Published in J Biol Chem on March 06, 2003
Ubiquitin signalling in the NF-kappaB pathway. Nat Cell Biol (2005) 8.06
RNA sequencing of pancreatic circulating tumour cells implicates WNT signalling in metastasis. Nature (2012) 3.40
Mitogen-activated protein kinases in innate immunity. Nat Rev Immunol (2013) 3.23
Molecular basis of NF-κB signaling. Annu Rev Biophys (2013) 2.03
Targeting innate immunity protein kinase signalling in inflammation. Nat Rev Drug Discov (2009) 2.01
Molecular mechanisms involved in the regulation of cytokine production by muramyl dipeptide. Biochem J (2007) 1.98
Resorcylic acid lactones with cytotoxic and NF-κB inhibitory activities and their structure-activity relationships. J Nat Prod (2011) 1.81
Transforming growth factor beta signaling in hepatocytes participates in steatohepatitis through regulation of cell death and lipid metabolism in mice. Hepatology (2013) 1.80
Targeted covalent inactivation of protein kinases by resorcylic acid lactone polyketides. Proc Natl Acad Sci U S A (2006) 1.73
Prolactin prevents hepatocellular carcinoma by restricting innate immune activation of c-Myc in mice. Proc Natl Acad Sci U S A (2014) 1.63
Syk kinase-coupled C-type lectin receptors engage protein kinase C-σ to elicit Card9 adaptor-mediated innate immunity. Immunity (2012) 1.61
Cisplatin causes cell death via TAB1 regulation of p53/MDM2/MDMX circuitry. Genes Dev (2013) 1.57
Phosphorylation and ubiquitination of the IkappaB kinase complex by two distinct signaling pathways. EMBO J (2007) 1.54
A polyketide macrolactone synthase from the filamentous fungus Gibberella zeae. Proc Natl Acad Sci U S A (2008) 1.54
An unexpected twist to the activation of IKKβ: TAK1 primes IKKβ for activation by autophosphorylation. Biochem J (2014) 1.52
Protection from cerebral ischemia by inhibition of TGFβ-activated kinase. Exp Neurol (2012) 1.51
Altered TAB1:I kappaB kinase interaction promotes transforming growth factor beta-mediated nuclear factor-kappaB activation during breast cancer progression. Cancer Res (2008) 1.47
Genes for the biosynthesis of the fungal polyketides hypothemycin from Hypomyces subiculosus and radicicol from Pochonia chlamydosporia. Appl Environ Microbiol (2008) 1.37
A cytosolic ATM/NEMO/RIP1 complex recruits TAK1 to mediate the NF-kappaB and p38 mitogen-activated protein kinase (MAPK)/MAPK-activated protein 2 responses to DNA damage. Mol Cell Biol (2011) 1.36
Polyubiquitin binding to optineurin is required for optimal activation of TANK-binding kinase 1 and production of interferon β. J Biol Chem (2011) 1.35
Modulation of pancreatic cancer chemoresistance by inhibition of TAK1. J Natl Cancer Inst (2011) 1.35
Role for compartmentalization in nephron progenitor differentiation. Proc Natl Acad Sci U S A (2013) 1.32
The IkappaB kinase family phosphorylates the Parkinson's disease kinase LRRK2 at Ser935 and Ser910 during Toll-like receptor signaling. PLoS One (2012) 1.27
TGF-{beta}1 protects against mesangial cell apoptosis via induction of autophagy. J Biol Chem (2010) 1.17
The E3 ligase Itch and deubiquitinase Cyld act together to regulate Tak1 and inflammation. Nat Immunol (2011) 1.14
TNF-like weak inducer of apoptosis (TWEAK) activates proinflammatory signaling pathways and gene expression through the activation of TGF-beta-activated kinase 1. J Immunol (2009) 1.14
The Yersinia enterocolitica effector YopP inhibits host cell signalling by inactivating the protein kinase TAK1 in the IL-1 signalling pathway. EMBO Rep (2006) 1.10
Essential role for IKKβ in production of type 1 interferons by plasmacytoid dendritic cells. J Biol Chem (2012) 1.10
TAK1 control of cell death. Cell Death Differ (2014) 1.09
TAK1-mediated serine/threonine phosphorylation of epidermal growth factor receptor via p38/extracellular signal-regulated kinase: NF-{kappa}B-independent survival pathways in tumor necrosis factor alpha signaling. Mol Cell Biol (2009) 1.09
