Published in Epigenomics on December 01, 2012
Methylome-wide association study of schizophrenia: identifying blood biomarker signatures of environmental insults. JAMA Psychiatry (2014) 2.11
A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects. Hum Mol Genet (2013) 1.24
MethylPCA: a toolkit to control for confounders in methylome-wide association studies. BMC Bioinformatics (2013) 1.06
Testing two models describing how methylome-wide studies in blood are informative for psychiatric conditions. Epigenomics (2013) 0.94
BayMeth: improved DNA methylation quantification for affinity capture sequencing data using a flexible Bayesian approach. Genome Biol (2014) 0.93
High quality methylome-wide investigations through next-generation sequencing of DNA from a single archived dry blood spot. Epigenetics (2013) 0.91
Base resolution methylome profiling: considerations in platform selection, data preprocessing and analysis. Epigenomics (2015) 0.86
High density methylation QTL analysis in human blood via next-generation sequencing of the methylated genomic DNA fraction. Genome Biol (2015) 0.85
Evaluation of Methyl-Binding Domain Based Enrichment Approaches Revisited. PLoS One (2015) 0.85
Correcting for cell-type effects in DNA methylation studies: reference-based method outperforms latent variable approaches in empirical studies. Genome Biol (2017) 0.84
DNA methylation in peripheral tissue of schizophrenia and bipolar disorder: a systematic review. BMC Genet (2016) 0.82
Mining for viral fragments in methylation enriched sequencing data. Front Genet (2015) 0.81
Genome-wide methylome analyses reveal novel epigenetic regulation patterns in schizophrenia and bipolar disorder. Biomed Res Int (2015) 0.81
Profiling the genome-wide DNA methylation pattern of porcine ovaries using reduced representation bisulfite sequencing. Sci Rep (2016) 0.79
Refinement of schizophrenia GWAS loci using methylome-wide association data. Hum Genet (2014) 0.79
Methylome Analysis in Chickens Immunized with Infectious Laryngotracheitis Vaccine. PLoS One (2015) 0.78
A Whole Methylome CpG-SNP Association Study of Psychosis in Blood and Brain Tissue. Schizophr Bull (2015) 0.77
MethylAction: detecting differentially methylated regions that distinguish biological subtypes. Nucleic Acids Res (2015) 0.77
Combined Whole Methylome and Genomewide Association Study Implicates CNTN4 in Alcohol Use. Alcohol Clin Exp Res (2015) 0.76
Role of Epigenetics in Biology and Human Diseases. Iran Biomed J (2016) 0.75
Microfluidics for genome-wide studies involving next generation sequencing. Biomicrofluidics (2017) 0.75
Conserved effect of aging on DNA methylation and association with EZH2 polycomb protein in mice and humans. Mech Ageing Dev (2017) 0.75
Genome-Wide Epigenetic Studies in Human Disease: A Primer on -Omic Technologies. Am J Epidemiol (2015) 0.75
Genome-wide epigenomic profiling for biomarker discovery. Clin Epigenetics (2016) 0.75
A genome-wide search for eigenetically regulated genes in zebra finch using MethylCap-seq and RNA-seq. Sci Rep (2016) 0.75
Differential SLC1A2 Promoter Methylation in Bipolar Disorder With or Without Addiction. Front Cell Neurosci (2017) 0.75
Study on the Interaction of the CpG Alternating DNA with CdTe Quantum Dots. J Fluoresc (2017) 0.75
PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet (2007) 209.92
Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet (2006) 115.71
Model-based analysis of ChIP-Seq (MACS). Genome Biol (2008) 51.63
Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature (2009) 33.26
A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands. Proc Natl Acad Sci U S A (1992) 29.51
A Bayesian deconvolution strategy for immunoprecipitation-based DNA methylome analysis. Nat Biotechnol (2008) 21.72
The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores. Nat Genet (2009) 18.90
Singular value decomposition for genome-wide expression data processing and modeling. Proc Natl Acad Sci U S A (2000) 18.42
DNA methylation profiling of human chromosomes 6, 20 and 22. Nat Genet (2006) 18.08
Computation for ChIP-seq and RNA-seq studies. Nat Methods (2009) 16.11
Sequence and structural variation in a human genome uncovered by short-read, massively parallel ligation sequencing using two-base encoding. Genome Res (2009) 15.15
Molecular basis of base substitution hotspots in Escherichia coli. Nature (1978) 13.79
Principles and challenges of genomewide DNA methylation analysis. Nat Rev Genet (2010) 10.71
Phenotypic plasticity and the epigenetics of human disease. Nature (2007) 10.37
The power and the promise of DNA methylation markers. Nat Rev Cancer (2003) 9.32
Genome-wide association study identifies five new schizophrenia loci. Nat Genet (2011) 9.07
Epigenome-wide association studies for common human diseases. Nat Rev Genet (2011) 7.96
