Beyond infection - Maternal immune activation by environmental factors, microglial development, and relevance for autism spectrum disorders.

PubWeight™: 0.75‹?›

🔗 View Article (PMID 28698032)

Published in Exp Neurol on July 08, 2017

Authors

Staci D Bilbo1, Carina L Block2, Jessica L Bolton3, Richa Hanamsagar4, Phuong K Tran4

Author Affiliations

1: Pediatrics and Neuroscience, Harvard Medical School, Lurie Center for Autism, Massachusetts General Hospital for Children, Boston, MA 02126, United States. Electronic address: sbilbo@mgh.harvard.edu.
2: Psychology and Neuroscience, Duke University, Durham, NC 27708, United States.
3: Pediatrics and Anatomy/Neurobiology, University of California-Irvine, Irvine, CA 92697, United States.
4: Pediatrics and Neuroscience, Harvard Medical School, Lurie Center for Autism, Massachusetts General Hospital for Children, Boston, MA 02126, United States.

Articles cited by this

(truncated to the top 100)

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol (2010) 24.08

The danger model: a renewed sense of self. Science (2002) 13.85

The inflammasomes: guardians of the body. Annu Rev Immunol (2009) 12.89

Fate mapping analysis reveals that adult microglia derive from primitive macrophages. Science (2010) 12.15

Microglia-mediated neurotoxicity: uncovering the molecular mechanisms. Nat Rev Neurosci (2007) 11.24

DAMPs, PAMPs and alarmins: all we need to know about danger. J Leukoc Biol (2006) 10.73

The classical complement cascade mediates CNS synapse elimination. Cell (2007) 9.06

A lineage of myeloid cells independent of Myb and hematopoietic stem cells. Science (2012) 8.42

Synaptic pruning by microglia is necessary for normal brain development. Science (2011) 7.35

The lasting impact of childhood health and circumstance. J Health Econ (2005) 7.00

Neuroglial activation and neuroinflammation in the brain of patients with autism. Ann Neurol (2005) 5.95

Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner. Neuron (2012) 5.84

Microglia in neurodegenerative disease. Nat Rev Neurol (2010) 5.83

An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex. J Neurosci (2014) 5.52

Hydrophobicity: an ancient damage-associated molecular pattern that initiates innate immune responses. Nat Rev Immunol (2004) 5.13

Microglia shape adult hippocampal neurogenesis through apoptosis-coupled phagocytosis. Cell Stem Cell (2010) 4.30

Systemic infections and inflammation affect chronic neurodegeneration. Nat Rev Immunol (2007) 4.13

Maternal immune activation alters fetal brain development through interleukin-6. J Neurosci (2007) 4.06

Maternal influenza infection causes marked behavioral and pharmacological changes in the offspring. J Neurosci (2003) 3.50

Anxiety in children and adolescents with autism spectrum disorders. Clin Psychol Rev (2009) 3.39

Immune modulation of learning, memory, neural plasticity and neurogenesis. Brain Behav Immun (2010) 3.37

Socioeconomic status and the brain: mechanistic insights from human and animal research. Nat Rev Neurosci (2010) 3.30

Colony-stimulating factor 1 receptor signaling is necessary for microglia viability, unmasking a microglia progenitor cell in the adult brain. Neuron (2014) 3.10

Regulation of class I MHC gene expression in the developing and mature CNS by neural activity. Neuron (1998) 2.90

Effects of familial risk factors and place of birth on the risk of autism: a nationwide register-based study. J Child Psychol Psychiatry (2005) 2.73

Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior. Nat Neurosci (2014) 2.69

Systemic inflammation induces acute behavioral and cognitive changes and accelerates neurodegenerative disease. Biol Psychiatry (2008) 2.66

The immune response in autism: a new frontier for autism research. J Leukoc Biol (2006) 2.65

Air pollution: mechanisms of neuroinflammation and CNS disease. Trends Neurosci (2009) 2.60

Microglia: biology and pathology. Acta Neuropathol (2009) 2.51

Stereotypies and hyperactivity in rhesus monkeys exposed to IgG from mothers of children with autism. Brain Behav Immun (2008) 2.50

