic cortical neurons: a bioinformatics strategy to sort out non-neuronal cells variability from transcriptome profiling. BMC Bioinformatics (2016) 0.75
Acute and crucial requirement for MeCP2 function upon transition from early to late adult stages of brain maturation. Hum Mol Genet (2016) 0.75
Microglia emerge as central players in brain disease. Nat Med (2017) 0.75
Function and Dysfunction of Microglia during Brain Development: Consequences for Synapses and Neural Circuits. Front Synaptic Neurosci (2017) 0.75
Connexins in Cardiovascular and Neurovascular Health and Disease: Pharmacological Implications. Pharmacol Rev (2017) 0.75
The Pathophysiological Role of Microglia in Dynamic Surveillance, Phagocytosis and Structural Remodeling of the Developing CNS. Front Mol Neurosci (2017) 0.75
Beyond infection - Maternal immune activation by environmental factors, microglial development, and relevance for autism spectrum disorders. Exp Neurol (2017) 0.75
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat Genet (2011) 10.07
Dopamine-dependent neurotoxicity of alpha-synuclein: a mechanism for selective neurodegeneration in Parkinson disease. Nat Med (2002) 3.31
Androgen receptor YAC transgenic mice recapitulate SBMA motor neuronopathy and implicate VEGF164 in the motor neuron degeneration. Neuron (2004) 2.52
Rett syndrome astrocytes are abnormal and spread MeCP2 deficiency through gap junctions. J Neurosci (2009) 2.35
Novel late-onset Alzheimer disease loci variants associate with brain gene expression. Neurology (2012) 2.08
Reduced hippocampal insulin-degrading enzyme in late-onset Alzheimer's disease is associated with the apolipoprotein E-epsilon4 allele. Am J Pathol (2003) 1.44
Congo red and thioflavin-T analogs detect Abeta oligomers. J Neurochem (2007) 1.43
Amyloid-beta protein oligomer at low nanomolar concentrations activates microglia and induces microglial neurotoxicity. J Biol Chem (2010) 1.37
Correlation of proton transverse relaxation rates (R2) with iron concentrations in postmortem brain tissue from alzheimer's disease patients. Magn Reson Med (2007) 1.27
Diet-induced hypercholesterolemia enhances brain A beta accumulation in transgenic mice. Neuroreport (2002) 1.23
A novel tricyclic pyrone compound ameliorates cell death associated with intracellular amyloid-beta oligomeric complexes. J Neurochem (2006) 1.18
Whole-body biodistribution and brain PET imaging with [18F]AV-45, a novel amyloid imaging agent--a pilot study. Nucl Med Biol (2010) 1.16
Apolipoprotein E isoforms and apolipoprotein AI protect from amyloid precursor protein carboxy terminal fragment-associated cytotoxicity. J Neurochem (2004) 1.14
Isoform-specific knockout of FE65 leads to impaired learning and memory. J Neurosci Res (2004) 1.11
Genetic modulation of tau phosphorylation in the mouse. J Neurosci (2003) 1.09
TMEM106B is a genetic modifier of frontotemporal lobar degeneration with C9orf72 hexanucleotide repeat expansions. Acta Neuropathol (2014) 1.08
Combining the rapid MTT formazan exocytosis assay and the MC65 protection assay led to the discovery of carbazole analogs as small molecule inhibitors of Abeta oligomer-induced cytotoxicity. Brain Res (2006) 1.07
Tumor necrosis factor alpha and interleukin 10 promoter region polymorphisms and risk of late-onset Alzheimer disease. Arch Neurol (2006) 1.05
Inhibition of Alzheimer's amyloid toxicity with a tricyclic pyrone molecule in vitro and in vivo. J Neurochem (2009) 1.05
Mapping the structural transition in an amyloidogenic apolipoprotein A-I. Biochemistry (2007) 1.03
MeCP2 modulates gene expression pathways in astrocytes. Mol Autism (2013) 1.03
New diphenylacetylenes as probes for positron emission tomographic imaging of amyloid plaques. J Med Chem (2007) 1.02
Early intraneuronal Abeta deposition in the hippocampus of APP transgenic mice. Neuroreport (2003) 0.97
A differential association of Apolipoprotein E isoforms with the amyloid-β oligomer in solution. Proteins (2011) 0.94
Clinical features, with video documentation, of the original familial lewy body parkinsonism caused by α-synuclein triplication (Iowa kindred). Mov Disord (2011) 0.93
Reduced CSF PLTP activity in Alzheimer's disease and other neurologic diseases; PLTP induces ApoE secretion in primary human astrocytes in vitro. J Neurosci Res (2005) 0.93
Widespread distribution of PLTP in human CNS: evidence for PLTP synthesis by glia and neurons, and increased levels in Alzheimer's disease. J Lipid Res (2003) 0.93
Niemann-Pick disease type C yields possible clue for why cerebellar neurons do not form neurofibrillary tangles. Neurobiol Dis (2002) 0.91
Amyloid β1-42 oligomer inhibits myelin sheet formation in vitro. Neurobiol Aging (2010) 0.90
Candidate anti-A beta fluorene compounds selected from analogs of amyloid imaging agents. Neurobiol Aging (2008) 0.90
Pathology of inherited manganese transporter deficiency. Ann Neurol (2014) 0.89
Neuropathologic features in the hippocampus and cerebellum of three older men with fragile X syndrome. Mol Autism (2011) 0.89
Radioiodinated aza-diphenylacetylenes as potential SPECT imaging agents for beta-amyloid plaque detection. Bioorg Med Chem Lett (2007) 0.85
Does microglial dysfunction play a role in autism and Rett syndrome? Neuron Glia Biol (2012) 0.84
Rarity of the Alzheimer disease-protective APP A673T variant in the United States. JAMA Neurol (2015) 0.84
Constitutive Wee1 activity in adult brain neurons with M phase-type alterations in Alzheimer neurodegeneration. J Alzheimers Dis (2001) 0.84
Characteristic transformation of blood transcriptome in Alzheimer's disease. J Alzheimers Dis (2013) 0.83
The influence of spin-labeled fluorene compounds on the assembly and toxicity of the aβ peptide. PLoS One (2012) 0.83
Myelin injury and degraded myelin vesicles in Alzheimer's disease. Curr Alzheimer Res (2014) 0.83
Alzheimer's disease drug candidates stabilize A-β protein native structure by interacting with the hydrophobic core. Biophys J (2011) 0.82
Syntheses of tricyclic pyrones and pyridinones and protection of Abeta-peptide induced MC65 neuronal cell death. Bioorg Med Chem Lett (2008) 0.82
Polarimetric imaging of amyloid. Micron (2005) 0.80
Muscle biopsy evaluation in neuromuscular disorders. Phys Med Rehabil Clin N Am (2012) 0.79
Characterization of radioiodinated ligand binding to amyloid beta plaques. J Mol Neurosci (2003) 0.77
A case of familial ALS due to multi-system proteinopathy 1 and Huntington disease. Amyotroph Lateral Scler Frontotemporal Degener (2014) 0.77
Distinctive RNA expression profiles in blood associated with Alzheimer disease after accounting for white matter hyperintensities. Alzheimer Dis Assoc Disord (2014) 0.77
Alterations of chaperone protein expression in presenilin mutant neurons in response to glutamate excitotoxicity. Pathol Int (2002) 0.77
Chromosome 19p in Alzheimer's disease: when genome meets transcriptome. J Alzheimers Dis (2014) 0.75