Aging and environmental exposures alter tissue-specific DNA methylation dependent upon CpG island context. PLoS Genet (2009) 7.07
Comparison of sequencing-based methods to profile DNA methylation and identification of monoallelic epigenetic modifications. Nat Biotechnol (2010) 7.00
Temporal and regional changes in DNA methylation in the embryonic, extraembryonic and germ cell lineages during mouse embryo development. Development (1987) 6.16
Genome-wide DNA methylation profiling using Infinium® assay. Epigenomics (2009) 6.08
Quantitative comparison of genome-wide DNA methylation mapping technologies. Nat Biotechnol (2010) 5.96
Genomic surveys by methylation-sensitive SNP analysis identify sequence-dependent allele-specific DNA methylation. Nat Genet (2008) 5.66
DNA methyltransferase Dnmt1 associates with histone deacetylase activity. Nat Genet (2000) 5.29
Molecular signals of epigenetic states. Science (2010) 4.81
The sva package for removing batch effects and other unwanted variation in high-throughput experiments. Bioinformatics (2012) 4.48
The DNA methylome of human peripheral blood mononuclear cells. PLoS Biol (2010) 4.25
Finding the fifth base: genome-wide sequencing of cytosine methylation. Genome Res (2009) 4.16
Epigenome-wide scans identify differentially methylated regions for age and age-related phenotypes in a healthy ageing population. PLoS Genet (2012) 4.05
Epigenetics as a unifying principle in the aetiology of complex traits and diseases. Nature (2010) 4.04
Epigenetic predictor of age. PLoS One (2011) 3.46
MBD-isolated Genome Sequencing provides a high-throughput and comprehensive survey of DNA methylation in the human genome. Nucleic Acids Res (2009) 3.29
Early nutrition, epigenetic changes at transposons and imprinted genes, and enhanced susceptibility to adult chronic diseases. Nutrition (2004) 3.08
Cancer immunology--analysis of host and tumor factors for personalized medicine. Nat Rev Clin Oncol (2011) 2.90
Computational analysis of genome-wide DNA methylation during the differentiation of human embryonic stem cells along the endodermal lineage. Genome Res (2010) 2.61
MEDME: an experimental and analytical methodology for the estimation of DNA methylation levels based on microarray derived MeDIP-enrichment. Genome Res (2008) 2.28
Inter-individual variation of DNA methylation and its implications for large-scale epigenome mapping. Nucleic Acids Res (2008) 2.19
Methylated DNA immunoprecipitation (MeDIP). Methods Mol Biol (2009) 2.17
Parental imprinting of autosomal mammalian genes. Curr Opin Genet Dev (1994) 2.14
Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder. Mol Psychiatry (2012) 2.09
Genomic methylation of peripheral blood leukocyte DNA: influences of arsenic and folate in Bangladeshi adults. Am J Clin Nutr (2007) 1.91
Are somatic cells inherently deficient in methylation metabolism? A proposed mechanism for DNA methylation loss, senescence and aging. Growth Dev Aging (1993) 1.84
Comparison of methyl-DNA immunoprecipitation (MeDIP) and methyl-CpG binding domain (MBD) protein capture for genome-wide DNA methylation analysis reveal CpG sequence coverage bias. Epigenetics (2011) 1.76
Epigenetics and cardiovascular disease. Nat Rev Cardiol (2010) 1.68
Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits. Circ Cardiovasc Genet (2012) 1.60
Epigenetic-aging-signature to determine age in different tissues. Aging (Albany NY) (2011) 1.55
Epigenetics and the environment. Ann N Y Acad Sci (2003) 1.47
The marks, mechanisms and memory of epigenetic states in mammals. Biochem J (2001) 1.43
Genome-wide DNA methylation profiles in hematopoietic stem and progenitor cells reveal overrepresentation of ETS transcription factor binding sites. Genome Res (2012) 1.37
High resolution detection and analysis of CpG dinucleotides methylation using MBD-Seq technology. PLoS One (2011) 1.35
Epigenetic mechanisms in systemic lupus erythematosus and other autoimmune diseases. Trends Mol Med (2011) 1.25
Diet and the epigenetic (re)programming of phenotypic differences in behavior. Brain Res (2008) 1.22
Estradiol down regulates the binding activity of an avian vitellogenin gene repressor (MDBP-2) and triggers a gradual demethylation of the mCpG pair of its DNA binding site. Nucleic Acids Res (1991) 1.21
Epigenetic alterations in aging. J Appl Physiol (1985) (2010) 1.20
Smoking and schizophrenia. Schizophr Res (1992) 1.18
Gene methylation patterns and expression. EXS (1993) 1.18
Differential repetitive DNA methylation in multiple myeloma molecular subgroups. Carcinogenesis (2009) 1.18
DNA methylation in repetitive elements and Alzheimer disease. Brain Behav Immun (2011) 1.15
BM-map: Bayesian mapping of multireads for next-generation sequencing data. Biometrics (2011) 1.11
Serum DNA can define tumor-specific genetic and epigenetic markers in gliomas of various grades. Neuro Oncol (2010) 1.01
