Published in Anesthesiology on May 01, 2010
Glia and pain: is chronic pain a gliopathy? Pain (2013) 2.21
Reversal of peripheral nerve injury-induced hypersensitivity in the postpartum period: role of spinal oxytocin. Anesthesiology (2013) 1.27
Targeting p38 Mitogen-activated Protein Kinase to Reduce the Impact of Neonatal Microglial Priming on Incision-induced Hyperalgesia in the Adult Rat. Anesthesiology (2015) 0.94
The Role of Glycogen Synthase Kinase 3 Beta in Neuroinflammation and Pain. J Pharm Pharmacol (Los Angel) (2013) 0.88
Involvement of spinal chemokine CCL2 in the hyperalgesia evoked by bone cancer in mice: a role for astroglia and microglia. Cell Mol Neurobiol (2014) 0.83
Minocycline, a microglial inhibitor, blocks spinal CCL2-induced heat hyperalgesia and augmentation of glutamatergic transmission in substantia gelatinosa neurons. J Neuroinflammation (2014) 0.83
Shifts in cell-type expression accompany a diminishing role of spinal p38-mapkinase activation over time during prolonged postoperative pain. Anesthesiology (2011) 0.80
TRPV1 antagonist attenuates postoperative hypersensitivity by central and peripheral mechanisms. Mol Pain (2014) 0.78
Monocyte chemoattractant protein-1 contributes to morphine tolerance in rats with cancer-induced bone pain. Exp Ther Med (2016) 0.75
ATP-sensitive potassium channels alleviate postoperative pain through JNK-dependent MCP-1 expression in spinal cord. Int J Mol Med (2015) 0.75
Disruption of Spinal Noradrenergic Activation Delays Recovery of Acute Incision-Induced Hypersensitivity and Increases Spinal Glial Activation in the Rat. J Pain (2015) 0.75
Quantitative assessment of tactile allodynia in the rat paw. J Neurosci Methods (1994) 23.05
An estimation of the global volume of surgery: a modelling strategy based on available data. Lancet (2008) 14.07
Postoperative pain experience: results from a national survey suggest postoperative pain continues to be undermanaged. Anesth Analg (2003) 7.95
The neuropathic pain triad: neurons, immune cells and glia. Nat Neurosci (2007) 5.38
Characterization of a rat model of incisional pain. Pain (1996) 3.55
Minocycline attenuates mechanical allodynia and proinflammatory cytokine expression in rat models of pain facilitation. Pain (2005) 3.34
Impaired neuropathic pain responses in mice lacking the chemokine receptor CCR2. Proc Natl Acad Sci U S A (2003) 3.17
p38 MAPK, microglial signaling, and neuropathic pain. Mol Pain (2007) 2.72
JNK-induced MCP-1 production in spinal cord astrocytes contributes to central sensitization and neuropathic pain. J Neurosci (2009) 2.64
Activation of p38 mitogen-activated protein kinase in spinal microglia is a critical link in inflammation-induced spinal pain processing. J Neurochem (2003) 2.42
Expression of CCR2 in both resident and bone marrow-derived microglia plays a critical role in neuropathic pain. J Neurosci (2007) 2.28
Spatial and temporal relationship between monocyte chemoattractant protein-1 expression and spinal glial activation following peripheral nerve injury. J Neurochem (2006) 2.14
CCL2 is a key mediator of microglia activation in neuropathic pain states. Eur J Pain (2008) 1.85
Intrathecal minocycline attenuates peripheral inflammation-induced hyperalgesia by inhibiting p38 MAPK in spinal microglia. Eur J Neurosci (2005) 1.77
Enhanced production of monocyte chemoattractant protein-1 in the dorsal root ganglia in a rat model of neuropathic pain: possible involvement in the development of neuropathic pain. Neurosci Res (2004) 1.63
Pain as a factor complicating recovery and discharge after ambulatory surgery. Anesth Analg (2002) 1.62
Visualization of chemokine receptor activation in transgenic mice reveals peripheral activation of CCR2 receptors in states of neuropathic pain. J Neurosci (2009) 1.59
CCL2 and CXCL1 trigger calcitonin gene-related peptide release by exciting primary nociceptive neurons. J Neurosci Res (2005) 1.48
Effects of laparotomy on spontaneous exploratory activity and conditioned operant responding in the rat: a model for postoperative pain. Anesthesiology (2004) 1.43