The influence of systemic inflammation on inflammation in the brain: implications for chronic neurodegenerative disease. Brain Behav Immun (2004) 2.44

The origin and cell lineage of microglia: new concepts. Brain Res Rev (2006) 2.36

Microglial activation and increased microglial density observed in the dorsolateral prefrontal cortex in autism. Biol Psychiatry (2010) 2.30

Traffic-related air pollution, particulate matter, and autism. JAMA Psychiatry (2013) 2.24

The microglial "activation" continuum: from innate to adaptive responses. J Neuroinflammation (2005) 2.23

Immunity, neuroglia and neuroinflammation in autism. Int Rev Psychiatry (2005) 2.19

Maternal metabolic conditions and risk for autism and other neurodevelopmental disorders. Pediatrics (2012) 2.18

Cytokines and CNS development. Neuron (2009) 2.15

The origin and nature of ramified and amoeboid microglia: a historical review and current concepts. Glia (1993) 2.11

Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer's disease. Acta Neuropathol (2009) 2.09

Migration and autism spectrum disorder: population-based study. Br J Psychiatry (2012) 2.07

Maternal smoking during pregnancy, environmental tobacco smoke exposure and childhood lung function. Thorax (2000) 2.06

Rett syndrome microglia damage dendrites and synapses by the elevated release of glutamate. J Neurosci (2010) 1.98

Autism prevalence following prenatal exposure to hurricanes and tropical storms in Louisiana. J Autism Dev Disord (2007) 1.92

Early-life programming of later-life brain and behavior: a critical role for the immune system. Front Behav Neurosci (2009) 1.89

Critical functions of priming and lysosomal damage for NLRP3 activation. Eur J Immunol (2010) 1.87

Differential monocyte responses to TLR ligands in children with autism spectrum disorders. Brain Behav Immun (2009) 1.86

Elevated cytokine levels in children with autism spectrum disorder. J Neuroimmunol (2005) 1.85

The origin and differentiation of microglial cells during development. Prog Neurobiol (1998) 1.79

Estimated risk for altered fetal growth resulting from exposure to fine particles during pregnancy: an epidemiologic prospective cohort study in Poland. Environ Health Perspect (2004) 1.78

Maternal immune activation yields offspring displaying mouse versions of the three core symptoms of autism. Brain Behav Immun (2012) 1.77

Cytokine induction in fetal rat brains and brain injury in neonatal rats after maternal lipopolysaccharide administration. Pediatr Res (2000) 1.77

Amniotic fluid interleukin-6: a sensitive test for antenatal diagnosis of acute inflammatory lesions of preterm placenta and prediction of perinatal morbidity. Am J Obstet Gynecol (1995) 1.76

Enduring consequences of maternal obesity for brain inflammation and behavior of offspring. FASEB J (2010) 1.73

Neonatal interleukin-1 beta, interleukin-6, and tumor necrosis factor: cord blood levels and cellular production. J Pediatr (1990) 1.69

Maternal neuronal antibodies associated with autism and a language disorder. Ann Neurol (2003) 1.69

Activation of the maternal immune system alters cerebellar development in the offspring. Brain Behav Immun (2008) 1.67

Familial clustering of autoimmune disorders and evaluation of medical risk factors in autism. J Child Neurol (1999) 1.66

Prenatal stress and risk for autism. Neurosci Biobehav Rev (2008) 1.64

Disturbance of oligodendrocyte development, hypomyelination and white matter injury in the neonatal rat brain after intracerebral injection of lipopolysaccharide. Brain Res Dev Brain Res (2003) 1.63

New horizons in the pathogenesis, assessment and management of delirium. Age Ageing (2013) 1.62

The outdoor air pollution and brain health workshop. Neurotoxicology (2012) 1.60

Microglial activation in young adults with autism spectrum disorder. JAMA Psychiatry (2013) 1.57

Correlation of interleukin-1 beta and cachectin concentrations in cerebrospinal fluid and outcome from bacterial meningitis. J Pediatr (1989) 1.56

Increased prevalence of familial autoimmunity in probands with pervasive developmental disorders. Pediatrics (2003) 1.56

The neural substrates of cognitive control deficits in autism spectrum disorders. Neuropsychologia (2009) 1.56

