Published in Cytokine on April 18, 2010
The roles of interleukin-6 in the pathogenesis of rheumatoid arthritis. Arthritis (2011) 1.33
Interleukin 6 and rheumatoid arthritis. Biomed Res Int (2014) 1.00
Baseline anti-citrullinated peptide antibody (ACPA) titers and serum interleukin-6 (IL-6) levels possibly predict progression of bone destruction in early stages of rheumatoid arthritis (ERA). Rheumatol Int (2012) 0.92
Potential role of fibroblast-like synoviocytes in joint damage induced by Brucella abortus infection through production and induction of matrix metalloproteinases. Infect Immun (2011) 0.91
Harpagoside suppresses IL-6 expression in primary human osteoarthritis chondrocytes. J Orthop Res (2016) 0.81
Intercellular adhesion molecule-1 on synovial cells attenuated interleukin-6-induced inhibition of osteoclastogenesis induced by receptor activator for nuclear factor κB ligand. Clin Exp Immunol (2010) 0.81
Decrease of CD68 Synovial Macrophages in Celastrol Treated Arthritic Rats. PLoS One (2015) 0.80
Selected cytokine pathways in rheumatoid arthritis. Semin Immunopathol (2017) 0.80
Inflammation induced loss of skeletal muscle. Bone (2015) 0.79
Histone deacetylase inhibitor vorinostat (SAHA, MK0683) perturb miR-9-MCPIP1 axis to block IL-1β-induced IL-6 expression in human OA chondrocytes. Connect Tissue Res (2016) 0.77
A Network Pharmacology Approach to Uncover the Pharmacological Mechanism of XuanHuSuo Powder on Osteoarthritis. Evid Based Complement Alternat Med (2016) 0.76
Blockade of interleukin-6 receptor enhances the anti-arthritic effect of glucocorticoids without decreasing bone mineral density in mice with collagen-induced arthritis. Clin Exp Immunol (2015) 0.75
Ilomastat, a synthetic inhibitor of MMPs, prevents lung injury induced by γ-ray irradiation in mice. Oncotarget (2017) 0.75
A Polyphenol-rich Pomegranate Fruit Extract Suppresses NF-κB and IL-6 Expression by Blocking the Activation of IKKβ and NIK in Primary Human Chondrocytes. Phytother Res (2017) 0.75
A resorcylic acid lactone, 5Z-7-oxozeaenol, prevents inflammation by inhibiting the catalytic activity of TAK1 MAPK kinase kinase. J Biol Chem (2003) 3.19
IL-6 blockade inhibits the induction of myelin antigen-specific Th17 cells and Th1 cells in experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A (2008) 2.60
IL-6/IL-6 receptor system and its role in physiological and pathological conditions. Clin Sci (Lond) (2012) 2.41
Blockade of interleukin-6 signaling augments regulatory T-cell reconstitution and attenuates the severity of graft-versus-host disease. Blood (2009) 1.80
Interleukin-6 blockade suppresses autoimmune arthritis in mice by the inhibition of inflammatory Th17 responses. Arthritis Rheum (2008) 1.55
Characterization of ribavirin uptake systems in human hepatocytes. J Hepatol (2010) 1.54
Murine tumor necrosis factor α-induced adipose-related protein (tumor necrosis factor α-induced protein 9) deficiency leads to arthritis via interleukin-6 overproduction with enhanced NF-κB, STAT-3 signaling, and dysregulated apoptosis of macrophages. Arthritis Rheum (2012) 1.52
Functional CD5+ B cells develop predominantly in the spleen of NOD/SCID/gammac(null) (NOG) mice transplanted either with human umbilical cord blood, bone marrow, or mobilized peripheral blood CD34+ cells. Exp Hematol (2003) 1.49
Crucial role of the interleukin-6/interleukin-17 cytokine axis in the induction of arthritis by glucose-6-phosphate isomerase. Arthritis Rheum (2008) 1.43
Blockade of interleukin-6 signaling aggravates ischemic cerebral damage in mice: possible involvement of Stat3 activation in the protection of neurons. J Neurochem (2005) 1.34
