Gene expression profiling of primary human articular chondrocytes in high-density micromasses reveals patterns of recovery, maintenance, re- and dedifferentiation.

PubWeight™: 0.95‹?› | Rank: Top 15%

🔗 View Article (PMID 20433912)

Published in Gene on April 28, 2010

Authors

Tilo Dehne1, Rita Schenk, Carsten Perka, Lars Morawietz, Axel Pruss, Michael Sittinger, Christian Kaps, Jochen Ringe

Author Affiliations

1: Tissue Engineering Laboratory and Berlin-Brandenburg Center for Regenerative Therapies, Department of Rheumatology and Clinical Immunology, Charité-Universitätsmedizin Berlin, Tucholskystrasse 2, 10117 Berlin, Germany. tilo.dehne@charite.de

Articles citing this

Relative percentage and zonal distribution of mesenchymal progenitor cells in human osteoarthritic and normal cartilage. Arthritis Res Ther (2011) 1.19

Simulated-physiological loading conditions preserve biological and mechanical properties of caprine lumbar intervertebral discs in ex vivo culture. PLoS One (2012) 1.05

Mesenchymal stem cells as a potent cell source for articular cartilage regeneration. World J Stem Cells (2014) 1.01

Gene markers of cellular aging in human multipotent stromal cells in culture. Stem Cell Res Ther (2014) 0.97

Enhancing chondrogenic phenotype for cartilage tissue engineering: monoculture and coculture of articular chondrocytes and mesenchymal stem cells. Tissue Eng Part B Rev (2014) 0.90

High density micromass cultures of a human chondrocyte cell line: a reliable assay system to reveal the modulatory functions of pharmacological agents. Biochem Pharmacol (2011) 0.84

Analysis of the effects of five factors relevant to in vitro chondrogenesis of human mesenchymal stem cells using factorial design and high throughput mRNA-profiling. PLoS One (2014) 0.79

Transforming growth factor beta signaling is essential for the autonomous formation of cartilage-like tissue by expanded chondrocytes. PLoS One (2015) 0.79

Differential gene expression of the intermediate and outer interzone layers of developing articular cartilage in murine embryos. Stem Cells Dev (2014) 0.78

Expression profiling and functional implications of a set of zinc finger proteins, ZNF423, ZNF470, ZNF521, and ZNF780B, in primary osteoarthritic articular chondrocytes. Mediators Inflamm (2014) 0.78

Targeted In Situ Biosynthetic Transcriptional Activation in Native Surface-Level Human Articular Chondrocytes during Lesion Stabilization. Cartilage (2012) 0.78

The Transient Chondrocyte Phenotype in Human Osteophytic Cartilage: A Role of Pigment Epithelium-Derived Factor? Cartilage (2013) 0.78

Molecular study of a Hoxa2 gain-of-function in chondrogenesis: a model of idiopathic proportionate short stature. Int J Mol Sci (2013) 0.77

Epigenetic regulation in chondrocyte phenotype maintenance for cell-based cartilage repair. Am J Transl Res (2015) 0.77

B2A peptide induces chondrogenic differentiation in vitro and enhances cartilage repair in rats. J Orthop Res (2012) 0.76

The roles of integrin β1 in phenotypic maintenance and dedifferentiation in chondroid cells differentiated from human adipose-derived stem cells. Nanoscale Res Lett (2013) 0.75

Silencing of TGIF1 in bone mesenchymal stem cells applied to the post-operative rotator cuff improves both functional and histologic outcomes. J Mol Histol (2015) 0.75

Articles by these authors

Charité total disc replacement--clinical and radiographical results after an average follow-up of 17 years. Eur Spine J (2005) 2.75

Chitosan: a versatile biopolymer for orthopaedic tissue-engineering. Biomaterials (2005) 2.60

Cytomegalovirus (CMV) phosphoprotein 65 makes a large contribution to shaping the T cell repertoire in CMV-exposed individuals. J Infect Dis (2002) 2.33

A prospective, randomized study of computer-assisted and conventional total knee arthroplasty. Three-dimensional evaluation of implant alignment and rotation. J Bone Joint Surg Am (2007) 2.33

Cytokine expression in human osteoblasts after antiseptic treatment: a comparative study between polyhexanide and chlorhexidine. J Invest Surg (2014) 1.95

Scaffold-based tissue engineering: rationale for computer-aided design and solid free-form fabrication systems. Trends Biotechnol (2004) 1.93

Towards in situ tissue repair: human mesenchymal stem cells express chemokine receptors CXCR1, CXCR2 and CCR2, and migrate upon stimulation with CXCL8 but not CCL2. J Cell Biochem (2007) 1.86

The surgical treatment of the lumbar disc prolapse: nucleotomy with additional transpedicular dynamic stabilization versus nucleotomy alone. Spine (Phila Pa 1976) (2005) 1.84

