Published in FEBS J on May 01, 2010
The effects of PEDF on cancer biology: mechanisms of action and therapeutic potential. Nat Rev Cancer (2013) 1.31
Pigment epithelium-derived factor regulates lipid metabolism via adipose triglyceride lipase. Diabetes (2011) 1.25
New insights regarding the regulation of chemotaxis by nucleotides, adenosine, and their receptors. Purinergic Signal (2012) 1.04
Pigment epithelium-derived factor (PEDF) prevents retinal cell death via PEDF Receptor (PEDF-R): identification of a functional ligand binding site. J Biol Chem (2013) 1.02
Opposing effects of pigment epithelium-derived factor on breast cancer cell versus neuronal survival: implication for brain metastasis and metastasis-induced brain damage. Cancer Res (2012) 0.96
Pigment epithelium-derived factor as an anticancer drug and new treatment methods following the discovery of its receptors: a patent perspective. Expert Opin Ther Pat (2011) 0.86
Host pigment epithelium-derived factor (PEDF) prevents progression of liver metastasis in a mouse model of uveal melanoma. Clin Exp Metastasis (2013) 0.85
Inhibition of tumor cell surface ATP synthesis by pigment epithelium-derived factor: implications for antitumor activity. Int J Oncol (2012) 0.82
PEDF and its roles in physiological and pathological conditions: implication in diabetic and hypoxia-induced angiogenic diseases. Clin Sci (Lond) (2015) 0.81
PEDF inhibits pancreatic tumorigenesis by attenuating the fibro-inflammatory reaction. Oncotarget (2016) 0.79
Pigment epithelium-derived factor (PEDF) shares binding sites in collagen with heparin/heparan sulfate proteoglycans. J Biol Chem (2011) 0.79
Pigment Epithelium-Derived Factor (PEDF) is a Determinant of Stem Cell Fate: Lessons from an Ultra-Rare Disease. J Dev Biol (2015) 0.77
ATP release mechanisms of endothelial cell-mediated stimulus-dependent hyperalgesia. J Pain (2014) 0.77
Pigment epithelium-derived factor (PEDF): a novel trophoblast-derived factor limiting feto-placental angiogenesis in late pregnancy. Angiogenesis (2016) 0.76
Pigment epithelium-derived factor: clinical significance in estrogen-dependent tissues and its potential in cancer therapy. Iran J Basic Med Sci (2015) 0.75
PEDF increases the tumoricidal activity of macrophages towards prostate cancer cells in vitro. PLoS One (2017) 0.75
Emetine Di-HCl attenuates Type 1 diabetes mellitus in mice. Mol Med (2016) 0.75
Anti-tumor effects of pigment epithelium-derived factor (PEDF): implication for cancer therapy. A mini-review. J Exp Clin Cancer Res (2016) 0.75
Pigment Epithelium-Derived Factor (PEDF) mediates cartilage matrix loss in an age-dependent manner under inflammatory conditions. BMC Musculoskelet Disord (2017) 0.75
Pigment epithelium-derived factor: a potent inhibitor of angiogenesis. Science (1999) 5.53
Identification of a lipase-linked cell membrane receptor for pigment epithelium-derived factor. J Biol Chem (2006) 2.28
Pigment epithelium-derived factor regulates the vasculature and mass of the prostate and pancreas. Nat Med (2003) 1.97
Angiostatin binds ATP synthase on the surface of human endothelial cells. Proc Natl Acad Sci U S A (1999) 1.95
Pigment epithelium-derived factor inhibits retinal and choroidal neovascularization. J Cell Physiol (2001) 1.94
Endothelial cell surface F1-F0 ATP synthase is active in ATP synthesis and is inhibited by angiostatin. Proc Natl Acad Sci U S A (2001) 1.83
Prevention of ischemia-induced retinopathy by the natural ocular antiangiogenic agent pigment epithelium-derived factor. Proc Natl Acad Sci U S A (2001) 1.83
Mechanism of inhibition of bovine F1-ATPase by resveratrol and related polyphenols. Proc Natl Acad Sci U S A (2007) 1.75
Loss of the antiangiogenic pigment epithelium-derived factor in patients with angiogenic eye disease. Diabetes (2001) 1.70
Two functional epitopes of pigment epithelial-derived factor block angiogenesis and induce differentiation in prostate cancer. Cancer Res (2005) 1.66
PEDF: anti-angiogenic guardian of ocular function. Trends Mol Med (2002) 1.60