TAK1 regulates cartilage and joint development via the MAPK and BMP signaling pathways. J Bone Miner Res (2010) 1.08
TAK1 MAPK kinase kinase mediates transforming growth factor-beta signaling by targeting SnoN oncoprotein for degradation. J Biol Chem (2007) 1.08
TAK1-binding protein 2 facilitates ubiquitination of TRAF6 and assembly of TRAF6 with IKK in the IL-1 signaling pathway. Genes Cells (2005) 1.07
Epidermal growth factor receptor transactivation by the cannabinoid receptor (CB1) and transient receptor potential vanilloid 1 (TRPV1) induces differential responses in corneal epithelial cells. Exp Eye Res (2010) 1.07
TAK1 inhibitor 5Z-7-oxozeaenol sensitizes neuroblastoma to chemotherapy. Apoptosis (2013) 1.06
A quantitative signaling screen identifies CARD11 mutations in the CARD and LATCH domains that induce Bcl10 ubiquitination and human lymphoma cell survival. Mol Cell Biol (2012) 1.06
The cytoplasmic domain of the HIV-1 glycoprotein gp41 induces NF-κB activation through TGF-β-activated kinase 1. Cell Host Microbe (2012) 1.06
Autoactivation of transforming growth factor beta-activated kinase 1 is a sequential bimolecular process. J Biol Chem (2010) 1.05
Greensporones: resorcylic acid lactones from an aquatic Halenospora sp. J Nat Prod (2014) 1.04
c-Jun N-terminal kinase phosphorylates DCP1a to control formation of P bodies. J Cell Biol (2011) 1.04
Amplification of cytokine production through synergistic activation of NFAT and AP-1 following stimulation of mast cells with antigen and IL-33. Eur J Immunol (2011) 1.03
Transforming growth factor beta-activated kinase 1 is a key mediator of ovine follicle-stimulating hormone beta-subunit expression. Endocrinology (2005) 1.02
Transforming growth factor β-activated kinase 1 signaling pathway critically regulates myocardial survival and remodeling. Circulation (2014) 0.99
TAK1 in brain endothelial cells mediates fever and lethargy. J Exp Med (2011) 0.99
Acute inhibition of TAK1 protects against neuronal death in cerebral ischemia. Cell Death Differ (2011) 0.98
RNAi screening identifies TAK1 as a potential target for the enhanced efficacy of topoisomerase inhibitors. Curr Cancer Drug Targets (2011) 0.96
The role of RIP2 in p38 MAPK activation in the stressed heart. J Biol Chem (2008) 0.96
TRAIL-activated stress kinases suppress apoptosis through transcriptional upregulation of MCL-1. Cell Death Differ (2010) 0.94
The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signalling network by targeting the ubiquitin system. Biochem J (2013) 0.94
LPS-mediated endothelial activation in pulmonary endothelial cells: role of Nox2-dependent IKK-β phosphorylation. Am J Physiol Lung Cell Mol Physiol (2013) 0.93
Microstructured titanium regulates interleukin production by osteoblasts, an effect modulated by exogenous BMP-2. Acta Biomater (2012) 0.93
TAK1 kinase signaling regulates embryonic angiogenesis by modulating endothelial cell survival and migration. Blood (2012) 0.93
Ablation of TAK1 upregulates reactive oxygen species and selectively kills tumor cells. Cancer Res (2010) 0.93
Effects of (5Z)-7-oxozeaenol on the oxidative pathway of cancer cells. Anticancer Res (2012) 0.93
SAPK pathways and p53 cooperatively regulate PLK4 activity and centrosome integrity under stress. Nat Commun (2013) 0.92
Hepatitis B virus protein X-induced expression of the CXC chemokine IP-10 is mediated through activation of NF-kappaB and increases migration of leukocytes. J Biol Chem (2010) 0.92
TAK1 is a component of the Epstein-Barr virus LMP1 complex and is essential for activation of JNK but not of NF-kappaB. J Biol Chem (2006) 0.92