Chemokines and pain mechanisms. Brain Res Rev (2008) 1.43
Spinal p38beta isoform mediates tissue injury-induced hyperalgesia and spinal sensitization. J Neurochem (2005) 1.41
Spinal CCL2 pronociceptive action is no longer effective in CCR2 receptor antagonist-treated rats. J Neurochem (2008) 1.37
Spinal cannabinoid receptor type 2 activation reduces hypersensitivity and spinal cord glial activation after paw incision. Anesthesiology (2007) 1.30
Spinal p38 MAP kinase is necessary for NMDA-induced spinal PGE(2) release and thermal hyperalgesia. Neuroreport (2003) 1.28
A comparison of spinal Iba1 and GFAP expression in rodent models of acute and chronic pain. Brain Res (2008) 1.26
Constitutive expression of CCR2 chemokine receptor and inhibition by MCP-1/CCL2 of GABA-induced currents in spinal cord neurones. J Neurochem (2005) 1.26
Spinal glial activation contributes to postoperative mechanical hypersensitivity in the rat. J Pain (2006) 1.18
Cyclooxygenase-1 in the spinal cord plays an important role in postoperative pain. Pain (2003) 1.17
Activation of p38 mitogen-activated protein kinase in spinal microglia contributes to incision-induced mechanical allodynia. Anesthesiology (2009) 1.12
A survey of pain and other symptoms that affect the recovery process after discharge from an ambulatory surgery unit. J Clin Anesth (2004) 1.11
Chemokines as pain mediators and modulators. Curr Opin Anaesthesiol (2008) 1.04
Preoperative inhibition of cyclooxygenase-1 in the spinal cord reduces postoperative pain. Anesth Analg (2005) 1.03
Monocyte chemoattractant protein-1 immunoreactivity in sensory ganglia and hindpaw after adjuvant injection. Neuroreport (2008) 0.95
Spinal microglial expression and mechanical hypersensitivity in a postoperative pain model: comparison with a neuropathic pain model. Anesthesiology (2009) 0.95
Characterization of a new animal model for evaluation of persistent postthoracotomy pain. Anesth Analg (2004) 0.94
Upregulation of dorsal horn microglial cyclooxygenase-1 and neuronal cyclooxygenase-2 after thoracic deep muscle incisions in the rat. Anesth Analg (2008) 0.82
Developmental differences in spinal cyclooxygenase 1 expression after surgical incision. Anesthesiology (2006) 0.82
Animal models and the prediction of efficacy in clinical trials of analgesic drugs: a critical appraisal and call for uniform reporting standards. Pain (2008) 3.08
Opioid self-administration in the nerve-injured rat: relevance of antiallodynic effects to drug consumption and effects of intrathecal analgesics. Anesthesiology (2007) 1.96
Individual differences in acute pain-induced endogenous analgesia predict time to resolution of postoperative pain in the rat. Anesthesiology (2015) 1.52
Neostigmine decreases bupivacaine use by patient-controlled epidural analgesia during labor: a randomized controlled study. Anesth Analg (2009) 1.50
Multifactorial preoperative predictors for postcesarean section pain and analgesic requirement. Anesthesiology (2006) 1.50
Gabapentin acts within the locus coeruleus to alleviate neuropathic pain. Anesthesiology (2008) 1.48
Data fabrication and article retraction: how not to get lost in the woods. Anesthesiology (2009) 1.47
Effects of laparotomy on spontaneous exploratory activity and conditioned operant responding in the rat: a model for postoperative pain. Anesthesiology (2004) 1.43
Peripheral nerve injury sensitizes the response to visceral distension but not its inhibition by the antidepressant milnacipran. Anesthesiology (2004) 1.43
Intrathecal ketorolac does not improve acute or chronic pain after hip arthroplasty: a randomized controlled trial. J Anesth (2014) 1.38
Spinal cannabinoid receptor type 2 activation reduces hypersensitivity and spinal cord glial activation after paw incision. Anesthesiology (2007) 1.30
Gabapentin activates spinal noradrenergic activity in rats and humans and reduces hypersensitivity after surgery. Anesthesiology (2007) 1.27
Reversal of peripheral nerve injury-induced hypersensitivity in the postpartum period: role of spinal oxytocin. Anesthesiology (2013) 1.27