AAV-mediated gene transfer of pigment epithelium-derived factor inhibits choroidal neovascularization. Invest Ophthalmol Vis Sci (2002) 1.58
Human microvascular endothelial cells immortalized with human telomerase catalytic protein: a model for the study of in vitro angiogenesis. Biochem Biophys Res Commun (2004) 1.56
Neuroprotective and antiangiogenic actions of PEDF in the eye: molecular targets and therapeutic potential. Prog Retin Eye Res (2004) 1.50
Pigment epithelium-derived factor (PEDF) in neuroblastoma: a multifunctional mediator of Schwann cell antitumor activity. J Cell Sci (2001) 1.46
Focus on Molecules: Pigment epithelium-derived factor (PEDF). Exp Eye Res (2005) 1.42
PEDF: a potential molecular therapeutic target with multiple anti-cancer activities. Trends Mol Med (2006) 1.41
Pigment epithelium-derived factor delays the death of photoreceptors in mouse models of inherited retinal degenerations. Neurobiol Dis (1999) 1.40
Binding of pigment epithelium-derived factor (PEDF) to retinoblastoma cells and cerebellar granule neurons. Evidence for a PEDF receptor. J Biol Chem (1999) 1.35
Pigment epithelium-derived factor is a substrate for matrix metalloproteinase type 2 and type 9: implications for downregulation in hypoxia. Invest Ophthalmol Vis Sci (2005) 1.32
Angiostatin's molecular mechanism: aspects of specificity and regulation elucidated. J Cell Biochem (2005) 1.30
Mapping the type I collagen-binding site on pigment epithelium-derived factor. Implications for its antiangiogenic activity. J Biol Chem (2002) 1.27
Identification of the neuroprotective molecular region of pigment epithelium-derived factor and its binding sites on motor neurons. J Neurosci (2002) 1.23
Possible role of cell surface H+ -ATP synthase in the extracellular ATP synthesis and proliferation of human umbilical vein endothelial cells. Mol Cancer Res (2003) 1.17
Ecto-F1Fo ATP synthase/F1 ATPase: metabolic and immunological functions. Curr Opin Lipidol (2006) 1.15
Pigment epithelium-derived factor inhibits TNF-alpha-induced interleukin-6 expression in endothelial cells by suppressing NADPH oxidase-mediated reactive oxygen species generation. J Mol Cell Cardiol (2004) 1.12
Pigment epithelium-derived factor (PEDF) binds to glycosaminoglycans: analysis of the binding site. Biochemistry (1998) 1.12
Identification of pigment epithelium-derived factor in the interphotoreceptor matrix of bovine eyes. Protein Expr Purif (1995) 1.10
Evidence for pigment epithelium-derived factor receptors in the neural retina. Invest Ophthalmol Vis Sci (2001) 1.08
Suppression of angiogenesis and tumor growth by adenoviral-mediated gene transfer of pigment epithelium-derived factor. Mol Ther (2003) 1.06
Effects of human recombinant PEDF protein and PEDF-derived peptide 34-mer on choroidal neovascularization. Invest Ophthalmol Vis Sci (2009) 1.05
Angiostatin is directly cytotoxic to tumor cells at low extracellular pH: a mechanism dependent on cell surface-associated ATP synthase. Cancer Res (2006) 1.04
Recombinant human pigment epithelium-derived factor (PEDF): characterization of PEDF overexpressed and secreted by eukaryotic cells. Protein Sci (1996) 1.04
Retinal neuroprotection against ischemic injury mediated by intraocular gene transfer of pigment epithelium-derived factor. Invest Ophthalmol Vis Sci (2003) 1.03
Ni-chelate-affinity purification and crystallization of the yeast mitochondrial F1-ATPase. Protein Expr Purif (2004) 1.02
Endothelial cell surface ATP synthase-triggered caspase-apoptotic pathway is essential for k1-5-induced antiangiogenesis. Cancer Res (2004) 0.97
Expression of pigment epithelium-derived factor in experimental choroidal neovascularization. Invest Ophthalmol Vis Sci (2002) 0.96
An Inhibitor of the F1 subunit of ATP synthase (IF1) modulates the activity of angiostatin on the endothelial cell surface. J Biol Chem (2004) 0.95
Adeno-associated virus type-2 expression of pigmented epithelium-derived factor or Kringles 1-3 of angiostatin reduce retinal neovascularization. Proc Natl Acad Sci U S A (2002) 0.95
Proteolytic activity directed toward pigment epithelium-derived factor in vitreous of bovine eyes. Implications of proteolytic processing. Invest Ophthalmol Vis Sci (1996) 0.95
