Published in Chem Pharm Bull (Tokyo) on April 01, 2010
Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK. J Clin Oncol (2009) 15.23
The impact of human EGFR kinase domain mutations on lung tumorigenesis and in vivo sensitivity to EGFR-targeted therapies. Cancer Cell (2006) 5.34
BIM mediates EGFR tyrosine kinase inhibitor-induced apoptosis in lung cancers with oncogenic EGFR mutations. PLoS Med (2007) 4.50
Differential effects of gefitinib and cetuximab on non-small-cell lung cancers bearing epidermal growth factor receptor mutations. J Natl Cancer Inst (2005) 4.19
Acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancers dependent on the epidermal growth factor receptor pathway. Clin Lung Cancer (2009) 3.37
Oligosaccharide specificity of galectins: a search by frontal affinity chromatography. Biochim Biophys Acta (2002) 3.35
Lectin affinity capture, isotope-coded tagging and mass spectrometry to identify N-linked glycoproteins. Nat Biotechnol (2003) 3.15
CSF concentration of the anaplastic lymphoma kinase inhibitor crizotinib. J Clin Oncol (2011) 3.00
EGFR exon 20 insertion mutations in non-small-cell lung cancer: preclinical data and clinical implications. Lancet Oncol (2011) 2.47
Experience dictates stem cell fate in the adult hippocampus. Neuron (2011) 2.18
Combined vascular endothelial growth factor receptor and epidermal growth factor receptor (EGFR) blockade inhibits tumor growth in xenograft models of EGFR inhibitor resistance. Clin Cancer Res (2009) 2.04
Effects of erlotinib in EGFR mutated non-small cell lung cancers with resistance to gefitinib. Clin Cancer Res (2008) 2.00
Hsp90 inhibition suppresses mutant EGFR-T790M signaling and overcomes kinase inhibitor resistance. Cancer Res (2008) 1.95
Pooled analysis of the prospective trials of gefitinib monotherapy for EGFR-mutant non-small cell lung cancers. Lung Cancer (2007) 1.87
Interferon regulatory factor-8 regulates bone metabolism by suppressing osteoclastogenesis. Nat Med (2009) 1.81
Novel PINK1 mutations in early-onset parkinsonism. Ann Neurol (2004) 1.72
Preclinical rationale for use of the clinically available multitargeted tyrosine kinase inhibitor crizotinib in ROS1-translocated lung cancer. J Thorac Oncol (2012) 1.66
Dual specificity phosphatase 6 (DUSP6) is an ETS-regulated negative feedback mediator of oncogenic ERK signaling in lung cancer cells. Carcinogenesis (2010) 1.64
A distal single nucleotide polymorphism alters long-range regulation of the PU.1 gene in acute myeloid leukemia. J Clin Invest (2007) 1.63
Carba analogs of cyclic phosphatidic acid are selective inhibitors of autotaxin and cancer cell invasion and metastasis. J Biol Chem (2006) 1.61
Analytic review of 2372 free flap transfers for head and neck reconstruction following cancer resection. J Reconstr Microsurg (2003) 1.61
Growth-regulatory human galectin-1: crystallographic characterisation of the structural changes induced by single-site mutations and their impact on the thermodynamics of ligand binding. J Mol Biol (2004) 1.57
Differential responses to erlotinib in epidermal growth factor receptor (EGFR)-mutated lung cancers with acquired resistance to gefitinib carrying the L747S or T790M secondary mutations. J Clin Oncol (2008) 1.53
Alterations in skin and stratified epithelia by constitutively activated PPARalpha. J Invest Dermatol (2006) 1.53
EGFR-mutated lung cancer: a paradigm of molecular oncology. Oncotarget (2010) 1.53
C-terminal fragment of presenilin is the molecular target of a dipeptidic gamma-secretase-specific inhibitor DAPT (N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester). J Biol Chem (2006) 1.48
Erlotinib at a dose of 25 mg daily for non-small cell lung cancers with EGFR mutations. J Thorac Oncol (2010) 1.42
Resistance to an irreversible epidermal growth factor receptor (EGFR) inhibitor in EGFR-mutant lung cancer reveals novel treatment strategies. Cancer Res (2007) 1.41
Alveolar ridge notching as a predictor for secondary bone grafting in incomplete alveolar clefts. Cleft Palate Craniofac J (2004) 1.40
Primary small-cell neuroendocrine carcinoma of the breast: report of a case. Surg Today (2008) 1.39
Sulindac sulfide is a noncompetitive gamma-secretase inhibitor that preferentially reduces Abeta 42 generation. J Biol Chem (2003) 1.37
Remote asymmetric induction with vinylketene silyl n,o-acetal. J Am Chem Soc (2004) 1.22
Apoptosis induced by JAK2 inhibition is mediated by Bim and enhanced by the BH3 mimetic ABT-737 in JAK2 mutant human erythroid cells. Blood (2010) 1.21
