Published in Proc Natl Acad Sci U S A on April 19, 2010
Profilin regulates F-actin network homeostasis by favoring formin over Arp2/3 complex. Dev Cell (2014) 1.61
New mechanisms and functions of actin nucleation. Curr Opin Cell Biol (2010) 1.45
Small molecules CK-666 and CK-869 inhibit actin-related protein 2/3 complex by blocking an activating conformational change. Chem Biol (2013) 1.30
Innate control of actin nucleation determines two distinct migration behaviours in dendritic cells. Nat Cell Biol (2015) 1.27
Mechanism of a concentration-dependent switch between activation and inhibition of Arp2/3 complex by coronin. J Biol Chem (2011) 1.10
The interaction of capping protein with the barbed end of the actin filament. J Mol Biol (2010) 1.00
Actin and endocytosis in budding yeast. Genetics (2015) 0.99
Arg/Abl2 modulates the affinity and stoichiometry of binding of cortactin to F-actin. Biochemistry (2012) 0.91
Discussing the morphology of actin filaments in lamellipodia. Trends Cell Biol (2011) 0.89
Microdomains in forebrain spines: an ultrastructural perspective. Mol Neurobiol (2012) 0.89
Two deafness-causing (DFNA20/26) actin mutations affect Arp2/3-dependent actin regulation. J Biol Chem (2012) 0.87
Key structural features of the actin filament Arp2/3 complex branch junction revealed by molecular simulation. J Mol Biol (2011) 0.85
Targeted proteomics of isolated glomeruli from the kidneys of diabetic rats: sorbin and SH3 domain containing 2 is a novel protein associated with diabetic nephropathy. Exp Diabetes Res (2011) 0.84
Phosphorylation of the Arp2 subunit relieves auto-inhibitory interactions for Arp2/3 complex activation. PLoS Comput Biol (2011) 0.83
Insertions within the actin core of actin-related protein 3 (Arp3) modulate branching nucleation by Arp2/3 complex. J Biol Chem (2012) 0.82
Importance of a Lys113-Glu195 intermonomer ionic bond in F-actin stabilization and regulation by yeast formins Bni1p and Bnr1p. J Biol Chem (2013) 0.81
Proteomic analysis identifies an NADPH oxidase 1 (Nox1)-mediated role for actin-related protein 2/3 complex subunit 2 (ARPC2) in promoting smooth muscle cell migration. Int J Mol Sci (2013) 0.79
Crucial roles of the Arp2/3 complex during mammalian corticogenesis. Development (2016) 0.79
Structural Basis of Arp2/3 Complex Inhibition by GMF, Coronin, and Arpin. J Mol Biol (2016) 0.75
Two Deafness-Causing Actin Mutations (DFNA20/26) Have Allosteric Effects on the Actin Structure. Biophys J (2016) 0.75
Scalable molecular dynamics with NAMD. J Comput Chem (2005) 59.49
The regulation of rabbit skeletal muscle contraction. I. Biochemical studies of the interaction of the tropomyosin-troponin complex with actin and the proteolytic fragments of myosin. J Biol Chem (1971) 35.39
Atomic model of the actin filament. Nature (1990) 11.33
The interaction of Arp2/3 complex with actin: nucleation, high affinity pointed end capping, and formation of branching networks of filaments. Proc Natl Acad Sci U S A (1998) 9.33
Protein-protein docking with simultaneous optimization of rigid-body displacement and side-chain conformations. J Mol Biol (2003) 8.35
Arp2/3 complex and actin depolymerizing factor/cofilin in dendritic organization and treadmilling of actin filament array in lamellipodia. J Cell Biol (1999) 8.24
The ARP2/3 complex: an actin nucleator comes of age. Nat Rev Mol Cell Biol (2006) 6.04
Scar, a WASp-related protein, activates nucleation of actin filaments by the Arp2/3 complex. Proc Natl Acad Sci U S A (1999) 5.62
Crystal structure of Arp2/3 complex. Science (2001) 5.51
Pyrene actin: documentation of the validity of a sensitive assay for actin polymerization. J Muscle Res Cell Motil (1983) 5.36
The crystal structure of uncomplexed actin in the ADP state. Science (2001) 5.27
A hierarchical approach to all-atom protein loop prediction. Proteins (2004) 5.18
Direct observation of dendritic actin filament networks nucleated by Arp2/3 complex and WASP/Scar proteins. Nature (2000) 4.73
Characterization of two classes of small molecule inhibitors of Arp2/3 complex. Nature (2009) 3.83