Perineural clonidine reduces mechanical hypersensitivity and cytokine production in established nerve injury. Anesthesiology (2006) 1.25
Intravenous remifentanil produces withdrawal hyperalgesia in volunteers with capsaicin-induced hyperalgesia. Anesth Analg (2003) 1.24
Cyclooxygenase-1 in the spinal cord is altered after peripheral nerve injury. Anesthesiology (2003) 1.23
Brain derived nerve growth factor induces spinal noradrenergic fiber sprouting and enhances clonidine analgesia following nerve injury in rats. Pain (2007) 1.19
Pain intensity and duration can be enhanced by prior challenge: initial evidence suggestive of a role of microglial priming. J Pain (2010) 1.19
Spinal glial activation contributes to postoperative mechanical hypersensitivity in the rat. J Pain (2006) 1.18
Cyclooxygenase-1 in the spinal cord plays an important role in postoperative pain. Pain (2003) 1.17
Morphological and pharmacological evidence for the role of peripheral prostaglandins in the pathogenesis of neuropathic pain. Eur J Neurosci (2002) 1.16
Chronic constriction injury of sciatic nerve induces the up-regulation of descending inhibitory noradrenergic innervation to the lumbar dorsal horn of mice. Brain Res (2003) 1.07
Alpha2-adrenoceptor stimulation transforms immune responses in neuritis and blocks neuritis-induced pain. J Neurosci (2005) 1.06
Spinal alpha 2-adrenoceptor-mediated analgesia in neuropathic pain reflects brain-derived nerve growth factor and changes in spinal cholinergic neuronal function. Anesthesiology (2010) 1.04
Preoperative inhibition of cyclooxygenase-1 in the spinal cord reduces postoperative pain. Anesth Analg (2005) 1.03
Role for both spinal cord COX-1 and COX-2 in maintenance of mechanical hypersensitivity following peripheral nerve injury. Brain Res (2002) 1.01
Spinal nerve ligation increases alpha2-adrenergic receptor G-protein coupling in the spinal cord. Brain Res (2005) 0.99
Age-dependent responses to thermal hyperalgesia and mechanical allodynia in a rat model of acute postoperative pain. Anesthesiology (2003) 0.99
Age-dependent responses to nerve injury-induced mechanical allodynia. Anesthesiology (2006) 0.98
Abdominal surgery decreases food-reinforced operant responding in rats: relevance of incisional pain. Anesthesiology (2005) 0.98
Estrogen amplifies pain responses to uterine cervical distension in rats by altering transient receptor potential-1 function. Anesth Analg (2007) 0.98
Riluzole and gabapentinoids activate glutamate transporters to facilitate glutamate-induced glutamate release from cultured astrocytes. Eur J Pharmacol (2011) 0.96
Epidural neostigmine produces analgesia but also sedation in women after cesarean delivery. Anesthesiology (2004) 0.96
Oral gabapentin activates spinal cholinergic circuits to reduce hypersensitivity after peripheral nerve injury and interacts synergistically with oral donepezil. Anesthesiology (2007) 0.95
Plasticity in action of intrathecal clonidine to mechanical but not thermal nociception after peripheral nerve injury. Anesthesiology (2003) 0.95
Up-regulation of spinal glutamate transporters contributes to anti-hypersensitive effects of valproate in rats after peripheral nerve injury. Neurosci Lett (2011) 0.94
Intrathecal morphine and ketorolac analgesia after surgery: comparison of spontaneous and elicited responses in rats. Pain (2005) 0.94
Intrathecal injection of cAMP response element binding protein (CREB) antisense oligonucleotide attenuates tactile allodynia caused by partial sciatic nerve ligation. Brain Res (2003) 0.94
Spinal noradrenergic activation mediates allodynia reduction from an allosteric adenosine modulator in a rat model of neuropathic pain. Pain (2002) 0.93
Preventing chronic pain after surgery: who, how, and when? Reg Anesth Pain Med (2006) 0.93
Perineural alpha(2A)-adrenoceptor activation inhibits spinal cord neuroplasticity and tactile allodynia after nerve injury. Anesthesiology (2002) 0.93
Depletion of endogenous noradrenaline does not prevent spinal cord plasticity following peripheral nerve injury. J Pain (2011) 0.92