Absence of the transcription factor CCAAT enhancer binding protein alpha results in loss of myeloid identity in bcr/abl-induced malignancy. Proc Natl Acad Sci U S A (2006) 1.20
Prediction of survival with squamous cell carcinoma antigen in patients with resectable esophageal squamous cell carcinoma. Surgery (2003) 1.20
Expression of podoplanin, CD44, and p63 in squamous cell carcinoma of the lung. Cancer Sci (2009) 1.15
Wandering spleen with chronic torsion. Am J Surg (2008) 1.14
Divergent synthesis of multifunctional molecular probes to elucidate the enzyme specificity of dipeptidic gamma-secretase inhibitors. ACS Chem Biol (2007) 1.14
Stimulation of proliferation of rat hepatic stellate cells by galectin-1 and galectin-3 through different intracellular signaling pathways. J Biol Chem (2003) 1.13
Frequent detection of K-ras mutation in stool samples of colorectal carcinoma patients after improved DNA extraction: comparison with tissue samples. Int J Oncol (2002) 1.10
Inhibition of transcellular tumor cell migration and metastasis by novel carba-derivatives of cyclic phosphatidic acid. Biochim Biophys Acta (2006) 1.10
Novel biological function of sialic acid (N-acetylneuraminic acid) as a hydrogen peroxide scavenger. FEBS Lett (2004) 1.08
Inhibition of lung cancer growth: ATP citrate lyase knockdown and statin treatment leads to dual blockade of mitogen-activated protein kinase (MAPK) and phosphatidylinositol-3-kinase (PI3K)/AKT pathways. J Cell Physiol (2012) 1.08
Hemangiopericytoma of the greater omentum. J Gastrointest Surg (2007) 1.08
Novel IRF6 mutations in Japanese patients with Van der Woude syndrome: two missense mutations (R45Q and P396S) and a 17-kb deletion. J Hum Genet (2003) 1.07
Novel immobilized zinc(II) affinity chromatography for phosphopeptides and phosphorylated proteins. J Sep Sci (2005) 1.06
Both Notch1 and Notch2 contribute to the regulation of melanocyte homeostasis. Pigment Cell Melanoma Res (2008) 1.06
Importance of preoperative imaging with 64-row three-dimensional multidetector computed tomography for safer video-assisted thoracic surgery in lung cancer. Surg Today (2009) 1.05
Analysis of salvage treatments following the failure of free flap transfer caused by vascular thrombosis in reconstruction for head and neck cancer. Plast Reconstr Surg (2007) 1.03
Frontal affinity chromatography as a tool for elucidation of sugar recognition properties of lectins. Methods Enzymol (2003) 1.03
Treatment for prolapse of the sigmoid neovagina in Mayer-Rokitansky-Kuster-Hauser syndrome. Obstet Gynecol (2002) 1.03
Association between nonsyndromic cleft lip with or without cleft palate and the glutamic acid decarboxylase 67 gene in the Japanese population. Am J Med Genet A (2004) 1.02
Synergistic induction of antigen-specific CTL by fusions of TLR-stimulated dendritic cells and heat-stressed tumor cells. J Immunol (2007) 1.02
Complete inhibition of tobamovirus multiplication by simultaneous mutations in two homologous host genes. J Virol (2002) 1.02
Pulmonary vein analysis using three-dimensional computed tomography angiography for thoracic surgery. Gen Thorac Cardiovasc Surg (2010) 1.01
CDDO induces granulocytic differentiation of myeloid leukemic blasts through translational up-regulation of p42 CCAAT enhancer binding protein alpha. Blood (2007) 1.00
Streptococcal preparation OK-432 promotes fusion efficiency and enhances induction of antigen-specific CTL by fusions of dendritic cells and colorectal cancer cells. J Immunol (2007) 1.00
Essential mesenchymal role of small GTPase Rac1 in interdigital programmed cell death during limb development. Dev Biol (2009) 1.00
Biological functions of a novel lipid mediator, cyclic phosphatidic acid. Biochim Biophys Acta (2002) 1.00
A new antibiotic, antimycin Ag, produced by Streptomyces sp. K01-0031. J Antibiot (Tokyo) (2005) 0.99
Steryl glucoside is a lipid mediator in stress-responsive signal transduction. Cell Struct Funct (2002) 0.99
CARM1 is required for proper control of proliferation and differentiation of pulmonary epithelial cells. Development (2010) 0.99
Small symptomatic pericardial diverticula treated by video-assisted thoracic surgical resection. Ann Thorac Cardiovasc Surg (2009) 0.99
Galectin-1 induces astrocyte differentiation, which leads to production of brain-derived neurotrophic factor. Glycobiology (2003) 0.98
Leucettamol A: a new inhibitor of Ubc13-Uev1A interaction isolated from a marine sponge, Leucetta aff. microrhaphis. Bioorg Med Chem Lett (2008) 0.97
Successful treatment of advanced gallbladder cancer with an anticancer drug S-1: assessment based on intratumoral gene. Int J Clin Oncol (2008) 0.96