Immunization with glucose-6-phosphate isomerase induces T cell-dependent peripheral polyarthritis in genetically unaltered mice. J Immunol (2004) 1.77

A prospective time-course study on serological testing for human immunodeficiency virus, hepatitis B virus and hepatitis C virus with blood samples taken up to 48 h after death. J Med Microbiol (2011) 1.77

Ten years of clinical results with a tissue-engineered pulmonary valve. Ann Thorac Surg (2011) 1.70

Specific plasma membrane protein phenotype of culture-amplified and native human bone marrow mesenchymal stem cells. Blood (2007) 1.70

Mechanical testing of fixation techniques for scaffold-based tissue-engineered grafts. J Biomed Mater Res B Appl Biomater (2007) 1.61

Cell-wall alterations as an attribute of Mycobacterium tuberculosis in latent infection. J Infect Dis (2003) 1.60

Diagnosis of periprosthetic infection following total hip arthroplasty--evaluation of the diagnostic values of pre- and intraoperative parameters and the associated strategy to preoperatively select patients with a high probability of joint infection. J Orthop Surg Res (2008) 1.60

Cis- and trans-acting gene regulation is associated with osteoarthritis. Am J Hum Genet (2006) 1.55

Stair climbing is more critical than walking in pre-clinical assessment of primary stability in cementless THA in vitro. J Biomech (2005) 1.54

Periosteal cells in bone tissue engineering. Tissue Eng (2003) 1.54

Insights into mesenchymal stem cell aging: involvement of antioxidant defense and actin cytoskeleton. Stem Cells (2009) 1.54

Mid-term clinical results using a tissue-engineered pulmonary valve to reconstruct the right ventricular outflow tract during the Ross procedure. Ann Thorac Surg (2007) 1.50

Cardiac surgery for carcinoid heart disease in 12 cases. Gen Thorac Cardiovasc Surg (2011) 1.46

Treatment of posttraumatic and focal osteoarthritic cartilage defects of the knee with autologous polymer-based three-dimensional chondrocyte grafts: 2-year clinical results. Arthritis Res Ther (2007) 1.45

BMP2 initiates chondrogenic lineage development of adult human mesenchymal stem cells in high-density culture. Differentiation (2003) 1.42

Small improvements in mechanical axis alignment achieved with MRI versus CT-based patient-specific instruments in TKA: a randomized clinical trial. Clin Orthop Relat Res (2014) 1.40

The early fracture hematoma and its potential role in fracture healing. Tissue Eng Part B Rev (2010) 1.38

Specific lineage-priming of bone marrow mesenchymal stem cells provides the molecular framework for their plasticity. Stem Cells (2009) 1.37

Priming integrin alpha5 promotes human mesenchymal stromal cell osteoblast differentiation and osteogenesis. Proc Natl Acad Sci U S A (2009) 1.35

Simvastatin attenuates ventilator-induced lung injury in mice. Crit Care (2010) 1.34

Human early fracture hematoma is characterized by inflammation and hypoxia. Clin Orthop Relat Res (2011) 1.29

Key regulatory molecules of cartilage destruction in rheumatoid arthritis: an in vitro study. Arthritis Res Ther (2008) 1.28

Modified immunohistological staining allows detection of Ziehl-Neelsen-negative Mycobacterium tuberculosis organisms and their precise localization in human tissue. J Pathol (2005) 1.26

The human nose harbors a niche of olfactory ectomesenchymal stem cells displaying neurogenic and osteogenic properties. Stem Cells Dev (2010) 1.25

Chondrogenic differentiation potential of osteoarthritic chondrocytes and their possible use in matrix-associated autologous chondrocyte transplantation. Arthritis Res Ther (2009) 1.21

Molecular HPV typing as a diagnostic tool to discriminate primary from metastatic squamous cell carcinoma of the lung. Am J Surg Pathol (2009) 1.19

A microcarrier-based cultivation system for expansion of primary mesenchymal stem cells. Biotechnol Prog (2007) 1.19

Human platelet-rich plasma stimulates migration and chondrogenic differentiation of human subchondral progenitor cells. J Orthop Res (2011) 1.19

Formation of cartilage repair tissue in articular cartilage defects pretreated with microfracture and covered with cell-free polymer-based implants. J Orthop Res (2009) 1.19

Relative percentage and zonal distribution of mesenchymal progenitor cells in human osteoarthritic and normal cartilage. Arthritis Res Ther (2011) 1.19

Identification of dialysis patients with panel-reactive memory T cells before kidney transplantation using an allogeneic cell bank. J Am Soc Nephrol (2006) 1.18

A frequent functional toll-like receptor 7 polymorphism is associated with accelerated HIV-1 disease progression. AIDS (2009) 1.18

Validity of frozen sections for analysis of periprosthetic loosening membranes. Clin Orthop Relat Res (2009) 1.15