The roles of interleukin-6 in the pathogenesis of rheumatoid arthritis. Arthritis (2011) 1.33
Characterization of anti-mouse interleukin-6 receptor antibody. Immunol Lett (2002) 1.25
Interleukin-6 receptor-mediated activation of signal transducer and activator of transcription-3 (STAT3) promotes choroidal neovascularization. Am J Pathol (2007) 1.23
Tocilizumab, a humanized anti-interleukin-6 receptor antibody, improved anemia in monkey arthritis by suppressing IL-6-induced hepcidin production. Rheumatol Int (2009) 1.13
Mechanism of action of combined short-term CTLA4Ig and anti-CD40 ligand in murine systemic lupus erythematosus. J Immunol (2002) 1.11
Blockade of interleukin-6 signaling suppressed cochlear inflammatory response and improved hearing impairment in noise-damaged mice cochlea. Neurosci Res (2009) 1.07
Instability of Foxp3 expression limits the ability of induced regulatory T cells to mitigate graft versus host disease. Clin Cancer Res (2011) 1.06
Association of a polymorphism of BTN2A1 with myocardial infarction in East Asian populations. Atherosclerosis (2010) 1.02
Oral intake of Lactobacillus pentosus strain b240 accelerates salivary immunoglobulin A secretion in the elderly: A randomized, placebo-controlled, double-blind trial. Immun Ageing (2010) 1.01
Effects of anti-CD154 treatment on B cells in murine systemic lupus erythematosus. Arthritis Rheum (2003) 1.00
Atherogenic effects of TNF-α and IL-6 via up-regulation of scavenger receptors. Cytokine (2012) 0.99
Tocilizumab, a humanized anti-interleukin-6 receptor antibody, ameliorates joint swelling in established monkey collagen-induced arthritis. Biol Pharm Bull (2008) 0.99
Anti-interleukin 6 receptor antibody inhibits murine AA-amyloidosis. J Rheumatol (2004) 0.99
IL-6/sIL-6R trans-signalling, but not TNF-alpha induced angiogenesis in a HUVEC and synovial cell co-culture system. Rheumatol Int (2009) 0.97
Anti-inflammatory mechanism of tocilizumab, a humanized anti-IL-6R antibody: effect on the expression of chemokine and adhesion molecule. Rheumatol Int (2009) 0.95
Anti-IL-6 receptor antibody increases blood IL-6 level via the blockade of IL-6 clearance, but not via the induction of IL-6 production. Int Immunopharmacol (2008) 0.94
Relationships between brachial-ankle pulse wave velocity and conventional atherosclerotic risk factors in community-dwelling people. Prev Med (2004) 0.94
Co-stimulatory blockade in the treatment of murine systemic lupus erythematosus (SLE). Ann N Y Acad Sci (2003) 0.94
A prospective study of gait performance and subsequent cognitive decline in a general population of older Japanese. J Gerontol A Biol Sci Med Sci (2012) 0.93
Arterial pulse wave velocity as a marker of poor cognitive function in an elderly community-dwelling population. J Gerontol A Biol Sci Med Sci (2005) 0.92
Masseter muscle tension and chewing ability in older persons. Geriatr Gerontol Int (2012) 0.91
The combination therapy with alfacalcidol and risedronate improves the mechanical property in lumbar spine by affecting the material properties in an ovariectomized rat model of osteoporosis. BMC Musculoskelet Disord (2009) 0.91
Effects of alfacalcidol on mechanical properties and collagen cross-links of the femoral diaphysis in glucocorticoid-treated rats. Calcif Tissue Int (2011) 0.91
Early effects of tocilizumab on bone and bone marrow lesions in a collagen-induced arthritis monkey model. Exp Mol Pathol (2008) 0.90
IL-6 plays an essential role in neutrophilia under inflammation. Cytokine (2011) 0.89
Overproduced interleukin 6 decreases blood lipid levels via upregulation of very-low-density lipoprotein receptor. Ann Rheum Dis (2009) 0.88