Influence of the C terminus of Wiskott-Aldrich syndrome protein (WASp) and the Arp2/3 complex on actin polymerization. Biochemistry (1999) 3.77
Structure, subunit topology, and actin-binding activity of the Arp2/3 complex from Acanthamoeba. J Cell Biol (1997) 3.11
Progress in modeling of protein structures and interactions. Science (2005) 3.05
Direct real-time observation of actin filament branching mediated by Arp2/3 complex using total internal reflection fluorescence microscopy. Proc Natl Acad Sci U S A (2001) 2.89
The structural basis of actin filament branching by the Arp2/3 complex. J Cell Biol (2008) 2.82
Structure of Arp2/3 complex in its activated state and in actin filament branch junctions. Science (2001) 2.58
Arp2/3 ATP hydrolysis-catalysed branch dissociation is critical for endocytic force generation. Nat Cell Biol (2006) 2.48
The Arp2/3 complex branches filament barbed ends: functional antagonism with capping proteins. Nat Cell Biol (2000) 2.46
On the edge: modeling protrusion. Curr Opin Cell Biol (2005) 2.26
Reconstitution of human Arp2/3 complex reveals critical roles of individual subunits in complex structure and activity. Mol Cell (2001) 2.14
Critical conformational changes in the Arp2/3 complex are induced by nucleotide and nucleation promoting factor. Mol Cell (2004) 2.12
Spatial regulation of actin dynamics: a tropomyosin-free, actin-rich compartment at the leading edge. J Cell Sci (2002) 2.11
Inhibition of the Arp2/3 complex-nucleated actin polymerization and branch formation by tropomyosin. Curr Biol (2001) 2.09
Arp2/3 complex requires hydrolyzable ATP for nucleation of new actin filaments. Proc Natl Acad Sci U S A (2001) 1.82
Pathway of actin filament branch formation by Arp2/3 complex. J Biol Chem (2007) 1.78
Crystal structures of actin-related protein 2/3 complex with bound ATP or ADP. Proc Natl Acad Sci U S A (2004) 1.70
Insights into the influence of nucleotides on actin family proteins from seven structures of Arp2/3 complex. Mol Cell (2007) 1.70
The F-actin side binding activity of the Arp2/3 complex is essential for actin nucleation and lamellipod extension. Curr Biol (2001) 1.62
Mechanism of filament nucleation and branch stability revealed by the structure of the Arp2/3 complex at actin branch junctions. PLoS Biol (2005) 1.52
Identification of functionally important residues of Arp2/3 complex by analysis of homology models from diverse species. J Mol Biol (2004) 1.45
Progress in protein-protein docking: atomic resolution predictions in the CAPRI experiment using RosettaDock with an improved treatment of side-chain flexibility. Proteins (2005) 1.44
Activation of Arp2/3 complex by Wiskott-Aldrich Syndrome protein is linked to enhanced binding of ATP to Arp2. J Biol Chem (2001) 1.21
Motility determinants in WASP family proteins. Mol Biol Cell (2002) 1.08
Functional surfaces on the p35/ARPC2 subunit of Arp2/3 complex required for cell growth, actin nucleation, and endocytosis. J Biol Chem (2008) 0.92
Involvement of an arginine residue of actin in tropomyosin binding. Biochem Biophys Res Commun (1978) 0.89
The ARP2/3 complex: an actin nucleator comes of age. Nat Rev Mol Cell Biol (2006) 6.04
A nucleator arms race: cellular control of actin assembly. Nat Rev Mol Cell Biol (2010) 5.33
Actin-based motility of intracellular pathogens. Curr Opin Microbiol (2005) 2.89
Actin-based motility drives baculovirus transit to the nucleus and cell surface. J Cell Biol (2010) 2.86
WHAMM is an Arp2/3 complex activator that binds microtubules and functions in ER to Golgi transport. Cell (2008) 2.71
Arp2/3 ATP hydrolysis-catalysed branch dissociation is critical for endocytic force generation. Nat Cell Biol (2006) 2.48
Formation of filopodia-like bundles in vitro from a dendritic network. J Cell Biol (2003) 2.44
Mycobacterium marinum escapes from phagosomes and is propelled by actin-based motility. J Exp Med (2003) 2.30
Critical conformational changes in the Arp2/3 complex are induced by nucleotide and nucleation promoting factor. Mol Cell (2004) 2.12
New insights into mechanism and regulation of actin capping protein. Int Rev Cell Mol Biol (2008) 2.11