Clonidine reduces hypersensitivity and alters the balance of pro- and anti-inflammatory leukocytes after local injection at the site of inflammatory neuritis. Brain Behav Immun (2006) 0.92
Allosteric adenosine receptor modulation reduces hypersensitivity following peripheral inflammation by a central mechanism. J Pharmacol Exp Ther (2003) 0.92
Chronic estrogen sensitizes a subset of mechanosensitive afferents innervating the uterine cervix. J Neurophysiol (2005) 0.92
Effect of kappa opioid agonists on visceral nociception induced by uterine cervical distension in rats. Pain (2002) 0.92
Differing neurophysiologic mechanosensory input from glabrous and hairy skin in juvenile rats. J Neurophysiol (2010) 0.91
alpha2-Adrenoceptor activation by clonidine enhances stimulation-evoked acetylcholine release from spinal cord tissue after nerve ligation in rats. Anesthesiology (2005) 0.90
Knock down of the alpha 5 nicotinic acetylcholine receptor in spinal nerve-ligated rats alleviates mechanical allodynia. Pharmacol Biochem Behav (2004) 0.90
Lack of analgesic efficacy of spinal ondansetron on thermal and mechanical hypersensitivity following spinal nerve ligation in the rat. Brain Res (2010) 0.90
Clonidine maintains intrathecal self-administration in rats following spinal nerve ligation. Pain (2006) 0.90
Intrathecal clonidine for postoperative analgesia in elderly patients: the influence of baricity on hemodynamic and analgesic effects. Anesth Analg (2004) 0.89
Predicting acute pain after cesarean delivery using three simple questions. Anesthesiology (2013) 0.89
Plasticity of spinal nicotinic acetylcholine receptors following spinal nerve ligation. Neurosci Res (2004) 0.89
Safety in numbers: how do we study toxicity of spinal analgesics? Anesthesiology (2002) 0.89
The effect of peripherally administered CDP-choline in an acute inflammatory pain model: the role of alpha7 nicotinic acetylcholine receptor. Anesth Analg (2009) 0.89
Immunocytochemical localization of the alpha3, alpha4, alpha5, alpha7, beta2, beta3 and beta4 nicotinic acetylcholine receptor subunits in the locus coeruleus of the rat. Brain Res (2003) 0.88
Preoperative sciatic nerve block decreases mechanical allodynia more in young rats: is preemptive analgesia developmentally modulated? Anesth Analg (2004) 0.87
Note of editorial concern. Anesthesiology (2011) 0.87
Hyperexcitability of axotomized and neighboring unaxotomized sensory neurons is reduced days after perineural clonidine at the site of injury. J Neurophysiol (2005) 0.87
Four PGE2 EP receptors are up-regulated in injured nerve following partial sciatic nerve ligation. Exp Neurol (2003) 0.86
Peripheral nerve injury alters the alpha2 adrenoceptor subtype activated by clonidine for analgesia. Anesthesiology (2002) 0.86
Intravenous butorphanol, meperidine, and their combination relieve pain and distress in women in labor. Anesthesiology (2005) 0.86
Prior laparotomy or corticosterone potentiates lipopolysaccharide-induced fever and sickness behaviors. J Neuroimmunol (2011) 0.85
Activation of glutamate transporters in the locus coeruleus paradoxically activates descending inhibition in rats. Brain Res (2010) 0.85
Epidural neostigmine: will it replace lipid soluble opioids for postoperative and labor analgesia? Anesth Analg (2009) 0.85
Spinal noradrenaline transporter inhibition by reboxetine and Xen2174 reduces tactile hypersensitivity after surgery in rats. Pain (2005) 0.85
Impaired Pain-evoked Analgesia after Nerve Injury in Rats Reflects Altered Glutamate Regulation in the Locus Coeruleus. Anesthesiology (2015) 0.84
Peripheral block of the hyperpolarization-activated cation current (Ih) reduces mechanical allodynia in animal models of postoperative and neuropathic pain. Reg Anesth Pain Med (2005) 0.84
Gabapentin inhibits γ-amino butyric acid release in the locus coeruleus but not in the spinal dorsal horn after peripheral nerve injury in rats. Anesthesiology (2012) 0.84
Uterine cervical distension induces cFos expression in deep dorsal horn neurons of the rat spinal cord. Anesthesiology (2003) 0.84