Inhibitory effects of active substances isolated from Cassia garrettiana heartwood on tumor growth and lung metastasis in Lewis lung carcinoma-bearing mice (Part 2). Anticancer Res (2000) 0.79
Direct mapping of adeno-associated virus capsid proteins B and C: a possible ACG initiation codon. Proc Natl Acad Sci U S A (1985) 3.31
Interaction of a G protein with an activated receptor opens the interdomain interface in the alpha subunit. Proc Natl Acad Sci U S A (2011) 2.10
Doxycycline's effect on ocular angiogenesis: an in vivo analysis. Ophthalmology (2010) 1.53
Age-related alterations in the dynamic behavior of microglia. Aging Cell (2010) 1.49
Pigment epithelium-derived factor delays the death of photoreceptors in mouse models of inherited retinal degenerations. Neurobiol Dis (1999) 1.40
Binding of pigment epithelium-derived factor (PEDF) to retinoblastoma cells and cerebellar granule neurons. Evidence for a PEDF receptor. J Biol Chem (1999) 1.35
Pigment epithelium-derived factor is a substrate for matrix metalloproteinase type 2 and type 9: implications for downregulation in hypoxia. Invest Ophthalmol Vis Sci (2005) 1.32
Studies on the mechanism of DNA polymerase alpha. Nascent chain elongation, steady state kinetics, and the initiation phase of DNA synthesis. J Biol Chem (1981) 1.31
Pigment epithelium-derived factor promotes the survival and differentiation of developing spinal motor neurons. J Comp Neurol (1999) 1.27
Structure/function studies of human immunodeficiency virus type 1 reverse transcriptase. Alanine scanning mutagenesis of an alpha-helix in the thumb subdomain. J Biol Chem (1994) 1.20
Site-directed mutagenesis of adeno-associated virus type 2 structural protein initiation codons: effects on regulation of synthesis and biological activity. J Virol (1994) 1.19
A novel imaging technique for experimental choroidal neovascularization. Invest Ophthalmol Vis Sci (2006) 1.17
Pigment epithelium-derived factor is a survival factor for cerebellar granule cells in culture. J Neurochem (1995) 1.16
Pigment epithelium-derived factor (PEDF) differentially protects immature but not mature cerebellar granule cells against apoptotic cell death. J Neurosci Res (1998) 1.14
Pigment epithelium-derived factor (PEDF) binds to glycosaminoglycans: analysis of the binding site. Biochemistry (1998) 1.12
Identification of pigment epithelium-derived factor in the interphotoreceptor matrix of bovine eyes. Protein Expr Purif (1995) 1.10
Evidence for pigment epithelium-derived factor receptors in the neural retina. Invest Ophthalmol Vis Sci (2001) 1.08
Pigment epithelium-derived factor protects cultured cerebellar granule cells against glutamate-induced neurotoxicity. J Neurochem (1997) 1.05
Recombinant human pigment epithelium-derived factor (PEDF): characterization of PEDF overexpressed and secreted by eukaryotic cells. Protein Sci (1996) 1.04
Alkyl gallates, intensifiers of beta-lactam susceptibility in methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother (2005) 0.99
Gene expression of the neurotrophic pigment epithelium-derived factor in the human ciliary epithelium. Synthesis and secretion into the aqueous humor. Invest Ophthalmol Vis Sci (1996) 0.98
Differentiation of Y79 retinoblastoma cells with pigment epithelial-derived factor and interphotoreceptor matrix wash: effects on tumorigenicity. Growth Factors (1994) 0.96
Doxycycline-mediated inhibition of choroidal neovascularization. Invest Ophthalmol Vis Sci (2009) 0.95
Proteolytic activity directed toward pigment epithelium-derived factor in vitreous of bovine eyes. Implications of proteolytic processing. Invest Ophthalmol Vis Sci (1996) 0.95
Structure/function studies of HIV-1(1) reverse transcriptase: dimerization-defective mutant L289K. Biochemistry (1993) 0.91
Variation in synergistic activity by flavone and its related compounds on the increased susceptibility of various strains of methicillin-resistant Staphylococcus aureus to beta-lactam antibiotics. Int J Antimicrob Agents (2004) 0.91