MiR-29a reduces TIMP-1 production by dermal fibroblasts via targeting TGF-β activated kinase 1 binding protein 1, implications for systemic sclerosis. PLoS One (2014) 0.90
Inhibition of transforming growth factor-activated kinase 1 (TAK1) blocks and reverses epithelial to mesenchymal transition of mesothelial cells. PLoS One (2012) 0.90
TAK1 is required for survival of mouse fibroblasts treated with TRAIL, and does so by NF-kappaB dependent induction of cFLIPL. PLoS One (2010) 0.89
The protein kinase TPL2 is essential for ERK1/ERK2 activation and cytokine gene expression in airway epithelial cells exposed to pathogen-associated molecular patterns (PAMPs). PLoS One (2013) 0.89
Transforming growth factor-beta-activated kinase 1 regulates natural killer cell-mediated cytotoxicity and cytokine production. J Biol Chem (2011) 0.88
K63-linked ubiquitination in kinase activation and cancer. Front Oncol (2012) 0.87
Discovery of type II inhibitors of TGFβ-activated kinase 1 (TAK1) and mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2). J Med Chem (2014) 0.87
The lysosome rupture-activated TAK1-JNK pathway regulates NLRP3 inflammasome activation. J Biol Chem (2014) 0.86
TAK1 regulates SOX9 expression in chondrocytes and is essential for postnatal development of the growth plate and articular cartilages. J Cell Sci (2013) 0.86
TTRAP is a novel component of the non-canonical TRAF6-TAK1 TGF-β signaling pathway. PLoS One (2011) 0.86
Targeting of TGF-β-activated protein kinase 1 inhibits chemokine (C-C motif) receptor 7 expression, tumor growth and metastasis in breast cancer. Oncotarget (2015) 0.86
Effects of (5Z)-7-oxozeaenol on MDA-MB-231 breast cancer cells. Anticancer Res (2012) 0.84
Ppm1b negatively regulates necroptosis through dephosphorylating Rip3. Nat Cell Biol (2015) 0.84
Kaposi's sarcoma associated herpesvirus encoded viral FLICE inhibitory protein K13 activates NF-κB pathway independent of TRAF6, TAK1 and LUBAC. PLoS One (2012) 0.84
BMP signalling regulates the pre-implantation development of extra-embryonic cell lineages in the mouse embryo. Nat Commun (2014) 0.84
Roles of the kinase TAK1 in TRAF6-dependent signaling by CD40 and its oncogenic viral mimic, LMP1. PLoS One (2012) 0.82
TGF-β1 induced transdifferentiation of rpe cells is mediated by TAK1. PLoS One (2015) 0.82
Inhibition of serum- and glucocorticoid-inducible kinase 1 enhances TLR-mediated inflammation and promotes endotoxin-driven organ failure. FASEB J (2015) 0.82
TAK1 modulates satellite stem cell homeostasis and skeletal muscle repair. Nat Commun (2015) 0.81
I kappa B kinase alpha (IKKα) activity is required for functional maturation of dendritic cells and acquired immunity to infection. EMBO J (2013) 0.81
Knockdown of both p120 catenin and Kaiso promotes expansion of human corneal endothelial monolayers via RhoA-ROCK-noncanonical BMP-NFκB pathway. Invest Ophthalmol Vis Sci (2014) 0.81
Recent progress regarding the bioactivities, biosynthesis and synthesis of naturally occurring resorcinolic macrolides. Acta Pharmacol Sin (2014) 0.80
Arsenic trioxide-dependent activation of thousand-and-one amino acid kinase 2 and transforming growth factor-beta-activated kinase 1. Mol Pharmacol (2010) 0.80
Macrophage-epithelial paracrine crosstalk inhibits lung edema clearance during influenza infection. J Clin Invest (2016) 0.80
Involvement of neuronal TGF-β activated kinase 1 in the development of tolerance to morphine-induced antinociception in rat spinal cord. Br J Pharmacol (2015) 0.79
TGFβ-activated Kinase 1 (TAK1) Inhibition by 5Z-7-Oxozeaenol Attenuates Early Brain Injury after Experimental Subarachnoid Hemorrhage. J Biol Chem (2015) 0.79
Unravelling druggable signalling networks that control F508del-CFTR proteostasis. Elife (2015) 0.78
Vpr Enhances Tumor Necrosis Factor Production by HIV-1-Infected T Cells. J Virol (2015) 0.78