High molecular weight hyaluronic acid relieved joint pain and prevented the progression of cartilage degeneration in a rabbit osteoarthritis model after onset of arthritis. Mod Rheumatol (2010) 0.87
Predictors of improvement or decline in instrumental activities of daily living among community-dwelling older Japanese. Gerontology (2008) 0.87
Anti-IL-6 receptor antibody causes less promotion of tuberculosis infection than anti-TNF-α antibody in mice. Clin Dev Immunol (2011) 0.87
The Hatoyama Cohort Study: design and profile of participants at baseline. J Epidemiol (2012) 0.87
[Research on screening for frailty: development of "the Kaigo-Yobo Checklist"]. Nihon Koshu Eisei Zasshi (2010) 0.87
Combination therapy with eldecalcitol and alendronate has therapeutic advantages over monotherapy by improving bone strength. Bone (2012) 0.86
Baseline levels of soluble interleukin-6 receptor predict clinical remission in patients with rheumatoid arthritis treated with tocilizumab: implications for molecular targeted therapy. Ann Rheum Dis (2013) 0.86
Blockade of IL-6 and TNF-α inhibited oxLDL-induced production of MCP-1 via scavenger receptor induction. Eur J Pharmacol (2012) 0.85
Immunoprotective effects of oral intake of heat-killed Lactobacillus pentosus strain b240 in elderly adults: a randomised, double-blind, placebo-controlled trial. Br J Nutr (2012) 0.85
Comparison of effects of alfacalcidol and alendronate on mechanical properties and bone collagen cross-links of callus in the fracture repair rat model. Bone (2009) 0.85
IL-6 blockade preferentially inhibits Th17 differentiation in collagen-induced arthritis. Rheumatol Int (2010) 0.84
Copper-catalysed bromoalkynylation of arynes. Chem Commun (Camb) (2009) 0.83
[Validity of the "Kaigo-Yobo Check-List" as a frailty index]. Nihon Koshu Eisei Zasshi (2013) 0.82
Copper-catalyzed three-component borylstannylation of alkynes. Chemistry (2012) 0.82
[The validity of the "Kihon Check-list" as an index of frailty and its biomarkers and inflammatory markers in elderly people]. Nihon Ronen Igakkai Zasshi (2011) 0.82
Anemia in monkey collagen-induced arthritis is correlated with serum IL-6, but not TNFalpha. Rheumatol Int (2008) 0.81
[The association between foot problems and falls in older adults -a covariance structure analysis-]. Nihon Ronen Igakkai Zasshi (2012) 0.81
Association of a genetic variant of BTN2A1 with metabolic syndrome in East Asian populations. J Med Genet (2011) 0.81
Anti-IL-6 receptor antibody suppressed T cell activation by inhibiting IL-2 production and inducing regulatory T cells. Eur J Pharmacol (2010) 0.81
Induction of high-dose tolerance to the rat anti-mouse IL-6 receptor antibody in NZB/NZW F1 mice. Rheumatol Int (2010) 0.81
[An intergenerational health promotion program involving older adults in urban areas. "Research of Productivity by Intergenerational Sympathy (REPRINTS)": first-year experience and short-term effects]. Nihon Koshu Eisei Zasshi (2006) 0.81
Development of human-human hybridoma from anti-Her-2 peptide-producing B cells in immunized NOG mouse. Exp Hematol (2006) 0.80
Actin cytoskeleton is required for early apoptosis signaling induced by anti-Fas antibody but not Fas ligand in murine B lymphoma A20 cells. Biochem Biophys Res Commun (2002) 0.80
[Predictors for the onset of different types of homeboundness among community-living older adults: two-year prospective study]. Nihon Koshu Eisei Zasshi (2005) 0.80
Anti-interleukin-6 receptor antibody prevents systemic bone mass loss via reducing the number of osteoclast precursors in bone marrow in a collagen-induced arthritis model. Clin Exp Immunol (2014) 0.80