Life and death of microglia. J Neuroimmune Pharmacol (2009) 1.54

Immune activation of peripheral blood and mucosal CD3+ lymphocyte cytokine profiles in children with autism and gastrointestinal symptoms. J Neuroimmunol (2006) 1.53

Neonatal infection induces memory impairments following an immune challenge in adulthood. Behav Neurosci (2005) 1.53

Perinatal air pollutant exposures and autism spectrum disorder in the children of Nurses' Health Study II participants. Environ Health Perspect (2013) 1.49

Lipopolysaccharide-induced inflammation and perinatal brain injury. Semin Fetal Neonatal Med (2006) 1.48

Prenatal exposure to maternal infection alters cytokine expression in the placenta, amniotic fluid, and fetal brain. Schizophr Res (2001) 1.47

A novel mouse model for acute and long-lasting consequences of early life stress. Endocrinology (2008) 1.46

Caspr2-reactive antibody cloned from a mother of an ASD child mediates an ASD-like phenotype in mice. Mol Psychiatry (2016) 1.45

Prenatal maternal stress and cord blood innate and adaptive cytokine responses in an inner-city cohort. Am J Respir Crit Care Med (2010) 1.43

Neonatal infection-induced memory impairment after lipopolysaccharide in adulthood is prevented via caspase-1 inhibition. J Neurosci (2005) 1.41

Prenatal exposure to antibodies from mothers of children with autism produces neurobehavioral alterations: A pregnant dam mouse model. J Neuroimmunol (2009) 1.40

Epidemiologic studies of exposure to prenatal infection and risk of schizophrenia and autism. Dev Neurobiol (2012) 1.39

Diesel exhaust particles induce oxidative stress, proinflammatory signaling, and P-glycoprotein up-regulation at the blood-brain barrier. FASEB J (2008) 1.39

Microglia and memory: modulation by early-life infection. J Neurosci (2011) 1.37

The immune system and developmental programming of brain and behavior. Front Neuroendocrinol (2012) 1.36

Systemic and local cytokine profiles in endotoxin-induced preterm parturition in mice. Am J Obstet Gynecol (1994) 1.36

Prenatal immune challenge disrupts sensorimotor gating in adult rats. Implications for the etiopathogenesis of schizophrenia. Neuropsychopharmacology (2002) 1.36

Autism spectrum traits in children with mood and anxiety disorders. J Child Adolesc Psychopharmacol (2005) 1.35

Specific neurodevelopmental damage in mice offspring following maternal inflammation during pregnancy. Neuropharmacology (2005) 1.34

Immunology. Dangers in and out. Science (2009) 1.32

Atypical inflammation in the central nervous system in prion disease. Curr Opin Neurol (2002) 1.32

Programmed cell death in the developing human telencephalon. Eur J Neurosci (2000) 1.31

Prenatal air pollution exposure induces neuroinflammation and predisposes offspring to weight gain in adulthood in a sex-specific manner. FASEB J (2012) 1.30

Environmental toxicants and autism spectrum disorders: a systematic review. Transl Psychiatry (2014) 1.30

Chronology of neuron development: animal studies and their clinical implications. Dev Med Child Neurol (1980) 1.30

Recent progress in animal modeling of immune inflammatory processes in schizophrenia: implication of specific cytokines. Neurosci Res (2006) 1.28

A trans-dimensional approach to the behavioral aspects of depression. Front Behav Neurosci (2009) 1.27

Multiple cognitive capabilities/deficits in children with an autism spectrum disorder: "weak" central coherence and its relationship to theory of mind and executive control. Dev Psychopathol (2006) 1.25

Interleukin-1 is an astroglial growth factor in the developing brain. J Neurosci (1988) 1.25

Age and neuroinflammation: a lifetime of psychoneuroimmune consequences. Neurol Clin (2006) 1.23

The five Rs of glucocorticoid action during inflammation: ready, reinforce, repress, resolve, and restore. Trends Endocrinol Metab (2013) 1.21

Early-life infection leads to altered BDNF and IL-1beta mRNA expression in rat hippocampus following learning in adulthood. Brain Behav Immun (2007) 1.19

Cytokine aberrations in autism spectrum disorder: a systematic review and meta-analysis. Mol Psychiatry (2014) 1.17