Presence of terminal EPIYA phosphorylation motifs in Helicobacter pylori CagA contributes to IL-8 secretion, irrespective of the number of repeats. PLoS One (2013) 0.78
Metabolic influences on reproduction: adiponectin attenuates GnRH neuronal activity in female mice. Endocrinology (2014) 0.78
CPEB regulation of TAK1 synthesis mediates cytokine production and the inflammatory immune response. Mol Cell Biol (2014) 0.78
Drugs to block cytokine signaling for the prevention and treatment of inflammation-induced preterm birth. Front Immunol (2015) 0.78
Exploring aigialomycin d and its analogues as protein kinase inhibitors for cancer targets. ACS Med Chem Lett (2011) 0.78
Transforming growth factor β-activated kinase 1 transcriptionally suppresses hepatitis B virus replication. Sci Rep (2017) 0.78
TAK1 Regulates the Nrf2 Antioxidant System Through Modulating p62/SQSTM1. Antioxid Redox Signal (2016) 0.77
Chiral kinase inhibitors. Curr Top Med Chem (2011) 0.77
The TAK1→IKKβ→TPL2→MKK1/MKK2 Signaling Cascade Regulates IL-33 Expression in Cystic Fibrosis Airway Epithelial Cells Following Infection by Pseudomonas aeruginosa. Front Cell Dev Biol (2016) 0.77
Activation of c-Src: a hub for exogenous pro-oxidant-mediated activation of Toll-like receptor 4 signaling. Free Radic Biol Med (2014) 0.77
TNFR-associated factor 6 and TGF-β-activated kinase 1 control signals for a senescence response by an endosomal NK cell receptor. J Immunol (2013) 0.77
Kinase inhibition by deoxy analogues of the resorcylic lactone L-783277. ACS Med Chem Lett (2010) 0.77
Macropinocytosis and TAK1 mediate anti-inflammatory to pro-inflammatory macrophage differentiation by HIV-1 Nef. Cell Death Dis (2014) 0.77
Systematic Analysis of Quantitative Logic Model Ensembles Predicts Drug Combination Effects on Cell Signaling Networks. CPT Pharmacometrics Syst Pharmacol (2016) 0.76
TAK1 regulates caspase 8 activation and necroptotic signaling via multiple cell death checkpoints. Cell Death Dis (2016) 0.76
Spatiotemporal rescue of memory dysfunction in Drosophila. Science (2003) 7.72
Essential function for the kinase TAK1 in innate and adaptive immune responses. Nat Immunol (2005) 6.13
A conserved p38 MAP kinase pathway in Caenorhabditis elegans innate immunity. Science (2002) 5.97
TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo. Genes Dev (2005) 5.56
ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity. Nat Immunol (2005) 4.32
Retracted A histone lysine methyltransferase activated by non-canonical Wnt signalling suppresses PPAR-gamma transactivation. Nat Cell Biol (2007) 3.97
The TAK1-NLK mitogen-activated protein kinase cascade functions in the Wnt-5a/Ca(2+) pathway to antagonize Wnt/beta-catenin signaling. Mol Cell Biol (2003) 3.53
WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1. J Biol Chem (2005) 3.26
TAK1 is critical for IkappaB kinase-mediated activation of the NF-kappaB pathway. J Mol Biol (2003) 3.17
The C. elegans p38 MAPK pathway regulates nuclear localization of the transcription factor SKN-1 in oxidative stress response. Genes Dev (2005) 2.81
Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling. EMBO J (2003) 2.69
IL-6 blockade inhibits the induction of myelin antigen-specific Th17 cells and Th1 cells in experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A (2008) 2.60
Interleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosol. Mol Cell Biol (2002) 2.47
IL-6/IL-6 receptor system and its role in physiological and pathological conditions. Clin Sci (Lond) (2012) 2.41
ATM-related Tel1 associates with double-strand breaks through an Xrs2-dependent mechanism. Genes Dev (2003) 2.38
Identification of soluble NH2-terminal fragment of glypican-3 as a serological marker for early-stage hepatocellular carcinoma. Cancer Res (2004) 2.34