ST91 [2-(2,6-diethylphenylamino)-2-imidazoline hydrochloride]-mediated spinal antinociception and synergy with opioids persists in the absence of functional alpha-2A- or alpha-2C-adrenergic receptors. J Pharmacol Exp Ther (2007) 0.84
Electrical field stimulation to study inhibitory mechanisms in individual sensory neurons in culture. Anesthesiology (2004) 0.84
Skin incision-induced receptive field responses of mechanosensitive peripheral neurons are developmentally regulated in the rat. J Neurophysiol (2012) 0.83
Pregnancy increases excitability of mechanosensitive afferents innervating the uterine cervix. Anesthesiology (2008) 0.83
Nicotinic acetylcholine receptor regulation of spinal norepinephrine release. Anesthesiology (2002) 0.83
Intrathecal administration of a cylcooxygenase-1, but not a cyclooxygenase-2 inhibitor, reverses the effects of laparotomy on exploratory activity in rats. Anesth Analg (2006) 0.83
Intrathecal lidocaine reverses tactile allodynia caused by nerve injuries and potentiates the antiallodynic effect of the COX inhibitor ketorolac. Anesthesiology (2003) 0.83
Predictors of headache before, during, and after pregnancy: a cohort study. Headache (2012) 0.83
Uterine cervical afferents in thoracolumbar dorsal root ganglia express transient receptor potential vanilloid type 1 channel and calcitonin gene-related peptide, but not P2X3 receptor and somatostatin. Anesthesiology (2006) 0.82
Nociceptor-selective peripheral nerve block induces delayed mechanical hypersensitivity and neurotoxicity in rats. Anesthesiology (2014) 0.82
Did experimenter bias conceal the efficacy of spinal opioids in previous studies with the spinal nerve ligation model of neuropathic pain? Anesthesiology (2004) 0.82
Developmental differences in spinal cyclooxygenase 1 expression after surgical incision. Anesthesiology (2006) 0.82
Intrathecal morphine reduces allodynia after peripheral nerve injury in rats via activation of a spinal A1 adenosine receptor. Anesthesiology (2005) 0.82
Developmental differences in peripheral glabrous skin mechanosensory nerve receptive field and intracellular electrophysiologic properties: phenotypic characterization in infant and juvenile rats. Int J Dev Neurosci (2011) 0.81
Oral donepezil reduces hypersensitivity after nerve injury by a spinal muscarinic receptor mechanism. Anesthesiology (2007) 0.81
Repeated dosing with oral allosteric modulator of adenosine A1 receptor produces tolerance in rats with neuropathic pain. Anesthesiology (2004) 0.81
Electrophysiologic characteristics of large neurons in dorsal root ganglia during development and after hind paw incision in the rat. Anesthesiology (2008) 0.80
Spinal adrenergic and cholinergic receptor interactions activated by clonidine in postincisional pain. Anesthesiology (2003) 0.80
Intrathecal adenosine following spinal nerve ligation in rat: short residence time in cerebrospinal fluid and no change in A(1) receptor binding. Anesthesiology (2002) 0.80
Oxytocin inhibits the membrane depolarization-induced increase in intracellular calcium in capsaicin sensitive sensory neurons: a peripheral mechanism of analgesic action. Anesth Analg (2011) 0.80
Ensuring transparency and minimization of methodologic bias in preclinical pain research: PPRECISE considerations. Pain (2016) 0.80
Allosteric modulation of adenosine A1 receptor coupling to G-proteins in brain. J Neurochem (2005) 0.80
Neuronal nitric oxide synthase is upregulated in a subset of primary sensory afferents after nerve injury which are necessary for analgesia from alpha2-adrenoceptor stimulation. Brain Res (2006) 0.80
Intrathecal clonidine reduces hypersensitivity after nerve injury by a mechanism involving spinal m4 muscarinic receptors. Anesth Analg (2003) 0.80
Valproate prevents dysregulation of spinal glutamate and reduces the development of hypersensitivity in rats after peripheral nerve injury. J Pain (2013) 0.80
Ondansetron reverses antihypersensitivity from clonidine in rats after peripheral nerve injury: role of γ-aminobutyric acid in α2-adrenoceptor and 5-HT3 serotonin receptor analgesia. Anesthesiology (2012) 0.80