Published in Methods on April 29, 2010
Epigenome-wide association studies for common human diseases. Nat Rev Genet (2011) 7.96
Cytosine methylation changes in enhancer regions of core pro-fibrotic genes characterize kidney fibrosis development. Genome Biol (2013) 1.52
Functional DNA methylation differences between tissues, cell types, and across individuals discovered using the M&M algorithm. Genome Res (2013) 1.33
MBD-seq as a cost-effective approach for methylome-wide association studies: demonstration in 1500 case--control samples. Epigenomics (2012) 1.16
Differential epigenome-wide DNA methylation patterns in childhood obesity-associated asthma. Sci Rep (2013) 0.91
Epigenomics: the science of no-longer-junk DNA. Why study it in chronic kidney disease? Semin Nephrol (2013) 0.90
Anticancer activity of green tea polyphenols in prostate gland. Oxid Med Cell Longev (2012) 0.84
DNA methylation is developmentally regulated for genes essential for cardiogenesis. J Am Heart Assoc (2014) 0.83
Sexual dimorphism in epigenomic responses of stem cells to extreme fetal growth. Nat Commun (2014) 0.83
Using DNA methylation to understand biological consequences of genetic variability. Neurodegener Dis (2011) 0.79
Human DNA methylomes at base resolution show widespread epigenomic differences. Nature (2009) 34.27
Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science (2009) 32.97
Highly integrated single-base resolution maps of the epigenome in Arabidopsis. Cell (2008) 32.65
Genome-scale DNA methylation maps of pluripotent and differentiated cells. Nature (2008) 30.29
Shotgun bisulphite sequencing of the Arabidopsis genome reveals DNA methylation patterning. Nature (2008) 26.78
The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain. Science (2009) 18.82
DNA methylation profiling of human chromosomes 6, 20 and 22. Nat Genet (2006) 18.08
Genome-wide analysis of Arabidopsis thaliana DNA methylation uncovers an interdependence between methylation and transcription. Nat Genet (2006) 11.88
Targeted and genome-scale strategies reveal gene-body methylation signatures in human cells. Nat Biotechnol (2009) 11.18
DNA methylation signatures identify biologically distinct subtypes in acute myeloid leukemia. Cancer Cell (2010) 6.72
Comparative isoschizomer profiling of cytosine methylation: the HELP assay. Genome Res (2006) 5.99
MDS and secondary AML display unique patterns and abundance of aberrant DNA methylation. Blood (2009) 4.00
Heritable rather than age-related environmental and stochastic factors dominate variation in DNA methylation of the human IGF2/H19 locus. Hum Mol Genet (2007) 3.06
CG dinucleotide clustering is a species-specific property of the genome. Nucleic Acids Res (2007) 2.48
Cytosine methylation dysregulation in neonates following intrauterine growth restriction. PLoS One (2010) 2.10
High-resolution genome-wide cytosine methylation profiling with simultaneous copy number analysis and optimization for limited cell numbers. Nucleic Acids Res (2009) 1.80
An integrative genomic and epigenomic approach for the study of transcriptional regulation. PLoS One (2008) 1.76
Genome-wide epigenetic analysis delineates a biologically distinct immature acute leukemia with myeloid/T-lymphoid features. Blood (2009) 1.75
Genome-wide determination of DNA methylation by Hpa II tiny fragment enrichment by ligation-mediated PCR (HELP) for the study of acute leukemias. Methods Mol Biol (2009) 1.71
An analytical pipeline for genomic representations used for cytosine methylation studies. Bioinformatics (2008) 1.64
A pipeline for the quantitative analysis of CG dinucleotide methylation using mass spectrometry. Bioinformatics (2009) 1.42
Kaiso contributes to DNA methylation-dependent silencing of tumor suppressor genes in colon cancer cell lines. Cancer Res (2008) 1.36
Experimental intrauterine growth restriction induces alterations in DNA methylation and gene expression in pancreatic islets of rats. J Biol Chem (2010) 1.36
Toxoplasma gondii and Cryptosporidium parvum lack detectable DNA cytosine methylation. Eukaryot Cell (2008) 1.03
Meta-analysis of microarray studies reveals a novel hematopoietic progenitor cell signature and demonstrates feasibility of inter-platform data integration. PLoS One (2008) 0.96
The HELP assay. Methods Mol Biol (2009) 0.92
Lack of evidence for green tea polyphenols as DNA methylation inhibitors in murine prostate. Cancer Prev Res (Phila) (2009) 0.90
Distinct factors control histone variant H3.3 localization at specific genomic regions. Cell (2010) 8.79
Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences. Nature (2007) 7.91
DNA methylation signatures identify biologically distinct subtypes in acute myeloid leukemia. Cancer Cell (2010) 6.72