Sexually dimorphic DNA demethylation in the promoter of the Slp (sex-limited protein) gene in mouse liver. Proc Natl Acad Sci U S A (1995) 1.01
Role of epigenetics in Alzheimer's and Parkinson's disease. Epigenomics (2010) 0.98
Methylome-wide comparison of human genomic DNA extracted from whole blood and from EBV-transformed lymphocyte cell lines. Eur J Hum Genet (2012) 0.96
DNA methylation profiling using HpaII tiny fragment enrichment by ligation-mediated PCR (HELP). Methods (2010) 0.94
Methylation induced gene silencing of HtrA3 in smoking-related lung cancer. Clin Cancer Res (2010) 0.93
Cellular epigenetic stability and cancer. Trends Genet (2012) 0.86
Methylation profile of DNA repetitive elements in human testicular germ cell tumor. Mol Carcinog (2011) 0.85
Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature (2009) 33.26
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
New models of collaboration in genome-wide association studies: the Genetic Association Information Network. Nat Genet (2007) 13.76
Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based study. Lancet (2009) 12.96
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet (2013) 8.02
Genome-wide association analysis identifies 13 new risk loci for schizophrenia. Nat Genet (2013) 7.44
Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence. N Engl J Med (2014) 6.89
A mega-analysis of genome-wide association studies for major depressive disorder. Mol Psychiatry (2012) 6.34
Microduplications of 16p11.2 are associated with schizophrenia. Nat Genet (2009) 6.13
Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs. Nat Genet (2012) 5.78
Synaptic, transcriptional and chromatin genes disrupted in autism. Nature (2014) 5.30
Genomewide association studies: history, rationale, and prospects for psychiatric disorders. Am J Psychiatry (2009) 4.74
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nat Genet (2012) 4.73
GWAS of 126,559 individuals identifies genetic variants associated with educational attainment. Science (2013) 4.71
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nat Genet (2012) 4.37
Autism and mental retardation among offspring born after in vitro fertilization. JAMA (2013) 4.28
Exome sequencing and the genetic basis of complex traits. Nat Genet (2012) 4.11
Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways. Diabetes (2010) 4.07
Identification of seven loci affecting mean telomere length and their association with disease. Nat Genet (2013) 3.87
The Swedish Twin Registry in the third millennium: an update. Twin Res Hum Genet (2006) 3.58
Discovery and statistical genotyping of copy-number variation from whole-exome sequencing depth. Am J Hum Genet (2012) 3.50
Combined genome scans for body stature in 6,602 European twins: evidence for common Caucasian loci. PLoS Genet (2007) 3.47
Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. Nat Genet (2010) 3.37
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet (2012) 3.21
Genome-wide association study of alcohol dependence. Arch Gen Psychiatry (2009) 3.08
Geographical structure and differential natural selection among North European populations. Genome Res (2009) 3.03
Prevalence, heritability, and prospective risk factors for anorexia nervosa. Arch Gen Psychiatry (2006) 3.02
A twin study of genetic and environmental influences on tobacco initiation, regular tobacco use and nicotine dependence. Psychol Med (2004) 2.98
A comprehensive family-based replication study of schizophrenia genes. JAMA Psychiatry (2013) 2.93
Common variants associated with plasma triglycerides and risk for coronary artery disease. Nat Genet (2013) 2.92
Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits. PLoS Genet (2013) 2.83
The risk of switch to mania in patients with bipolar disorder during treatment with an antidepressant alone and in combination with a mood stabilizer. Am J Psychiatry (2014) 2.82
Recurrence risks for schizophrenia in a Swedish national cohort. Psychol Med (2006) 2.75
Genome-wide association of major depression: description of samples for the GAIN Major Depressive Disorder Study: NTR and NESDA biobank projects. Eur J Hum Genet (2008) 2.75
Advancing paternal age and bipolar disorder. Arch Gen Psychiatry (2008) 2.56
A genomewide screen of 345 families for autism-susceptibility loci. Am J Hum Genet (2003) 2.51
Incidence of hospitalization for postpartum psychotic and bipolar episodes in women with and without prior prepregnancy or prenatal psychiatric hospitalizations. Arch Gen Psychiatry (2007) 2.50
Extremely low-coverage sequencing and imputation increases power for genome-wide association studies. Nat Genet (2012) 2.50
Association of body size and muscle strength with incidence of coronary heart disease and cerebrovascular diseases: a population-based cohort study of one million Swedish men. Int J Epidemiol (2008) 2.33