High molecular weight hyaluronic acid inhibits IL-6-induced MMP production from human chondrocytes by up-regulating the ERK inhibitor, MKP-1. Biochem Biophys Res Commun (2010) 0.80
Intellectual activity and likelihood of subsequently improving or maintaining instrumental activities of daily living functioning in community-dwelling older Japanese: a longitudinal study. Int J Geriatr Psychiatry (2009) 0.80
[Physical and psychological predictors for the onset of certification of long-term care insurance among older adults living independently in a community a 40-month follow-up study]. Nihon Koshu Eisei Zasshi (2006) 0.79
Tocilizumab, a humanized anti-IL-6R antibody, as an emerging therapeutic option for rheumatoid arthritis: molecular and cellular mechanistic insights. Int Rev Immunol (2014) 0.79
Interleukin-6 regulates anti-arthritic effect of methotrexate via reduction of SLC19A1 expression in a mouse arthritis model. Arthritis Res Ther (2012) 0.79
[Physical activity level and physical, mental and social factors in community-dwelling elderly people]. Nihon Koshu Eisei Zasshi (2006) 0.79
Association of a polymorphism of BTN2A1 with hypertension in Japanese individuals. Am J Hypertens (2011) 0.79
Single and local blockade of interleukin-6 signaling promotes neuronal differentiation from transplanted embryonic stem cell-derived neural precursor cells. J Neurosci Res (2011) 0.79
Three-component coupling using arynes and aminosilanes for ortho-selective double functionalization of aromatic skeletons. J Org Chem (2008) 0.78
The mycotoxin penicillic acid inhibits Fas ligand-induced apoptosis by blocking self-processing of caspase-8 in death-inducing signaling complex. J Biol Chem (2002) 0.78
[Indirect effects of school volunteering by senior citizens on parents through the "REPRINTS" intergenerational health promotion program]. Nihon Koshu Eisei Zasshi (2010) 0.77
[A 10-year community intervention for disability prevention and changes in physical, nutritional, psychological and social functions among community-dwelling older adults in Kusatsu, Gunma Prefecture, Japan]. Nihon Koshu Eisei Zasshi (2014) 0.77
Adiponectin induces CCL20 expression synergistically with IL-6 and TNF-α in THP-1 macrophages. Cytokine (2012) 0.77
Influence of humanized anti-IL-6R antibody, tocilizumab on the activity of soluble gp130, natural inhibitor of IL-6 signaling. Rheumatol Int (2008) 0.77
[Test-retest variation in the Tokyo Metropolitan Institute of Gerontology Index of Competence in community-dwelling older people independent in daily living toward individual assessment of functional capacity]. Nihon Koshu Eisei Zasshi (2003) 0.77
Association of a polymorphism of BTN2A1 with chronic kidney disease in individuals with or without hypertension or diabetes mellitus. Exp Ther Med (2011) 0.77
Association of polymorphisms of BTN2A1 and ILF3 with myocardial infarction in Japanese individuals with different lipid profiles. Mol Med Rep (2011) 0.77
[Toward constructing a system for detecting and coping with senile dementia in early stages among community-dwelling older people]. Nihon Koshu Eisei Zasshi (2003) 0.76
[Longitudinal analysis of factors associated with participation in community-based mass screening for the frail elderly in need of care]. Nihon Koshu Eisei Zasshi (2006) 0.76
[Factors related to discrepancy in evaluation on functional capacity between reports by community-dwelling older people with cognitive decline and their family members]. Nihon Ronen Igakkai Zasshi (2003) 0.76
Association of a polymorphism of BTN2A1 with dyslipidemia in East Asian populations. Exp Ther Med (2011) 0.76