SEK-1 MAPKK mediates Ca2+ signaling to determine neuronal asymmetric development in Caenorhabditis elegans. EMBO Rep (2001) 2.22
TAK1 is a master regulator of epidermal homeostasis involving skin inflammation and apoptosis. J Biol Chem (2006) 2.19
Retracted Cytokines suppress adipogenesis and PPAR-gamma function through the TAK1/TAB1/NIK cascade. Nat Cell Biol (2003) 2.08
Regulation of the Caenorhabditis elegans oxidative stress defense protein SKN-1 by glycogen synthase kinase-3. Proc Natl Acad Sci U S A (2005) 2.04
Regulation of lymphoid enhancer factor 1/T-cell factor by mitogen-activated protein kinase-related Nemo-like kinase-dependent phosphorylation in Wnt/beta-catenin signaling. Mol Cell Biol (2003) 2.03
Integration of Caenorhabditis elegans MAPK pathways mediating immunity and stress resistance by MEK-1 MAPK kinase and VHP-1 MAPK phosphatase. Proc Natl Acad Sci U S A (2004) 1.99
Wnt-1 signal induces phosphorylation and degradation of c-Myb protein via TAK1, HIPK2, and NLK. Genes Dev (2004) 1.87
The C. elegans thermosensory neuron AFD responds to warming. Curr Biol (2004) 1.87
Blockade of interleukin-6 signaling augments regulatory T-cell reconstitution and attenuates the severity of graft-versus-host disease. Blood (2009) 1.80
Identification of guanylyl cyclases that function in thermosensory neurons of Caenorhabditis elegans. Genetics (2006) 1.79
LRK-1, a C. elegans PARK8-related kinase, regulates axonal-dendritic polarity of SV proteins. Curr Biol (2007) 1.76
The Caenorhabditis elegans MAPK phosphatase VHP-1 mediates a novel JNK-like signaling pathway in stress response. EMBO J (2004) 1.76
Enterocyte-derived TAK1 signaling prevents epithelium apoptosis and the development of ileitis and colitis. J Immunol (2008) 1.68
TAK1 regulates reactive oxygen species and cell death in keratinocytes, which is essential for skin integrity. J Biol Chem (2008) 1.67
Axon regeneration requires coordinate activation of p38 and JNK MAPK pathways. Proc Natl Acad Sci U S A (2011) 1.65
Temperature sensing by an olfactory neuron in a circuit controlling behavior of C. elegans. Science (2008) 1.65
Bronchioloalveolar carcinoma of the lung 3 centimeters or less in diameter: a prognostic assessment. Ann Thorac Surg (2004) 1.64
LRRK2 modulates vulnerability to mitochondrial dysfunction in Caenorhabditis elegans. J Neurosci (2009) 1.64
An NDPase links ADAM protease glycosylation with organ morphogenesis in C. elegans. Nat Cell Biol (2003) 1.63
The Khd1 protein, which has three KH RNA-binding motifs, is required for proper localization of ASH1 mRNA in yeast. EMBO J (2002) 1.62
TAB2 is essential for prevention of apoptosis in fetal liver but not for interleukin-1 signaling. Mol Cell Biol (2003) 1.61
Resveratrol enhances neovascularization in the infarcted rat myocardium through the induction of thioredoxin-1, heme oxygenase-1 and vascular endothelial growth factor. J Mol Cell Cardiol (2005) 1.59
Phosphorylation of the conserved transcription factor ATF-7 by PMK-1 p38 MAPK regulates innate immunity in Caenorhabditis elegans. PLoS Genet (2010) 1.55
Interleukin-6 blockade suppresses autoimmune arthritis in mice by the inhibition of inflammatory Th17 responses. Arthritis Rheum (2008) 1.55
Silent information regulator (Sir)T1 inhibits NF-κB signaling to maintain normal skeletal remodeling. J Bone Miner Res (2013) 1.54
Receptor activator of NF-kappaB ligand (RANKL) activates TAK1 mitogen-activated protein kinase kinase kinase through a signaling complex containing RANK, TAB2, and TRAF6. Mol Cell Biol (2002) 1.53
Murine tumor necrosis factor α-induced adipose-related protein (tumor necrosis factor α-induced protein 9) deficiency leads to arthritis via interleukin-6 overproduction with enhanced NF-κB, STAT-3 signaling, and dysregulated apoptosis of macrophages. Arthritis Rheum (2012) 1.52