Regeneration of ovine articular cartilage defects by cell-free polymer-based implants. Biomaterials (2007) 1.12

Effect of Nigella sativa (black seed) on subjective feeling in patients with allergic diseases. Phytother Res (2003) 1.12

Inducible costimulator (ICOS) blockade inhibits accumulation of polyfunctional T helper 1/T helper 17 cells and mitigates autoimmune arthritis. Ann Rheum Dis (2010) 1.12

Varus malalignment has no influence on clinical outcome in midterm follow-up after total knee replacement. Arch Orthop Trauma Surg (2010) 1.11

CCR5Delta32 genotypes in a German HIV-1 seroconverter cohort and report of HIV-1 infection in a CCR5Delta32 homozygous individual. PLoS One (2008) 1.10

Porcine mesenchymal stem cells. Induction of distinct mesenchymal cell lineages. Cell Tissue Res (2002) 1.10

Treatment of focal degenerative cartilage defects with polymer-based autologous chondrocyte grafts: four-year clinical results. Arthritis Res Ther (2009) 1.10

Standardized AP radiographs do not provide reliable diagnostic measures for the assessment of acetabular retroversion. J Orthop Res (2012) 1.09

Coexistence of autoantibodies and alloantibodies to red blood cells due to blood transfusion. Transfusion (2007) 1.08

Highly efficient magnetic stem cell labeling with citrate-coated superparamagnetic iron oxide nanoparticles for MRI tracking. Biomaterials (2012) 1.08

Abnormalities in peripheral B cell memory of patients with primary Sjögren's syndrome. Arthritis Rheum (2004) 1.08

Quantitative determination of the diagnostic accuracy of the synovitis score and its components. Histopathology (2010) 1.07

Regulatory T cells control the transition from acute into chronic inflammation in glucose-6-phosphate isomerase-induced arthritis. Ann Rheum Dis (2010) 1.06

Prevention of liver cancer cachexia-induced cardiac wasting and heart failure. Eur Heart J (2013) 1.06

Influence of changes in stem positioning on femoral loading after THR using a short-stemmed hip implant. Clin Biomech (Bristol, Avon) (2007) 1.06

Stem cells for regenerative medicine: advances in the engineering of tissues and organs. Naturwissenschaften (2002) 1.04

Twenty-three neutrophil granulocytes in 10 high-power fields is the best histopathological threshold to differentiate between aseptic and septic endoprosthesis loosening. Histopathology (2009) 1.04

Hypoxia promotes osteogenesis but suppresses adipogenesis of human mesenchymal stromal cells in a hypoxia-inducible factor-1 dependent manner. PLoS One (2012) 1.04

Joint line elevation in revision TKA leads to increased patellofemoral contact forces. J Orthop Res (2010) 1.04

Decrease in expression of bone morphogenetic proteins 4 and 5 in synovial tissue of patients with osteoarthritis and rheumatoid arthritis. Arthritis Res Ther (2006) 1.04

Dynamic stabilization adjacent to single-level fusion: part II. No clinical benefit for asymptomatic, initially degenerated adjacent segments after 6 years follow-up. Eur Spine J (2010) 1.04

Human periosteum-derived progenitor cells express distinct chemokine receptors and migrate upon stimulation with CCL2, CCL25, CXCL8, CXCL12, and CXCL13. Eur J Cell Biol (2008) 1.04

Mesenchymal stem cell-dependent formation of heterotopic tendon-bone insertions (osteotendinous junctions). Stem Cells (2010) 1.03

Inflammatory phase of bone healing initiates the regenerative healing cascade. Cell Tissue Res (2011) 1.03

Dynamic stabilization adjacent to single-level fusion: part I. Biomechanical effects on lumbar spinal motion. Eur Spine J (2010) 1.03

Decellularized xenogenic heart valves reveal remodeling and growth potential in vivo. Tissue Eng (2006) 1.03

Tissue engineering: advances in in vitro cartilage generation. Trends Biotechnol (2002) 1.03

BMP7 promotes adipogenic but not osteo-/chondrogenic differentiation of adult human bone marrow-derived stem cells in high-density micro-mass culture. J Cell Biochem (2007) 1.02

Pre-operative frontal plane malalignment predicts the extension gap asymmetry in knee osteoarthritis. Int Orthop (2011) 1.02

Osteoarthritis synovial fluid activates pro-inflammatory cytokines in primary human chondrocytes. Int Orthop (2012) 1.02

Differential regulation of blood vessel formation between standard and delayed bone healing. J Orthop Res (2009) 1.01

Tumoral calcinosis revisited: pathophysiology and treatment. Rheumatol Int (2003) 1.01

Gene expression profile of adult human bone marrow-derived mesenchymal stem cells stimulated by the chemokine CXCL7. Int J Biochem Cell Biol (2008) 1.01