Strategies and issues in the detection of pathway enrichment in genome-wide association studies. Hum Genet (2009) 2.31
Genome-wide association study implicates chromosome 9q21.31 as a susceptibility locus for asthma in mexican children. PLoS Genet (2009) 2.27
Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. Nat Genet (2012) 2.12
Most reported genetic associations with general intelligence are probably false positives. Psychol Sci (2012) 2.10
Fertility of first-degree relatives of patients with schizophrenia: a three generation perspective. Schizophr Res (2007) 2.08
All SNPs are not created equal: genome-wide association studies reveal a consistent pattern of enrichment among functionally annotated SNPs. PLoS Genet (2013) 2.08
Evidence of soil nutrient availability as the proximate constraint on growth of treeline trees in northwest Alaska. Ecology (2015) 2.05
False discoveries and models for gene discovery. Trends Genet (2003) 2.03
The genetic architecture of economic and political preferences. Proc Natl Acad Sci U S A (2012) 1.89
zCall: a rare variant caller for array-based genotyping: genetics and population analysis. Bioinformatics (2012) 1.87
Genome-wide association study of suicide attempts in mood disorder patients. Am J Psychiatry (2010) 1.85
Meta-analysis of genome-wide association studies with overlapping subjects. Am J Hum Genet (2009) 1.83
Genetic and environmental contributions to abdominal aortic aneurysm development in a twin population. J Vasc Surg (2009) 1.80
Parental psychiatric disorders associated with autism spectrum disorders in the offspring. Pediatrics (2008) 1.77
Simulating association studies: a data-based resampling method for candidate regions or whole genome scans. Bioinformatics (2007) 1.77
Twins and the study of rater (dis)agreement. Psychol Methods (2007) 1.77
Family history of schizophrenia and bipolar disorder as risk factors for autism. Arch Gen Psychiatry (2012) 1.76
Advancing maternal age is associated with increasing risk for autism: a review and meta-analysis. J Am Acad Child Adolesc Psychiatry (2012) 1.73
A genome-wide association search for type 2 diabetes genes in African Americans. PLoS One (2012) 1.72
seeQTL: a searchable database for human eQTLs. Bioinformatics (2011) 1.72
Studying gene and gene-environment effects of uncommon and common variants on continuous traits: a marker-set approach using gene-trait similarity regression. Am J Hum Genet (2011) 1.71
Prenatal ultrasound scanning and the risk of schizophrenia and other psychoses. Epidemiology (2007) 1.71
The use of race variables in genetic studies of complex traits and the goal of reducing health disparities: a transdisciplinary perspective. Am Psychol (2005) 1.71
Familial confounding of the association between maternal smoking during pregnancy and offspring criminality: a population-based study in Sweden. Arch Gen Psychiatry (2010) 1.67
The Promises and Pitfalls of Genoeconomics* Annu Rev Econom (2012) 1.66
Does obesity modify the effect of blood pressure on the risk of cardiovascular disease? A population-based cohort study of more than one million Swedish men. Circulation (2008) 1.65
Estimation of SNP heritability from dense genotype data. Am J Hum Genet (2013) 1.64
MicroRNA expression profiling in the prefrontal cortex of individuals affected with schizophrenia and bipolar disorders. Schizophr Res (2010) 1.61
Advanced paternal and grandpaternal age and schizophrenia: a three-generation perspective. Schizophr Res (2011) 1.57
TAMAL: an integrated approach to choosing SNPs for genetic studies of human complex traits. Bioinformatics (2006) 1.57
Irritable bowel syndrome: a co-twin control analysis. Am J Gastroenterol (2007) 1.56
Gene × physical activity interactions in obesity: combined analysis of 111,421 individuals of European ancestry. PLoS Genet (2013) 1.51
A multi-dimensional evidence-based candidate gene prioritization approach for complex diseases-schizophrenia as a case. Bioinformatics (2009) 1.50
Chronic widespread pain and its comorbidities: a population-based study. Arch Intern Med (2006) 1.49
Enhanced neurocognitive functioning and positive temperament in twins discordant for bipolar disorder. Am J Psychiatry (2014) 1.48
Cigarettes and oral snuff use in Sweden: Prevalence and transitions. Addiction (2006) 1.48
Extensions to the modeling of initiation and progression: applications to substance use and abuse. Behav Genet (2006) 1.48
Population structure, migration, and diversifying selection in the Netherlands. Eur J Hum Genet (2013) 1.47
Medical and psychiatric morbidity in obese women with and without binge eating. Int J Eat Disord (2002) 1.46
Initiating therapy with antidepressants after discontinuation of hormone therapy. Menopause (2013) 1.43