Comparative isoschizomer profiling of cytosine methylation: the HELP assay. Genome Res (2006) 5.99
MDS and secondary AML display unique patterns and abundance of aberrant DNA methylation. Blood (2009) 4.00
LINE-1 activity in facultative heterochromatin formation during X chromosome inactivation. Cell (2010) 3.70
Epigenomics: beyond CpG islands. Nat Rev Genet (2004) 3.21
CG dinucleotide clustering is a species-specific property of the genome. Nucleic Acids Res (2007) 2.48
Recommendations for the design and analysis of epigenome-wide association studies. Nat Methods (2013) 2.19
Cytosine methylation dysregulation in neonates following intrauterine growth restriction. PLoS One (2010) 2.10
Transcriptional signature with differential expression of BCL6 target genes accurately identifies BCL6-dependent diffuse large B cell lymphomas. Proc Natl Acad Sci U S A (2007) 2.06
Stem and progenitor cells in myelodysplastic syndromes show aberrant stage-specific expansion and harbor genetic and epigenetic alterations. Blood (2012) 1.98
Tissue-specific dysregulation of DNA methylation in aging. Aging Cell (2010) 1.90
High-resolution genome-wide cytosine methylation profiling with simultaneous copy number analysis and optimization for limited cell numbers. Nucleic Acids Res (2009) 1.80
DNA methylation signatures define molecular subtypes of diffuse large B-cell lymphoma. Blood (2010) 1.77
An integrative genomic and epigenomic approach for the study of transcriptional regulation. PLoS One (2008) 1.76
Genome-wide epigenetic analysis delineates a biologically distinct immature acute leukemia with myeloid/T-lymphoid features. Blood (2009) 1.75
Genome-wide determination of DNA methylation by Hpa II tiny fragment enrichment by ligation-mediated PCR (HELP) for the study of acute leukemias. Methods Mol Biol (2009) 1.71
Epigenetics: perceptive enzymes. Nature (2007) 1.71
Epigenomic modifications predict active promoters and gene structure in Toxoplasma gondii. PLoS Pathog (2007) 1.69
A stain upon the silence: genes escaping X inactivation. Trends Genet (2003) 1.65
An analytical pipeline for genomic representations used for cytosine methylation studies. Bioinformatics (2008) 1.64
The potential role of epigenomic dysregulation in complex human disease. Trends Genet (2007) 1.63
Genome-wide and locus-specific DNA hypomethylation in G9a deficient mouse embryonic stem cells. Genes Cells (2007) 1.52
Cytosine methylation changes in enhancer regions of core pro-fibrotic genes characterize kidney fibrosis development. Genome Biol (2013) 1.52
Repressor element-1 silencing transcription factor (REST)-dependent epigenetic remodeling is critical to ischemia-induced neuronal death. Proc Natl Acad Sci U S A (2012) 1.48
Redistribution of H3K27me3 upon DNA hypomethylation results in de-repression of Polycomb target genes. Genome Biol (2013) 1.47
Widespread hypomethylation occurs early and synergizes with gene amplification during esophageal carcinogenesis. PLoS Genet (2011) 1.47
A pipeline for the quantitative analysis of CG dinucleotide methylation using mass spectrometry. Bioinformatics (2009) 1.42
Mammalian linker-histone subtypes differentially affect gene expression in vivo. Proc Natl Acad Sci U S A (2003) 1.37
Kaiso contributes to DNA methylation-dependent silencing of tumor suppressor genes in colon cancer cell lines. Cancer Res (2008) 1.36
Experimental intrauterine growth restriction induces alterations in DNA methylation and gene expression in pancreatic islets of rats. J Biol Chem (2010) 1.36
Genomics: Encyclopaedia of humble DNA. Nature (2007) 1.35
Cell type-specific methylation profiles occurring disproportionately in CpG-less regions that delineate developmental similarity. Genes Cells (2007) 1.29
Comparative sequence and x-inactivation analyses of a domain of escape in human xp11.2 and the conserved segment in mouse. Genome Res (2004) 1.29
Optimized design and data analysis of tag-based cytosine methylation assays. Genome Biol (2010) 1.23
Reduced-representation methylation mapping. Genome Biol (2008) 1.07
Epigenetic functions of smchd1 repress gene clusters on the inactive X chromosome and on autosomes. Mol Cell Biol (2013) 1.07
Genomic organization of the genes Gtf2ird1, Gtf2i, and Ncf1 at the mouse chromosome 5 region syntenic to the human chromosome 7q11.23 Williams syndrome critical region. Genomics (2002) 1.05
Identification of a candidate regulatory region in the human CD8 gene complex by colocalization of DNase I hypersensitive sites and matrix attachment regions which bind SATB1 and GATA-3. J Immunol (2002) 1.05
Toxoplasma gondii and Cryptosporidium parvum lack detectable DNA cytosine methylation. Eukaryot Cell (2008) 1.03
DNA methylation alterations in multiple myeloma as a model for epigenetic changes in cancer. Wiley Interdiscip Rev Syst Biol Med (2010) 1.03