Pigment epithelium-derived factor (PEDF) has direct effects on the metabolism and proliferation of microglia and indirect effects on astrocytes. J Neurosci Res (1997) 0.91
Flavone markedly affects phenotypic expression of beta-lactam resistance in methicillin-resistant Staphylococcus aureus strains isolated clinically. Biol Pharm Bull (2003) 0.90
Possible role of mitochondrial remodelling on cellular triacylglycerol accumulation. J Biochem (2009) 0.90
Erythropoietin--an endogenous retinal survival factor. N Engl J Med (2002) 0.89
Clinico-pathologic findings in end-stage pediatric heart transplant grafts. Pediatr Transplant (2008) 0.87
Sterculic acid antagonizes 7-ketocholesterol-mediated inflammation and inhibits choroidal neovascularization. Biochim Biophys Acta (2012) 0.86
Clusterin protein diversity in the primate eye. Mol Vis (2000) 0.86
Anomalous electrophoretic migration of oligodeoxynucleotides with terminal -OH groups: applications for DNA exonuclease characterization. Anal Biochem (1983) 0.84
Sequence and expression analysis of bovine pigment epithelium-derived factor. Biochim Biophys Acta (1998) 0.83
6,7-dihydroxyflavone dramatically intensifies the susceptibility of methicillin-resistant or -sensitive Staphylococcus aureus to beta-lactams. Antimicrob Agents Chemother (2004) 0.82
Properties of a novel oligonucleotide-releasing bidirectional DNA exonuclease from mouse myeloma. Biochemistry (1984) 0.81
Mapping of nucleic acid binding in proteolytic domains of HIV-1 reverse transcriptase. Biochemistry (1993) 0.81
Expression of bovine F1-ATPase with functional complementation in yeast Saccharomyces cerevisiae. J Biol Chem (2005) 0.81
Identification of pigment epithelium-derived factor protein forms with distinct activities on tumor cell lines. J Biomed Biotechnol (2012) 0.79
Transplantation of adult recipients by single cadaveric kidneys from pediatric donors weighing < or = 25 kg can be a reliable option. Transpl Int (2006) 0.79
No relationship exists between PBP 2a amounts expressed in different MRSA strains obtained clinically and their beta-lactam MIC values. J Med Invest (2008) 0.79
The role of macrophage class a scavenger receptors in a laser-induced murine choroidal neovascularization model. Invest Ophthalmol Vis Sci (2013) 0.79
Identification of the up- and down-regulated genes in the heart of juvenile visceral steatosis mice. Biol Pharm Bull (2004) 0.78
Sustained subconjunctival protein delivery using a thermosetting gel delivery system. J Ocul Pharmacol Ther (2010) 0.77
Simvastatin represses translocation of Pseudomonas aeruginosa across Madin-Darby canine kidney cell monolayers. J Med Invest (2012) 0.77
Survival effects of pigment epithelium-derived factor expressed by a lentiviral vector in rat cerebellar granule cells. Dev Neurosci (2001) 0.77
Expression and purification of the HIV-1 reverse transcriptase using the baculovirus expression vector system. Protein Expr Purif (1993) 0.77
Triple combinations of lower and longer alkyl gallates and oxacillin improve antibiotic synergy against methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother (2009) 0.77
Enrichment of low-abundant protein targets by immunoprecipitation upstream of mass spectrometry. Methods Mol Biol (2015) 0.77
Functional disorders of the oxidative phosphorylation system in the heart mitochondria of mice with juvenile visceral steatosis. Biol Pharm Bull (2003) 0.76
Synthesis and evaluation of water-soluble resveratrol and piceatannol via BGLation. Bioorg Med Chem Lett (2012) 0.75
Capillary atmospheric pressure electron capture ionization (cAPECI): a highly efficient ionization method for nitroaromatic compounds. J Am Soc Mass Spectrom (2014) 0.75
Hand-assisted laparoscopic donor nephrectomy: a low rate of complications. Prog Transplant (2005) 0.75
Contribution of extracellular ATP on the cell-surface F1F0-ATP synthase-mediated intracellular triacylglycerol accumulation. Biomed Res (2015) 0.75
Biomechanical evaluation of the Femoral Neck System in unstable Pauwels III femoral neck fractures: A comparison to the Dynamic Hip Screw and Cannulated Screws. J Orthop Trauma (2016) 0.75