Rickettsia Sca2 is a bacterial formin-like mediator of actin-based motility. Nat Cell Biol (2010) 1.91
Dynamic nuclear actin assembly by Arp2/3 complex and a baculovirus WASP-like protein. Science (2006) 1.88
Identification of a bacterial factor required for actin-based motility of Burkholderia pseudomallei. Mol Microbiol (2005) 1.83
WASH and the Arp2/3 complex regulate endosome shape and trafficking. Cytoskeleton (Hoboken) (2010) 1.77
Defining a core set of actin cytoskeletal proteins critical for actin-based motility of Rickettsia. Cell Host Microbe (2010) 1.75
Myo1c binds phosphoinositides through a putative pleckstrin homology domain. Mol Biol Cell (2006) 1.74
A Rickettsia WASP-like protein activates the Arp2/3 complex and mediates actin-based motility. Cell Microbiol (2004) 1.64
Pathogens and polymers: microbe-host interactions illuminate the cytoskeleton. J Cell Biol (2011) 1.63
Salmonella effectors translocated across the vacuolar membrane interact with the actin cytoskeleton. Mol Microbiol (2003) 1.55
Unusual kinetic and structural properties control rapid assembly and turnover of actin in the parasite Toxoplasma gondii. Mol Biol Cell (2005) 1.50
New mechanisms and functions of actin nucleation. Curr Opin Cell Biol (2010) 1.45
A multiscale model linking ion-channel molecular dynamics and electrostatics to the cardiac action potential. Proc Natl Acad Sci U S A (2009) 1.43
Overlapping and distinct functions for cofilin, coronin and Aip1 in actin dynamics in vivo. J Cell Sci (2010) 1.35
Dinitroanilines bind alpha-tubulin to disrupt microtubules. Mol Biol Cell (2004) 1.34
Structure/function analysis of the interaction of phosphatidylinositol 4,5-bisphosphate with actin-capping protein: implications for how capping protein binds the actin filament. J Biol Chem (2006) 1.30
An epilepsy/dyskinesia-associated mutation enhances BK channel activation by potentiating Ca2+ sensing. Neuron (2010) 1.30
The kinetics of cooperative cofilin binding reveals two states of the cofilin-actin filament. Biophys J (2010) 1.24
Taxol allosterically alters the dynamics of the tubulin dimer and increases the flexibility of microtubules. Biophys J (2008) 1.24
Neurodegeneration mutations in dynactin impair dynein-dependent nuclear migration. Proc Natl Acad Sci U S A (2009) 1.23
Evolutionarily divergent, unstable filamentous actin is essential for gliding motility in apicomplexan parasites. PLoS Pathog (2011) 1.22
Antibacterial autophagy occurs at PI(3)P-enriched domains of the endoplasmic reticulum and requires Rab1 GTPase. Autophagy (2011) 1.20
Nanoparticle pharmacokinetic profiling in vivo using magnetic resonance imaging. Magn Reson Med (2008) 1.19
Nucleotide effects on the structure and dynamics of actin. Biophys J (2007) 1.18
NMR analyses of the activation of the Arp2/3 complex by neuronal Wiskott-Aldrich syndrome protein. Biochemistry (2005) 1.16
Binding of myotrophin/V-1 to actin-capping protein: implications for how capping protein binds to the filament barbed end. J Biol Chem (2006) 1.09
Mapping the cofilin binding site on yeast G-actin by chemical cross-linking. J Mol Biol (2008) 1.09
Motility determinants in WASP family proteins. Mol Biol Cell (2002) 1.08
Repetitive N-WASP-binding elements of the enterohemorrhagic Escherichia coli effector EspF(U) synergistically activate actin assembly. PLoS Pathog (2008) 1.08
An actin cytoskeleton with evolutionarily conserved functions in the absence of canonical actin-binding proteins. Proc Natl Acad Sci U S A (2011) 1.05
A genetic dissection of Aip1p's interactions leads to a model for Aip1p-cofilin cooperative activities. Mol Biol Cell (2006) 1.04
Localization of the antimitotic peptide and depsipeptide binding site on beta-tubulin. Biochemistry (2004) 1.04
Multivariate analyses of amyloid-beta oligomer populations indicate a connection between pore formation and cytotoxicity. PLoS One (2012) 1.02
The unusual dynamics of parasite actin result from isodesmic polymerization. Nat Commun (2013) 1.01