Introduction to epigenomics and epigenome-wide analysis. Methods Mol Biol (2010) 1.02
A new class of tissue-specifically methylated regions involving entire CpG islands in the mouse. Genes Cells (2007) 1.02
The Wasp System: an open source environment for managing and analyzing genomic data. Genomics (2012) 1.01
Epigenetic abnormalities associated with a chromosome 18(q21-q22) inversion and a Gilles de la Tourette syndrome phenotype. Proc Natl Acad Sci U S A (2003) 1.01
Genome-wide hydroxymethylation tested using the HELP-GT assay shows redistribution in cancer. Nucleic Acids Res (2013) 1.00
Late-replicating heterochromatin is characterized by decreased cytosine methylation in the human genome. Genome Res (2011) 0.99
Aberrant epigenetic and genetic marks are seen in myelodysplastic leukocytes and reveal Dock4 as a candidate pathogenic gene on chromosome 7q. J Biol Chem (2011) 0.97
CG dinucleotide periodicities recognized by the Dnmt3a-Dnmt3L complex are distinctive at retroelements and imprinted domains. Mamm Genome (2009) 0.93
Unusual characteristics of the DNA binding domain of epigenetic regulatory protein MeCP2 determine its binding specificity. Biochemistry (2014) 0.93
The HELP assay. Methods Mol Biol (2009) 0.92
Methylome profiling reveals distinct alterations in phenotypic and mutational subgroups of myeloproliferative neoplasms. Cancer Res (2012) 0.92
Differential epigenome-wide DNA methylation patterns in childhood obesity-associated asthma. Sci Rep (2013) 0.91
Lack of evidence for green tea polyphenols as DNA methylation inhibitors in murine prostate. Cancer Prev Res (Phila) (2009) 0.90
Homez, a homeobox leucine zipper gene specific to the vertebrate lineage. Proc Natl Acad Sci U S A (2003) 0.90
Epigenetic changes in B lymphocytes associated with house dust mite allergic asthma. Epigenetics (2011) 0.89
Post-conversion targeted capture of modified cytosines in mammalian and plant genomes. Nucleic Acids Res (2015) 0.89
HSC commitment-associated epigenetic signature is prognostic in acute myeloid leukemia. J Clin Invest (2014) 0.88
Epigenetic silencing of the circadian clock gene CRY1 is associated with an indolent clinical course in chronic lymphocytic leukemia. PLoS One (2012) 0.88
A blueprint for an international cancer epigenome consortium. A report from the AACR Cancer Epigenome Task Force. Cancer Res (2012) 0.87
Opposing roles of Dnmt1 in early- and late-stage murine prostate cancer. Mol Cell Biol (2010) 0.87
Phase II trial of the histone deacetylase inhibitor romidepsin in patients with recurrent/metastatic head and neck cancer. Oral Oncol (2012) 0.85
Genetic mapping of putative Chrna7 and Luzp2 neuronal transcriptional enhancers due to impact of a transgene-insertion and 6.8 Mb deletion in a mouse model of Prader-Willi and Angelman syndromes. BMC Genomics (2005) 0.85
Large, male germ cell-specific hypomethylated DNA domains with unique genomic and epigenomic features on the mouse X chromosome. DNA Res (2013) 0.83
Astrogenomics: big data, old problems, old solutions? Genome Biol (2013) 0.83
Automated computational analysis of genome-wide DNA methylation profiling data from HELP-tagging assays. Methods Mol Biol (2012) 0.82
How might epigenetic dysregulation in early embryonic life contribute to autism spectrum disorder? Epigenomics (2015) 0.81
DNA methylation changes in murine breast adenocarcinomas allow the identification of candidate genes for human breast carcinogenesis. Mamm Genome (2011) 0.80
The Einstein Genome Gateway using WASP - a high throughput multi-layered life sciences portal for XSEDE. Stud Health Technol Inform (2012) 0.80
MEN1 tumor-suppressor protein localizes to telomeres during meiosis. Genes Chromosomes Cancer (2002) 0.80
Predictive properties of DNA methylation patterns in primary tumor samples for osteosarcoma relapse status. Epigenetics (2015) 0.79
Genome-wide DNA methylation analysis using massively parallel sequencing technologies. Semin Hematol (2013) 0.77
Experimental approaches to the study of epigenomic dysregulation in ageing. Exp Gerontol (2010) 0.77
Maternal gametic transmission of translocations or inversions of human chromosome 11p15.5 results in regional DNA hypermethylation and downregulation of CDKN1C expression. Genomics (2011) 0.77
Convergent and divergent evolution of genomic imprinting in the marsupial Monodelphis domestica. BMC Genomics (2012) 0.77
Allele-specific transcriptional elongation regulates monoallelic expression of the IGF2BP1 gene. Epigenetics Chromatin (2011) 0.76
LINE-1 Activity in Facultative Heterochromatin Formation during X Chromosome Inactivation. Cell (2016) 0.75
The Einstein Center for Epigenomics: studying the role of epigenomic dysregulation in human disease. Epigenomics (2009) 0.75