Anomalous pulmonary vein detected using three-dimensional computed tomography in a patient with lung cancer undergoing thoracoscopic lobectomy. Gen Thorac Cardiovasc Surg (2008) 0.96
Where is the best surgical incision for laparoscopic anterior resection? Hepatogastroenterology (2010) 0.96
Acupuncture to Danzhong but not to Zhongting increases the cardiac vagal component of heart rate variability. Auton Neurosci (2011) 0.95
Microarray analysis using amplified mRNA from laser capture microdissection of microscopic hepatocellular precancerous lesions and frozen hepatocellular carcinomas reveals unique and consistent gene expression profiles. Toxicol Pathol (2003) 0.94
Enrichment of phosphorylated proteins from cell lysate using a novel phosphate-affinity chromatography at physiological pH. Proteomics (2006) 0.94
Peroxisome proliferator-activated receptor alpha activation during pregnancy severely impairs mammary lobuloalveolar development in mice. Endocrinology (2006) 0.93
Caenorhabditis elegans galectins LEC-1-LEC-11: structural features and sugar-binding properties. Biochim Biophys Acta (2008) 0.93
A missense mutation in the SH3BP2 gene on chromosome 4p16.3 found in a case of nonfamilial cherubism. Cleft Palate Craniofac J (2003) 0.92
Effect of sugars on storage stability of lyophilized liposome/DNA complexes with high transfection efficiency. Int J Pharm (2007) 0.91
Acquired resistance to the ALK inhibitor crizotinib in the absence of an ALK mutation. J Thorac Oncol (2012) 0.91
Concise total synthesis of (-)-myxalamide A. Angew Chem Int Ed Engl (2012) 0.91
Caenorhabditis elegans N-glycans containing a Gal-Fuc disaccharide unit linked to the innermost GlcNAc residue are recognized by C. elegans galectin LEC-6. Glycobiology (2008) 0.91
Regulation of the nuclear factor (NF)-kappaB pathway by ISGylation. Biol Pharm Bull (2008) 0.91
Retrospective comparison of non-skin-sparing mastectomy and skin-sparing mastectomy with immediate breast reconstruction. Int J Surg Oncol (2011) 0.89
Cyclic phosphatidic acid inhibits RhoA-mediated autophosphorylation of FAK at Tyr-397 and subsequent tumor-cell invasion. Int J Oncol (2003) 0.89
Choice of flaps for breast reconstruction. Int J Clin Oncol (2005) 0.89
Fluorescence-labeled peptide pI markers for capillary isoelectric focusing. Anal Chem (2002) 0.89
Development of dioxin toxicity evaluation method in human milk by enzyme-linked immunosorbent assay--assay validation for human milk. Chemosphere (2002) 0.88
Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry of phosphorylated compounds using a novel phosphate capture molecule. Rapid Commun Mass Spectrom (2003) 0.88
Structural relationship of curcumin derivatives binding to the BRCT domain of human DNA polymerase lambda. Genes Cells (2006) 0.88
Neoechinulin A protects PC12 cells against MPP+-induced cytotoxicity. J Antibiot (Tokyo) (2008) 0.88
Fabrication of left-handed metal microcoil from spiral vessel of vascular plant. Adv Mater (2011) 0.88
Separation technologies for glycomics. J Chromatogr B Analyt Technol Biomed Life Sci (2002) 0.88
Alteration of integrin expression relates to malignant progression of human papillomavirus-immortalized esophageal keratinocytes. Cancer Lett (2002) 0.88
Voice quality after surgical treatment for thyroid cancer. Thyroid (2013) 0.87
Lumbar puncture-related cerebrospinal fluid leakage on magnetic resonance myelography: is it a clinically significant finding? BMC Anesthesiol (2013) 0.87
Structure-activity relationships of neoechinulin A analogues with cytoprotection against peroxynitrite-induced PC12 cell death. J Antibiot (Tokyo) (2007) 0.87
Cdc42 is required for chondrogenesis and interdigital programmed cell death during limb development. Mech Dev (2012) 0.87
Synthesis and biological activities of neoechinulin A derivatives: new aspects of structure-activity relationships for neoechinulin A. Chem Pharm Bull (Tokyo) (2008) 0.87
Three-dimensional magnetic resonance microscopy of pulmonary solitary tumors in transgenic mice. Magn Reson Med (2006) 0.87
Histologic evaluation of temporomandibular arthritis induced by mild mechanical loading in rabbits. J Oral Pathol Med (2005) 0.87
Comparison of the course of biomarker changes and kidney injury in a rat model of drug-induced acute kidney injury. Biomarkers (2011) 0.87
Attenuation by cyclic phosphatidic acid of peritoneal metastasis of azoxymethane-induced intestinal cancers in Wistar rats. Int J Cancer (2004) 0.87
Cdc42 is critical for cartilage development during endochondral ossification. Endocrinology (2015) 0.86