Functional CD5+ B cells develop predominantly in the spleen of NOD/SCID/gammac(null) (NOG) mice transplanted either with human umbilical cord blood, bone marrow, or mobilized peripheral blood CD34+ cells. Exp Hematol (2003) 1.49
Suppression of PPAR transactivation switches cell fate of bone marrow stem cells from adipocytes into osteoblasts. Ann N Y Acad Sci (2007) 1.48
Aortic valve papillary fibroelastoma that developed rapidly after open-heart surgery. Interact Cardiovasc Thorac Surg (2008) 1.48
Retracted Molecular characterization of Legionella pneumophila-induced interleukin-8 expression in T cells. BMC Microbiol (2010) 1.46
Targeted disruption of the Tab1 gene causes embryonic lethality and defects in cardiovascular and lung morphogenesis. Mech Dev (2002) 1.46
A redox-sensitive peroxiredoxin that is important for longevity has tissue- and stress-specific roles in stress resistance. Proc Natl Acad Sci U S A (2008) 1.44
Crucial role of the interleukin-6/interleukin-17 cytokine axis in the induction of arthritis by glucose-6-phosphate isomerase. Arthritis Rheum (2008) 1.43
Involvement of ASK1 in Ca2+-induced p38 MAP kinase activation. EMBO Rep (2004) 1.42
Nemo-like kinase suppresses Notch signalling by interfering with formation of the Notch active transcriptional complex. Nat Cell Biol (2010) 1.41
Late regression of left internal thoracic artery graft stenosis at the anastomotic site without intervention therapy. J Thorac Cardiovasc Surg (2005) 1.40
Protein phosphatase 6 down-regulates TAK1 kinase activation in the IL-1 signaling pathway. J Biol Chem (2006) 1.37
Anti-glypican 3 antibody as a potential antitumor agent for human liver cancer. Cancer Res (2008) 1.35
Role of the TAK1-NLK-STAT3 pathway in TGF-beta-mediated mesoderm induction. Genes Dev (2004) 1.34
Blockade of interleukin-6 signaling aggravates ischemic cerebral damage in mice: possible involvement of Stat3 activation in the protection of neurons. J Neurochem (2005) 1.34
The roles of interleukin-6 in the pathogenesis of rheumatoid arthritis. Arthritis (2011) 1.33
TAK1 is a central mediator of NOD2 signaling in epidermal cells. J Biol Chem (2007) 1.30
The Caenorhabditis elegans UNC-14 RUN domain protein binds to the kinesin-1 and UNC-16 complex and regulates synaptic vesicle localization. Mol Biol Cell (2004) 1.28
Association of Rad9 with double-strand breaks through a Mec1-dependent mechanism. Mol Cell Biol (2004) 1.28
First-in-man phase I study of GC33, a novel recombinant humanized antibody against glypican-3, in patients with advanced hepatocellular carcinoma. Clin Cancer Res (2013) 1.27
Characterization of anti-mouse interleukin-6 receptor antibody. Immunol Lett (2002) 1.25
Interleukin-6 receptor-mediated activation of signal transducer and activator of transcription-3 (STAT3) promotes choroidal neovascularization. Am J Pathol (2007) 1.23
STAT3 regulates Nemo-like kinase by mediating its interaction with IL-6-stimulated TGFbeta-activated kinase 1 for STAT3 Ser-727 phosphorylation. Proc Natl Acad Sci U S A (2005) 1.22
Leucine-rich repeat kinase LRRK1 regulates endosomal trafficking of the EGF receptor. Nat Commun (2011) 1.22
The ATM-related Tel1 protein of Saccharomyces cerevisiae controls a checkpoint response following phleomycin treatment. Nucleic Acids Res (2003) 1.20
Overexpression of MUC13 is associated with intestinal-type gastric cancer. Cancer Sci (2005) 1.19
The p38 signal transduction pathway participates in the oxidative stress-mediated translocation of DAF-16 to Caenorhabditis elegans nuclei. Mech Ageing Dev (2005) 1.18
Shp2, an SH2-containing protein-tyrosine phosphatase, positively regulates receptor tyrosine kinase signaling by dephosphorylating and inactivating the inhibitor Sprouty. J Biol Chem (2004) 1.18