The interaction of capping protein with the barbed end of the actin filament. J Mol Biol (2010) 1.00
Mathematical modeling of cell migration. Methods Cell Biol (2008) 0.98
Plasma membrane organization is essential for balancing competing pseudopod- and uropod-promoting signals during neutrophil polarization and migration. Mol Biol Cell (2005) 0.95
SnapShot: actin regulators I. Cell (2007) 0.94
Effects of solution crowding on actin polymerization reveal the energetic basis for nucleotide-dependent filament stability. J Mol Biol (2008) 0.93
The actin nucleation factor JMY is a negative regulator of neuritogenesis. Mol Biol Cell (2011) 0.93
F-actin structure destabilization and DNase I binding loop: fluctuations mutational cross-linking and electron microscopy analysis of loop states and effects on F-actin. J Mol Biol (2009) 0.92
Regulation of integrin trafficking, cell adhesion, and cell migration by WASH and the Arp2/3 complex. Cytoskeleton (Hoboken) (2012) 0.92
SnapShot: actin regulators II. Cell (2007) 0.92
The NH2 terminus of RCK1 domain regulates Ca2+-dependent BK(Ca) channel gating. J Gen Physiol (2005) 0.92
Structural insights into WHAMM-mediated cytoskeletal coordination during membrane remodeling. J Cell Biol (2012) 0.91
Pharmacokinetic modeling of tumor bioluminescence implicates efflux, and not influx, as the bigger hurdle in cancer drug therapy. Cancer Res (2010) 0.91
Mechanism for CARMIL protein inhibition of heterodimeric actin-capping protein. J Biol Chem (2012) 0.91
Rickettsia parkeri invasion of diverse host cells involves an Arp2/3 complex, WAVE complex and Rho-family GTPase-dependent pathway. Cell Microbiol (2012) 0.91
Binding and interaction of dinitroanilines with apicomplexan and kinetoplastid alpha-tubulin. J Med Chem (2006) 0.90
Single-particle characterization of Aβ oligomers in solution. ACS Nano (2012) 0.90
Mechanical properties of doubly stabilized microtubule filaments. Biophys J (2013) 0.89
Mutations in alpha-tubulin confer dinitroaniline resistance at a cost to microtubule function. Mol Biol Cell (2007) 0.88
A model for the interfacial kinetics of phospholipase D activity on long-chain lipids. Biophys J (2013) 0.87
Energetics and dynamics of constrained actin filament bundling. Biophys J (2006) 0.87
Assessing the barriers to image-guided drug delivery. Wiley Interdiscip Rev Nanomed Nanobiotechnol (2013) 0.86
Carboxyl group footprinting mass spectrometry and molecular dynamics identify key interactions in the HER2-HER3 receptor tyrosine kinase interface. J Biol Chem (2013) 0.85
Turning on the Arp2/3 complex at atomic resolution. Structure (2002) 0.84
Protein-protein interactions: making drug design second nature. Nat Chem (2009) 0.84
A role for cortactin in Listeria monocytogenes invasion of NIH 3T3 cells, but not in its intracellular motility. Cell Motil Cytoskeleton (2006) 0.83
Dinitroaniline activity in Toxoplasma gondii expressing wild-type or mutant alpha-tubulin. Antimicrob Agents Chemother (2010) 0.81
The interaction of cofilin with the actin filament. J Mol Biol (2011) 0.81
Nuclear localization of actin requires AC102 in Autographa californica multiple nucleopolyhedrovirus-infected cells. J Gen Virol (2012) 0.81
Drug-like leads for steric discrimination between substrate and inhibitors of human acetylcholinesterase. Chem Biol Drug Des (2011) 0.81
First-contact time to a patch in a multidimensional potential well. Phys Rev E Stat Nonlin Soft Matter Phys (2007) 0.80
Synthetic chondramide A analogues stabilize filamentous actin and block invasion by Toxoplasma gondii. J Nat Prod (2013) 0.79
Membrane-deforming proteins play distinct roles in actin pedestal biogenesis by enterohemorrhagic Escherichia coli. J Biol Chem (2012) 0.79
Molecular modeling of the cytoskeleton. Methods Cell Biol (2008) 0.78
The basic concepts of molecular modeling. Methods Enzymol (2009) 0.78
Microtubules: sizing up the GTP cap. Curr Biol (2012) 0.76
Synthesis of chondramide A analogues with modified β-tyrosine and their biological evaluation. Chemistry (2011) 0.76
Fluorescent protein integrated white LEDs for displays. Nanotechnology (2016) 0.75