Anti-glypican 3 antibodies cause ADCC against human hepatocellular carcinoma cells. Biochem Biophys Res Commun (2008) 1.16
Apoptosis inducing bivalent single-chain antibody fragments against CD47 showed antitumor potency for multiple myeloma. Leuk Res (2004) 1.16
Predictors of residual tricuspid regurgitation after mitral valve surgery. Ann Thorac Surg (2003) 1.15
Posttranscriptional regulation of HO expression by the Mkt1-Pbp1 complex. Mol Cell Biol (2004) 1.13
Tocilizumab, a humanized anti-interleukin-6 receptor antibody, improved anemia in monkey arthritis by suppressing IL-6-induced hepcidin production. Rheumatol Int (2009) 1.13
Elucidation of the c-Jun N-terminal kinase pathway mediated by Estein-Barr virus-encoded latent membrane protein 1. Mol Cell Biol (2004) 1.12
Identification of ROBO1 as a novel hepatocellular carcinoma antigen and a potential therapeutic and diagnostic target. Clin Cancer Res (2006) 1.11
Mechanism of action of combined short-term CTLA4Ig and anti-CD40 ligand in murine systemic lupus erythematosus. J Immunol (2002) 1.11
The Caenorhabditis elegans JIP3 protein UNC-16 functions as an adaptor to link kinesin-1 with cytoplasmic dynein. J Neurosci (2011) 1.11
Osmotic stress activates the TAK1-JNK pathway while blocking TAK1-mediated NF-kappaB activation: TAO2 regulates TAK1 pathways. J Biol Chem (2006) 1.11
GLH-1, the C. elegans P granule protein, is controlled by the JNK KGB-1 and by the COP9 subunit CSN-5. Development (2007) 1.10
The Yersinia enterocolitica effector YopP inhibits host cell signalling by inactivating the protein kinase TAK1 in the IL-1 signalling pathway. EMBO Rep (2006) 1.10
The ERK-MAPK pathway regulates longevity through SKN-1 and insulin-like signaling in Caenorhabditis elegans. J Biol Chem (2010) 1.09
Aven-dependent activation of ATM following DNA damage. Curr Biol (2008) 1.08
TAK1 MAPK kinase kinase mediates transforming growth factor-beta signaling by targeting SnoN oncoprotein for degradation. J Biol Chem (2007) 1.08
TAK1-binding protein 2 facilitates ubiquitination of TRAF6 and assembly of TRAF6 with IKK in the IL-1 signaling pathway. Genes Cells (2005) 1.07
TAK1 kinase switches cell fate from apoptosis to necrosis following TNF stimulation. J Cell Biol (2014) 1.07
Mib-Jag1-Notch signalling regulates patterning and structural roles of the notochord by controlling cell-fate decisions. Development (2010) 1.07
Blockade of interleukin-6 signaling suppressed cochlear inflammatory response and improved hearing impairment in noise-damaged mice cochlea. Neurosci Res (2009) 1.07
TGF-beta-activated kinase 1 signaling maintains intestinal integrity by preventing accumulation of reactive oxygen species in the intestinal epithelium. J Immunol (2010) 1.07
Clinical implication of plasma natriuretic peptides in children with ventricular septal defect. Pediatr Int (2003) 1.06
Mice lacking Nf1 in osteochondroprogenitor cells display skeletal dysplasia similar to patients with neurofibromatosis type I. Hum Mol Genet (2011) 1.06
TAK1-binding protein 1, TAB1, mediates osmotic stress-induced TAK1 activation but is dispensable for TAK1-mediated cytokine signaling. J Biol Chem (2008) 1.06
Instability of Foxp3 expression limits the ability of induced regulatory T cells to mitigate graft versus host disease. Clin Cancer Res (2011) 1.06
Regulation of the interleukin-1-induced signaling pathways by a novel member of the protein phosphatase 2C family (PP2Cepsilon). J Biol Chem (2003) 1.05
Nrarp functions to modulate neural-crest-cell differentiation by regulating LEF1 protein stability. Nat Cell Biol (2005) 1.05
NLK positively regulates Wnt/β-catenin signalling by phosphorylating LEF1 in neural progenitor cells. EMBO J (2012) 1.05
Generation of a humanized anti-glypican 3 antibody by CDR grafting and stability optimization. Anticancer Drugs (2010) 1.04